A Diet Low in FODMAPs Reduces Symptoms of Irritable Bowel Syndrome
Abstract
Background & aims A diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) often is used to manage functional gastrointestinal symptoms in patients with irritable bowel syndrome (IBS), yet there is limited evidence of its efficacy, compared with a normal Western diet. We investigated the effects of a diet low in FODMAPs compared with an Australian diet, in a randomized, controlled, single-blind, cross-over trial of patients with IBS. Methods In a study of 30 patients with IBS and 8 healthy individuals (controls, matched for demographics and diet), we collected dietary data from subjects for 1 habitual week. Participants then randomly were assigned to groups that received 21 days of either a diet low in FODMAPs or a typical Australian diet, followed by a washout period of at least 21 days, before crossing over to the alternate diet. Daily symptoms were rated using a 0- to 100-mm visual analogue scale. Almost all food was provided during the interventional diet periods, with a goal of less than 0.5 g intake of FODMAPs per meal for the low-FODMAP diet. All stools were collected from days 17-21 and assessed for frequency, weight, water content, and King's Stool Chart rating. Results Subjects with IBS had lower overall gastrointestinal symptom scores (22.8; 95% confidence interval, 16.7-28.8 mm) while on a diet low in FODMAPs, compared with the Australian diet (44.9; 95% confidence interval, 36.6-53.1 mm; P Conclusions In a controlled, cros…
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The minimum clinically important difference for VAS of GI symptoms is 10 mm.
“the minimum clinically important difference, the smallest difference in an outcome that can clinically improve patient management, has been recommended to be 10 mm for VAS of GI symptoms [30].”
Interventional studies showing the positive effects of treatments directed at gut microbiota also support the role of microbial alterations in IBD.
“Interventional studies showing the positive effects of treatments directed at gut microbiota also support the role of microbial alterations in IBD [57,58] .”
From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [58]
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- Authors
- Halmos, E. P., Power, V. A., Shepherd, S. J., Gibson, P. R., & Muir, J. G.
- Affiliations
- Eastern Health (AU)
- Corresponding author
- Halmos, Emma P.
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 146
- Issue
- 1
- Pages
- 67-75.e5
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2028507955
- Cited by
- 1,249
- References
- 32
- Citations by year
- 2026: 54 · 2025: 76 · 2024: 65 · 2023: 70 · 2022: 105 · 2021: 120 · 2020: 102 · 2019: 103 · 2018: 104 · 2017: 146 · 2016: 130 · 2015: 108 · 2014: 59 · 2013: 4 · 2012: 1
- FWCI
- 94.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Health and Medical Research Council
- Faculty of Medicine, Nursing and Health Sciences, Monash University
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Health Professions › Pharmacy › Infant Health and Development
- Keywords
- irritable bowel syndrome, low FODMAP diet, FODMAPs, functional gastrointestinal symptoms, bloating, abdominal pain, stool consistency, diarrhea-predominant irritable bowel syndrome, Western diet, dietary intervention, dietary adherence, IBS subtypes
- MeSH terms
- Adult, Disaccharides, Female, Fermentation, Humans, Male, Middle Aged, Monosaccharides, Oligosaccharides, Sugar Alcohols, Case-Control Studies, Single-Blind Method, Treatment Outcome, Cross-Over Studies, Irritable Bowel Syndrome, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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