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Maternal Alcohol Consumption During Pregnancy and the Risk of Autism Spectrum Disorders in Offspring: A Retrospective Analysis of the Millennium Cohort Study
Open accessAbstract
The objective of this retrospective analysis of the longitudinal Millennium Cohort Study was to examine whether maternal alcohol consumption in pregnancy (MACP) is associated with the development of childhood autism spectrum disorders (ASD). Data on MACP and ASD were obtained from parental questionnaires. There were 18,168 singleton mother-child pairs with data on MACP, and 12,595 answered the question on ASD when the children were 11 years old. No statistically significant association was found between MACP and ASD for light (OR 0.78, 95% CI 0.48-1.29), moderate (OR 0.89, 95% CI 0.35-2.27), or heavy (OR 1.54, 95% CI 0.56-4.21) MACP. Alcohol consumption during pregnancy was not associated with the risk of developing ASD in this study cohort.
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Five cohort or case-control studies examining ASD risk through alcohol consumption directly indicate that mild to moderate maternal alcohol consumption poses no risk for autism.
“To date, five cohort or case–control studies have examined ASD risk through alcohol consumption more directly, indicating that mild to moderate maternal alcohol consumption poses no risk for autism [150–154].”
From The contribution of environmental exposure to the etiology of autism spectrum disorder (2019) · cites this paper as [154]
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Citations
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Flagged first, then by citations
Research works printed but not linked: 1
- Wallace, E., Gibb, J., & Vanessa, G. (2013). Millenium cohort study participant engagement research. London: National Children’s Bureau.
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The contribution of environmental exposure to the etiology of autism spectrum disorder
Bölte, S., Girdler, S., & Marschik, P. B. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2988-4 · Cited by 509
Metadata
- Authors
- Gallagher, C., McCarthy, F. P., Ryan, R. M., & Khashan, A. S.
- Affiliations
- University College Cork (IE)
- St Thomas' Hospital (GB)
- London School of Hygiene & Tropical Medicine (GB)
- Corresponding author
- McCarthy, F. P.
- Venue
- Journal of Autism and Developmental Disorders
- Published
- 2018-06-13
- Volume
- 48
- Issue
- 11
- Pages
- 3773-3782
- ISSN
- 0162-3257 (ISSN-L)
- 1573-3432
- PMC
- PMC6182718
- OpenAlex
- W2807952345
- Cited by
- 35
- References
- 36
- Citations by year
- 2026: 1 · 2024: 9 · 2023: 3 · 2022: 6 · 2021: 3 · 2020: 8 · 2019: 3 · 2018: 2
- FWCI
- 4.41
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Autism and Developmental Disorders (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Arrow@dit (Dublin Institute of Technology) (acceptedVersion)
- Cork Open Research Archive (University College Cork, Ireland) (submittedVersion, cc-by)
- Funders
- Health Research Board
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Keywords
- maternal alcohol consumption, pregnancy, autism spectrum disorder, childhood autism, prenatal alcohol exposure, Millennium Cohort Study, singleton births, offspring risk
- MeSH terms
- Autism Spectrum Disorder, Adult, Alcohol Drinking, Child, Child, Preschool, Female, Humans, Male, Pregnancy, Prenatal Exposure Delayed Effects
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