The DOI matches its Crossref record; 93 of the 94 references it cites were found in a registry or an index.
Systemic inflammation in heart failure – The whys and wherefores
Abstract
Patients with chronic heart failure (HF) are characterized by systemic inflammation, as evident by raised circulating levels of several inflammatory cytokines with increasing levels according to the degree of disease severity. In addition to the myocardium itself, several tissues and cells can contribute to this inflammation, including leukocytes, platelets, tissue macrophages and endothelial cells. Although the mechanisms for the systemic inflammation is unknown, both infectious (e.g., endotoxins) and non-infectious (e.g., oxidative stress and hemodynamic overload) events could be operating, also including activation of Toll-like receptors as well as interaction with the neurohormone system. A growing body of evidence suggests that this systemic inflammation in chronic HF may play a role in the development and progression of this disorder, not only by promoting myocardial dysfunction, but also by inducing pathogenic consequences in other organs and tissues, thereby contributing to additional aspects of the HF syndrome such as cachexia, endothelial dysfunction and anemia. Although this inappropriate immune activation and inflammation could represent a new target for therapy in patients with chronic HF, the anti-tumor necrosis factor trials have been disappointing, and future research in this area will have to more precisely identify the most important mechanisms and actors in the immunopathogenesis of chronic HF in order to develop better immunomodulating agents for this disorder.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“and an inflammatory state is both a causative factor in inducing MI and a primary constituent of the response to MI (210, 341, 385).”
From Cardiac remodeling in obesity (2008) · cites this paper as [385]
Citations
Cites
Elevated Circulating Levels of Tumor Necrosis Factor in Severe Chronic Heart Failure
Levine, B., Kalman, J., Mayer, L., Fillit, H. M., & Packer, M. (1990) · New England Journal of Medicine · doi:10.1056/nejm199007263230405 · Cited by 2,582 · cited 1×
“[3], numerous studies have demonstrated that HF patients have raised”
BackgroundChung, E. S., Packer, M., Lo, K. H., Fasanmade, A. A., & Willerson, J. T. (2003) · Circulation · doi:10.1161/01.cir.0000077913.60364.d2 · Cited by 1,644
Jessup, M. L., & Brozena, S. C. (2003) · New England Journal of Medicine · doi:10.1056/nejmra021498 · Cited by 1,582
Mann, D. L., McMurray, J. J. V., Packer, M., Swedberg, K., Borer, J. S., Colucci, W. S., Djian, J., Drexler, H., Feldman, A., Kober, L., et al. (2004) · Circulation · doi:10.1161/01.cir.0000124490.27666.b2 · Cited by 1,240
Torre-Amione, G., Kapadia, S., Benedict, C., Oral, H., Young, J. B., & Mann, D. L. (1996) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(95)00589-7 · Cited by 1,211
Kremer, J. M., Westhovens, R., Leon, M., Giorgio, E. D., Alten, R., Steinfeld, S. D., RUSSELL, A. S., Dougados, M., Emery, P., Nuamah, I. F., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa035075 · Cited by 1,053
Cytokines and Cytokine Receptors in Advanced Heart Failure
Deswal, A. M., Petersen, N. J., Feldman, A. M., Young, J. B., White, B. G., & Mann, D. L. (2001) · Circulation · doi:10.1161/01.cir.103.16.2055 · Cited by 1,014
Complexities of CD28/B7: CTLA-4 Costimulatory Pathways in Autoimmunity and Transplantation
Salomon, B. L., & Bluestone, J. A. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.225 · Cited by 1,001
Tumor Necrosis Factor-α and Tumor Necrosis Factor Receptors in the Failing Human Heart
Torre‐Amione, G., Kapadia, S. R., Lee, J. J., Durand, J., Bies, R. D., Young, J. B., & Mann, D. L. (1996) · Circulation · doi:10.1161/01.cir.93.4.704 · Cited by 991
Inflammatory Mediators and the Failing Heart
Mann, D. L. (2002) · Circulation Research · doi:10.1161/01.res.0000043825.01705.1b · Cited by 987
Cited by
Sorted by citations
Abel, E. D., Litwin, S. E., & Sweeney, G. (2008) · Physiological Reviews · doi:10.1152/physrev.00017.2007 · Cited by 736
Cardiovascular disease and COPD: dangerous liaisons?
Rabe, K. F., Hurst, J. R., & Suissa, S. (2018) · European Respiratory Review · doi:10.1183/16000617.0057-2018 · Cited by 426
Trøseid, M., Andersen, G. Ø., Broch, K., & Hov, J. R. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.102649 · Cited by 416
Suthahar, N., Meijers, W. C., Silljé, H. H. W., & de Boer, R. A. (2017) · Current Heart Failure Reports · doi:10.1007/s11897-017-0343-y · Cited by 307
Left Ventricular T-Cell Recruitment Contributes to the Pathogenesis of Heart Failure
Nevers, T. A., Salvador, A. M., Grodecki‐Pena, A., Knapp, A., Velázquez, F., Aronovitz, M. J., Kapur, N. K., Karas, R. H., Blanton, R. M., & Alcaide, P. (2015) · Circulation Heart Failure · doi:10.1161/circheartfailure.115.002225 · Cited by 281
Proinflammatory cytokines in heart failure: double-edged swords
Hedayat, M., Mahmoudi, M. J., Rose, N. R., & Rezaei, N. (2010) · Heart Failure Reviews · doi:10.1007/s10741-010-9168-4 · Cited by 210
T cell costimulation blockade blunts pressure overload-induced heart failure
Kallikourdis, M., Martini, E., Carullo, P., Sardi, C., Roselli, G., Greco, C. M., Vignali, D., Riva, F., Berre, A. M. O., Stølen, T., et al. (2017) · Nature Communications · doi:10.1038/ncomms14680 · Cited by 203
Hillard, C. J., Weinlander, K. M., & Stuhr, K. L. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.11.020 · Cited by 190
Cardiovascular effects of leptin
Sweeney, G. (2009) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2009.224 · Cited by 186
Gastrointestinal and Liver Issues in Heart Failure
Sundaram, V., & Fang, J. C.-T. (2016) · Circulation · doi:10.1161/circulationaha.115.020894 · Cited by 179
Up‐regulated TLR 4 in cardiomyocytes exacerbates heart failure after long‐term myocardial infarction
Liu, L., Wang, Y., Cao, Z., Wang, M., Liu, X., Gao, T., Hu, Q., Yuan, W., & Lin, L. (2015) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12659 · Cited by 166
Connective tissue growth factor and cardiac fibrosis
Daniels, A., van Bilsen, M., Goldschmeding, R., Vusse, G. J., & van Nieuwenhoven, F. A. (2008) · Acta Physiologica · doi:10.1111/j.1748-1716.2008.01936.x · Cited by 165
The Role of Toll-Like Receptor Signaling in the Progression of Heart Failure
Yu, L., & Feng, Z. (2018) · Mediators of Inflammation · doi:10.1155/2018/9874109 · Cited by 169
A Review of Interleukin-1 in Heart Disease: Where Do We Stand Today?
Szekely, Y., & Arbel, Y. (2018) · Cardiology and Therapy · doi:10.1007/s40119-018-0104-3 · Cited by 157
Inflammation in Human Heart Failure: Major Mediators and Therapeutic Targets
Reina‐Couto, M., Pereira‐Terra, P., Quelhas‐Santos, J., Silva-Pereira, C., Albino‐Teixeira, A., & Sousa, T. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.746494 · Cited by 164
Interleukin-6: A Novel Target for Cardio-Cerebrovascular Diseases
Su, J.-H., Luo, M.-Y., Liang, N., Gong, S.-X., Chen, W., Huang, W., Tian, Y., & Wang, A. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.745061 · Cited by 165
Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio are Predictors of Heart Failure
Durmuş, E., Kıvrak, T., Gerin, F., Sünbül, M., Sarı, İ., & Erdoğan, O. (2015) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.20150126 · Cited by 152
Soluble ST2 is Associated with Adverse Outcome in Patients with Heart Failure of Ischaemic Aetiology
Broch, K., Ueland, T., Nymo, S. H., KJEKSHUS, J. K., Hulthe, J., Muntendam, P., McMurray, J. J. V., Wikstrand, J., Cleland, J. G. F., Aukrust, P., et al. (2012) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfs006 · Cited by 132
Self-citationExercise Intolerance in Chronic Heart Failure
Okita, K., Kinugawa, S., & Tsutsui, H. (2013) · Circulation Journal · doi:10.1253/circj.cj-12-1235 · Cited by 124
A Review of Chinese Herbal Medicine for the Treatment of Chronic Heart Failure
Wang, Y., Wang, Q., Li, C., Lu, L., Zhang, Q., Zhu, R., & Wang, W. (2017) · Current Pharmaceutical Design · doi:10.2174/1381612823666170925163427 · Cited by 123
Smeets, P. J. H., Teunissen, B. E. J., Planavila, A., den Bosch, H. D. V.-V., Willemsen, P. H. M., Vusse, G. J., & van Bilsen, M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802143200 · Cited by 120
Kang, Y., Zhang, Z., Xue, B., Weiss, R. M., & Felder, R. B. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01157.2007 · Cited by 112
Bellagambi, F. G., Baraket, A., Longo, A., Vatteroni, M., Zine, N., Bausells, J., Fuoco, R., Francesco, F. D., Salvo, P., Karanasiou, G. S., et al. (2017) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2017.05.169 · Cited by 103
Leukocyte Count and Incidence of Hospitalizations Due to Heart Failure
Engström, G., Melander, O., & Hedblad, B. (2009) · Circulation Heart Failure · doi:10.1161/circheartfailure.108.827071 · Cited by 100
Targeting Interleukin-1 in Heart Failure and Inflammatory Heart Disease
Tassell, B. W. V., Raleigh, J. M. V., & Abbate, A. (2014) · Current Heart Failure Reports · doi:10.1007/s11897-014-0231-7 · Cited by 91
Weis, F. C., Beiras-Fernández, A., Sodian, R., Kaczmarek, I., Reichart, B., Beiras, A., Schelling, G., & Kreth, S. (2009) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2009.10.025 · Cited by 89
Tang, T., Ding, Y., Liao, Y., Yu, X., Xiao, H., Xie, J.-J., Yuan, J., Zhou, Z.-H., Liao, M., Yao, R., et al. (2010) · Cellular Physiology and Biochemistry · doi:10.1159/000303050 · Cited by 87
Liu, L., Zhao, Q., Kong, M., Mao, L., Yang, Y., & Xu, Y. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab110 · Cited by 85
Metabolic Syndrome, Inflammation, and Incident Heart Failure in the Elderly
Suzuki, T., Katz, R., Jenny, N. S., Zakai, N. A., LeWinter, M. M., Barzilay, J. I., & Cushman, M. (2008) · Circulation Heart Failure · doi:10.1161/circheartfailure.108.785485 · Cited by 83
Multiple Levels of PGC-1α Dysregulation in Heart Failure
Oka, S., Sabry, A. D., Cawley, K. M., & Warren, J. S. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.00002 · Cited by 85
Role of cardiac inflammation in right ventricular failure
Sun, X., Abbate, A., & Bogaard, H. J. (2017) · Cardiovascular Research · doi:10.1093/cvr/cvx159 · Cited by 80
Overbeek, M. J., Mouchaers, K. T. B., Niessen, H. W. M., Hadi, A. M., Kupreishvili, K., Boonstra, A., Voskuyl, A. E., Beliën, J. A. M., Smit, E. F., Dijkmans, B. A. C., et al. (2010) · International Journal of Rheumatology · doi:10.1155/2010/604615 · Cited by 79
Risk Stratification for Sudden Cardiac Death in Non-Ischaemic Dilated Cardiomyopathy
Akhtar, M. M., & Elliot, P. M. (2019) · Current Cardiology Reports · doi:10.1007/s11886-019-1236-3 · Cited by 77
The lymphocyte-to-monocyte ratio: An added value for death prediction in heart failure
Silva, N., Bettencourt, P., & Guimarães, J. T. (2015) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2015.07.004 · Cited by 75
Yt, Z., Shao, L., Teng, L., Hu, B., Luo, Y., Yu, X., Zhang, D., & Zhang, H. (2009) · Journal of International Medical Research · doi:10.1177/147323000903700619 · Cited by 75
Yu, Y., Zhang, Z.-H., Wei, S., Chu, Y., Weiss, R. M., Heistad, D. D., & Felder, R. B. (2007) · Circulation Research · doi:10.1161/circresaha.107.148940 · Cited by 72
Gutiérrez-Calabrés, E., Ortega‐Hernández, A., Modrego, J., Gómez-Gordo, R., Caro‐Vadillo, A., Rodríguez-Bobada, C., González, P., & Gómez‐Garré, D. (2020) · Hypertension · doi:10.1161/hypertensionaha.120.15123 · Cited by 70
Nunes, R. B., Alves, J. P., Kessler, L. P., & Lago, P. D. (2013) · Clinics · doi:10.6061/clinics/2013(06)24 · Cited by 70
A novel chronoamperometric immunosensor for rapid detection of TNF-α in human saliva
Barhoumi, L., Baraket, A., Bellagambi, F. G., Karanasiou, G. S., Ali, M. B., Fotiadis, D. I., Bausells, J., Zine, N., Sigaud, M., & Errachid, A. (2018) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2018.03.135 · Cited by 70
Li, H., Han, M., Guo, L., Li, G., & Sang, N. (2010) · Chemosphere · doi:10.1016/j.chemosphere.2010.11.055 · Cited by 67
de Meirelles, L. R., Matsuura, C., Resende, Â. C., Salgado, Â. A., Pereira, N. R., Coscarelli, P. G., Mendes‐Ribeiro, A. C., & Brunini, T. M. C. (2013) · European Journal of Preventive Cardiology · doi:10.1177/2047487313491662 · Cited by 68
Yáñez‐Sedeño, P., Campuzano, S., & Pingarrón, J. M. (2019) · Chemical Communications · doi:10.1039/c8cc08815b · Cited by 65
López, B., González, A., Querejeta, R., Zubillaga, E., Larman, M., & Dı́ez, J. (2015) · European Journal of Heart Failure · doi:10.1002/ejhf.246 · Cited by 65
The Mononuclear Phagocyte System in Homeostasis and Disease: A Role for Heme Oxygenase-1
Hull, T. D., Agarwal, A., & George, J. F. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5673 · Cited by 65
Borné, Y., Persson, M., Melander, O., Smith, J. G., & Engström, G. (2014) · European Journal of Heart Failure · doi:10.1002/ejhf.49 · Cited by 64
Tungjai, M., Whorton, E. B., & Rithidech, K. N. (2013) · Radiation and Environmental Biophysics · doi:10.1007/s00411-013-0479-4 · Cited by 63
CARD9 knockout ameliorates myocardial dysfunction associated with high fat diet-induced obesity
Cao, L., Qin, X., Peterson, M. R., Haller, S. E., Wilson, K. A., Hu, N., Lin, X., Nair, S., Ren, J. T., & He, G. (2016) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2016.02.014 · Cited by 62
Extracellular Vesicles in Aging: An Emerging Hallmark?
Manni, G., Buratta, S., Pallotta, M. T., Chiasserini, D., Michele, A. D., Emiliani, C., Giovagnoli, S., Pascucci, L., Romani, R., Bellezza, I., et al. (2023) · Cells · doi:10.3390/cells12040527 · Cited by 64
Bekwelem, W., Lutsey, P. L., Loehr, L. R., Agarwal, S. K., Astor, B. C., Guild, C., Ballantyne, C. M., & Folsom, A. R. (2011) · Annals of Epidemiology · doi:10.1016/j.annepidem.2011.06.005 · Cited by 60
Mamic, P., Heidenreich, P. A., Hedlin, H., Tennakoon, L., & Staudenmayer, K. L. (2016) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2016.06.005 · Cited by 59
Anti-inflammatory effect of physical training in heart failure: role of TNF-alpha and IL-10.
Júnior, M. L. B., Júnior, M. L. B., Lópes, R. D., Seelaender, M. C. L., & Lopes, A. C. (2009) · PubMed · Cited by 58
Heart failure epicardial fat increases atrial arrhythmogenesis
Lin, Y., Chen, Y., Chang, S., Lin, Y., Chen, J.-H., Yeh, Y., Chen, S.-A., & Chen, Y. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.05.009 · Cited by 56
Zhang, Y., Ji, X., Ku, T., & Sang, N. (2015) · Environmental Toxicology · doi:10.1002/tox.22200 · Cited by 57
Barhoumi, L., Bellagambi, F. G., Vivaldi, F. M., Baraket, A., Clément, Y., Zine, N., Ali, M. B., Elaı̈ssari, A., & Errachid, A. (2019) · Sensors · doi:10.3390/s19030692 · Cited by 55
Wang, X., Ni, Q., Wang, J., Wu, S., Chen, P., & Xing, D. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.871031 · Cited by 52
Engström, G., Hedblad, B., Tydén, P., & Lindgärde, F. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.05.038 · Cited by 52
Torp, M., Vaage, J., & Stensløkken, K. (2023) · Acta Physiologica · doi:10.1111/apha.13920 · Cited by 54
Low-level laser therapy improves the inflammatory profile of rats with heart failure
Hentschke, V. S., Jaenisch, R. B., Schmeing, L. A., Cavinato, P. R., Xavier, L. L., & Lago, P. D. (2012) · Lasers in Medical Science · doi:10.1007/s10103-012-1190-4 · Cited by 54
Vitamin D deficiency is an independent predictor of anemia in end-stage heart failure
Zittermann, A., Jungvogel, A., Prokop, S., Kühn, J., Dreier, J., Fuchs, U., Schulz, U., Gummert, J. F., & Börgermann, J. (2011) · Clinical Research in Cardiology · doi:10.1007/s00392-011-0312-5 · Cited by 55
Interleukin-6 Signaling, Soluble Glycoprotein 130, and Inflammation in Heart Failure
Askevold, E. T., Gullestad, L. L., Dahl, C. P., Yndestad, A., Ueland, T., & Aukrust, P. (2014) · Current Heart Failure Reports · doi:10.1007/s11897-014-0185-9 · Cited by 49
Self-citationFröhlich, G., Keller, P., Schmid, F. A., Wolfrum, M., Osranek, M., Falk, C., Noll, G., Enseleit, F., Reinthaler, M., Meier, P., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht006 · Cited by 50
Circulating cytokine levels in mice with heart failure are etiology dependent
Vistnes, M., Wæhre, A., Nygård, S., Sjaastad, I., Andersson, K. B., Husberg, C., & Christensen, G. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01084.2009 · Cited by 49
Analysis of liver metabolism in a rat model of heart failure
Kato, T., Niizuma, S., Inuzuka, Y., Kawashima, T., Okuda, J., Kawamoto, A., Tamaki, Y., Iwanaga, Y., Soga, T., Kita, T., et al. (2011) · International Journal of Cardiology · doi:10.1016/j.ijcard.2011.07.056 · Cited by 48
Shirakawa, R., Yokota, T., Nakajima, T., Takada, S., Yamane, M., Furihata, T., Maekawa, S., Nambu, H., Katayama, T., Fukushima, A., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-51298-3 · Cited by 49
Peroxisome proliferator‐activated receptors and inflammation: take it to heart
Smeets, P., Planavila, A., Vusse, G. J., & van Bilsen, M. (2007) · Acta Physiologica · doi:10.1111/j.1748-1716.2007.01752.x · Cited by 49
Xin, W., Wei, W., & Li, X. (2012) · BMC Cardiovascular Disorders · doi:10.1186/1471-2261-12-77 · Cited by 47
Pearson, M. J., Mungovan, S. F., & Smart, N. A. (2018) · Heart Failure Reviews · doi:10.1007/s10741-018-9677-0 · Cited by 48
Regulation of skeletal muscle oxidative phenotype by classical NF-κB signalling
Remels, A. H. V., Gosker, H. R., Bakker, J. A., Guttridge, D. C., Schols, A. M. W. J., & LANGEN, R. C. J. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.03.018 · Cited by 46
Cerebral blood flow alteration following acute myocardial infarction in mice
Kaplan, A., Yabluchanskiy, A., Ghali, R., Altara, R., Booz, G. W., & Zouein, F. A. (2018) · Bioscience Reports · doi:10.1042/bsr20180382 · Cited by 45
Heart Failure-Induced Cachexia
Okoshi, M. P., Romeiro, F. G., de Paiva, S. A. R., & Okoshi, K. (2013) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.20130060 · Cited by 44
Recent insights on the molecular mechanisms and therapeutic approaches for cardiac cachexia
Martins, T., Vitorino, R. M. P., Moreira‐Gonçalves, D., Amado, F. M. L., Duarte, J. A., & Ferreira, R. M. (2013) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2013.10.025 · Cited by 44
Mechanisms for Cachexia in Heart Failure
Pureza, V. S., & Florea, V. G. (2013) · Current Heart Failure Reports · doi:10.1007/s11897-013-0153-9 · Cited by 44
Dube, P., Weber, K. T., & Weber, K. T. (2011) · The American Journal of the Medical Sciences · doi:10.1097/maj.0b013e318232750d · Cited by 43
Amir, O., Spivak, I., Lavi, I., & Rahat, M. A. (2012) · Mediators of Inflammation · doi:10.1155/2012/616384 · Cited by 48
Effect of Biologics on Cardiovascular Inflammation: Mechanistic Insights and Risk Reduction
Fragoulis, G., Σουλαϊδόπουλος, Σ., Sfikakis, P. P., Dimitroulas, T., & Kitas, G. D. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s282691 · Cited by 46
Dworakowski, R., Walker, S., Momin, A., Desai, J. B., El‐Gamel, A., Wendler, O., Kearney, M. T., & Shah, A. M. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.12.033 · Cited by 42
Serum YKL-40 Predicts Adverse Clinical Outcomes in Patients With Chronic Heart Failure
Bilim, O., Takeishi, Y., Kitahara, T., Ishino, M., Sasaki, T., Suzuki, S., Shishido, T., & Kubota, I. (2010) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2010.05.029 · Cited by 42
Inflammation and its association with oxidative stress in dogs with heart failure
Svete, A. N., Verk, B., Čebulj-Kadunc, N., Salobir, J., Rezar, V., & Petrič, A. D. (2021) · BMC Veterinary Research · doi:10.1186/s12917-021-02878-x · Cited by 41
Panagiotou, M., Peacock, A. J., & Johnson, M. (2015) · Pulmonary Circulation · doi:10.1086/682431 · Cited by 40
Systemic inflammation in dogs with advanced-stage heart failure
Petrič, A. D., Lukman, T., Verk, B., & Svete, A. N. (2018) · Acta veterinaria Scandinavica · doi:10.1186/s13028-018-0372-x · Cited by 40
Stanciu, A. E. (2019) · Advances in clinical chemistry · doi:10.1016/bs.acc.2019.07.002 · Cited by 42
Rubio, C. P., SARIL, A., KOCATÜRK, M., Tanaka, R., Koch, J., Cerón, J. M. C., & Yılmaz, Z. (2020) · BMC Veterinary Research · doi:10.1186/s12917-020-02650-7 · Cited by 40
Bondar, G., Cadeiras, M., Wisniewski, N., Maque, J., Chittoor, J., Chang, E., Bakir, M., Starling, C., Shahzad, K., Ping, P., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115097 · Cited by 39
Morphological and Molecular Changes of the Myocardium After Left Ventricular Mechanical Support
Baba, H. A., & Wohlschlaeger, J. (2008) · Current Cardiology Reviews · doi:10.2174/157340308785160606 · Cited by 39
Macrophage-modulating cytokines predict adverse outcome in heart failure
Hohensinner, P. J., Rychli, K., Zorn, G., Hülsmann, M., Berger, R., Mörtl, D., Richter, B., Huber, K., Wojta, J., Niessner, A., et al. (2010) · Thrombosis and Haemostasis · doi:10.1160/th09-06-0399 · Cited by 40
Erectile dysfunction in heart failure patients: a critical reappraisal
Alberti, L., Torlasco, C., Lauretta, L., Loffi, M., Maranta, F., Salonia, A., Margonato, A., Montorsi, F., & Fragasso, G. (2013) · Andrology · doi:10.1111/j.2047-2927.2012.00048.x · Cited by 37
Charniot, J.-C., Bittar, R., Albertini, J., Giral, P., Cherfils, C., Cosson, C., Guillerm, E., Leprince, P. N., Gandjbakhch, I., & Bonnefont‐Rousselot, D. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.09.054 · Cited by 37
Increased Expression of LIGHT/TNFSF14 and its Receptors in Experimental and Clinical Heart Failure
Dahl, C. P., Gullestad, L. L., Fevang, B., Holm, A. M., Landrø, L., Vinge, L. E., Fiane, A. E., Sandberg, W. J., Otterdal, K., Frøland, S. S., et al. (2008) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2008.02.010 · Cited by 37
Self-citationHoyer-Kimura, C. H., Konhilas, J. P., Mansour, H. M., Polt, R. L., Doyle, K. P., Billheimer, D. D., & Hay, M. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02281-1 · Cited by 36
Núñez, J. E., Núñez, E., Miñana, G., Sanchís, J. M., Bodı́, V., Rúmiz, E., Palau, P., Olivares, M., Merlos, P., Bonanad, C., et al. (2011) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2010.11.029 · Cited by 36
Byrkjeland, R., Nilsson, B. B., Westheim, A. S., Arnesen, H., & Seljeflot, I. (2011) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365513.2011.598943 · Cited by 36
van Wezenbeek, J., Canada, J. M., Ravindra, K., Carbone, S., Trankle, C. R., Kadariya, D., Buckley, L. F., Buono, M. G. D., Billingsley, H., Viscusi, M. M., et al. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00178 · Cited by 36
Heidarpour, M., Bashiri, S., Vakhshoori, M., Heshmat‐Ghahdarijani, K., Khanizadeh, F., Ferdowsian, S., & Shafie, D. (2021) · BMC Cardiovascular Disorders · doi:10.1186/s12872-021-02260-7 · Cited by 36
Muscle Mass and Mortality After Cardiac Transplantation
Bibas, L., Saleh, E., Alkharji, S., Chetrit, J., Mullie, L., Cantarovich, M., Cecere, R., Giannetti, N., & Afilalo, J. (2018) · Transplantation · doi:10.1097/tp.0000000000002311 · Cited by 36
Interleukin-1 in Coronary Artery Disease
Oikonomou, E. K., Tsaplaris, P., Anastasiou, A., Xenou, M., Lampsas, S., Siasos, G., Pantelidis, P., Theofilis, P., Tsatsaragkou, A., Κατσαρού, Ο., et al. (2022) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026623666221017144734 · Cited by 35
Hsu, W.-T., Jui, H., Huang, Y., Su, M.-Y. M., Wu, Y., Tseng, W. I., Hsu, M., Chiang, B., Wu, K. K., & Lee, C. (2014) · Cell Transplantation · doi:10.3727/096368914x681739 · Cited by 35
Li, C., Zhang, Y., Wang, Q., Meng, H., Zhang, Q., Wu, Y. L., Xiao, W., Wang, Y., & Tu, P. (2018) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2018.09.010 · Cited by 34
Tang, T., Zhu, Z., Wang, J., Zhang, W.-C., Tu, X., Xiao, H., Du, X., Xia, J., Dong, N., Su, W., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024272 · Cited by 34
Cardiac telomere length in heart development, function, and disease
Booth, S. A., & Charchar, F. J. (2017) · Physiological Genomics · doi:10.1152/physiolgenomics.00024.2017 · Cited by 33
Chen, K., Lin‐Tan, D., Huang, W., Hung, C., Chang, C., Huang, J., & Lin, J. (2008) · Kidney & Blood Pressure Research · doi:10.1159/000127388 · Cited by 33
Metadata
- Authors
- Yndestad, A., Kristian Damås, J., Øie, E., Ueland, T., Gullestad, L., & Aukrust, P.
- Affiliations
- University of Oslo (NO)
- Oslo University Hospital (NO)
- Corresponding author
- Aukrust, Pål
- Venue
- Heart Failure Reviews
- Published
- 2006-03
- Volume
- 11
- Issue
- 1
- Pages
- 83-92
- ISSN
- 1382-4147 (ISSN-L)
- 1573-7322
- OpenAlex
- W2065027534
- Cited by
- 294
- References
- 94
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 12 · 2023: 15 · 2022: 17 · 2021: 20 · 2020: 15 · 2019: 13 · 2018: 24 · 2017: 16 · 2016: 13 · 2015: 17 · 2014: 13 · 2013: 23 · 2012: 15
- FWCI
- 1.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Heart Failure Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Keywords
- systemic inflammation, chronic heart failure, inflammatory cytokines, Toll-like receptors, oxidative stress, endotoxin, hemodynamic overload, endothelial dysfunction, cachexia, anemia, cardiac dysfunction, immunopathogenesis, anti-TNF therapy, immunomodulatory therapy, macrophages, platelets
- MeSH terms
- Anemia, Cachexia, Endothelium, Vascular, Endotoxins, Heart Failure, Humans, Immunologic Factors, Inflammation, Leukocytes, Myocardium, Tumor Necrosis Factor-alpha, Cytokines, Neurotransmitter Agents, Oxidative Stress, Disease Progression, Inflammation Mediators, Toll-Like Receptors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
