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Induction of Alzheimer-like β-Amyloid Immunoreactivity in the Brains of Rabbits with Dietary Cholesterol
Abstract
beta-amyloid and ALZ-50 immunocytochemical reactivity were determined in the brains of rabbits fed either a control or 2% cholesterol diet. Control rabbits demonstrated no accumulation of intracellular immunolabeled beta-amyloid within 3 min after death. In animals fed the experimental diet for 4, 6, and 8 weeks (postmortem interval < 3 min), there was an increasingly mild-to-moderate-to-severe accumulation of intracellular immunolabeled beta-amyloid. Whether or not beta-amyloid is causally linked to processes leading to dementia, it is related in some way to the prime cause of human death; heart disease. Hypercholesterolemic rabbits may provide an animal model to study altered beta-APP metabolism leading to Alzheimer-like beta-amyloid accumulation xe03and extracellular deposition in brain.
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Hypercholesterolaemia is linked to the appearance of Aβ deposits in the brains of rabbits.
“reporting it linked to the appearance of Aβ deposits in the brains of rabbits [7], [8]”
From ApoB100/LDLR-/- Hypercholesterolaemic Mice as a Model for Mild Cognitive Impairment and Neuronal Damage (2011) · cites this paper as [7]
Little attention has been paid to neurodegeneration in hypercholesterolaemic mice; most studies have focused on the accumulation of amyloid plaques.
“However, while much attention has been focused on the effect of cholesterol in murine AD models, little attention has been paid to neurodegeneration in hypercholesterolaemic mice; most studies have focused on the accumulation of amyloid plaques [7], [8], [9].”
From ApoB100/LDLR-/- Hypercholesterolaemic Mice as a Model for Mild Cognitive Impairment and Neuronal Damage (2011) · cites this paper as [7]
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Metadata
- Authors
- Sparks, D. L., Scheff, S. W., Hunsaker, J. C., Liu, H., Landers, T., & Gross, D. R.
- Venue
- Experimental Neurology
- Publisher
- Elsevier BV
- Published
- 1994-03
- Volume
- 126
- Issue
- 1
- Pages
- 88-94
- ISSN
- 0014-4886
- Cited by
- 443
- References
- 0
- Language
- en
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