CoChat
Sign Up
Cited by 59Clostridium difficile and Clostridium perfringens researchHeart Failure Treatment and ManagementSepsis Diagnosis and Treatment

Hospitalized Patients with Heart Failure and Common Bacterial Infections: A Nationwide Analysis of Concomitant Clostridium Difficile Infection Rates and In-Hospital Mortality

Mamic, Petra, Heidenreich, Paul A., Hedlin, Haley, Tennakoon, Lakshika, Staudenmayer, Kristan L.·2016·Journal of Cardiac Failure
DOI 10.1016/j.cardfail.2016.06.005
Open this paper in CoChat — free account

Abstract

Background Patients with heart failure (HF) are frequently hospitalized with common bacterial infections. It is unknown whether they experience concomitant Clostridium difficile infection (CDI) more frequently than patients without HF, and whether CDI affects their mortality.Methods We used 2012 National Inpatient Sample data to determine the rate of CDI and associated in-hospital mortality for hospitalized patients with comorbid HF and urinary tract infection (UTI), pneumonia (PNA), or sepsis. Univariate and multivariate analyses were performed. Weighted data are presented.Results There were an estimated 5,851,582 patient hospitalizations with discharge diagnosis of UTI, PNA, or sepsis in 2012 in the United States. Of these, 23.4% had discharge diagnosis of HF. Patients with HF were on average older and had more comorbidities. CDI rates were higher in hospitalizations with discharge diagnosis of HF compared with those without HF (odds ratio 1.13, 95% confidence interval 1.10-1.16) after controlling for patient demographics and comorbidities and hospital characteristics. Among HF hospitalizations with UTI, PNA, or sepsis, those with concomitant CDI had a higher in-hospital mortality than those without concomitant CDI (odds ratio 1.81, 95% confidence interval 1.71-1.92) after controlling for the covariates outlined previously.Conclusions HF is associated with higher CDI rates among hospitalized patients with other common bacterial infections, even when adjusting for other known risk factors for CDI. Among these patients with comorbid HF, CDI is associated with markedly higher in-hospital mortality. These findings may suggest an opportunity to improve outcomes for hospitalized patients with HF and common bacterial infections, possibly through improved Clostridium difficile screening and prophylaxis protocols.

Integrity signals

Registry

Crossref · 10.1016/j.cardfail.2016.06.005

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Across these hospitalizations, patients admitted with urinary tract infections, pneumonia, or sepsis with concomitant C. difficile infection had higher in-hospital mortality compared to those without.

    “Moreover, across these hospitalizations, patients admitted with urinary tract infections, pneumonia, or sepsis with concomitant C. difficile infection had higher in-hospital mortality compared to those without89.”

    From Dietary metabolism, the gut microbiome, and heart failure (2019) · cites this paper as [89]

  • Mamic et al. observed significant increases in Clostridium difficile infections amongst patients with a heart failure diagnosis at discharge after controlling for relevant patient and hospital characteristics.

    “Supporting these findings, using a national inpatient data registry, Mamic et al. observed significant increases in Clostridium difficile infections amongst patients with a heart failure diagnosis at discharge after controlling for relevant patient and hospital characteristics89.”

    From Dietary metabolism, the gut microbiome, and heart failure (2019) · cites this paper as [89]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Mamic, P., Heidenreich, P. A., Hedlin, H., Tennakoon, L., & Staudenmayer, K. L.
Affiliations
  • Stanford Medicine (US)
  • VA Palo Alto Health Care System (US)
Corresponding author
Mamic, Petra
ORCID
Venue
Journal of Cardiac Failure
Publisher
Elsevier BV
Published
2016-11
Volume
22
Issue
11
Pages
891-900
ISSN
1071-9164 (ISSN-L)
DOI
10.1016/j.cardfail.2016.06.005
OpenAlex
W2438632305
Cited by
59
References
42
Citations by year
2026: 3 · 2025: 7 · 2024: 7 · 2023: 12 · 2022: 6 · 2021: 7 · 2020: 6 · 2019: 3 · 2018: 6 · 2017: 2
FWCI
3.39
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Cardiac Failure (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
  • Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
Keywords
heart failure, Clostridium difficile infection, bacterial infection, urinary tract infection, pneumonia, sepsis, in-hospital mortality, comorbidities
MeSH terms
Aged, Analysis of Variance, Anti-Bacterial Agents, Bacterial Infections, Cause of Death, Clostridium Infections, Diuretics, Female, Follow-Up Studies, Heart Failure, Hospitalization, Humans, Male, Middle Aged, Reference Values, Retrospective Studies, Cohort Studies, Comorbidity, Incidence, Multivariate Analysis, Survival Analysis, Databases, Factual, Clostridioides difficile, Treatment Outcome, Hospital Mortality, Kaplan-Meier Estimate

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review