The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Parkinson’s disease risk from ambient exposure to pesticides
Open accessAbstract
Due to the heavy and expanding agricultural use of neurotoxic pesticides suspected to affect dopaminergic neurons, it is imperative to closely examine the role of pesticides in the development of Parkinson’s disease (PD). We focus our investigation on pesticide use in California’s heavily agricultural central valley by utilizing a unique pesticide use reporting system. From 2001 to 2007, we enrolled 362 incident PD cases and 341 controls living in the Central Valley of California. Employing our geographic information system model, we estimated ambient exposures to the pesticides ziram, maneb, and paraquat at work places and residences from 1974 to 1999. At workplaces, combined exposure to ziram, maneb, and paraquat increased risk of PD three-fold (OR: 3.09; 95% CI: 1.69, 5.64) and combined exposure to ziram and paraquat, excluding maneb exposure, was associated with a 80% increase in risk (OR:1.82; 95% CI: 1.03, 3.21). Risk estimates for ambient workplace exposure were greater than for exposures at residences and were especially high for younger onset PD patients and when exposed in both locations. Our study is the first to implicate ziram in PD etiology. Combined ambient exposure to ziram and paraquat as well as combined ambient exposure to maneb and paraquat at both workplaces and residences increased PD risk substantially. Those exposed to ziram, maneb, and paraquat together experienced the greatest increase in PD risk. Our results suggest that pesticides affecting different mechanisms that contribute to dopaminergic neuron death may act together to increase the risk of PD considerably.
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1 retracted
Thiruchelvam, M., Prokopenko, O., Cory-Slechta, D., Richfield, E., Buckley, B., & Mirochnitchenko, O. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500417200 · Cited by 84
RetractedMcCormack, A. L., Thiruchelvam, M., Manning-Bog, A. B., Thiffault, C., Langston, J. W., Cory-Slechta, D. A., & Di Monte, D. A. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2002.0507 · Cited by 838
Pesticide use in developing countries
Ecobichon, D. J. (2001) · Toxicology · doi:10.1016/s0300-483x(00)00452-2 · Cited by 661
Epidemiology of parkinson’s disease
Tanner, C. M., & Goldman, S. M. (1996) · Neurologic Clinics · doi:10.1016/s0733-8619(05)70259-0 · Cited by 640
Public health impact of pesticides used in agriculture
Townson, H. (1992) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(92)90345-d · Cited by 639
Systematic review of incidence studies of Parkinson's disease
Twelves, D., Perkins, K. S. M., & Counsell, C. (2003) · Movement Disorders · doi:10.1002/mds.10305 · Cited by 622
Environmental risk factors and Parkinson's disease: A case‐control study in Taiwan
Liou, H. H., Tsai, M. C., Chen, C. J., Jeng, J. S., Chang, Y. C., Chen, S. Y., & Chen, R. C. (1997) · Neurology · doi:10.1212/wnl.48.6.1583 · Cited by 616
Costello, S., Cockburn, M., Bronstein, J., Zhang, X., & Ritz, B. (2009) · American Journal of Epidemiology · doi:10.1093/aje/kwp006 · Cited by 581
Self-citationEnvironmental Risk Factors and Parkinson's Disease: A Metaanalysis
Priyadarshi, A., Khuder, S. A., Schaub, E. A., & Priyadarshi, S. S. (2001) · Environmental Research · doi:10.1006/enrs.2001.4264 · Cited by 446
Pesticide exposure and risk for Parkinson's disease
Ascherio, A., Chen, H., Weisskopf, M. G., O'Reilly, E., McCullough, M. L., Calle, E. E., Schwarzschild, M. A., & Thun, M. J. (2006) · Annals of Neurology · doi:10.1002/ana.20904 · Cited by 445
Cited by
The Generation R Study: design and cohort update 2010
Jaddoe, V. W. V., van Duijn, C. M., van der Heijden, A. J., Mackenbach, J. P., Moll, H. A., Steegers, E. A. P., Tiemeier, H., Uitterlinden, A. G., Verhulst, F. C., & Hofman, A. (2010) · European Journal of Epidemiology · doi:10.1007/s10654-010-9516-7 · Cited by 1,027
Pesticides: an update of human exposure and toxicity
Mostafalou, S., & Abdollahi, M. (2017) · Archives of Toxicology · doi:10.1007/s00204-016-1849-x · Cited by 786
Chin-Chan, M., Navarro-Yepes, J., & Quintanilla-Vega, B. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00124 · Cited by 707
The Generation R Study: Design and cohort update 2012
Jaddoe, V. W. V., van Duijn, C. M., Franco, O. H., van der Heijden, A. J., van IIzendoorn, M. H., de Jongste, J. C., van der Lugt, A., Mackenbach, J. P., Moll, H. A., Raat, H., et al. (2012) · European Journal of Epidemiology · doi:10.1007/s10654-012-9735-1 · Cited by 546
Epidemiology of Parkinson's disease
Elbaz, A., Carcaillon, L., Kab, S., & Moisan, F. (2016) · Revue Neurologique · doi:10.1016/j.neurol.2015.09.012 · Cited by 445
Metadata
- Authors
- Wang, A., Costello, S., Cockburn, M., Zhang, X., Bronstein, J., & Ritz, B.
- Venue
- European Journal of Epidemiology
- Published
- 2011-04-20
- Volume
- 26
- Issue
- 7
- Pages
- 547-555
- ISSN
- 0393-2990 (ISSN-L)
- 1573-7284
- OpenAlex
- W2003263954
- Cited by
- 349
- References
- 35
- FWCI
- 31.24
- Type
- journal article
- Language
- en
- Open access
- green
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