The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Cytokine IL-6 and IL-10 as Biomarkers in Systemic Lupus Erythematosus
Abstract
There is a great deal of interest in the identification of biomarkers that are closely associated with disease activity in systemic lupus erythematosus (SLE), but few biomarkers have been validated. Cytokines play an important role in the pathogenesis of SLE. Therefore, we evaluated the levels of cytokines and their possible association with disease activity. In the present study, we found that the SLE patients had higher IL-6, IL-10, IL-12, and IFN-γ levels, but lower IL-2, than normal controls. Serum IL-6 level was significantly elevated in active SLE patients and correlated with the SLE activity index (SLEDAI), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP). Serum IL-10 level was also significantly elevated in active SLE patients and revealed positive correlation with SLEDAI and anti-double-stranded DNA (dsDNA) titer and negative correlation with C3, C4, and lymphocyte counts. No significant differences in the levels of cytokines were observed between SLE patients with nephritis and those without nephritis. These data suggest that IL-6 and IL-10 may be a useful biomarker for disease activity in SLE.
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VIALLARD, J. F., PELLEGRIN, J. L., RANCHIN, V, SCHAEVERBEKE, T., DEHAIS, J., LONGY-BOURSIER, M., RAGNAUD, J. M., LENG, B., & MOREAU, J. F. (2001) · Clinical and Experimental Immunology · doi:10.1046/j.1365-2249.1999.00766.x · Cited by 247 · cited 1×
“Concentrations of IFN-γ are increased in SLE patients, and the production of IFN-γ by PBMCs from SLE patients is significantly correlated with global disease activity [13, 29].”
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Cited by
Gaforio, J. J., Visioli, F., Alarcón-de-la-Lastra, C., Castañer, O., Delgado-Rodríguez, M., Fitó, M., Hernández, A. F., Huertas, J. R., Martínez-González, M. A., Menendez, J. A., et al. (2019) · Nutrients · doi:10.3390/nu11092039 · Cited by 187
Prado, C., de Paz, B., Gómez, J., López, P., Rodríguez-Carrio, J., & Suárez, A. (2011) · Rheumatology · doi:10.1093/rheumatology/ker227 · Cited by 33
Polarization of TH2 response is decreased during pregnancy in systemic lupus erythematosus
Iaccarino, L., Ghirardello, A., Zen, M., Villalta, D., Tincani, A., Punzi, L., & Doria, A. (2012) · Reumatismo · doi:10.4081/reumatismo.2012.314 · Cited by 25
C-reactive protein and the acute phase reaction in geriatric patients
Bertsch, T., Triebel, J., Bollheimer, C., Christ, M., Sieber, C., Fassbender, K., & Heppner, H. J. (2015) · Zeitschrift für Gerontologie und Geriatrie · doi:10.1007/s00391-015-0938-4 · Cited by 24
Metadata
- Authors
- Chun, H.-Y., Chung, J.-W., Kim, H.-A., Yun, J.-M., Jeon, J.-Y., Ye, Y.-M., Kim, S.-H., Park, H.-S., & Suh, C.-H.
- Venue
- Journal of Clinical Immunology
- Published
- 2007-06-21
- Volume
- 27
- Issue
- 5
- Pages
- 461-466
- ISSN
- 0271-9142 (ISSN-L)
- 1573-2592
- OpenAlex
- W1966335538
- Cited by
- 390
- References
- 1
- FWCI
- 11.58
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Cytokine IL-6 and IL-10 as Biomarkers in Systemic Lupus Erythematosus. https://app.cochat.ai/papers/10.1007/s10875-007-9104-0
- The paper
- Chun, H.-Y., Chung, J.-W., Kim, H.-A., Yun, J.-M., Jeon, J.-Y., Ye, Y.-M., Kim, S.-H., Park, H.-S., & Suh, C.-H. (2007). Cytokine IL-6 and IL-10 as Biomarkers in Systemic Lupus Erythematosus. Journal of Clinical Immunology. https://doi.org/10.1007/s10875-007-9104-0
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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