Ganglionated plexi ablation in right atrium to treat cardioinhibitory neurocardiogenic syncope

Guidelines for the diagnosis and management of syncope (version 2009): The Task Force for the Diagnosis and Management of Syncope of the European Society of Cardiology (ESC)

Developed in collaboration with, European Heart Rhythm Association (EHRA), Heart Failure Association (HFA), and Heart Rhythm Society (HRS), societies, E. B. T. F., European Society of Emergency Medicine (EuSEM), European Federation of Internal Medicine (EFIM), European Union Geriatric Medicine Society (EUGMS), American Geriatrics Society (AGS), European Neurological Society (ENS), et al. (2009) · European Heart Journal · doi:10.1093/eurheartj/ehp298 · Cited by 2,040 · see citing works

Incidence and Prognosis of Syncope

Soteriades, E. S., Evans, J. C., Larson, M. G., Chen, M. H., Chen, L., Benjamin, E. J., & Levy, D. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012407 · Cited by 1,364 · see citing works

“Cardioneuroablation” – new treatment for neurocardiogenic syncope, functional AV block and sinus dysfunction using catheter RF-ablation

M, J. C. P., M, E. I. P., M, J. C. P., Lobo, T. J., Pachón, M. Z. C., Vargas, R. N. A., & Jatene, A. D. (2005) · EP Europace · doi:10.1016/j.eupc.2004.10.003 · Cited by 358 · see citing works

Efferent Vagal Innervation of the Canine Atria and Sinus and Atrioventricular Nodes

Chiou, C.-W., Eble, J. N., & Zipes, D. P. (1997) · Circulation · doi:10.1161/01.cir.95.11.2573 · Cited by 348 · see citing works

Localization of Left Atrial Ganglionated Plexi in Patients with Atrial Fibrillation

Po, S. S., Nakagawa, H., & Jackman, W. M. (2009) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2009.01515.x · Cited by 298 · see citing works

Guía de práctica clínica para el diagnóstico y manejo del síncope (versión 2009)

Moya‐Mitjans, À., Sutton, R., Ammirati, F., Blanc, J., Brignole, M., Dahm, J. B., Deharo, J., Gajek, J. J., Gjesdal, K., Krahn, A. D., et al. (2009) · Revista Española de Cardiología (English Edition) · doi:10.1016/s1885-5857(09)73541-8 · Cited by 277 · see citing works

Selective ganglionated plexi ablation for paroxysmal atrial fibrillation

Pokushalov, E. A., Romanov, A. B., Леонидович, Ш. П., Николаевич, А. С., Shirokova, N., Туров, А. Н., & Katritsis, D. G. (2009) · Heart Rhythm · doi:10.1016/j.hrthm.2009.05.018 · Cited by 230 · see citing works

The expectation effect and cardiac pacing for refractory vasovagal syncope

Sud, S., Massel, D., Klein, G. J., Leong-Sit, P., Yee, R., Skanes, A. C., Gula, L. J., & Krahn, A. D. (2007) · The American Journal of Medicine · doi:10.1016/j.amjmed.2006.05.046 · Cited by 151 · see citing works

Topography of cardiac ganglia in the adult human heart

Singh, S., Johnson, P. I., Lee, R. E., Orfei, E., Lonchyna, V. A., Sullivan, H. J., Montoya, A., Tran, H., Wehrmacher, W. H., & Wurster, R. D. (1996) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(96)70094-6 · Cited by 135 · see citing works

The Clinical Spectrum of Neurocardiogenic Syncope

Sutton, R., & PETERSEN, M. E. V. (1995) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.1995.tb00429.x · Cited by 84 · see citing works

Selective Vagal Denervation of the Sinus and Atrioventricular Nodes, Guided by Vagal Reflexes Induced by High Frequency Stimulation, to Treat Refractory Neurally Mediated Syncope

Scanavacca, M., HACHUL, D. T., Pisani, C. F., & Sosa, E. (2008) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2008.01385.x · Cited by 51 · see citing works

Immunocytochemical changes in the fetal pancreatic islet following fetal administration of streptozotocin in the rat

Yamamoto, M., Kudoh, A., Arishima, K., & EGUCHI, Y. (1997) · The Anatomical Record · doi:10.1002/(sici)1097-0185(199702)247:2 · Cited by 12 · see citing works

Neurotrophin receptor (p75) in the trigeminal thalamus of the rat: Development, response to injury, transient vibrissa-related patterning, and retrograde transport

Crockett, D. P., Harris, S. L., & Egger, M. D. (2000) · The Anatomical Record · doi:10.1002/1097-0185(20000801)259:4 · Cited by 8 · see citing works

2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope

Shen, W.-K., Sheldon, R. S., Benditt, D. G., Cohen, M. I., Forman, D. E., Goldberger, Z. D., Grubb, B. P., Hamdan, M. H., Krahn, A. D., Link, M. S., et al. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2017.03.004 · Cited by 484 · see citing works

2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society

Shen, W.-K., Sheldon, R. S., Benditt, D. G., Cohen, M. I., Forman, D. E., Goldberger, Z. D., Grubb, B. P., Hamdan, M. H., Krahn, A. D., Link, M. S., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000499 · Cited by 453 · see citing works

2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society

Shen, W.-K., Sheldon, R. S., Benditt, D. G., Cohen, M. I., Forman, D. E., Goldberger, Z. D., Grubb, B. P., Hamdan, M. H., Krahn, A. D., Link, M. S., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000498 · Cited by 408 · see citing works

2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope

Shen, W.-K., Sheldon, R. S., Benditt, D. G., Cohen, M. I., Forman, D. E., Goldberger, Z. D., Grubb, B. P., Hamdan, M. H., Krahn, A. D., Link, M. S., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.03.003 · Cited by 327 · see citing works

Right anterior ganglionated plexus: The primary target of cardioneuroablation?

Hu, F., Zheng, L., Liang, E., Ding, L., Wu, L., Chen, G., Fan, X., & Yao, Y. (2019) · Heart Rhythm · doi:10.1016/j.hrthm.2019.07.018 · Cited by 151 · see citing works

Simplified Cardioneuroablation in the Treatment of Reflex Syncope, Functional AV Block, and Sinus Node Dysfunction

Aksu, T., Gölcük, E., Yalın, K., Güler, T. E., & Erden, İ. (2015) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.12756 · Cited by 145 · see citing works

Catheter Ablation as a Treatment for Vasovagal Syncope: Long‐Term Outcome of Endocardial Autonomic Modification of the Left Atrium

Sun, W., Zheng, L., Yu, Q., Shi, R., Hou, B., Wu, L., Guo, J., Zhang, S., & Yao, Y. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.116.003471 · Cited by 133 · see citing works

Electroanatomic-mapping-guided cardioneuroablation versus combined approach for vasovagal syncope: a cross-sectional observational study

Aksu, T., Güler, T. E., Mutluer, F. O., Bozyel, S., Gölcük, Ş. E., & Yalın, K. (2018) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-018-0421-4 · Cited by 113 · see citing works

Relation of Fractionated Atrial Potentials With the Vagal Innervation Evaluated by Extracardiac Vagal Stimulation During Cardioneuroablation

Mateos, E. I. P., Pachón-M, J. C., Higuti, C., Santillana‐P, T. G., Lobo, T. J., Pachón, C. T. C., PACHÓN-MATEOS, J. C., Zerpa, J. C., Ortencio, F. A., Amarante, R. C., et al. (2020) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.119.007900 · Cited by 67 · see citing works

Syncope in Children and Adolescents

Kanjwal, K., & Calkins, H. (2015) · Cardiology Clinics · doi:10.1016/j.ccl.2015.04.008 · Cited by 52 · see citing works

Catheter ablation of right atrial ganglionated plexi to treat cardioinhibitory neurocardiogenic syncope: a long-term follow-up prospective study

Calò, L., Rebecchi, M., Sette, A., Sciarra, L., Borrelli, A., Scarà, A., Grieco, D., Politano, A., Sgueglia, M., Luca, L. D., et al. (2020) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-020-00840-9 · Cited by 52 · see citing works

Cardioneuroablation in the treatment of neurally mediated reflex syncope: a review of the current literature

Aksu, T. (2016) · Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology · doi:10.5543/tkda.2016.55250 · Cited by 47 · see citing works

Catheter Ablation of Bradyarrhythmia: From the Beginning to the Future

Aksu, T., Güler, T. E., Yalın, K., Mutluer, F. O., Özcan, K. S., & Calò, L. (2017) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2017.11.016 · Cited by 37 · see citing works

Differential effect of ganglionic plexi ablation in a patient with neurally mediated syncope and intermittent atrioventricular block

Fukunaga, M., Wichterle, D., Peichl, P., Aldhoon, B., Cihak, R. J., & Kautzner, J. (2016) · EP Europace · doi:10.1093/europace/euw100 · Cited by 32 · see citing works

Atrial fibrillation and autonomic nervous system: A translational approach to guide therapeutic goals

Rebecchi, M., Panattoni, G., Bressi, E., Ruvo, E. D., Sciarra, L., Politano, A., Sgueglia, M., Ricagni, C., Verbena, S., Crescenzi, C., et al. (2021) · Journal of Arrhythmia · doi:10.1002/joa3.12512 · Cited by 27 · see citing works

Cardioneuroablation using an anatomical approach: a new and promising method for the treatment of cardioinhibitory neurocardiogenic syncope

Piotrowski, R., Baran, J. M., & Kułakowski, P. (2018) · Kardiologia Polska · doi:10.5603/kp.a2018.0200 · Cited by 25 · see citing works

Selective vagal innervation principles of ganglionated plexi: step-by-step cardioneuroablation in a patient with vasovagal syncope

Aksu, T., Güler, T. E., Bozyel, S., & Yalın, K. (2020) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-020-00757-3 · Cited by 23 · see citing works

Cardioinhibitory syncope: from pathophysiology to treatment—should we think on cardioneuroablation?

García, A., Márquez, M. F., Fierro, E. F., Baez, J. J., Campos, L. P. R., & Gómez-Flores, J. R. (2020) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-020-00758-2 · Cited by 22 · see citing works

“Cardio‐Neuromodulation” With a Multielectrode Irrigated Catheter: A Potential New Approach for Patients With Cardio‐Inhibitory Syncope

Debruyne, P. (2016) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.13031 · Cited by 20 · see citing works

Comparative effects of intensive ganglionated plexus ablation in treating paroxysmal atrial fibrillation and vasovagal syncope

Huang, X., Chen, Y., Huang, Y., Zhao, H., He, L., Tan, Z., Xu, D., & Peng, J. (2020) · Clinical Cardiology · doi:10.1002/clc.23446 · Cited by 17 · see citing works

Procedural Characteristics, Safety, and Follow-up of Modified Right-Sided Approach for Cardioneuroablation

Candemır, B., Baskovski, E., Beton, O., Shanableh, N., Akbulut, İ. M., Kozluca, V., Esenboğa, K., Tan, T. S., Altın, T., & Tutar, E. (2022) · The Anatolian Journal of Cardiology · doi:10.5152/anatoljcardiol.2022.217 · Cited by 14 · see citing works

Selective ablation of atrial ganglionated plexus attenuates vasovagal reflex in a canine model

Wang, X., Luo, D., Liu, S., Qu, W., Ma, R., Yu, X., Xie, J., Lu, Z., & He, W. (2018) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.13547 · Cited by 13 · see citing works

Step-by-Step Cardioneuroablation Approach in Two Patients with Functional Atrioventricular Block

Aksu, T., Güler, T. E., & Yalın, K. (2019) · Balkan Medical Journal · doi:10.4274/balkanmedj.galenos.2019.2019.9.47 · Cited by 11 · see citing works

A computed tomography–based evaluation and comparison of ganglionated plexus targeting techniques for cardioneuroablation

Benabou, L., Ascione, C., Soré, B., Cherbi, M., Labrousse, R., Tixier, R., Bouyer, B., Arnaud, M., Buliard, S., Pambrun, T., et al. (2025) · Heart Rhythm · doi:10.1016/j.hrthm.2025.01.013 · Cited by 10 · see citing works

Treatment of Neurocardiogenic Syncope: From Conservative to Cutting-edge

Gampa, A., & Upadhyay, G. A. (2018) · Journal of Innovations in Cardiac Rhythm Management · doi:10.19102/icrm.2018.090702 · Cited by 10 · see citing works

Ganglionated Plexi Ablation to Treat Patients with Refractory Neurally Mediated Syncope and Severe Vagal-Induced Bradycardia

Scanavacca, M., & HACHUL, D. T. (2019) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.20190107 · Cited by 9 · see citing works

Cardioneuroablation guided by real-time spectral analysis: The Omnipolar Technology Near Field

Giomi, A., Bernardini, A., Perini, A. P., Zaccaria, C. S., Padeletti, M., & Milli, M. (2024) · HeartRhythm Case Reports · doi:10.1016/j.hrcr.2024.08.027 · Cited by 8 · see citing works

Efficacy of cardioneuroablation for vasodepressor vasovagal syncope

Chen, Z., Li, Y., Liu, Y., Shen, G., Xiong, G., Wu, B., Liu, Y., Huang, X.-T., Li, H., Zhou, H., et al. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1514513 · Cited by 7 · see citing works

Syncope in Children and Adolescents

Kanjwal, K., & Calkins, H. G. (2013) · Cardiac Electrophysiology Clinics · doi:10.1016/j.ccep.2013.08.007 · Cited by 6 · see citing works

Ganglionated plexi ablation in the right atrium for the treatment of cardioinhibitory syncope

Rebecchi, M., Ruvo, E. D., Borrelli, A., Sette, A., Sgueglia, M., Grieco, D., Canestrelli, S., Politano, A., Panattoni, G., Licciardello, C., et al. (2023) · European Heart Journal Supplements · doi:10.1093/eurheartjsupp/suad002 · Cited by 5 · see citing works

Ganglionated Plexus Ablation Procedures to Treat Vasovagal Syncope

Yarkoni, M., Rehman, W. U., Bajwa, A. U. R., Yarkoni, A., & Rehman, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713264 · Cited by 4 · see citing works

Endocardial gaglionated plexi ablation in different vagally-mediated clinical settings: From cardioneuroablation to cardio-neuromodulation

Rebecchi, M., Ruvo, E. D., Sette, A., Grieco, D., Luca, L. D., Strano, S., Tomaino, M., Giamundo, D. M., Sasso, S., Carabotta, C., et al. (2025) · European Heart Journal Supplements · doi:10.1093/eurheartjsupp/suae109 · Cited by 2 · see citing works

Cardioneuroablation for Asystolic Reflex Syncope: How to Identify the Best Candidate and How to Predict Success

Kułakowski, P. (2025) · Arrhythmia & Electrophysiology Review · doi:10.15420/aer.2025.25 · Cited by 1 · see citing works

Syncope for the General Pediatrician

Blevins, B. (2015) · Current Treatment Options in Pediatrics · doi:10.1007/s40746-015-0017-5 · Cited by 1 · see citing works

Syncope for the General

Blevins, P. (2015)

Selective ablation of atrial ganglionated plexus as a therapeutic option for vasovagal syncope

Kishihara, J. (2018) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.13548

Rare Cause of Syncope in an Athlete, Matter of Brain and Heart Electricity

Navot-Mintzer, D., Ekstein, D., Nof, E., Fogelman, R., Beinart, R., Honig, A., & Constantini, N. (2021) · Clinical Journal of Sport Medicine · doi:10.1097/jsm.0000000000000967

Endocardial ablation of epicardial ganglionated plexi: history, open questions and future prospects of cardioneuroablation

Magnano, M., Bissolino, A., Budano, C., Occhetta, E., & Rametta, F. (2022) · Minerva Cardiology and Angiology · doi:10.23736/s2724-5683.22.06131-2

Catheter Ablation for Frequent Premature Ventricular Contractions or Paroxysmal Supraventricular Tachycardia With Vagal Bradycardia: A New Clinical Application of Superior Vena Cava–Aorta Ganglionated Plexus Modification

Meng, X., Huang, S. H. M., He, L., Liu, T., Chen, Y., Li, H., & Huang, X. (2026) · Clinical Cardiology · doi:10.1002/clc.70282

Parasympathetic Tone Selectively Modulates Electrogram Fragmentation and Spectral Properties in Right Atrial Ganglionated Plexi

Giomi, A., Bernardini, A., Perini, A. P., Padeletti, M., Zaccaria, C. S., Michelotti, F., Signorini, U., Marcucci, R., & Milli, M. (2026) · Journal of Arrhythmia · doi:10.1002/joa3.70424

Ganglionated plexi ablation in the right atrium for the treatment of cardioinhibitory syncope

Rebecchi, M., Ruvo, E. D., Borrelli, A., Sette, A., Sgueglia, M., Grieco, D., Canestrelli, S., Politano, A., Panattoni, G., Licciardello, C., et al. (2023) · European Heart Journal Supplements · doi:10.1093/eurheartjsupp/suad002 · Cited by 5 · see citing works

Catheter ablation of right atrial ganglionated plexi to treat cardioinhibitory neurocardiogenic syncope: a long-term follow-up prospective study

Calò, L., Rebecchi, M., Sette, A., Sciarra, L., Borrelli, A., Scarà, A., Grieco, D., Politano, A., Sgueglia, M., Luca, L. D., et al. (2020) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-020-00840-9 · Cited by 52 · see citing works

Cardioneuroablation of severe neurally mediated reflex syncope: the experience of two Portuguese centres

Silva, G., Cardoso, A. F., Almeida, J. G., Fonseca, P., Ribeiro, S., de Oliveira, M. C., Sanfins, V., Gonçalves, H., Primo, J. J., Lourenço, A., et al. (2022) · EP Europace · doi:10.1093/europace/euac053.326

Cardioneuroablation for neurocardiogenic syncope

Pachón-M, J. C. (2019) · Heart Rhythm · doi:10.1016/j.hrthm.2019.08.008 · Cited by 7 · see citing works

P3752Ablation of the superior left ganglionic plexus is not necessary for effective denervation of the sinoatrial and atrioventricular nodes

Jansová, H., Stiavnicky, P., Stojadinovic, P., Konecny, P., Cihak, R., Peichl, P., Kautzner, J., & Wichterle, D. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehz745.0604