The DOI matches its Crossref record; 88 of the 88 references it cites were found in a registry or an index.
A meta-analysis of prospective studies of coffee consumption and mortality for all causes, cancers and cardiovascular diseases
Abstract
Several prospective studies considered the relation between coffee consumption and mortality. Most studies, however, were underpowered to detect an association, since they included relatively few deaths. To obtain quantitative overall estimates, we combined all published data from prospective studies on the relation of coffee with mortality for all causes, all cancers, cardiovascular disease (CVD), coronary/ischemic heart disease (CHD/IHD) and stroke. A bibliography search, updated to January 2013, was carried out in PubMed and Embase to identify prospective observational studies providing quantitative estimates on mortality from all causes, cancer, CVD, CHD/IHD or stroke in relation to coffee consumption. A systematic review and meta-analysis was conducted to estimate overall relative risks (RR) and 95 % confidence intervals (CI) using random-effects models. The pooled RRs of all cause mortality for the study-specific highest versus low (≤1 cup/day) coffee drinking categories were 0.88 (95 % CI 0.84-0.93) based on all the 23 studies, and 0.87 (95 % CI 0.82-0.93) for the 19 smoking adjusting studies. The combined RRs for CVD mortality were 0.89 (95 % CI 0.77-1.02, 17 smoking adjusting studies) for the highest versus low drinking and 0.98 (95 % CI 0.95-1.00, 16 studies) for the increment of 1 cup/day. Compared with low drinking, the RRs for the highest consumption of coffee were 0.95 (95 % CI 0.78-1.15, 12 smoking adjusting studies) for CHD/IHD, 0.95 (95 % CI 0.70-1.29, 6 studies) for stroke, and 1.03 (95 % CI 0.97-1.10, 10 studies) for all cancers. This meta-analysis provides quantitative evidence that coffee intake is inversely related to all cause and, probably, CVD mortality.
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“one recent meta-analysis paper showed that heavy coffee consumption was not associated with risk of CVD mortality.20”
From Long-Term Coffee Consumption and Risk of Cardiovascular Disease: A Systematic Review and a Dose–Response Meta-Analysis of Prospective Cohort Studies (2014) · cites this paper as [20]
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“and the fact that studies included in these meta-analyses did not consider genetic variants associated with coffee drinking, such as CYP1A2, which is responsible for more than 95 % of caffeine metabolism, and consequently of the effects of caffeine and coffee consumption [80].”
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Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes
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“Moreover, a number of additional studies have been published since the publication of these meta-analyses, and 1 recent meta-analysis showed that heavy coffee consumption was not associated with risk of CVD mortality.(20) To examine the dose–response association of coffee consumption with CVD risk, we conducted a syst…”
Coffee, Caffeine, and Health Outcomes: An Umbrella Review
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The Rotterdam Study: 2016 objectives and design update
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Maternal obesity during pregnancy and cardiovascular development and disease in the offspring
Gaillard, R. (2015) · European Journal of Epidemiology · doi:10.1007/s10654-015-0085-7 · Cited by 322
Metadata
- Authors
- Malerba, S., Turati, F., Galeone, C., Pelucchi, C., Verga, F., La Vecchia, C., & Tavani, A.
- Affiliations
- Università Cattolica del Sacro Cuore (IT)
- Mario Negri Institute for Pharmacological Research (IT)
- University of Milan (IT)
- University of Turin (IT)
- Corresponding author
- Malerba, Stefano
- Venue
- European Journal of Epidemiology
- Published
- 2013-07
- Volume
- 28
- Issue
- 7
- Pages
- 527-539
- ISSN
- 0393-2990 (ISSN-L)
- 1573-7284
- OpenAlex
- W2109219983
- Cited by
- 119
- References
- 88
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 6 · 2023: 4 · 2022: 7 · 2021: 6 · 2020: 10 · 2019: 8 · 2018: 11 · 2017: 20 · 2016: 8 · 2015: 19 · 2014: 13 · 2013: 2
- FWCI
- 1.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Journal of Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fondazione Italiana per la Ricerca sul Cancro
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- coffee consumption, mortality, all-cause mortality, cancer mortality, cardiovascular mortality, coronary artery disease, ischemic heart disease, stroke, relative risk
- MeSH terms
- Cardiovascular Diseases, Cause of Death, Coffee, Humans, Mortality, Neoplasms, Prospective Studies, Risk Factors
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