Cited by 3,413Microplastics and Plastic PollutionPharmaceutical and Antibiotic Environmental ImpactsEnvironmental Toxicology and Ecotoxicology

Plastic and Human Health: A Micro Issue?

Wright, Stephanie L., Kelly, Frank J.·2017·Environmental Science & Technology

Abstract

Microplastics are a pollutant of environmental concern. Their presence in food destined for human consumption and in air samples has been reported. Thus, microplastic exposure via diet or inhalation could occur, the human health effects of which are unknown. The current review article draws upon cross-disciplinary scientific literature to discuss and evaluate the potential human health impacts of microplastics and outlines urgent areas for future research. Key literature up to September 2016 relating to accumulation, particle toxicity, and chemical and microbial contaminants was critically examined. Although microplastics and human health is an emerging field, complementary existing fields indicate potential particle, chemical and microbial hazards. If inhaled or ingested, microplastics may accumulate and exert localized particle toxicity by inducing or enhancing an immune response. Chemical toxicity could occur due to the localized leaching of component monomers, endogenous additives, and adsorbed environmental pollutants. Chronic exposure is anticipated to be of greater concern due to the accumulative effect that could occur. This is expected to be dose-dependent, and a robust evidence-base of exposure levels is currently lacking. Although there is potential for microplastics to impact human health, assessing current exposure levels and burdens is key. This information will guide future research into the potential mechanisms of toxicity and hence therein possible health effects.

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Crossref · 10.1021/acs.est.7b00423

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  • The impact on human health of the consumption of microplastics and nanoplastics is somewhat unclear, and the literature presents inconclusive and contradictory findings.

    “The impact on human health of the consumption of microplastics and nanoplastics is somewhat unclear as of yet [101]; the literature presents inconclusive and contradictory findings.”

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Authors
Wright, S. L., & Kelly, F. J.
Affiliations
King's College London (GB)
Corresponding author
Wright, Stephanie L.
Venue
Environmental Science & Technology
Published
2017-06-07
Volume
51
Issue
12
Pages
6634-6647
ISSN
  • 0013-936X (ISSN-L)
  • 1520-5851
OpenAlex
W2620099204
Cited by
3,413
References
163
Citations by year
2026: 471 · 2025: 579 · 2024: 556 · 2023: 466 · 2022: 470 · 2021: 370 · 2020: 267 · 2019: 143 · 2018: 74 · 2017: 17
FWCI
6.47
Type
journal article
Language
en
Open access
closed
Locations
  • Environmental Science & Technology (publishedVersion)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (submittedVersion)
Funders
Medical Research Council (MR/M501669/1)
Topics
  • Physical Sciences › Environmental Science › Pollution › Microplastics and Plastic Pollution
  • Physical Sciences › Environmental Science › Pollution › Pharmaceutical and Antibiotic Environmental Impacts
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Environmental Toxicology and Ecotoxicology
Keywords
microplastics, human health effects, dietary exposure, inhalation exposure, microplastic accumulation, particle toxicity, immune response, chemical leaching, long-term exposure, exposure assessment, food contamination, air pollution
MeSH terms
Environmental Health, Environmental Monitoring, Environmental Pollutants, Humans, Plastics, Water Pollutants, Chemical

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