The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Coffee, Alcohol, and Artificial Sweeteners Have Temporal Associations with Gastrointestinal Symptoms
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Considering the evidence, while coffee may help protect against IBS in healthy individuals [100], in diagnosed patients, especially women, overweight individuals and those with IBS-C, it may precipitate and aggravate symptoms, particularly diarrhea and abdominal pain [101,102].”
From Natural Remedies for Irritable Bowel Syndrome: A Comprehensive Review of Herbal-Based Therapies (2025) · cites this paper as [101]
In the citing paper
“An analysis of 9710 symptom and dietary diaries showed that coffee, particularly caffeinated coffee, was acutely associated with episodes of diarrhea occurring within 1–2 h post-consumption; although decaffeinated coffee could also trigger symptoms, its effect was less pronounced [101].”
From Natural Remedies for Irritable Bowel Syndrome: A Comprehensive Review of Herbal-Based Therapies (2025) · cites this paper as [101]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
FRANCIS, C. Y., MORRIS, J., & WHORWELL, P. J. (1997) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.1997.142318000.x · Cited by 1,708
Böhn, L., Störsrud, S., Törnblom, H., Bengtsson, U., & Simrén, M. (2013) · American Journal of Gastroenterology · doi:10.1038/ajg.2013.105 · Cited by 655
Self-citationAkbar, A., Yiangou, Y., Facer, P., Walters, J. R. F., Anand, P., & Ghosh, S. (2008) · Gut · doi:10.1136/gut.2007.138982 · Cited by 526 · cited 1×
“However, pain can arise from stimulation by capsaicin found in red pepper [19 ].”
Ford, A. C., Lacy, B. E., Harris, L. A., Quigley, E. M. M., & Moayyedi, P. (2019) · American Journal of Gastroenterology · doi:10.1038/s41395-018-0222-5 · Cited by 467
Effect of alcohol consumption on the gut.
Bode, C., & Christian Bode, J. (2003) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/s1521-6918(03)00034-9 · Cited by 379
Wouters, M. M., Balemans, D., Van Wanrooy, S., Dooley, J., Cibert-Goton, V., Alpizar, Y. A., Valdez-Morales, E. E., Nasser, Y., Van Veldhoven, P. P., Vanbrabant, W., et al. (2016) · Gastroenterology · doi:10.1053/j.gastro.2015.12.034 · Cited by 372 · cited 1×
“Treatments include neuromodulators [7], antidiarrheals [8], prokinet-ics [9], antihistamines [10], psychological therapies such as hypnotherapy [11], and cognitive behavioral therapy [12] as well as several diets such as the NICE diet (NICE: UK National Institute for health and Care Excellence)…”
Local immune response to food antigens drives meal-induced abdominal pain
Aguilera-Lizarraga, J., Florens, M. V., Viola, M. F., Jain, P., Decraecker, L., Appeltans, I., Cuende-Estevez, M., Fabre, N., Van Beek, K., Perna, E., et al. (2021) · Nature · doi:10.1038/s41586-020-03118-2 · Cited by 311 · cited 1×
“The immune system plays a known role in the symptomatology of some patients [17], possibly triggered by food components such as milk, wheat, and/or soy proteins [18].”
Fritscher-Ravens, A., Pflaum, T., Mösinger, M., Ruchay, Z., Röcken, C., Milla, P. J., Das, M., Böttner, M., Wedel, T., & Schuppan, D. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.03.046 · Cited by 248
Work Productivity and Activity Impairment in Irritable Bowel Syndrome (IBS): A Multifaceted Problem
Frändemark, Å., Törnblom, H., Jakobsson, S., & Simrén, M. (2018) · American Journal of Gastroenterology · doi:10.1038/s41395-018-0262-x · Cited by 209
Self-citationChapman, R. W., Stanghellini, V, Geraint, M., & Halphen, M. (2013) · American Journal of Gastroenterology · doi:10.1038/ajg.2013.197 · Cited by 180
Research works printed but not linked: 28
- Lacy BE, Mearin F, Chang L, et al. Bowel disorders. Gastroenterology 2016; 150: 1393–1407.
- Sperber AD, Bangdiwala SI, Drossman DA, Ghoshal UC, Simren M, Tack J, et al. Worldwide Prevalence and Burden of Functional Gastrointestinal Disorders, Results of Rome Foundation Global Study. Gastroenterology. 2021;160(1):99–114.e3. · DOI · Paper page
- Cassar GE, Youssef GJ, Knowles S, Moulding R, Austin DW. Health-Related Quality of Life in Irritable Bowel Syndrome: A Systematic Review and Meta-analysis. Gastroenterol Nurs. 2020 May/Jun;43(3):E102-E122. · DOI
- Canavan C, West J, Card T. Review article: the economic impact of the irritable bowel syndrome. Aliment Pharmacol Ther. 2014;40(9):1023–34. · DOI · Paper page
- Efskind PS, Bernklev T, Vatn MH. A double-blind placebo-controlled trial with loperamide in irritable bowel syndrome. Scand J Gastroenterol. 1996;31(5):463–8. · DOI
- Bonnert M, Olén O, Lalouni M, Benninga MA, Bottai M, Engelbrektsson J, et al. Internet-Delivered Cognitive Behavior Therapy for Adolescents With Irritable Bowel Syndrome: A Randomized Controlled Trial. Am J Gastroenterol. 2017;112(1):152–162. · DOI
- Halmos EP, Power VA, Shepherd SJ, Gibson PR, Muir JG. A diet low in FODMAPs reduces symptoms of irritable bowel syndrome. Gastroenterology. 2014;146(1):67–75.e5. · DOI · Paper page
- Biesiekierski JR, Manning LP, Murray HB, Vlaeyen JWS, Ljótsson B, Van Oudenhove L. Review article: exclude or expose? The paradox of conceptually opposite treatments for irritable bowel syndrome. Aliment Pharmacol Ther. 2022;56(4):592–605. · DOI
- Harer KN, Eswaran SL. Irritable Bowel Syndrome: Food as a Friend or Foe? Gastroenterol Clin North Am. 2021;50(1):183–199. · DOI
- Murray K, Wilkinson-Smith V, Hoad C, Costigan C, Cox E, Lam C, et al. Differential effects of FODMAPs (fermentable oligo-, di-, mono-saccharides and polyols) on small and large intestinal contents in healthy subjects shown by MRI. Am J Gastroenterol. 2014;109(1):110–9. · DOI · Paper page
- Nilholm C, Larsson E, Sonestedt E, Roth B, Ohlsson B. Assessment of a 4-Week Starch- and Sucrose-Reduced Diet and Its Effects on Gastrointestinal Symptoms and Inflammatory Parameters among Patients with Irritable Bowel Syndrome. Nutrients. 2021;13(2):416. · DOI
- Paduano D, Cingolani A, Tanda E, Usai P. Effect of Three Diets (Low-FODMAP, Gluten-free and Balanced) on Irritable Bowel Syndrome Symptoms and Health-Related Quality of Life. Nutrients. 2019;11(7):1566. · DOI
- Clevers E, Nordqvist A, Törnblom H, Tack J, Masclee A, Keszthelyi D, et al. Food-symptom diaries can generate personalized lifestyle advice for managing gastrointestinal symptoms: A pilot study. Neurogastroenterol Motil. 2020;32(8):e13820. · DOI
- Casellas F, Aparici A, Casaus M, Rodríguez P, Malagelada JR. Subjective perception of lactose intolerance does not always indicate lactose malabsorption. Clin Gastroenterol Hepatol. 2010;8(7):581–6. · DOI
- O’Donnell LJ, Virjee J, Heaton KW. Detection of pseudodiarrhoea by simple clinical assessment of intestinal transit rate. BMJ. 1990;300(6722):439–40. · DOI
- McRorie JW Jr, McKeown NM. Understanding the Physics of Functional Fibers in the Gastrointestinal Tract: An Evidence-Based Approach to Resolving Enduring Misconceptions about Insoluble and Soluble Fiber. J Acad Nutr Diet. 2017;117(2):251–64. · DOI
- Shulpekova YO, Nechaev VM, Popova IR, et al. Food Intolerance: The Role of Histamine. Nutrients. 2021;13(9):3207. · DOI
- Hahn BA, Kirchdoerfer LJ, Fullerton S, Mayer E. Evaluation of a new quality of life questionnaire for patients with irritable bowel syndrome. Aliment Pharmacol Ther. 1997;11(3):547–52. · DOI
- Brown SR, Cann PA, Read NW. Effect of coffee on distal colon function. Gut. 1990;31(4):450–3. · DOI · Paper page
- Börger HW, Schafmayer A, Arnold R, Becker HD, Creutzfeldt W. [The influence of coffee and caffeine on gastrin and acid secretion in man (author’s transl)]. Dtsch Med Wochenschr. 1976;101(12):455–7.
- Rubach M, Lang R, Hofmann T, Somoza V. Time-dependent component-specific regulation of gastric acid secretion-related proteins by roasted coffee constituents. Ann N Y Acad Sci. 2008;1126:310–4. · DOI · Paper page
- Rajendram R, Preedy VR. Effect of alcohol consumption on the gut. Dig Dis. 2005;23(3–4):214–21. · DOI
- European Food Safety Authority (EFSA). Scientific Opinion on the re-evaluation of aspartame (E 951) as a food additive. EFSA Journal 2013;11(12):3496.
- Sathyapalan T, Thatcher NJ, Hammersley R, Rigby AS, Courts FL, Pechlivanis A, et al. Aspartame sensitivity? A double blind randomised crossover study. PLoS One. 2015;10(3):e0116212. · DOI
- Mendoza-Martínez VM, Zavala-Solares MR, Espinosa-Flores AJ, León-Barrera KL, Alcántara-Suárez R, Carrillo-Ruíz JD, et al. Is a Non-Caloric Sweetener-Free Diet Good to Treat Functional Gastrointestinal Disorder Symptoms? A Randomized Controlled Trial. Nutrients. 2022;14(5):1095. · DOI
- Uebanso T, Ohnishi A, Kitayama R, Yoshimoto A, Nakahashi M, Shimohata T, et al. Effects of Low-Dose Non-Caloric Sweetener Consumption on Gut Microbiota in Mice. Nutrients. 2017;9(6):560. · DOI
- Basson AR, Rodriguez-Palacios A, Cominelli F. Artificial Sweeteners: History and New Concepts on Inflammation. Front Nutr. 2021;8:746247. · DOI
- Black CJ, Staudacher HM, Ford AC. Efficacy of a low FODMAP diet in irritable bowel syndrome: systematic review and network meta-analysis. Gut. 2022;71(6):1117–26. · DOI · Paper page
Cited by
Natural Remedies for Irritable Bowel Syndrome: A Comprehensive Review of Herbal-Based Therapies
Abalo, R., Gallego-Barceló, P., & Gabbia, D. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26199345 · Cited by 5
Metadata
- Authors
- Clevers, E., Launders, D., Helme, D., Nybacka, S., Störsrud, S., Corsetti, M., Van Oudenhove, L., Simrén, M., & Tack, J.
- ORCID
- Clevers, Egbert
- Venue
- Digestive Diseases and Sciences
- Published
- 2024-04-25
- Volume
- 69
- Issue
- 7
- Pages
- 2522-2529
- ISSN
- 0163-2116
- 1573-2568
- Cited by
- 13
- References
- 14
- Language
- en
- Licence
- www.springernature.com/gp/researchers/text-and-data-mining (tdm)
- www.springernature.com/gp/researchers/text-and-data-mining (vor)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.