The Structure of Autism Symptoms as Measured by the Autism Diagnostic Observation Schedule
Abstract
The current study tested several competing models of the autism phenotype using data from modules 1 and 3 of the ADOS. Participants included individuals with ASDs aged 3-18 years (N = 1,409) from the AGRE database. Confirmatory factor analyses were performed on total samples and subsamples based on age and level of functioning. Three primary models were tested, including a one-factor model, the DSM-IV model, and the anticipated DSM-V model. Results indicated all models fit similarly. Module 1 ratings yielded better indices of fit across all models and higher inter-factor correlations than Model 3. Model fits were impacted by age and level of functioning. The lack of differentiation between models suggests that the structure of ASD symptoms is complex to measure statistically.
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Specificity using DSM-5 criteria was substantially improved compared with DSM-IV criteria.
“and the specificity using the new diagnostic criteria was substantially improved compared with the DSM-IV criteria.”
From DSM-5 and autism spectrum disorders (ASDs): an opportunity for identifying ASD subtypes (2013) · cites this paper as [21]
Cites
Wing, L., & Gould, J. (1979) · Journal of Autism and Developmental Disorders · doi:10.1007/bf01531288 · Cited by 2,587 · cited 1× · see citing works
“Indeed, other studies have reported a strong relationship between domains, including the RRB domain (e.g., Wing and Gould 1979; Lecavalier et al. 2009).”
BackgroundAdvances in autism genetics: on the threshold of a new neurobiology
Abrahams, B. S., & Geschwind, D. H. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2346 · Cited by 1,866 · see citing works
Time to give up on a single explanation for autism
Happé, F., Ronald, A., & Plomin, R. (2006) · Nature Neuroscience · doi:10.1038/nn1770 · Cited by 987 · see citing works
A Replication of the Autism Diagnostic Observation Schedule (ADOS) Revised Algorithms
GOTHAM, K., RISI, S., DAWSON, G., TAGER-FLUSBERG, H., JOSEPH, R., CARTER, A., HEPBURN, S., McMAHON, W., RODIER, P., HYMAN, S. L., et al. (2008) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e31816bffb7 · Cited by 374 · see citing works
de Bildt, A., Sytema, S., Ketelaars, C., Kraijer, D., Mulder, E., Volkmar, F., & Minderaa, R. (2004) · Journal of Autism and Developmental Disorders · doi:10.1023/b:jadd.0000022604.22374.5f · Cited by 278 · see citing works
Diagnostic Instruments in Autistic Spectrum Disorders
Lord, C., & Corsello, C. (2005) · Handbook of Autism and Pervasive Developmental Disorders · doi:10.1002/9780470939352.ch2 · Cited by 156 · see citing works
The structure of the Autism Diagnostic Interview—Revised: diagnostic and phenotypic implications
Snow, A. V., Lecavalier, L., & Houts, C. (2009) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2008.02018.x · Cited by 104 · see citing works
Self-citationOosterling, I., Roos, S., de Bildt, A., Rommelse, N., de Jonge, M., Visser, J., Lappenschaar, M., Swinkels, S., van der Gaag, R. J., & Buitelaar, J. (2010) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-009-0915-0 · Cited by 79 · see citing works
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DSM-5 and autism spectrum disorders (ASDs): an opportunity for identifying ASD subtypes
Grzadzinski, R., Huerta, M., & Lord, C. (2013) · Molecular Autism · doi:10.1186/2040-2392-4-12 · Cited by 378 · see citing works
“Researchers should therefore consider both the quality and quantity of specific ASD symptoms across social-communication and RRBs, as these may provide useful constructs to define ASD subgroups.”
BackgroundInfluentialGrzadzinski, R., Dick, C., Lord, C., & Bishop, S. (2016) · Molecular Autism · doi:10.1186/s13229-016-0072-1 · Cited by 192 · see citing works
“One study described ASD symptoms in children with ADHD as loading on two factors, social communication and restricted, repetitive behaviors [19], the same way that these constructs have been shown to organize in ASD samples [20, 21].”
BackgroundBrief Report: Comparability of DSM-IV and DSM-5 ASD Research Samples
Mazefsky, C. A., McPartland, J. C., Gastgeb, H. Z., & Minshew, N. J. (2013) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-012-1665-y · Cited by 88 · see citing works
Extracting Latent Subdimensions of Social Communication: A Cross-Measure Factor Analysis
Zheng, S., Kaat, A., Farmer, C., Kanne, S., Georgiades, S., Lord, C., Esler, A., & Bishop, S. L. (2021) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2020.08.444 · Cited by 26 · see citing works
- Authors
- Norris, M., Lecavalier, L., & Edwards, M. C.
- Affiliations
- Nationwide Children's Hospital (US)
- The Ohio State University (US)
- Corresponding author
- Lecavalier, Luc
- Venue
- Journal of Autism and Developmental Disorders
- Published
- 2011-08-20
- Volume
- 42
- Issue
- 6
- Pages
- 1075-1086
- ISSN
- 0162-3257 (ISSN-L)
- 1573-3432
- OpenAlex
- W2054194216
- Cited by
- 32
- References
- 8
- Citations by year
- 2025: 1 · 2024: 2 · 2021: 1 · 2020: 1 · 2017: 4 · 2016: 5 · 2015: 6 · 2014: 4 · 2013: 6 · 2012: 2
- FWCI
- 1.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Autism and Developmental Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Social Sciences › Decision Sciences › Management Science and Operations Research › Psychometric Methodologies and Testing
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Keywords
- autism spectrum disorder, Autism Diagnostic Observation Schedule, factor structure, one-factor model, level of functioning, age differences
- MeSH terms
- Adolescent, Child, Child Development Disorders, Pervasive, Child, Preschool, Factor Analysis, Statistical, Female, Humans, Male, Models, Psychological, Phenotype, Databases, Factual, Diagnostic and Statistical Manual of Mental Disorders
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