Cited by 1,027Birth, Development, and HealthHealth, Environment, Cognitive AgingMaternal and Neonatal Healthcare

The Generation R Study: design and cohort update 2010

Open access
Jaddoe, Vincent W. V., van Duijn, Cock M., van der Heijden, Albert J., Mackenbach, Johan P., Moll, Henriëtte A., Steegers, Eric A. P., Tiemeier, Henning, Uitterlinden, Andre G. +2 more·2010·European Journal of Epidemiology

Abstract

The Generation R Study is a population-based prospective cohort study from fetal life until adulthood. The study is designed to identify early environmental and genetic causes and causal pathways leading to normal and abnormal growth, development and health from fetal life, childhood and young adulthood. This multidisciplinary study focuses on several health outcomes including behaviour and cognition, body composition, eye development, growth, hearing, heart and vascular development, infectious disease and immunity, oral health and facial growth, respiratory health, allergy and skin disorders of children and their parents. Main exposures of interest include environmental, endocrine, genomic (genetic, epigenetic, microbiome), lifestyle related, nutritional and socio-demographic determinants. In total, 9778 mothers with a delivery date from April 2002 until January 2006 were enrolled in the study. Response at baseline was 61%, and general follow-up rates until the age of 10 years were around 80%. Data collection in children and their parents includes questionnaires, interviews, detailed physical and ultrasound examinations, behavioural observations, lung function, Magnetic Resonance Imaging and biological sampling. Genome and epigenome wide association screens are available. Eventually, results from the Generation R Study contribute to the development of strategies for optimizing health and healthcare for pregnant women and children.

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  • Only recently sizeable multimodal normative brain developmental data have become available, with large prospective studies ongoing in Rotterdam, San Diego and Philadelphia.

    “The tools that we have for measuring brain functioning and connectivity are growing, but only recently sizeable multimodal normative brain developmental data have become available, with large prospective studies ongoing in Rotterdam (68), San Diego (69) and Philadelphia (70).”

    From Pediatric psychopharmacology: Too much or too little? (2013) · cites this paper as [68]

    The Study design > Overview and Study area sections identify Generation R as a prospective cohort in Rotterdam, and the postnatal assessments section reports brain ultrasound in a subgroup. But Measurements from the age of 5 years says detailed MRI studies were still being discussed and tested; this copy does not establish that sizeable multimodal normative brain data had already become available from the Rotterdam study. Page numbers are not provided in our copy. (LLM, conf=0.84)

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Authors
Jaddoe, V. W. V., van Duijn, C. M., van der Heijden, A. J., Mackenbach, J. P., Moll, H. A., Steegers, E. A. P., Tiemeier, H., Uitterlinden, A. G., Verhulst, F. C., & Hofman, A.
Affiliations
  • Erasmus MC (NL)
  • Erasmus MC - Sophia Children’s Hospital (NL)
Corresponding author
Jaddoe, Vincent W. V.
Venue
European Journal of Epidemiology
Published
2010-10-22
Volume
25
Issue
11
Pages
823-841
ISSN
  • 0393-2990 (ISSN-L)
  • 1573-7284
OpenAlex
W2157465110
Cited by
1,027
References
521
Citations by year
2026: 5 · 2025: 22 · 2024: 46 · 2023: 60 · 2022: 73 · 2021: 98 · 2020: 119 · 2019: 91 · 2018: 66 · 2017: 69 · 2016: 62 · 2015: 74 · 2014: 61 · 2013: 59 · 2012: 76
FWCI
51.31
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • European Journal of Epidemiology (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, other-oa)
  • RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, other-oa)
  • HAL (submittedVersion, other-oa)
  • RePub (Erasmus University Rotterdam) (submittedVersion)
  • Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion)
Funders
  • ZonMw (907.00303, ZonMw 90700303, 916.10159)
  • Erasmus Universiteit Rotterdam
  • Erasmus Medisch Centrum
  • Nederlandse Organisatie voor Wetenschappelijk Onderzoek (90700303, 916.10159)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
  • Health Sciences › Health Professions › General Health Professions › Maternal and Neonatal Healthcare
Keywords
Generation R Study, prospective cohort, prenatal exposure, fetal development, child growth, developmental origins of health and disease, epigenetics, microbiome, body composition, eye development, hearing, oral health, facial growth, respiratory health, allergy, skin diseases, genome-wide association study, cohort studies
MeSH terms
Adult, Child, Child Behavior, Child Development, Child, Preschool, Cognition, Environmental Exposure, Female, Health Status Indicators, Humans, Infant, Infant, Newborn, Interviews as Topic, Male, Maternal-Child Health Centers, Netherlands, Physical Examination, Pregnancy, Prenatal Care, Prospective Studies, Surveys and Questionnaires, Cohort Studies, Epidemiologic Research Design, Genetic Diseases, Inborn, Genome-Wide Association Study, Young Adult

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