The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.
Manufactured nanoparticles: their uptake and effects on fish—a mechanistic analysis
Abstract
There is an emerging literature reporting toxic effects of manufactured nanomaterials (NMs) and nanoparticles (NPs) in fish, but the mechanistic basis of both exposure and effect are poorly understood. This paper critically evaluates some of the founding assumptions in fish toxicology, and likely mechanisms of absorption, distribution, metabolism and excretion (ADME) of NPs in fish compared to other chemicals. Then, using a case study approach, the paper compares these assumptions for two different NPs; TiO2 and C60 fullerenes. Adsorption of NPs onto the gill surface will involve similar processes in the gill microenvironment and mucus layer to other substances, but the uptake mechanisms for NPs by epithelial cells are more likely to occur via vesicular processes (e.g., endocytosis) than uptake on membrane transporters or by diffusion through the cell membranes. Target organs may include the gills, gut, liver and sometimes the brain. Information on metabolism and excretion of NPs in fish is limited; but hepatic excretion into the bile seems a more likely mechanism, rather than mainly by renal or branchial excretion. TiO2 and C60 share some common chemical properties that appear to be associated with some similar toxic effects, but there are also differences, that highlight the notion that chemical reactivity can inform toxic effect of NPs in a fundamentally similar way to other chemicals. In this paper we identify many knowledge gaps including the lack of field observations on fish and other wildlife species for exposure and effects of manufactured NMs. Systematic studies of the abiotic factors that influence bioavailability, and investigation of the cell biology that informs on the mechanisms of metabolism and excretion of NMs, will greatly advance our understanding of the potential for adverse effects. There are also opportunities to apply existing tools and techniques to fundamental studies of fish toxicology with NPs, such as perfused organs and fish cell culture systems.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Mechanisms of translocation have been proposed for micro- and nanoplastic particles, including by vesicular processes, such as endocytosis19 by enterocytes.20”
From Microplastics and Anthropogenic Particles in Recreationally Caught Freshwater Fish from an Urbanized Region of the North American Great Lakes (2024) · cites this paper as [19]
Citations
Cites
Helical microtubules of graphitic carbon
Iijima, S. (1991) · Nature · doi:10.1038/354056a0 · Cited by 43,126
Kroto, H. W., Heath, J. R., O’Brien, S. C., Curl, R. F., & Smalley, R. E. (1985) · Nature · doi:10.1038/318162a0 · Cited by 16,169
The potential environmental impact of engineered nanomaterials
Colvin, V. L. (2003) · Nature Biotechnology · doi:10.1038/nbt875 · Cited by 2,161
Oberdörster, E. (2004) · Environmental Health Perspectives · doi:10.1289/ehp.7021 · Cited by 1,393
Do nanoparticles present ecotoxicological risks for the health of the aquatic environment?
Moore, M. N. (2006) · Environment International · doi:10.1016/j.envint.2006.06.014 · Cited by 1,255
Photophysical properties of sixty atom carbon molecule (C60)
Arbogast, J. W., Darmanyan, A. P., Foote, C. S., Diederich, F., Whetten, R. L., Rubin, Y. F., Alvarez, M. M., & Anz, S. J. (1991) · The Journal of Physical Chemistry · doi:10.1021/j100154a006 · Cited by 1,213
Particle Deposition and Aggregation: Measurement, Modelling and Simulation
Elimelech, M. (1995) · Cited by 1,190
Wang, J., Zhou, G.-D., Chen, C., YU, H., WANG, T., Ma, Y., JIA, G., Gao, Y., Li, B., & SUN, J. (2006) · Toxicology Letters · doi:10.1016/j.toxlet.2006.12.001 · Cited by 1,145
The Differential Cytotoxicity of Water-Soluble Fullerenes
Sayes, C. M., Fortner, J. D., Guo, W., Lyon, D. Y., Boyd, A. M., Ausman, K. D., Tao, Y. J., Sitharaman, B., Wilson, L. J., Hughes, J. B., et al. (2004) · Nano Letters · doi:10.1021/nl0489586 · Cited by 1,090
Pulskamp, K., Diabaté, S., & Krug, H. F. (2006) · Toxicology Letters · doi:10.1016/j.toxlet.2006.11.001 · Cited by 1,014
Cited by
Sorted by citations
Plastic and Human Health: A Micro Issue?
Wright, S. L., & Kelly, F. J. (2017) · Environmental Science & Technology · doi:10.1021/acs.est.7b00423 · Cited by 3,413
Bouwmeester, H., Hollman, P. C. H., & Peters, R. (2015) · Environmental Science & Technology · doi:10.1021/acs.est.5b01090 · Cited by 1,310
Ju‐Nam, Y., & Lead, J. R. (2008) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2008.06.042 · Cited by 1,067
Presence of microplastics and nanoplastics in food, with particular focus on seafood
(CONTAM), E. P. O. C. I. T. F. C. (2016) · EFSA Journal · doi:10.2903/j.efsa.2016.4501 · Cited by 958
Barboza, L. G. A., Lopes, C., Oliveira, P., Bessa, F., Otero, V., Henriques, B., Raimundo, J., Caetano, M., Vale, C., & Guilhermino, L. (2020) · Science of The Total Environment · doi:10.1016/j.scitotenv.2019.134625 · Cited by 951
Metadata
- Authors
- Handy, R. D., Henry, T. B., Scown, T. M., Johnston, B. D., & Tyler, C. R.
- Affiliations
- University of Plymouth (GB)
- University of Exeter (GB)
- Corresponding author
- Handy, Richard D.
- Venue
- Ecotoxicology
- Published
- 2008-04-12
- Volume
- 17
- Issue
- 5
- Pages
- 396-409
- ISSN
- 0963-9292 (ISSN-L)
- 1573-3017
- OpenAlex
- W2056008081
- Cited by
- 447
- References
- 71
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 18 · 2023: 26 · 2022: 20 · 2021: 42 · 2020: 27 · 2019: 25 · 2018: 28 · 2017: 27 · 2016: 28 · 2015: 26 · 2014: 30 · 2013: 23 · 2012: 31
- FWCI
- 16.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Ecotoxicology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Environmental Protection Agency
- Natural Environment Research Council (NE/E014496/1, NE/E014348/1)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Environmental Toxicology and Ecotoxicology
- Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Keywords
- engineered nanomaterials, nanoparticles, fish toxicology, nanoparticle uptake, ADME, titanium dioxide, C60, endocytosis, bioavailability, hepatic excretion, chemical reactivity, mechanistic toxicology, fish cell culture
- MeSH terms
- Animals, Fishes, Titanium, Ecosystem, Fullerenes, Nanotubes, Carbon, Nanoparticles
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
