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Cited by 53Epilepsy research and treatmentAntioxidant Activity and Oxidative StressNeurological Disease Mechanisms and Treatments

Interweaving epilepsy and neurodegeneration: Vitamin E as a treatment approach

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Upaganlawar, Aman B., Wankhede, Nitu L., Kale, Mayur B., Umare, Mohit D., Sehgal, Aayush, Singh, Sukhbir, Bhatia, Saurabh, Al-Harrasi, Ahmed +4 more·2021·Biomedicine & Pharmacotherapy
DOI 10.1016/j.biopha.2021.112146
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Abstract

Epilepsy is the most common neurological disorder, affecting nearly 50 million people worldwide. The condition can be manifested either due to genetic predisposition or acquired from acute insult which leads to alteration of cellular and molecular mechanisms. Evaluating the latest and the current knowledge in regard to the mechanisms underlying molecular and cellular alteration, hyperexcitability is a consequence of an imbalanced state wherein enhance excitatory glutamatergic and reduced inhibitory GABAergic signaling is considered to be accountable for seizures associated damage. However, neurodegeneration contributing to epileptogenesis has become increasingly appreciated. The components at the helm of neurodegenerative alterations during epileptogenesis include GABAergic neuronal and receptor changes, neuroinflammation, alteration in axonal transport, oxidative stress, excitotoxicity, and other cellular as well as functional changes. Targeting neurodegeneration with vitamin E as an antioxidant, anti-inflammatory and neuroprotective may prove to be one of the therapeutic approaches useful in managing epilepsy. In this review, we discuss and converse about the seizure-induced episodes as a link for the development of neurodegenerative and pathological consequences of epilepsy. We also put forth a summary of the potential intervention with vitamin E therapy in the management of epilepsy.

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  • Plants with antioxidants (flavonoids, beta-carotene, vitamin C, and vitamin E) can help reduce the pathophysiology of neurodegenerative symptoms through countering oxidative stress that is scientifically linked to one of the accelerators of Alzheimer disorder.

    “These plants with antioxidants (flavonoids, beta-carotene, vitamin C, and vitamin E) can help reduce the pathophysiology of neurodegenerative symptoms through countering of oxidative stress that is scientifically linked to one of the accelerators of Alzheimer disorder [4 , 18] .”

    From Phytotherapy: A promising approach for the treatment of Alzheimer's disease (2022) · cites this paper as [4]

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  1. K.J. Barnham, C.L. Masters, A.I. Bush, Neurodegenerative diseases and oxidatives stress, Nat. Rev. Drug Discov. 3 (2004) 205-214, https://doi.org/10.1038/ nrd1330. · DOI · Paper page
  2. V.M. Kovalenko, G.N. Kryzhanovsky, V.S. Kovalenko, Tocopherol in the multiple modality therapy of some forms of epilepsy, Zh. . Nevropatol. i Psikhiatrii Im. S. S. Korsakova 84 (1984) 892-897. https://europepmc.org/article/med/6431729.

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Authors
Upaganlawar, A. B., Wankhede, N. L., Kale, M. B., Umare, M. D., Sehgal, A., Singh, S., Bhatia, S., Al-Harrasi, A., Najda, A., Nurzyńska-Wierdak, R., Bungau, S., & Behl, T.
Affiliations
  • Chitkara University (IN)
  • University of Nizwa (OM)
  • University of Life Sciences in Lublin (PL)
  • University of Oradea (RO)
Corresponding author
  • Najda, Agnieszka
  • Behl, Tapan
ORCID
Venue
Biomedicine & Pharmacotherapy
Publisher
Elsevier BV
Published
2021-11
Volume
143
Pages
112146
ISSN
0753-3322 (ISSN-L)
DOI
10.1016/j.biopha.2021.112146
OpenAlex
W3196289918
Cited by
53
References
196
Citations by year
2026: 4 · 2025: 10 · 2024: 15 · 2023: 12 · 2022: 9 · 2021: 3
FWCI
1.74
Type
journal article
Language
en
Open access
Licence
Locations
  • Biomedicine & Pharmacotherapy (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords
epilepsy, neurodegeneration, vitamin E, epileptogenesis, oxidative stress, neuroinflammation, excitotoxicity, axonal transport, GABAergic neurotransmission, glutamatergic signaling, neuroprotection, antioxidant therapy, seizures
MeSH terms
Animals, Anti-Inflammatory Agents, Anticonvulsants, Antioxidants, Brain, Epilepsy, Humans, Nerve Degeneration, Prognosis, Risk Factors, Vitamin E, Signal Transduction, Oxidative Stress, Risk Assessment, Neuroprotective Agents, Inflammation Mediators, Neurodegenerative Diseases, Brain Waves

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