Cited by 334Birth, Development, and HealthGestational Diabetes Research and ManagementObesity, Physical Activity, Diet

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Maternal obesity during pregnancy and cardiovascular development and disease in the offspring

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Gaillard, Romy·2015·European Journal of Epidemiology

DOI 10.1007/s10654-015-0085-7PMC PMC4684830

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Abstract

Maternal obesity during pregnancy is an important public health problem in Western countries. Currently, obesity prevalence rates in pregnant women are estimated to be as high as 30%. In addition, approximately 40% of women gain an excessive amount of weight during pregnancy in Western countries. An accumulating body of evidence suggests a long-term impact of maternal obesity and excessive weight gain during pregnancy on adiposity, cardiovascular and metabolic related health outcomes in the offspring in fetal life, childhood and adulthood. In this review, we discuss results from recent studies, potential underlying mechanisms and challenges for future epidemiological studies.

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Fig. 1 Maternal obesity during pregnancy and offspring developmental adaptations (conceptual model for potential underlying mechanisms for the associations of maternal obesity during pregnancy with adverse cardiovascular and metabolic health outcomes in offspring)CC BY · PubMed Central

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Authors: Gaillard, R.
Affiliations: Erasmus MC (NL)
Corresponding author: Gaillard, Romy
ORCID: Gaillard, Romy
Venue: European Journal of Epidemiology
Publisher: Springer Science and Business Media LLC
Published: 2015-09-16
Volume: 30
Issue: 11
Pages: 1141-1152
ISSN: 0393-2990 (ISSN-L)
1573-7284
DOI: 10.1007/s10654-015-0085-7
PMC: PMC4684830
OpenAlex: W1679099184
Cited by: 322
References: 143
Citations by year: 2026: 21 · 2025: 27 · 2024: 24 · 2023: 37 · 2022: 55 · 2021: 32 · 2020: 35 · 2019: 25 · 2018: 29 · 2017: 17 · 2016: 16 · 2015: 2
FWCI: 3.25
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (unspecified)
Locations: European Journal of Epidemiology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, other-oa)
EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, other-oa)
RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
Funders: European Commission (2007–2013, FP7 2007-2013, FP7/2007, 289346)
Topics: Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
Keywords: maternal obesity, pregnancy, excessive weight gain, cardiovascular disease, offspring adiposity, metabolic outcomes, fetal programming, childhood obesity, adult obesity
MeSH terms: Cardiovascular Diseases, Female, Humans, Mothers, Obesity, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Prenatal Exposure Delayed Effects, Risk Factors, Weight Gain, Body Mass Index, Fetal Development

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Maternal obesity during pregnancy and cardiovascular development and disease in the offspring

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