Cited by 164DNA Repair MechanismsGenetic factors in colorectal cancerNonmelanoma Skin Cancer Studies

The DOI matches its Crossref record; 125 of the 125 references it cites were found in a registry or an index.

Nucleotide excision repair and cancer

Leibeling, Diana, Laspe, Petra, Emmert, Steffen·2006·Journal of Molecular Histology

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Abstract

Nucleotide excision repair (NER) is the most versatile and best studied DNA repair system in humans. NER can repair a variety of bulky DNA damages including UV-light induced DNA photoproducts. NER consists of a multistep process in which the DNA lesion is recognized and demarcated by DNA unwinding. Then, an approximately 28 bp DNA damage containing oligonucleotide is excised followed by gap filling using the undamaged DNA strand as a template. The consequences of defective NER are demonstrated by three rare autosomal-recessive NER-defective syndromes: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). XP patients show severe sun sensitivity, freckling in sun exposed skin, and develop skin cancers already during childhood. CS patients exhibit sun sensitivity, severe neurologic abnormalities, and cachectic dwarfism. Clinical symptoms of TTD patients include sun sensitivity, freckling in sun exposed skin areas, and brittle sulfur-deficient hair. In contrast to XP patients, CS and TTD patients are not skin cancer prone. Studying these syndromes can increase the knowledge of skin cancer development including cutaneous melanoma as well as basal and squamous cell carcinoma in general that may lead to new preventional and therapeutic anticancer strategies in the normal population.

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4 retracted

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Authors: Leibeling, D., Laspe, P., & Emmert, S.
Affiliations: University of Göttingen (DE)
Corresponding author: Emmert, Steffen
ORCID: Emmert, Steffen
Venue: Journal of Molecular Histology
Publisher: Springer Science and Business Media LLC
Published: 2006-07-20
Volume: 37
Issue: 5-7
Pages: 225-238
ISSN: 1567-2379 (ISSN-L)
1567-2387
DOI: 10.1007/s10735-006-9041-x
OpenAlex: W2140447069
Cited by: 164
References: 124
Citations by year: 2026: 1 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 9 · 2019: 6 · 2018: 12 · 2017: 5 · 2016: 8 · 2015: 8 · 2014: 9 · 2013: 15 · 2012: 13
FWCI: 0.95
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Journal of Molecular Histology (publishedVersion)
PubMed (publishedVersion)
GRO (submittedVersion)
Funders: Deutsche Forschungsgemeinschaft
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
Health Sciences › Medicine › Dermatology › Nonmelanoma Skin Cancer Studies
Keywords: nucleotide excision repair, DNA repair, xeroderma pigmentosum, Cockayne syndrome, trichothiodystrophy, UV-induced DNA damage, DNA photoproducts, skin cancer, cutaneous melanoma, basal cell carcinoma, squamous cell carcinoma, sun sensitivity, DNA damage recognition, gap filling
MeSH terms: Cockayne Syndrome, DNA Repair, Hair Diseases, Humans, Neoplasms, Syndrome, Xeroderma Pigmentosum

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