Painful and painless constipation: All roads lead to (A change in) Rome
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Lubiprostone improved stool frequency and consistency as well as abdominal discomfort and bloating.
“Lubiprostone improved stool frequency and consistency as well as abdominal discomfort and bloating, which is a both-ersome symptom in some individuals with CIC. 60,61”
From American Gastroenterological Association-American College of Gastroenterology Clinical Practice Guideline: Pharmacological Management of Chronic Idiopathic Constipation (2023) · cites this paper as [61]
The main text (page unavailable) reports that some patients with IBS-C responded significantly better to lubiprostone than to placebo. It does not specify improvements in stool frequency, stool consistency, abdominal discomfort, or bloating, and it does not establish those outcomes for CIC. (LLM, conf=0.82)
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Cites
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Self-citationDifferences Between Painless and Painful Constipation Among Community Women
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Mechanisms, evaluation, and management of chronic constipation
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Self-citationConstipation and Fecal Incontinence in the Elderly
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Self-citationMore Movement with Evaluating Colonic Transit in Humans
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Constipation and Fecal Incontinence
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- Authors
- Bharucha, A. E., & Sharma, M.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Bharucha, Adil E.
- Venue
- Digestive Diseases and Sciences
- Published
- 2018-03-21
- Volume
- 63
- Issue
- 7
- Pages
- 1671-1674
- ISSN
- 0163-2116 (ISSN-L)
- 1573-2568
- PMC
- PMC6293467
- OpenAlex
- W2790017065
- Cited by
- 18
- References
- 12
- Citations by year
- 2025: 3 · 2024: 5 · 2023: 6 · 2020: 2 · 2019: 2
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Digestive Diseases and Sciences (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (DK078924)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK078924)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Rheumatology › Pelvic floor disorders treatments
- Health Sciences › Medicine › Surgery › Congenital gastrointestinal and neural anomalies
- Keywords
- constipation, Rome criteria, functional gastrointestinal disorders, irritable bowel syndrome with constipation
- MeSH terms
- Constipation, Humans, Pain, Irritable Bowel Syndrome
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