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Decreased content, rate of synthesis and export of cholesterol in the brain of apoE knockout mice

Nunes, Valéria Sutti, Cazita, Patrícia Miralda, Catanozi, Sérgio, Nakandakare, Edna Regina, Quintão, Eder Carlos Rocha·2018·Journal of Bioenergetics and Biomembranes
DOI 10.1007/s10863-018-9757-9
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Abstract

Apolipoprotein E knockout (apoE-KO) mice present synaptic loss, cognitive dysfunction, and high plasma lipid levels that may affect brain function simulating Alzheimer disease. Plasma and brain sterols were measured in apoE-KO and in wild type control mice on a cholesterol-free, phytosterol-containing diet by gas chromatography coupled to a mass spectrometer. Plasma cholesterol and phytosterols (campesterol and sitosterol) were higher in apoE-KO compared to control mice. Cholesterol precursors (desmosterol and lathosterol) were not detected in plasma of control mice but were present in apoE-KO mice. In the brain amounts of cholesterol, desmosterol, campesterol and 24-hydroxycholesterol were significantly lower in apoE-KO than in controls. There is a tendency in apoE-KO for lower values of 7α-hydroxycholesterol and 7β-hydroxycholesterol. Cholesterol content, synthesis rates (desmosterol) and export of 24-hydroxycholesterol are reduced in the brain of the severe hypercholesterolemic apoE-KO mice.

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Metadata

Authors
Nunes, V. S., Cazita, P. M., Catanozi, S., Nakandakare, E. R., & Quintão, E. C. R.
Venue
Journal of Bioenergetics and Biomembranes
Publisher
Springer Science and Business Media LLC
Published
2018-04-20
Volume
50
Issue
4
Pages
283-287
ISSN
  • 0145-479X
  • 1573-6881
DOI
10.1007/s10863-018-9757-9
Cited by
32
References
1
Language
en
Licence
www.springer.com/tdm (tdm)
Funders
São Paulo Research Foundation (2015-17566-2)

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