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In vitro degradation behavior and cytocompatibility of Mg–Zn–Zr alloys
Open accessAbstract
Zinc and zirconium were selected as the alloying elements in biodegradable magnesium alloys, considering their strengthening effect and good biocompatibility. The degradation rate, hydrogen evolution, ion release, surface layer and in vitro cytotoxicity of two Mg-Zn-Zr alloys, i.e. ZK30 and ZK60, and a WE-type alloy (Mg-Y-RE-Zr) were investigated by means of long-term static immersion testing in Hank's solution, non-static immersion testing in Hank's solution and cell-material interaction analysis. It was found that, among these three magnesium alloys, ZK30 had the lowest degradation rate and the least hydrogen evolution. A magnesium calcium phosphate layer was formed on the surface of ZK30 sample during non-static immersion and its degradation caused minute changes in the ion concentrations and pH value of Hank's solution. In addition, the ZK30 alloy showed insignificant cytotoxicity against bone marrow stromal cells as compared with biocompatible hydroxyapatite (HA) and the WE-type alloy. After prolonged incubation for 7 days, a stimulatory effect on cell proliferation was observed. The results of the present study suggested that ZK30 could be a promising material for biodegradable orthopedic implants and worth further investigation to evaluate its in vitro and in vivo degradation behavior.
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Cited by
Park, J., Jiang, Q., Feng, D., Mao, L., & Zhou, H.-C. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b00007 · Cited by 915
Mg and Mg alloys: How comparable are in vitro and in vivo corrosion rates? A review
Sanchez, A. H. M., Luthringer, B. J. C., Feyerabend, F., & Willumeit, R. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2014.11.048 · Cited by 503
Surface modification of biodegradable magnesium and its alloys for biomedical applications
Tian, P., & Liu, X. (2015) · Regenerative Biomaterials · doi:10.1093/rb/rbu013 · Cited by 218
Magnesium-based biodegradable alloys: Degradation, application, and alloying elements
Pogorielov, M., Husak, E., Solodivnik, A., & Zhdanov, S. (2017) · Interventional Medicine and Applied Science · doi:10.1556/1646.9.2017.1.04 · Cited by 150
Metadata
- Authors
- Huan, Z. G., Leeflang, M. A., Zhou, J., Fratila-Apachitei, L. E., & Duszczyk, J.
- Venue
- Journal of Materials Science: Materials in Medicine
- Published
- 2010-06-09
- Volume
- 21
- Issue
- 9
- Pages
- 2623-2635
- ISSN
- 0957-4530 (ISSN-L)
- 1573-4838
- OpenAlex
- W1983702781
- Cited by
- 234
- References
- 0
- FWCI
- 4.88
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Huan, Z. G., Leeflang, M. A., Zhou, J., Fratila-Apachitei, L. E., & Duszczyk, J. (2010). In vitro degradation behavior and cytocompatibility of Mg–Zn–Zr alloys. Journal of Materials Science: Materials in Medicine. https://doi.org/10.1007/s10856-010-4111-8
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