Diabetes and Cardiovascular Disease: A Statement for Healthcare Professionals From the American Heart Association
Abstract
Background: According to several studies in population of high-income countries (HIC), patients with Type 2 diabetes mellitus (DM) have a considerably higher risk of cardiovascular morbidity and mortality.However, it is not clear if the magnitude of this association can be widespread in other populations.The objective of this study was to determine the independent association between Type 2 DM and first cardiovascular event in Colombian Caribbean poor population with no records of previous cardiovascular events reported.Methods: We retrospectively reviewed the individual records from the hospitalizations database of 64,668 patients of cardiovascular risk management program from July 2014 to December 2015.We used a propensity score matching cohort analysis for this study.The Kaplan-Meier curves were constructed for the cardiovascular events related endpoints and matched Cox-regression analysis to estimate associations of a history of Type 2 DM with cardiovascular outcomes during 1.5 years of follow-up.A formal sensitivity analysis using The Breslow-Day and Tarone Homogeneity tests was conducted.Results: Out of 56,351 patients with no previous cardiovascular events records, 19,368 (34.4%) patients were found to suffer Type 2 DM.Using propensity scores for Type 2 DM, we gathered a cohort of 18,449 pairs of patients with and without Type 2 DM who were balanced on 22 baseline characteristics.A first cardiovascular event occurred in 650 (3.5%) and 403 (2.1%) matched patients with a…
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Statin prescriptions also appeared among important predictors, consistent with their indication for patients with diabetes and cardiovascular risk factors whose greater clinical complexity increases the likelihood of experiencing acute events requiring emergency care.
“Statin prescriptions also appeared among important predictors, consistent with their indication for patients with diabetes and cardiovascular risk factors whose greater clinical complexity [86,87] increases the likelihood of experiencing acute events requiring emergency care [88–90].”
From Machine learning-driven risk prediction for post-hospitalization diabetes case management: Integrating clinical and social determinants of health (2026) · cites this paper as [87]
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Lee, S.-Y., Saleem, M., Land, A. M., DeLaney, E. W., Garretson, A. R., Patel, M., Hall, A. G., Westrick, S., Ovalle, F., Cherrington, A. L., et al. (2026) · International Journal of Medical Informatics · doi:10.1016/j.ijmedinf.2026.106604
- Authors
- Grundy, S. M., Benjamin, I. J., Burke, G. L., Chait, A., Eckel, R. H., Howard, B. V., Mitch, W., Smith, S. C., & Sowers, J. R.
- ORCID
- Venue
- Circulation
- Published
- 1999-09-07
- Volume
- 100
- Issue
- 10
- Pages
- 1134-1146
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2975364463
- Cited by
- 2,698
- References
- 15
- Citations by year
- 2026: 15 · 2025: 36 · 2024: 39 · 2023: 51 · 2022: 61 · 2021: 57 · 2020: 59 · 2019: 85 · 2018: 61 · 2017: 97 · 2016: 118 · 2015: 151 · 2014: 162 · 2013: 119 · 2012: 138
- FWCI
- 20.46
- Type
- journal article
- Language
- en
- Update notices
- correction (2000-04-04)
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- type 2 diabetes, cardiovascular disease, cardiovascular risk, myocardial infarction, stroke, cardiovascular mortality, all-cause mortality, cardiovascular hospitalization, low-income populations, cardiovascular risk stratification, cardiovascular risk education, cardiovascular risk management
- MeSH terms
- American Heart Association, Cardiovascular Diseases, Health Personnel, Humans, Risk Factors, Diabetes Complications
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