CoChat
Sign Up
Cited by 11Autism Spectrum Disorder ResearchLanguage Development and DisordersNeurobiology of Language and Bilingualism

A Spectrotemporal Correlate of Language Impairment in Autism Spectrum Disorder

Open access
Bloy, Luke, Shwayder, Kobey, Blaskey, Lisa, Roberts, Timothy P. L., Embick, David·2019·Journal of Autism and Developmental Disorders
DOI 10.1007/s10803-019-04040-xPMC PMC6625831
Open this paper in CoChat — free account

Abstract

This study introduces an objective neurophysiological marker of language ability, the integral of event-related desynchronization in the 5-20 Hz band during 0.2-1 seconds post auditory stimulation with interleaved word/non-word tokens. This measure correlates with clinical assessment of language function in both ASD and neurotypical pediatric populations. The measure does not appear related to general cognitive ability nor autism symptom severity (beyond degree of language impairment). We suggest that this oscillatory brain activity indexes lexical search and thus increases with increased search in the mental lexicon. While specificity for language impairment in ASD remains to be determined, such an objective index has potential utility in low functioning individuals with ASD and young children during language acquisition.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1007/s10803-019-04040-x

Cites

2 of 2 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 49

  1. Association AP (2013). Diagnostic and Statistical Manual of Mental Disorders (5th ed.). Arlington, VA: American Psychiatric Association.
  2. Avants BB, Tustison NJ, Song G, Cook PA, Klein A, & Gee JC (2011). A reproducible evaluation of ANTs similarity metric performance in brain image registration. Neuroimage, 54(3), 2033– 2044. 20851191 PMC3065962
  3. Baio J, Wiggins L, Christensen DL, Maenner MJ, Daniels J, Warren Z,... Dowling NF (2018). Prevalence of Autism Spectrum Disorder Among Children Aged 8 Years - Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2014. MMWR Surveill Summ, 67(6), 1– 23. doi: 10.15585/mmwr.ss6706a1 PMC5919599 29701730 · DOI · Paper page
  4. Balota DA, Yap MJ, Cortese MJ, Hutchison KA, Kessler B, Loftis B,... Treiman R (2007). The English Lexicon Project. Behav Res Methods, 39(3), 445– 459. 17958156
  5. Bastiaansen MC, Mazaheri A, & Jensen O (2012). Beyond ERPs: Oscillatory neuronal dynamics The Oxford handbook of event-related potential components. (pp. 31– 49). New York, NY, US: Oxford University Press.
  6. Bastiaansen MC, Oostenveld R, Jensen O, & Hagoort P (2008). I see what you mean: theta power increases are involved in the retrieval of lexical semantic information. Brain Lang, 106(1), 15– 28. doi: 10.1016/j.bandl.2007.10.006 18262262 · DOI
  7. Bastiaansen MC, van der Linden M, Ter Keurs M, Dijkstra T, & Hagoort P (2005). Theta responses are involved in lexical-semantic retrieval during language processing. J Cogn Neurosci, 17(3), 530– 541. doi: 10.1162/0898929053279469 15814011 · DOI
  8. Bishop DV, Bishop SJ, Bright P, James C, Delaney T, & Tallal P (1999). Different origin of auditory and phonological processing problems in children with language impairment: evidence from a twin study. J Speech Lang Hear Res, 42(1), 155– 168. 10025551
  9. Bishop DV, North T, & Donlan C (1996). Nonword repetition as a behavioural marker for inherited language impairment: evidence from a twin study. J Child Psychol Psychiatry, 37(4), 391– 403. 8735439
  10. Brennan J, Lignos C, Embick D, & Roberts TP (2014). Spectro-temporal correlates of lexical access during auditory lexical decision. Brain and language, 133, 39– 46. doi: 10.1016/j.bandl.2014.03.006 24769280 PMC4104786 · DOI
  11. Constantino JN, Davis SA, Todd RD, Schindler MK, Gross MM, Brophy SL,... Reich W (2003). Validation of a brief quantitative measure of autistic traits: comparison of the social responsiveness scale with the autism diagnostic interview-revised. Journal of autism and developmental disorders, 33(4), 427– 433. 12959421
  12. Constantino JN, & Gruber C (2012). The Social Responsiveness Scale (SRS-2) (2nd ed.). Torrance, CA: Western Psychological Services.
  13. Edgar JC, Khan SY, Blaskey L, Chow VY, Rey M, Gaetz W,... Roberts TP (2015). Neuromagnetic oscillations predict evoked-response latency delays and core language deficits in autism spectrum disorders. J Autism Dev Disord, 45(2), 395– 405. doi: 10.1007/s10803-013-1904-x 23963591 PMC5012005 · DOI · Paper page
  14. Embick D, Hackl M, Schaeffer J, Kelepir M, & Marantz A (2001). A magnetoencephalographic component whose latency reflects lexical frequency. Brain Res Cogn Brain Res, 10(3), 345– 348. 11167059
  15. Fischl B (2012). FreeSurfer. Neuroimage, 62(2), 774– 781. 22248573 PMC3685476
  16. Gage NM, Siegel B, & Roberts TP (2003). Cortical auditory system maturational abnormalities in children with autism disorder: an MEG investigation. Brain Res Dev Brain Res, 144(2), 201– 209. 12935917
  17. Gallon N, Harris J, & van der Lely H (2007). Non-word repetition: an investigation of phonological complexity in children with Grammatical SLI. Clin Linguist Phon, 21(6), 435– 455. doi: 10.1080/02699200701299982 17516230 · DOI
  18. Gilhooly KJ, & Logie RH (1980). Age-of-acquisition, imagery, concreteness, familiarity, and ambiguity measures for 1,944 words. Behavior research methods & instrumentation, 12(4), 395– 427.
  19. Gotham K, Pickles A, & Lord C (2009). Standardizing ADOS scores for a measure of severity in autism spectrum disorders. J Autism Dev Disord, 39(5), 693– 705. doi: 10.1007/s10803-008-0674-3 19082876 PMC2922918 · DOI · Paper page
  20. Gramfort A, Luessi M, Larson E, Engemann DA, Strohmeier D, Brodbeck C,... Hämäläinen MS (2014). MNE software for processing MEG and EEG data. Neuroimage, 86, 446– 460. 24161808 PMC3930851
  21. Hämäläinen MS, & Ilmoniemi RJ (1994). Interpreting magnetic fields of the brain: minimum norm estimates. Medical & biological engineering & computing, 32(1), 35– 42. 8182960
  22. Hickok G, & Poeppel D (2000). Towards a functional neuroanatomy of speech perception. Trends Cogn Sci, 4(4), 131– 138. 10740277
  23. Kandel ER, Schwartz JH, & Jessel TM (2000). Principles of Neural Science (Fourth ed.): McGrawHill.
  24. Kikuchi M, Yoshimura Y, Mutou K, & Minabe Y (2016). Magnetoencephalography in the study of children with autism spectrum disorder. Psychiatry Clin Neurosci, 70(2), 74– 88. doi: 10.1111/pcn.12338 26256564 · DOI
  25. Krause CM, Pesonen M, & Hamalainen H (2007). Brain oscillatory responses during the different stages of an auditory memory search task in children. Neuroreport, 18(3), 213– 216. doi: 10.1097/WNR.0b013e3280148ea0 17314659 · DOI
  26. Lord C, Luyster RJ, Gotham K, & Guthrie W (2012). Autism diagnostic observation schedule (ADOS): Manual (2nd ed.): Western Psychological Services.
  27. Matsuzaki J, Kagitani-Shimono K, Sugata H, Hanaie R, Nagatani F, Yamamoto T,... Taniike M (2017). Delayed Mismatch Field Latencies in Autism Spectrum Disorder with Abnormal Auditory Sensitivity: A Magnetoencephalographic Study. Front Hum Neurosci, 11, 446. doi: 10.3389/fnhum.2017.00446 28932189 PMC5592220 · DOI
  28. McFadden KL, Hepburn S, Winterrowd E, Schmidt GL, & Rojas DC (2012). Abnormalities in gamma-band responses to language stimuli in first-degree relatives of children with autism spectrum disorder: an MEG study. BMC Psychiatry, 12, 213. doi: 10.1186/1471-244X-12-213 23194079 PMC3557147 · DOI
  29. Mody M, & Belliveau JW (2013). Speech and Language Impairments in Autism: Insights from Behavior and Neuroimaging. N Am J Med Sci (Boston), 5(3), 157– 161. 24349628 PMC3862077
  30. Murray WS, & Forster KI (2004). Serial mechanisms in lexical access: the rank hypothesis. Psychological Review, 111(3), 721. 15250781
  31. Nelson DL, McEvoy CL, & Schreiber TA (1998). The University of South Florida word association, rhyme, and word fragment norms. http://w3.usf.edu/FreeAssociation/. 15641430
  32. Nolan H, Whelan R, & Reilly R (2010). FASTER: fully automated statistical thresholding for EEG artifact rejection. Journal of neuroscience methods, 192(1), 152– 162. 20654646
  33. Oram Cardy JE, Ferrari P, Flagg EJ, Roberts W, & Roberts TP (2004). Prominence of M50 auditory evoked response over M100 in childhood and autism. Neuroreport, 15(12), 1867– 1870. 15305126
  34. Oram Cardy JE, Flagg EJ, Roberts W, & Roberts TP (2008). Auditory evoked fields predict language ability and impairment in children. Int J Psychophysiol, 68(2), 170– 175. doi: 10.1016/j.ijpsycho.2007.10.015 18304666 · DOI · Paper page
  35. Pesonen M, Bjornberg CH, Hamalainen H, & Krause CM (2006). Brain oscillatory 1–30 Hz EEG ERD/ERS responses during the different stages of an auditory memory search task. Neurosci Lett, 399(1–2), 45– 50. doi: 10.1016/j.neulet.2006.01.053 16490308 · DOI
  36. Pylkkanen L, & Marantz A (2003). Tracking the time course of word recognition with MEG. Trends Cogn Sci, 7(5), 187– 189. 12757816
  37. Pylkkanen L, Stringfellow A, & Marantz A (2002). Neuromagnetic evidence for the timing of lexical activation: an MEG component sensitive to phonotactic probability but not to neighborhood density. Brain Lang, 81(1–3), 666– 678. 12081430
  38. Roberts TP, Cannon KM, Tavabi K, Blaskey L, Khan SY, Monroe JF,... Edgar JC (2011). Auditory magnetic mismatch field latency: a biomarker for language impairment in autism. Biol Psychiatry, 70(3), 263– 269. doi: 10.1016/j.biopsych.2011.01.015 21392733 PMC3134608 · DOI
  39. Roberts TP, Khan SY, Rey M, Monroe JF, Cannon K, Blaskey L,... Edgar JC (2010). MEG detection of delayed auditory evoked responses in autism spectrum disorders: towards an imaging biomarker for autism. Autism Res, 3(1), 8– 18. doi: 10.1002/aur.111 20063319 PMC3099241 · DOI
  40. Rojas DC, Teale PD, Maharajh K, Kronberg E, Youngpeter K, Wilson LB,... Hepburn S (2011). Transient and steady-state auditory gamma-band responses in first-degree relatives of people with autism spectrum disorder. Mol Autism, 2, 11. doi: 10.1186/2040-2392-2-11 21729257 PMC3143088 · DOI · Paper page
  41. Schwartz S, Shinn-Cunningham B, & Tager-Flusberg H (2018). Meta-analysis and systematic review of the literature characterizing auditory mismatch negativity in individuals with autism. Neurosci Biobehav Rev, 87, 106– 117. doi: 10.1016/j.neubiorev.2018.01.008 29408312 PMC5845770 · DOI · Paper page
  42. Tager-Flusberg H, Joseph R, & Folstein S (2001). Current directions in research on autism. Ment Retard Dev Disabil Res Rev, 7(1), 21– 29. doi: 10.1002/1098-2779(200102)7:1<21::AID-MRDD1004>3.0.CO; 2–3 11241879 · DOI
  43. Tavabi K, Embick D, & Roberts TP (2011). Spectral-temporal analysis of cortical oscillations during lexical processing. Neuroreport, 22(10), 474– 478. 21597392
  44. Volden J, Coolican J, Garon N, White J, & Bryson S (2009). Brief report: pragmatic language in autism spectrum disorder: relationships to measures of ability and disability. J Autism Dev Disord, 39(2), 388– 393. doi: 10.1007/s10803-008-0618-y 18626760 · DOI
  45. Wechsler D (2003). Wechsler intelligence scale for children-WISC-IV (Fourth ed.). San Antonio, TX: Psychological Corporation.
  46. Wilson M (1988). MRC psycholinguistic database: Machine-usable dictionary, version 2.00. Behavior research methods, instruments, & computers, 20(1), 6– 10.
  47. Wilson TW, Rojas DC, Reite ML, Teale PD, & Rogers SJ (2007). Children and adolescents with autism exhibit reduced MEG steady-state gamma responses. Biol Psychiatry, 62(3), 192– 197. doi: 10.1016/j.biopsych.2006.07.002 16950225 PMC2692734 · DOI · Paper page
  48. Yoshimura Y, Kikuchi M, Shitamichi K, Ueno S, Munesue T, Ono Y,... Minabe Y (2013). Atypical brain lateralisation in the auditory cortex and language performance in 3- to 7-year-old children with high-functioning autism spectrum disorder: a child-customised magnetoencephalography (MEG) study. Molecular Autism, 4(1). doi: 10.1186/2040-2392-4-38 PMC4021603 24103585 · DOI
  49. Young EC, Diehl JJ, Morris D, Hyman SL, & Bennetto L (2005). The use of two language tests to identify pragmatic language problems in children with autism spectrum disorders. Lang Speech Hear Serv Sch, 36(1), 62– 72. 15801508

Cited by

Sorted by citations

Authors
Bloy, L., Shwayder, K., Blaskey, L., Roberts, T. P. L., & Embick, D.
Affiliations
  • Children's Hospital of Philadelphia (US)
  • University of Pennsylvania (US)
Corresponding author
Bloy, Luke
ORCID
Venue
Journal of Autism and Developmental Disorders
Publisher
Springer Science and Business Media LLC
Published
2019-05-08
Volume
49
Issue
8
Pages
3181-3190
ISSN
  • 0162-3257 (ISSN-L)
  • 1573-3432
DOI
10.1007/s10803-019-04040-x
PMC
PMC6625831
OpenAlex
W2944450772
Cited by
11
References
2
Citations by year
2026: 2 · 2024: 2 · 2023: 4 · 2022: 1 · 2021: 1 · 2020: 1
FWCI
0.44
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Autism and Developmental Disorders (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health (R01DC008871, R01HD073258, K01MH108762, U54HD086984)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Social Sciences › Psychology › Developmental and Educational Psychology › Language Development and Disorders
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
Keywords
autism spectrum disorder, language impairment, event-related desynchronization, lexical search, mental lexicon, neurophysiological markers, language acquisition, low-functioning autism, children
MeSH terms
Autism Spectrum Disorder, Acoustic Stimulation, Child, Child, Preschool, Cortical Synchronization, Evoked Potentials, Female, Humans, Language Development, Language Development Disorders, Male, Magnetoencephalography

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review