Cited by 164DNA Repair MechanismsGenetic factors in colorectal cancerNonmelanoma Skin Cancer Studies

The DOI matches its Crossref record; 125 of the 125 references it cites were found in a registry or an index.

Nucleotide excision repair and cancer

Leibeling, Diana, Laspe, Petra, Emmert, Steffen·2006·Journal of Molecular Histology

Open this paper in CoChat — free account

Abstract

Nucleotide excision repair (NER) is the most versatile and best studied DNA repair system in humans. NER can repair a variety of bulky DNA damages including UV-light induced DNA photoproducts. NER consists of a multistep process in which the DNA lesion is recognized and demarcated by DNA unwinding. Then, an approximately 28 bp DNA damage containing oligonucleotide is excised followed by gap filling using the undamaged DNA strand as a template. The consequences of defective NER are demonstrated by three rare autosomal-recessive NER-defective syndromes: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). XP patients show severe sun sensitivity, freckling in sun exposed skin, and develop skin cancers already during childhood. CS patients exhibit sun sensitivity, severe neurologic abnormalities, and cachectic dwarfism. Clinical symptoms of TTD patients include sun sensitivity, freckling in sun exposed skin areas, and brittle sulfur-deficient hair. In contrast to XP patients, CS and TTD patients are not skin cancer prone. Studying these syndromes can increase the knowledge of skin cancer development including cutaneous melanoma as well as basal and squamous cell carcinoma in general that may lead to new preventional and therapeutic anticancer strategies in the normal population.

Integrity signals

Registry

Crossref · 10.1007/s10735-006-9041-x

Cites

125 of 125 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

4 retracted

Defective Transcription-Coupled Repair of Oxidative Base Damage in Cockayne Syndrome Patients from XP Group G
Cooper, P. K., Nouspikel, T. P., Clarkson, S. G., & Leadon, S. A. (1997) · Science · doi:10.1126/science.275.5302.990 · Cited by 306
Retracted
RETRACTED: Transcription-Coupled Repair of 8-oxoGuanine
Page, F. L., Kwoh, E. E., Avrutskaya, A. V., Gentil, A., Leadon, S. A., Sarasin, A. R., & Cooper, P. K. (2000) · Cell · doi:10.1016/s0092-8674(00)80827-2 · Cited by 280
Retracted
Transcription-Coupled Repair of 8-oxoguanine: Requirement for XPG, TFIIH, and CSB and Implications for Cockayne Syndrome
Page, F. L., Kwoh, E. E., Avrutskaya, A. V., Gentil, A., Leadon, S. A., Sarasin, A. R., & Cooper, P. K. (2005) · Cell · doi:10.1016/j.cell.2005.11.005 · Cited by 271
Retracted
RETRACTED: A common mutational pattern in Cockayne syndrome patients from xeroderma pigmentosum group G: Implications for a second XPG function
Nouspikel, T., Lalle, P., Leadon, S. A., Cooper, P. K., & Clarkson, S. G. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.7.3116 · Cited by 163
Retracted
Genome maintenance mechanisms for preventing cancer
Hoeijmakers, J. H. J. (2001) · Nature · doi:10.1038/35077232 · Cited by 3,939
Human DNA Repair Genes
Wood, R., Mitchell, M., Sgouros, J., & Lindahl, T. (2001) · Science · doi:10.1126/science.1056154 · Cited by 1,719
Quality Control by DNA Repair
Lindahl, T. L., & Wood, R. D. (1999) · Science · doi:10.1126/science.286.5446.1897 · Cited by 1,521
The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase η
Masutani, C., Kusumoto, R., Yamada, A., Dohmae, N., Yokoi, M., Yuasa, M., Araki, M., Iwai, S., Takio, K., & Hanaoka, F. (1999) · Nature · doi:10.1038/21447 · Cited by 1,292
Xeroderma Pigmentosum
Kraemer, K. H. (1987) · Archives of Dermatology · doi:10.1001/archderm.123.2.241 · Cited by 1,216
Cockayne syndrome: Review of 140 cases
Nance, M. A., & Berry, S. A. (1992) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320420115 · Cited by 806
Xeroderma Pigmentosum
Robbins, J. H., Kraemer, K. H., Lutzner, M. A., Festoff, B. W., & COON, H. G. (1974) · Annals of Internal Medicine · doi:10.7326/0003-4819-80-2-221 · Cited by 748
hRAD30 Mutations in the Variant Form of Xeroderma Pigmentosum
Johnson, R. E., Kondratick, C. M., Prakash, S., & Prakash, L. (1999) · Science · doi:10.1126/science.285.5425.263 · Cited by 732
The Genetic Basis of Human Cancer
Michels, V. V. (1999) · Mayo Clinic Proceedings · doi:10.4065/74.1.107-a · Cited by 729
Nucleotide excision repair and human syndromes
de Boer, J., & Hoeijmakers, J. H. J. (2000) · Carcinogenesis · doi:10.1093/carcin/21.3.453 · Cited by 674
THE BIOLOGY OF THE (6–4) PHOTOPRODUCT
MITCHELL, D. L., & NAIRN, R. S. (1989) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1989.tb05578.x · Cited by 592
Replicative Senescence: Implications for in Vivo Aging and Tumor Suppression
Smith, J. R., & Pereira-Smith, O. M. (1996) · Science · doi:10.1126/science.273.5271.63 · Cited by 547
A Review of Sunscreen Safety and Efficacy
Gasparro, F. P., Mitchnick, M. A., & Nash, J. F. (1998) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1998.tb09677.x · Cited by 434
Xeroderma pigmentosum variant (XP‐V) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activity
Masutani, C., Araki, M., Yamada, A., Kusumoto, R., Nogimori, T., Maekawa, T., Iwai, S., & Hanaoka, F. (1999) · The EMBO Journal · doi:10.1093/emboj/18.12.3491 · Cited by 434
DNA repair and aging in basal cell carcinoma: a molecular epidemiology study.
Wei, Q., Matanoski, G. M., Farmer, E. R., Hedayati, M. A., & Grossman, L. I. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.4.1614 · Cited by 409
Effect of topically applied T4 endonuclease V in liposomes on skin cancer in xeroderma pigmentosum: a randomised study
Yarosh, D., Klein, J., O'Connor, A., Hawk, J., Rafal, E., & Wolf, P. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04214-8 · Cited by 390
The xeroderma pigmentosum group D (XPD) gene: one gene, two functions, three diseasesPreprint
Lehmann, A. R. (2001) · Genes & Development · doi:10.1101/gad.859501 · Cited by 370
In vitro repair of oxidative DNA damage by human nucleotide excision repair system: Possible explanation for neurodegeneration in Xeroderma pigmentosum patients
Reardon, J. T., Bessho, T., Kung, H. C., Bolton, P. H., & Sancar, A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.17.9463 · Cited by 366
Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair
Takebayashi, Y., Pourquier, P., Zimonjic, D. B., Nakayama, K., Emmert, S., Ueda, T., Urasaki, Y., Kanzaki, A., Akiyama, S., Popescu, N. C., et al. (2001) · Nature Medicine · doi:10.1038/91008 · Cited by 357
Self-citation
A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A
Giglia‐Mari, G., Coin, F., Ranish, J. A., Hoogstraten, D., Theil, A. F., Wijgers, N., Jaspers, N. G. J., Raams, A., Argentini, M., van der Spek, P. J., et al. (2004) · Nature Genetics · doi:10.1038/ng1387 · Cited by 334
Xeroderma Pigmentosum Complementation Group C Cells Remove Pyrimidine Dimers Selectively from the Transcribed Strand of Active Genes
Venema, J., van Hoffen, A., Karcagi, V., Natarajan, A. T., van Zeeland, A. A., & Mullenders, L. H. F. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.8.4128 · Cited by 319
Defective repair of cisplatin-induced DNA damage caused by reduced XPA protein in testicular germ cell tumours
Köberle, B., Masters, J. R., Hartley, J. A., & Wood, R. D. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80118-3 · Cited by 302
Reduced DNA repair capacity in lung cancer patients.
Wei, Q., Cheng, L., Hong, W. K., & Spitz, M. R. (1996) · PubMed · Cited by 299
Enzyme plus light therapy to repair DNA damage in ultraviolet-B-irradiated human skin
Stege, H., Roza, L., Vink, A. A., Grewe, M., Ruzicka, T., Grether-Beck, S., & Krutmann, J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.030528897 · Cited by 292
Trichothiodystrophy: Update on the sulfur-deficient brittle hair syndromes
Itin, P. H., Sarasin, A. R., & Pittelkow, M. R. (2001) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2001.114294 · Cited by 292
Base Excision Repair of Oxidative DNA Damage Activated by XPG Protein
Klungland, A., Höss, M., Gunz, D., Constantinou, A., Clarkson, S. G., Doetsch, P. W., Bolton, P. H., Wood, R. D., & Lindahl, T. L. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80172-0 · Cited by 291
Unified catalytic mechanism for DNA glycosylases
Dodson, M. L., Michaels, M. L., & Lloyd, R. S. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)30047-8 · Cited by 268
DNA damage recognition during nucleotide excision repair in mammalian cells
Wood, R. D. (1999) · Biochimie · doi:10.1016/s0300-9084(99)80036-4 · Cited by 264
Modulation of repair of ultraviolet damage in the host-cell reactivation assay by polymorphic XPC and XPD/ERCC2 genotypes
Qiao, Y., Spitz, M. R., Shen, H., Guo, Z., Shete, S. S., Hedayati, M. A., Grossman, L. I., Mohrenweiser, H. W., & Wei, Q. (2002) · Carcinogenesis · doi:10.1093/carcin/23.2.295 · Cited by 263
Xeroderma pigmentosum and trichothiodystrophy are associated with different mutations in the XPD ( ERCC 2) repair/transcription gene
Taylor, E. M., Broughton, B. C., Botta, E., Stefanini, M., Sarasin, A. R., Jaspers, N. G. J., Fawcett, H., Harcourt, S. A., Arlett, C. F., & Lehmann, A. R. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.16.8658 · Cited by 262
Opening of an RNA polymerase II promoter occurs in two distinct steps and requires the basal transcription factors IIE and IIH.
Holstege, F. C. P., van der Vliet, P. C., & Timmers, H. T. M. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00512.x · Cited by 257
Cockayne syndrome and xeroderma pigmentosum
Rapin, I., Lindenbaum, Y., Dickson, D. W., Kraemer, K. H., & Robbins, J. H. (2000) · Neurology · doi:10.1212/wnl.55.10.1442 · Cited by 255
DNA mismatch repair and mutation avoidance pathways
Marti, T. M., Kunz, C., & Fleck, O. (2002) · Journal of Cellular Physiology · doi:10.1002/jcp.10077 · Cited by 253
Xeroderma Pigmentosum: Variants with Normal Dna Repair and Normal Sensitivity to Ultraviolet Light
Cleaver, J. E. (1972) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12538913 · Cited by 245
Nucleotide excision repair: From E. coli to man
Petit, C. R., & Sancar, A. (1999) · Biochimie · doi:10.1016/s0300-9084(99)80034-0 · Cited by 237
Engagement with transcription
Bootsma, D., & Hoeijmakers, J. H. J. (1993) · Nature · doi:10.1038/363114a0 · Cited by 229
On diseases of the skin, including the exanthemata
Hebra, F., Kaposi, M., Fagge, C. H., Pye-Smith, P. H., & Tay, W. K. (1866) · Medical Entomology and Zoology · Cited by 228
Photocarcinogenesis: Mechanisms, Models and Human Health Implications: Introduction
Mukhtar, H., & Elmets, C. A. (1996) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1996.tb03040.x · Cited by 219
Characterization of a human DNA damage binding protein implicated in xeroderma pigmentosum E.
Keeney, S., Chang, G. J., & Linn, S. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36923-6 · Cited by 213
Xeroderma pigmentosum and the role of UV-induced DNA damage in skin cancer
STEEG, H. V., & Kraemer, K. H. (1999) · Molecular Medicine Today · doi:10.1016/s1357-4310(98)01394-x · Cited by 212
Restoration of ultraviolet-induced unscheduled DNA synthesis of xeroderma pigmentosum cells by the concomitant treatment with bacteriophage T4 endonuclease V and HVJ (Sendai virus).
Tanaka, K., Sekiguchi, M., & Okada, Y. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.10.4071 · Cited by 209
Purification and interaction properties of the human RNA polymerase B(II) general transcription factor BTF2.
Gérard, M., Fischer, L., Moncollin, V., Chipoulet, J.-M., Chambon, P., & Egly, J. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54801-8 · Cited by 200
Trichothiodystrophy: sulfur-deficient brittle hair as a marker for a neuroectodermal symptom complex
Price, V. H. (1980) · Archives of Dermatology · doi:10.1001/archderm.116.12.1375 · Cited by 199
Reduced DNA repair capacity in head and neck cancer patients.
Cheng, L., Eicher, S. A., Guo, Z., Hong, W. K., Spitz, M. R., & Wei, Q. (1998) · PubMed · Cited by 192
Polymorphisms in the DNA repair gene XPD: correlations with risk and age at onset of basal cell carcinoma.
Dybdahl, M., Vogel, U. B., FRENTZ, G., Wallin, H., & Nexø, B. A. (1999) · PubMed · Cited by 182
Three complementation groups in Cockayne syndrome
Lehmann, A. R. (1982) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(82)90115-4 · Cited by 176
Molecular analysis of mutations in DNA polymerase η in xeroderma pigmentosum-variant patients
Broughton, B. C., Cordonnier, A. M., Kleijer, W. J., Jaspers, N. G. J., Fawcett, H., Raams, A., Garritsen, V. H., Stary, A., Avril, M., Boudsocq, F., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.022473899 · Cited by 176
XPA polymorphism associated with reduced lung cancer risk and a modulating effect on nucleotide excision repair capacity
Wu, X. (2003) · Carcinogenesis · doi:10.1093/carcin/24.3.505 · Cited by 175
A mutation in the XPB/ERCC3 DNA repair transcription gene, associated with trichothiodystrophy.
Weeda, G., Eveno, E., Donker, I., Vermeulen, W., Chevallier, O., Taı̈eb, A., Stary, A., Hoeijmakers, J. H. J., Mezzina, M., & Sarasin, A. R. (1997) · Europe PMC (PubMed Central) · Cited by 169
The human XPC DNA repair gene: arrangement, splice site information content and influence of a single nucleotide polymorphism in a splice acceptor site on alternative splicing and function
Khan, S. G. (2002) · Nucleic Acids Research · doi:10.1093/nar/gkf469 · Cited by 163
Cockayne Syndrome Group B Cellular and Biochemical Functions
Licht, C. L., Stevnsner, T., & Bohr, V. A. (2003) · The American Journal of Human Genetics · doi:10.1086/380399 · Cited by 161
Molecular Analysis of Mutations in the CSB(ERCC6) Gene in Patients with Cockayne Syndrome
Mallery, D. L., Tanganelli, B., Colella, S., Steingrimsdottir, H., van Gool, A. J., Troelstra, C., Stefanini, M., & Lehmann, A. R. (1998) · The American Journal of Human Genetics · doi:10.1086/301686 · Cited by 161
Pyrimidine dimer removal enhanced by DNA repair liposomes reduces the incidence of UV skin cancer in mice.
Yarosh, D. B., Alas, L., Yee, V., Oberyszyn, T. M., Kibitel, J. T., Mitchell, D. L., Rosenstein, R. B., Spinowitz, A. L., & Citron, M. L. (1992) · PubMed · Cited by 152
Repair of UV Light-Induced DNA Damage and Risk of Cutaneous Malignant Melanoma
Wei, Q., Lee, J. E., Gershenwald, J. E., Ross, M. I., Mansfield, P. F., Strom, S. S., Wang, L., Guo, Z., Qiao, Y., Amos, C. I., et al. (2003) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/95.4.308 · Cited by 148
Nucleotide excision repair gene XPD polymorphisms and genetic predisposition to melanoma
Tomescu, D. (2001) · Carcinogenesis · doi:10.1093/carcin/22.3.403 · Cited by 145
Three Unusual Repair Deficiencies Associated with Transcription Factor BTF2(TFIIH): Evidence for the Existence of a Transcription SyndromePreprint
Vermeulen, W., van Vuuren, A. J., Chipoulet, M., Schaeffer, L., Appeldoorn, E., Weeda, G., Jaspers, N. G. J., Priestley, A., Arlett, C. F., Lehmann, A. R., et al. (1994) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1994.059.01.036 · Cited by 143
Localization of Liposomes Containing a DNA Repair Enzyme in Murine Skin
Yarosh, D., Bucana, C., Cox, P. A. T., Alas, L., Kibitel, J., & Kripke, M. (1994) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12395551 · Cited by 142
X-Ray Structure of T4 Endonuclease V: an Excision Repair Enzyme Specific for a Pyrimidine Dimer
Morikawa, K., Matsumoto, O., Tsujimoto, M., Katayanagi, K., Ariyoshi, M., Doi, T., Ikehara, M., Inaoka, T., & Ohtsuka, E. (1992) · Science · doi:10.1126/science.1575827 · Cited by 140
Xeroderma pigmentosum (complementation group D) mutation is present in patients affected by trichothiodystrophy with photosensitivity
Stefanini, M., Lagomarsini, P., Arlett, C. F., Marinoni, S., Borrone, C., Crovato, F., Trevisan, G., Cordone, G., & Nuzzo, F. (1986) · Human Genetics · doi:10.1007/bf00282072 · Cited by 138
Cerebro-Oculo-Facio-Skeletal Syndrome with a Nucleotide Excision–Repair Defect and a Mutated XPD Gene, with Prenatal Diagnosis in a Triplet Pregnancy
Graham, J. M., Anyane‐Yeboa, K., Raams, A., Appeldoorn, E., Kleijer, W. J., Garritsen, V. H., Busch, D. B., Edersheim, T. G., & Jaspers, N. G. J. (2001) · The American Journal of Human Genetics · doi:10.1086/321295 · Cited by 133
Xeroderma pigmentosum
Kraemer, K. H., & Slor, H. (1985) · Clinics in Dermatology · doi:10.1016/0738-081x(85)90096-3 · Cited by 133
Mutations in the xeroderma pigmentosum group D DNA repair/transcription gene in patients with trichothiodystrophy
Broughton, B. C., Steingrimsdottir, H., Weber, C. A., & Lehmann, A. R. (1994) · Nature Genetics · doi:10.1038/ng0694-189 · Cited by 132
Xeroderma Pigmentosum
Robbins, J. H. (1988) · JAMA · doi:10.1001/jama.260.3.384 · Cited by 131
Role of Two Histidines in the (6-4) Photolyase Reaction
Hitomi, K., Nakamura, H., Kim, S., Mizukoshi, T., Ishikawa, T., Iwai, S., & Todo, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008828200 · Cited by 126
A new nucleotide-excision-repair gene associated with the disorder trichothiodystrophy.
Stefanini, M., Vermeulen, W., Weeda, G., Giliani, S. C., Nardò, T., Mezzina, M., Sarasin, A. R., Harper, J. I., Arlett, C. F., & Hoeijmakers, J. H. J. (1993) · Europe PMC (PubMed Central) · Cited by 119
Xeroderma Pigmentosum and Related Disorders: Examining the Linkage Between Defective DNA Repair and Cancer
Kraemer, K. H., Levy, D. D., Parris, C. N., Gozukara, E. M., Moriwaki, S., Adelberg, S., & Seidman, M. M. (1994) · Journal of Investigative Dermatology · doi:10.1038/jid.1994.17 · Cited by 118
Manitoba Aboriginal Kindred with Original Cerebro-Oculo-Facio-Skeletal Syndrome Has a Mutation in the Cockayne Syndrome Group B (CSB) Gene
Meira, L. B., Graham, J. M., Greenberg, C. R., Busch, D. B., Doughty, A. T. B., Ziffer, D. W., Coleman, D. M., Savre‐Train, I., & Friedberg, E. C. (2000) · The American Journal of Human Genetics · doi:10.1086/302867 · Cited by 111
Relationship of neurologic degeneration to genotype in three xeroderma pigmentosum group G patients
Emmert, S., Slor, H., Busch, D. B., Batko, S., Albert, R. B., Coleman, D., Khan, S. G., Abu-Libdeh, B., DiGiovanna, J. J., Cunningham, B. B., et al. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2002.01782.x · Cited by 111
Self-citation
Assessment of 3 xeroderma pigmentosum group C gene polymorphisms and risk of cutaneous melanoma: a case–control study
Blankenburg, S., König, I. R., Mößner, R., Laspe, P., Thoms, K., Krüger, U., Khan, S. G., Westphal, G., Berking, C., Volkenandt, M., et al. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi055 · Cited by 109
Self-citation
Model for XPC-independent Transcription-coupled Repair of Pyrimidine Dimers in Humans
Mu, D., & Sancar, A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.12.7570 · Cited by 107
Two individuals with features of both xeroderma pigmentosum and trichothiodystrophy highlight the complexity of the clinical outcomes of mutations in the XPD gene
Broughton, B. C. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.22.2539 · Cited by 106
Recognition of nonhybridizing base pairs during nucleotide excision repair of DNA
Buschta-Hedayat, N., Buterin, T., Hess, M. T., Missura, M., & Naegeli, H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.11.6090 · Cited by 103
NEUROLOGICAL DISEASE IN XERODERMA PIGMENTOSUM: DOCUMENTATION OF A LATE ONSET TYPE OF THE JUVENILE ONSET FORM
Robbins, J. H., Brumback, R. A., MENDIONES, M., Barrett, S. F., Carl, J. R., Cho, S., DENCKLA, M. B., Ganges, M. B., Gerber, L. H., Guthrie, R. A., et al. (1991) · Brain · doi:10.1093/brain/114.3.1335 · Cited by 102
Reduced XPC DNA repair gene mRNA levels in clinically normal parents of xeroderma pigmentosum patients
Khan, S. G., Oh, K., Shahlavi, T., Ueda, T., Busch, D. B., Inui, H., Emmert, S., Imoto, K., Muniz-Medina, V. M., Baker, C. C., et al. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi204 · Cited by 100
Self-citation
The human XPG gene: gene architecture, alternative splicing and single nucleotide polymorphisms
Emmert, S. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.7.1443 · Cited by 95
Self-citation
Cancer in Families With Xeroderma Pigmentosum 2
Swift, M., & Chase, C. L. (1979) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/62.6.1415 · Cited by 94
Xeroderma Pigmentosum Complementation Group C Cells Remove Pyrimidine Dimers Selectively from the Transcribed Strand of Active Genes
Venema, J., van Hoffen, A., Karcagi, V., et al. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.8.4128-4134.1991 · Cited by 92
Genetic analysis of twenty-two patients with Cockayne syndrome
Stefanini, M., Fawcett, H., Botta, E., Nardò, T., & Lehmann, A. R. (1996) · Human Genetics · doi:10.1007/bf02267059 · Cited by 89
The xeroderma pigmentosum group C gene leads to selective repair of cyclobutane pyrimidine dimers rather than 6-4 photoproducts
Emmert, S., Kobayashi, N., Khan, S. G., & Kraemer, K. H. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.040559697 · Cited by 87
Self-citation
Molecular genetics of xeroderma pigmentosum variant
Gratchev, A., Strein, P., Utikal, J., & Goerdt, S. (2003) · Experimental Dermatology · doi:10.1034/j.1600-0625.2003.00124.x · Cited by 83
Enzyme therapy of xeroderma pigmentosum: safety and efficacy testing of T4N5 liposome lotion containing a prokaryotic DNA repair enzyme
Yarosh, D., Klein, J., Kibitel, J., Alas, L., O'Connor, A., Cummings, B., Grab, D., Gerstein, D., Gilchrest, B. A., Ichihashi, M., et al. (1996) · Photodermatology, Photoimmunology & Photomedicine · doi:10.1111/j.1600-0781.1996.tb00188.x · Cited by 81
DNA Repair Capacity for Ultraviolet Light-Induced Damage Is Reduced in Peripheral Lymphocytes from Patients with Basal Cell Carcinoma
Wei, Q., Matanoski, G. M., Farmer, E. R., Hedayati, M. A., & Grossrnan, L. (1995) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12606207 · Cited by 80
Neurological manifestations in xeroderma pigmentosum
Mimaki, T., Itoh, N., Abe, J., Tagawa, T., Sato, K., Yabuuchi, H., & Takebe, H. (1986) · Annals of Neurology · doi:10.1002/ana.410200112 · Cited by 73
Genetics and skin cancer of xeroderma pigmentosum in Japan.
Takebe, H., Nishigori, C., & Satoh, Y. (1987) · PubMed · Cited by 71
Xeroderma Pigmentosum Group C Splice Mutation Associated with Autism and Hypoglycinemia11An abstract of this manuscript was presented at the annual meeting of the Society for Investigative Dermatology in Washington, DC
Khan, S. G., Levy, H. L., Legerski, R. J., Quackenbush, E. J., Reardon, J. T., Emmert, S., Sancar, A., Li, L., Schneider, T. D., Cleaver, J. E., et al. (1998) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1998.00391.x · Cited by 71
Self-citation
Xeroderma Pigmentosum Complementation Group E Protein (XPE/DDB2): Purification of Various Complexes of XPE and Analyses of Their Damaged DNA Binding and Putative DNA Repair Properties
Kulaksiz-Erkmen, G., Reardon, J. T., & Sancar, A. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.22.9784-9792.2005 · Cited by 71
DNA repair, immunosuppression, and skin cancer.
Gupta, A. K., & Lynch, L. E. (2004) · PubMed · Cited by 65
Molecular mechanisms of deletion formation in Escherichia coli plasmids
Dianov, G. L., Kuzminov, A. V., Mazin, A. V., & Salganik, R. I. (1991) · Molecular and General Genetics MGG · doi:10.1007/bf00282460 · Cited by 64
Mutations that disable the DNA repair gene XPG in a xeroderma pigmentosum group G patient
Nouspikel, T., & Clarkson, S. G. (1994) · Human Molecular Genetics · doi:10.1093/hmg/3.6.963 · Cited by 62
Five polymorphisms in the coding sequence of the xeroderma pigmentosum group D gene
Broughton, B. C., Steingrimsdottir, H., & Lehmann, A. R. (1996) · Mutation Research/DNA Repair · doi:10.1016/0921-8777(95)00054-2 · Cited by 61
DNA Repair and Ultraviolet Mutagenesis in Cells From a New Patient With Xeroderma Pigmentosum Group G and Cockayne Syndrome Resemble Xeroderma Pigmentosum Cells
Moriwaki, S., Stafanim, M., Lehmann, A. R., Hoeijmakers, J. H. J., Robbins, J. H., Rapin, I., Botta, E., Tanganelli, B., Vermeulen, W., Broughton, B. C., et al. (1996) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12584287 · Cited by 61
Genomic structure, chromosomal localization and identification of mutations in the xeroderma pigmentosum variant (XPV) gene
Yuasa, M., Masutani, C., Eki, T., & Hanaoka, F. (2000) · Oncogene · doi:10.1038/sj.onc.1203842 · Cited by 61 · cited 2×
“This polymerase can bypass UV-induced DNA photoproducts (Broughton et al. 2002; Johnson et al. 1999; Masutani et al. 1999a, b; Yuasa et al. 2000).”
Background
Xeroderma pigmentosum: From Symptoms and Genetics to Gene-Based Skin Therapy
Magnaldo, T., & Sarasin, A. R. (2004) · Cells Tissues Organs · doi:10.1159/000079993 · Cited by 59
Ultraviolet-induced mutations in Cockayne syndrome cells are primarily caused by cyclobutane dimer photoproducts while repair of other photoproducts is normal.
Parris, C. N., & Kraemer, K. H. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.15.7260 · Cited by 58
Alterations of DNA Repair in Melanoma Cell Lines Resistant to Cisplatin, Fotemustine, or Etoposide
Rünger, T. M., Emmert, S., Schadendorf, D., Diem, C., Epe, B., & Hellfritsch, D. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00844.x · Cited by 58
Self-citation
MICRO syndrome: An entity distinct from COFS syndrome
Graham, J. M., Hennekam, R. C. M., Dobyns, W. B., Roeder, E. R., & Busch, D. B. (2004) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.30060 · Cited by 58
Translesion DNA synthesis in the dihydrofolate reductase domain of UV-irradiated CHO cells
Spivak, G., & Hanawalt, P. C. (1992) · Biochemistry · doi:10.1021/bi00144a021 · Cited by 56
Noncomplementary DNA double-strand-break rejoining in bacterial and human cells
King, J. S., Valcarcel, E. R., Rufer, J. T., Phillips, J. W., & William, F. (1993) · Nucleic Acids Research · doi:10.1093/nar/21.5.1055 · Cited by 56
The Founding Members of Xeroderma Pigmentosum Group G Produce XPG Protein with Severely Impaired Endonuclease Activity
Lalle, P., Nouspikel, T. P., Constantinou, A., Thorel, F., & Clarkson, S. G. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01673.x · Cited by 55
Xeroderma Pigmentosum and Related Disorders: Examining the Linkage Between Defective DNA Repair and Cancer.
Kraemer, K. H., Levy, D. D., Parris, C. N., Gözükara, E. M., Moriwaki, S., Adelberg, S. A., & Seidman, M. M. (1994) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12399329 · Cited by 55
Liposomes in investigative dermatology
Yarosh, D. B. (2001) · Photodermatology Photoimmunology & Photomedicine · doi:10.1034/j.1600-0781.2001.170501.x · Cited by 47
Physical mapping and complete nucleotide sequence of the denV gene of bacteriophage T4
Radany, E. H., Naumovski, L., Love, J. D., Gutekunst, K. A., Hall, D. H., & Friedberg, E. C. (1984) · Journal of Virology · doi:10.1128/jvi.52.3.846-856.1984 · Cited by 45
Mapping the multiple self-healing squamous epithelioma (MSSE) gene and investigation of xeroderma pigmentosum group A (XPA) and PATCHED (PTCH) as candidate genes
Richards, F. M., Goudie, D. R., Cooper, W. N., Jene, Q., Barroso, I., Wicking, C., Wainwright, B. J., & Ferguson-Smith, M. A. (1997) · Human Genetics · doi:10.1007/s004390050635 · Cited by 44
Participation of glutamic acid 23 of T4 endonuclease V in theβ-elimination reaction of an abasic site in a synthetic duplex DNA
Hori, N., Doi, T., Karaki, Y., Kituchi, M., Ikehara, M., & Ohtsuka, E. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.18.4761 · Cited by 44
No association between three xeroderma pigmentosum group C and one group G gene polymorphisms and risk of cutaneous melanoma
Blankenburg, S., König, I. R., Mößner, R., Laspe, P., Thoms, K., Krüger, U., Khan, S. G., Westphal, G., Volkenandt, M., Neumann, C. R., et al. (2004) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201296 · Cited by 40
Self-citation
Role of DNA damage in local suppression of contact hypersensitivity in mice by UV radiation
Kripke, M. L., Cox, P. A., Bucana, C., Vink, A. A., Alas, L., & Yarosh, D. B. (1996) · Experimental Dermatology · doi:10.1111/j.1600-0625.1996.tb00113.x · Cited by 36
Cockayne syndrome in two adult siblings
Miyauchi, H., Horio, T., Akaeda, T., Asada, Y., Chang, H. R., Ishizaki, K., & Ikenaga, M. (1994) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(94)70034-6 · Cited by 36
DNA repair and resistance to chemotherapy.
Harris, A. L. (1985) · PubMed · Cited by 33
An XPG DNA Repair Defect Causing Mutagen Hypersensitivity in Mouse Leukemia L1210 Cells
Vilpo, J., Vilpo, L. M., Szymkowski, D. E., O’Donovan, A., & Wood, R. D. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.1.290 · Cited by 30
ENHANCEMENT OF ULTRAVIOLET‐DNA REPAIR IN den V GENE TRANSFECTANTS and T4 ENDONUCLEASE V‐LIPOSOME RECIPIENTS
Kibitel, J. T., Yee, V., & Yarosh, D. B. (1991) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1991.tb02086.x · Cited by 29
Syndromes with genetic instability: Model diseases for (skin) cancerogenesis
Emmert, S., Leibeling, D., & Rünger, T. M. (2006) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/j.1610-0387.2006.06047.x · Cited by 21
Self-citation
Enhanced pyrimidine dimer removal in repair-proficient murine fibroblasts transforme with the denV gene of bacteriophage T4
Kusewitt, D. F., Ley, R. D., & Henderson, E. E. (1991) · Mutation Research/DNA Repair · doi:10.1016/0921-8777(91)90012-e · Cited by 18
FREQUENCY OF ULTRAVIOLET RADIATION‐INDUCED MUTATION AT THE hprt LOCUS IN REPAIR‐PROFICIENT MURINE FIBROBLASTS TRANSFECTED WITH THE denV GENE OF BACTERIOPHAGE T4
Kusewitt, D. F., Budge, C. L., Anderson, M. M., Ryan, S. L., & Ley, R. D. (1993) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1993.tb09589.x · Cited by 16
Morphological and biochemical characteristics of trichothiodystrophy-variant hair are maintained after grafting of scalp specimens on to nude mice
Neste, D. J. J. V., Gillespie, J. M., MARSHALL, R. C., Taı̈eb, A., & Brouwer, B. D. (1993) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1993.tb00195.x · Cited by 14
DNA Damage and Repair in Human Skin: Pathways and Questions
Sutherland, B. M., Hacham, H., Gange, R. W., Maytum, D. J., & Sutherland, J. C. (1990) · Springer eBooks · doi:10.1007/978-1-4613-0637-5_12 · Cited by 11
Enhanced Pyrimidine Dimer Repair in Cultured Murine Epithelial Cells Transfected with the denV Gene of Bacteriophage T4
Kusewitt, D. F., Budge, C. L., & Ley, R. D. (1994) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12373084 · Cited by 10
The Association of Xeroderma Pigmentosum with Trichothiodystrophy: A Clue to a Better Understanding of XP-D?
Nuzzo, F., & Stefanini, M. (1989) · doi:10.1007/978-1-4757-5016-4_8 · Cited by 9
Repair of cyclobutyl pyrimidine dimers in human skin: variability among normal humans in nucleotide excision and in photorepair
Sutherland, B. M., Hacham, H., Bennett, P. V., Sutherland, J. C., Moran, M. N., & Gange, R. W. (2002) · Photodermatology Photoimmunology & Photomedicine · doi:10.1034/j.1600-0781.2002.00748.x · Cited by 8
Measurement of Activities of Cyclobutane-Pyrimidine-Dimer and (6-4)-Photoproduct Photolyases
Hays, J. B., & Hoffman, P. D. (2003) · Humana Press eBooks · doi:10.1385/1-59259-675-4:133 · Cited by 7
Photoprotektive Mechanismen in menschlicher Haut Modulation durch Oligonukleotide
Hadshiew, I., Eller, M. S., Moll, I., & Gilchrest, B. A. (2002) · Der Hautarzt · doi:10.1007/s001050100286 · Cited by 5
Trichothiodystrophic Hair Reveals an Abnormal Pattern of Viscoelastic Parameters
Tsambaos, D., Nikiforidis, G., Balas, C., & Marinoni, S. (2009) · Skin Pharmacology · doi:10.1159/000211302 · Cited by 3

Research works printed but not linked: 2

Lehmann AR (1987) Cockayne‘s syndrome and trichothiodystrophy: defective repair without cancer. Cancer Rev 7:82–103
Yarosh D, Tsimis J, Yee V (1992b) Enhancement of DNA repair of UVR damage in mouse and human skin by liposomes containing a DNA repair enzyme. J Soc Cosmet Chem 41:85–92

Sorted by citations

UV radiation and the skin
D'Orazio, J., Jarrett, S., Amaro-Ortiz, A., & Scott, T. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140612222 · Cited by 1,984
Base excision repair of oxidative DNA damage and association with cancer and aging
Maynard, S., Schurman, S. H., Harboe, C., de Souza-Pinto, N. C., & Bohr, V. A. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn250 · Cited by 712
Eukaryotic Translesion Polymerases and Their Roles and Regulation in DNA Damage Tolerance
Waters, L. S., Minesinger, B. K., Wiltrout, M. E., D'Souza, S., Woodruff, R. V., & Walker, G. C. (2009) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00034-08 · Cited by 591
DNA‐damage repair; the good, the bad, and the ugly
Hakem, R. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.15 · Cited by 577
DNA repair mechanisms in cancer development and therapy
Torgovnick, A., & Schumacher, B. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00157 · Cited by 427

See all 164

Authors: Leibeling, D., Laspe, P., & Emmert, S.
Affiliations: University of Göttingen (DE)
Corresponding author: Emmert, Steffen
ORCID: Emmert, Steffen
Venue: Journal of Molecular Histology
Publisher: Springer Science and Business Media LLC
Published: 2006-07-20
Volume: 37
Issue: 5-7
Pages: 225-238
ISSN: 1567-2379 (ISSN-L)
1567-2387
DOI: 10.1007/s10735-006-9041-x
OpenAlex: W2140447069
Cited by: 164
References: 124
Citations by year: 2026: 1 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 9 · 2019: 6 · 2018: 12 · 2017: 5 · 2016: 8 · 2015: 8 · 2014: 9 · 2013: 15 · 2012: 13
FWCI: 0.95
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Journal of Molecular Histology (publishedVersion)
PubMed (publishedVersion)
GRO (submittedVersion)
Funders: Deutsche Forschungsgemeinschaft
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
Health Sciences › Medicine › Dermatology › Nonmelanoma Skin Cancer Studies
Keywords: nucleotide excision repair, DNA repair, xeroderma pigmentosum, Cockayne syndrome, trichothiodystrophy, UV-induced DNA damage, DNA photoproducts, skin cancer, cutaneous melanoma, basal cell carcinoma, squamous cell carcinoma, sun sensitivity, DNA damage recognition, gap filling
MeSH terms: Cockayne Syndrome, DNA Repair, Hair Diseases, Humans, Neoplasms, Syndrome, Xeroderma Pigmentosum

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Nucleotide excision repair and cancer

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks