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Maternal obesity during pregnancy and cardiovascular development and disease in the offspring
Open accessAbstract
Maternal obesity during pregnancy is an important public health problem in Western countries. Currently, obesity prevalence rates in pregnant women are estimated to be as high as 30%. In addition, approximately 40% of women gain an excessive amount of weight during pregnancy in Western countries. An accumulating body of evidence suggests a long-term impact of maternal obesity and excessive weight gain during pregnancy on adiposity, cardiovascular and metabolic related health outcomes in the offspring in fetal life, childhood and adulthood. In this review, we discuss results from recent studies, potential underlying mechanisms and challenges for future epidemiological studies.
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“In contrast, altered fetal programming in modern societies may be secondary to maternal overnutrition, sedentary behavior, obesity, emotional stress, circadian rhythm disruption, poor gut health or environmental chemical exposure [35,101,112,113].”
From Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment (2022) · cites this paper as [112]
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Metadata
- Authors
- Gaillard, R.
- Affiliations
- Erasmus MC (NL)
- Corresponding author
- Gaillard, Romy
- ORCID
- Gaillard, Romy
- Venue
- European Journal of Epidemiology
- Published
- 2015-09-16
- Volume
- 30
- Issue
- 11
- Pages
- 1141-1152
- ISSN
- 0393-2990 (ISSN-L)
- 1573-7284
- PMC
- PMC4684830
- OpenAlex
- W1679099184
- Cited by
- 322
- References
- 143
- Citations by year
- 2026: 21 · 2025: 27 · 2024: 24 · 2023: 37 · 2022: 55 · 2021: 32 · 2020: 35 · 2019: 25 · 2018: 29 · 2017: 17 · 2016: 16 · 2015: 2
- FWCI
- 3.25
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- European Journal of Epidemiology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, other-oa)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, other-oa)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- Funders
- European Commission (2007–2013, FP7 2007-2013, FP7/2007, 289346)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Keywords
- maternal obesity, pregnancy, excessive weight gain, cardiovascular disease, offspring adiposity, metabolic outcomes, fetal programming, childhood obesity, adult obesity
- MeSH terms
- Cardiovascular Diseases, Female, Humans, Mothers, Obesity, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Prenatal Exposure Delayed Effects, Risk Factors, Weight Gain, Body Mass Index, Fetal Development
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