Th1 (IL-2, interferon-gamma (IFN-γ)) and Th2 (IL-10, IL-4) cytokine production by peripheral blood mononuclear cells (PBMC) from patients with systemic lupus erythematosus (SLE)

VIALLARD, J F; PELLEGRIN, J L; RANCHIN, V; SCHAEVERBEKE, T; DEHAIS, J; LONGY-BOURSIER, M; RAGNAUD, J M; LENG, B; MOREAU, J F

doi:10.1046/j.1365-2249.1999.00766.x

Cited by 248Systemic Lupus Erythematosus ResearchT-cell and B-cell ImmunologyRheumatoid Arthritis Research and Therapies

Th1 (IL-2, interferon-gamma (IFN-γ)) and Th2 (IL-10, IL-4) cytokine production by peripheral blood mononuclear cells (PBMC) from patients with systemic lupus erythematosus (SLE)

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VIALLARD, J F, PELLEGRIN, J L, RANCHIN, V, SCHAEVERBEKE, T, DEHAIS, J, LONGY-BOURSIER, M, RAGNAUD, J M, LENG, B +1 more·2001·Clinical and Experimental Immunology

DOI 10.1046/j.1365-2249.1999.00766.xPMC PMC1905189

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Abstract

SUMMARY: We investigated the production of IL-2, IFN-γ, IL-10 and IL-4 by PBMC from 24 patients with SLE and 10 healthy individuals. Basal and mitogen-stimulated (lipopolysaccharide and phytohaemagglutinin (LPS + PHA)) cytokine production was determined in a whole blood assay (WBA). Supernatants were collected and assayed with specific ELISAs. Although the IL-2 and IFN-γ contents did not differ significantly between patients and controls under both conditions, statistically significant correlations were found between each cytokine and disease activity (SLAM index) after stimulation (respectively, r= 0.501, P = 0.01 and r = 0.631, P = 0.001). PBMC IL-10 production was significantly higher for patients than controls (P = 0.05), but no correlation between IL-10 levels and the SLAM index was obtained. IL-4 production was not statistically different between SLE patients and controls. For stimulated WBAs, the IL-10/IL-2 and IL-10/IFN-γ ratios were significantly correlated with disease severity (P = 0.02; P = 0.001, respectively). Overall, our data suggest that SLE is characterized by an elevated production of IL-10, reflecting the basal state of activation of the immune system. During exacerbation of SLE, IL-2 and IFN-γ are synthesized in larger amounts and may cause the tissue damage observed.

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In adaptive immune regulation, •NO inhibits T helper 1 lymphocytes and promotes Th2 lymphocytes, which leads to humoral immunity and allergic responses.
“In adaptative immune regulation, •NO inhibits the lymphocytes T helper 1 (Th1 is a population characterized by the release of IL-2 and IFN-γ) and promotes Th2 lymphocytes, which leads to humoral immunity and allergic responses [113].”
From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [113]

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Background
Biomarkers in systemic lupus erythematosus: II. Markers of disease activity
Illei, G. G., Tackey, E., Lapteva, L., & Lipsky, P. E. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20345 · Cited by 142 · see citing works
The Role of Reactive Species on Innate Immunity
Andrés, C., Pérez de la Lastra, J., Juan, C., Plou, F., & Pérez-Lebeña, E. (2022) · Vaccines · doi:10.3390/vaccines10101735 · Cited by 142 · see citing works
“In adaptative immune regulation, •NO inhibits the lymphocytes T helper 1 (Th1 is a population characterized by the release of IL-2 and IFN-γ) and promotes Th2 lymphocytes, which leads to humoral immunity and allergic responses [113].”
Background
Immunomodulation by metals
Lawrence, D. A., & McCabe, M. J. (2002) · International Immunopharmacology · doi:10.1016/s1567-5769(01)00180-1 · Cited by 139 · see citing works
Increased serum interleukin 17 in patients with systemic lupus erythematosus
Zhao, X., Pan, H., Yuan, H., Zhang, W., Li, X.-P., Wang, G., Wu, G., Su, H., Pan, F., Li, W.-X., et al. (2009) · Molecular Biology Reports · doi:10.1007/s11033-009-9533-3 · Cited by 137 · see citing works
Elevated Production of B Cell Chemokine CXCL13 is Correlated with Systemic Lupus Erythematosus Disease Activity
Wong, C. K., Wong, P. T. Y., Tam, L., Li, E. K., Chen, D. P., & Lam, C. W. K. (2009) · Journal of Clinical Immunology · doi:10.1007/s10875-009-9325-5 · Cited by 137 · see citing works
Suppressive oligodeoxynucleotides delay the onset of glomerulonephritis and prolong survival in lupus‐prone NZB × NZW mice
Dong, L., Ito, S., Ishii, K. J., & Klinman, D. M. (2005) · Arthritis & Rheumatism · doi:10.1002/art.20810 · Cited by 134 · see citing works
Immune complexes from SLE sera induce IL10 production from normal peripheral blood mononuclear cells by an FcγRII dependent mechanism: implications for a possible vicious cycle maintaining B cell hyperactivity in SLE
Rönnelid, J., Tejde, A., Mathsson, L., Nilsson-Ekdahl, K., & Nilsson, B. (2002) · Annals of the Rheumatic Diseases · doi:10.1136/ard.62.1.37 · Cited by 130 · see citing works
Foxp3, Regulatory T Cell, and Autoimmune Diseases
Tao, J.-H., Cheng, M., Tang, J.-P., Liu, Q., Pan, F., & Li, X.-P. (2016) · Inflammation · doi:10.1007/s10753-016-0470-8 · Cited by 129 · see citing works
Enhanced Tryptophan Degradation in Systemic Lupus Erythematosus
Widner, B., Sepp, N. T., Kowald, E., Ortner, U., Wirleitner, B., Fritsch, P. O., Baier-Bitterlich, G., & Fuchs, D. (2000) · Immunobiology · doi:10.1016/s0171-2985(00)80079-0 · Cited by 128 · see citing works
Elevation of plasma interleukin‐18 concentration is correlated with disease activity in systemic lupus erythematosus
Wong, C. K., Li, E. K., Ho, C. Y., & Lam, C. W. K. (2000) · Lara D. Veeken · doi:10.1093/rheumatology/39.10.1078 · Cited by 122 · see citing works
Laser microdissection-based analysis of cytokine balance in the kidneys of patients with lupus nephritis
Wang, Y., Ito, S., Chino, Y., Goto, D., Matsumoto, I., 村田, 秀., Tsutsumi, A., Hayashi, T., Uchida, K., Usui, J., et al. (2009) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2009.04031.x · Cited by 120 · see citing works
Up-regulation of IL-18 and predominance of a Th1 immune response is a hallmark of lupus nephritis
Calvani, N., Richards, H., Tucci, M., Pannarale, G., & Silvestris, F. (2004) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2004.02588.x · Cited by 120 · see citing works
Elevation of plasma osteopontin concentration is correlated with disease activity in patients with systemic lupus erythematosus.
Wong, C., Lit, L. C., Tam, L.-S., Li, E., & Lam, C.-W.-K. (2005) · Rheumatology · doi:10.1093/rheumatology/keh558 · Cited by 115 · see citing works
Aberrant activation profile of cytokines and mitogen-activated protein kinases in type 2 diabetic patients with nephropathy
Wong, C. K., Ho, A. M. ‐., Tong, P. C. Y., Yeung, C. Y., Kong, A. P. S., Lun, S. W., Chan, J. C. N., & Lam, C. W. K. (2007) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2007.03389.x · Cited by 115 · see citing works
The PPAR-γ antagonist GW9662 elicits differentiation of M2c-like cells and upregulation of the MerTK/Gas6 axis: a key role for PPAR-γ in human macrophage polarization
Zizzo, G., & Cohen, P. (2015) · Journal of Inflammation · doi:10.1186/s12950-015-0081-4 · Cited by 94 · see citing works
Oxidative stress in systemic lupus erythematosus: Relationship to Th1 cytokine and disease activity
Shah, D., Kiran, R., Wanchu, A., & Bhatnagar, A. (2010) · Immunology Letters · doi:10.1016/j.imlet.2010.01.005 · Cited by 100 · see citing works
IFN-γ, should not be ignored in SLE
Liu, W., Zhang, S., & Wang, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.954706 · Cited by 100 · see citing works
Glucocorticoid Regulates Interleukin-37 in Systemic Lupus Erythematosus
Song, L., Qiu, F., Fan, Y., Ding, F., Liu, H., Shu, Q., Liu, W., & Li, X. (2012) · Journal of Clinical Immunology · doi:10.1007/s10875-012-9791-z · Cited by 95 · see citing works
“Studies showed that IFN-γ was increased at both the RNA and protein levels in SLE patients, particularly those in the active stages of the disease [6, 7, 31, 32], and the overexpression of IFN-γ contributed to the immunopathogenesis of SLE.”
Estrogen Receptor Signaling and Its Relationship to Cytokines in Systemic Lupus Erythematosus
Kassi, E. N., & Moutsatsou, P. (2010) · BioMed Research International · doi:10.1155/2010/317452 · Cited by 95 · see citing works
Macrophage subpopulations in systemic lupus erythematosus.
Orme, J. J., & Mohan, C. (2012) · PubMed · Cited by 93 · see citing works
The association of cytokines with disease activity and damage scores in systemic lupus erythematosus patients
McCarthy, E. M., Smith, S. M., Lee, R. Z., Cunnane, G., Doran, M. F., Donnelly, S. C., Howard, D., O’Connell, P. R., Kearns, G. M., Gabhann, J. N., et al. (2014) · Lara D. Veeken · doi:10.1093/rheumatology/ket428 · Cited by 88 · see citing works
Effective Radiotherapy in Tumor Assisted by Ganoderma lucidum Polysaccharide-Conjugated Bismuth Sulfide Nanoparticles through Radiosensitization and Dendritic Cell Activation
Yu, H., Yang, Y., Jiang, T., Zhang, X., Zhao, Y., Pang, G., Feng, Y., Zhang, S., Wang, F., Wang, Y., et al. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b07804 · Cited by 87 · see citing works
Evaluating the effects of immunosuppressants on human immunity using cytokine profiles of whole blood
Liu, Z., Yuan, X., Luo, Y., He, Y., Jiang, Y., Chen, Z. K., & Sun, E. (2009) · Cytokine · doi:10.1016/j.cyto.2008.12.003 · Cited by 85 · see citing works
Elevated production of interleukin-18 is associated with renal disease in patients with systemic lupus erythematosus
Wong, C. K., Ho, C. Y., Li, E. K., Tam, L., & Lam, C. W. K. (2002) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2002.01989.x · Cited by 85 · see citing works
A whole genome methylation analysis of systemic lupus erythematosus: hypomethylation of the IL10 and IL1R2 promoters is associated with disease activity
Lin, S.-Y., Hsieh, S.-C., Lin, Y.-C., Lee, C.-N., Tsai, M.-H., Lai, L.-C., Chuang, E. Y.-Y., Chen, P.-C., Hung, C.-C., Chen, L.-Y., et al. (2011) · Genes and Immunity · doi:10.1038/gene.2011.74 · Cited by 83 · see citing works
Immunopathological Roles of Cytokines, Chemokines, Signaling Molecules, and Pattern-Recognition Receptors in Systemic Lupus Erythematosus
Yu, S., Kuan, W.-P., Wong, C. K., Li, E. K., & Tam, L. (2012) · Clinical and Developmental Immunology · doi:10.1155/2012/715190 · Cited by 83 · see citing works
“The ratios of Th1 and Th2 cytokines have been investigated to determine the cytokine homeostasis in order to determine whether Th1 or Th2 predominance during the development of SLE [2, 3].”
Background
Activation of the STAT1 signalling pathway in lupus nephritis in MRL/lpr mice
Dong, J., Wang, Q.-X., Zhou, C.-Y., Ma, X.-F., & Zhang, Y.-C. (2007) · Lupus · doi:10.1177/0961203306075383 · Cited by 77 · see citing works
Resistance/susceptibility to Echinococcus multilocularis infection and cytokine profile in humans. II. Influence of the HLA B8, DR3, DQ2 haplotype
Godot, V., Harraga, S., Beurton, I., Tiberghien, P., Sarciron, M. E., Gottstein, B., & Vuitton, D. A. (2000) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2000.01309.x · Cited by 77 · see citing works
Susceptibility of Lupus-Prone Nzm Mouse Strains to Lead Exacerbation of Systemic Lupus Erythematosus Symptoms
Hudson, C. A., Cao, L., Kasten‐Jolly, J., Kirkwood, J., & Lawrence, D. A. (2003) · Journal of Toxicology and Environmental Health · doi:10.1080/15287390306456 · Cited by 75 · see citing works
“It has also been found that, at the time of initiation, there is a transient increase in the IL-10/IL-12 ratio that is followed by an increase in the Th1 cytokines (Horwitz et al., 1997; Viallard et al., 1999).”
Background
Tolerogenic probiotics: potential immunoregulators in Systemic Lupus Erythematosus
Esmaeili, S., Mahmoudi, M., Momtazi‐Borojeni, A. A., Sahebkar, A., Doulabi, H., & Rastin, M. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25748 · Cited by 77 · see citing works
“During exacerbation of SLE, IFN-γ is synthesized in larger amounts which may contribute in the tissue damage observed (Viallard et al., 1999).”
Background
Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus
Wang, J., Mizui, M., Zeng, L., Bronson, R. T., Finnell, M. D., Terhorst, C., Kyttaris, V. C., Tsokos, G. C., Zhang, Z., & Kontaridis, M. I. (2016) · Journal of Clinical Investigation · doi:10.1172/jci87037 · Cited by 74 · see citing works
Mathematical model of sarcoidosis
Hao, W., Crouser, E. D., & Friedman, A. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1417789111 · Cited by 73 · see citing works
Biomarkers in systemic lupus erythematosus
Illei, G. G., & Lipsky, P. E. (2004) · Current Rheumatology Reports · doi:10.1007/s11926-004-0013-4 · Cited by 73 · see citing works
Systemic lupus erythematosus: pathogenesis and targeted therapy
Su, X., Yu, H. M., Lei, Q., Chen, X., Tong, Y., Zhang, Z., Yang, W., Guo, Y., & Lin, L. (2024) · Molecular Biomedicine · doi:10.1186/s43556-024-00217-8 · Cited by 84 · see citing works
“Research has demonstrated that SLE patients exhibit elevated serum levels of IFN-γ compared to healthy controls [233–236].”
Genetic Susceptibility to Atopic Dermatitis
Kiyohara, C., Tanaka, K., & Miyake, Y. (2008) · Allergology International · doi:10.2332/allergolint.r-07-150 · Cited by 69 · see citing works
Inflammatory cytokine gene expression in the urinary sediment of patients with lupus nephritis
Chan, R. W. Y., Tam, L., Li, E. K., Lai, F. M., Chow, K., Lai, K., Li, P. K., & Szeto, C. (2003) · Arthritis & Rheumatism · doi:10.1002/art.11062 · Cited by 68 · see citing works
In vitro quantification of anti-red blood cell antibody production in idiopathic autoimmune haemolytic anaemia: effect of mitogen and cytokine stimulation
Barcellini, W., Clerici, G., Montesano, R., Taioli, E., Morelati, F., Rebulla, P., & Zanella, A. (2000) · British Journal of Haematology · doi:10.1046/j.1365-2141.2000.02380.x · Cited by 67 · see citing works
Increased expression of costimulatory markers CD134 and CD80 on interleukin-17 producing T cells in patients with systemic lupus erythematosus
Dolff, S., Quandt, D., Wilde, B., Feldkamp, T., Hua, F., Cai, X., Specker, C., Kribben, A., Kallenberg, C. G. M., & Witzke, O. (2010) · Arthritis Research & Therapy · doi:10.1186/ar3100 · Cited by 65 · see citing works
“Th1 cells secrete interferon gamma (INF-g) and are induced by IL-12, whereas Th2 cells secrete IL-4, IL-5 and IL-13 and are induced by IL-4 [1,2].”
Background
Proinflammatory cytokine (IL-1β, IL-6, IL-12, IL-18 and TNF-α) levels in sera of patients with subacute cutaneous lupus erythematosus (SCLE)
Mączyńska, I., Millo, B., Ratajczak-Stefańska, V., Maleszka, R., Szych, Z., Kurpisz, M. K., & Giedrys‐Kalemba, S. (2005) · Immunology Letters · doi:10.1016/j.imlet.2005.08.001 · Cited by 66 · see citing works
Decreased serum IL-22 levels in patients with systemic lupus erythematosus
Pan, H., Zhao, X., Yuan, H., Zhang, W., Li, X.-P., Wang, G., Wu, G., Tang, X., Li, W.-X., Li, L., et al. (2008) · Clinica Chimica Acta · doi:10.1016/j.cca.2008.11.009 · Cited by 64 · see citing works
“Until recently, Th1 dominant immune responses have been generally considered to be pathological in autoimmune disease via the induction of inflammatory reaction, and large amounts of Th1 cytokines such as interferon (IFN)-γ, tumor necrosis factor (TNF)-α, and IL-12 have been found in SLE [3,4].”
Background
A surface charge dependent enhanced Th1 antigen-specific immune response in lymph nodes by transfersome-based nanovaccine-loaded dissolving microneedle-assisted transdermal immunization
Wu, X., Li, Y., Chen, X., Zhou, Z., Pang, J., Luo, X., & Kong, M. (2019) · Journal of Materials Chemistry B · doi:10.1039/c9tb00448c · Cited by 60 · see citing works
T cell receptor repertoire of T cells in the kidneys of patients with lupus nephritis
村田, 秀., Matsumura, R., Kôyama, A., Sugiyama, T., Sueishi, M., Shibuya, K., Tsutsumi, A., & Sumida, T. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10432 · Cited by 57 · see citing works
Immunomodulatory effect of exo-polysaccharides from submerged cultured Cordyceps sinensis: enhancement of cytokine synthesis, CD11b expression, and phagocytosis
Kuo, M.-C., Chang, C.-Y., Cheng, T.-L., & Wu, M. (2007) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-007-0880-5 · Cited by 56 · see citing works
“In peripheral blood, not only is the natural cell–cell interactions preserved but also circulating stimulatory and inhibitory mediators are present at their physiological concentrations (Viallard et al. 1999).”
Background
High-intensity interval training can modulate the systemic inflammation and HSP70 in the breast cancer: a randomized control trial
Alizadeh, A. M., Isanejad, A., Sadighi, S., Mardani, M., Kalaghchi, B., & Hassan, Z. M. (2019) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-019-02996-y · Cited by 56 · see citing works
Immunomodulatory effects of Yun Zhi and Danshen capsules in health subjects—a randomized, double-blind, placebo-controlled, crossover study
Wong, C. K., Tse, P. S., Wong, E. L., Leung, P. C., Fung, K., & Lam, C. W. K. (2003) · International Immunopharmacology · doi:10.1016/j.intimp.2003.12.003 · Cited by 55 · see citing works
Patients with Systemic Lupus Erythematosus
Byun (1999) · American family physician · Cited by 53 · see citing works
Immunoregulation of NKT Cells in Systemic Lupus Erythematosus
Chen, J., Wu, M. C., Wang, J., & Li, X. (2015) · Journal of Immunology Research · doi:10.1155/2015/206731 · Cited by 52 · see citing works
“The imbalance between Th1 and Th2 cytokines participates in the immunoregulation of SLE [29, 40].”
Background
Incidence of Autoantibodies Against Type I and Type II Interferons in a Cohort of Systemic Lupus Erythematosus Patients in Slovakia
Slavíková, M., Schmeisser, H., Kontseková, E., Mateička, F., Borecky, L., & KONTSEK, P. (2003) · Journal of Interferon & Cytokine Research · doi:10.1089/107999003321532475 · Cited by 51 · see citing works
MIF promotes a differential Th1/Th2/Th17 inflammatory response in human primary cell cultures: Predominance of Th17 cytokine profile in PBMC from healthy subjects and increase of IL-6 and TNF-α in PBMC from active SLE patients
la Cruz-Mosso, U. D., García‐Iglesias, T., Bucala, R., Estrada‐García, I., González-López, L., Cerpa‐Cruz, S., Parra‐Rojas, I., Gámez-Nava, J. I., Pérez-Guerrero, E. E., & Muñóz-Valle, J. F. (2017) · Cellular Immunology · doi:10.1016/j.cellimm.2017.12.010 · Cited by 51 · see citing works
The effect of immunosuppressive therapy on the messenger RNA expression of target genes in the urinary sediment of patients with active lupus nephritis
Chan, R. W. Y., Lai, F. M., Li, E. K., Tam, L., Chow, K., Li, P. K., & Szeto, C. (2006) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfk102 · Cited by 47 · see citing works
Cathepsin S inhibition suppresses autoimmune-triggered inflammatory responses in macrophages
Thanei, S., Theron, M., Silva, A. P., Reis, B., Branco, L., Schirmbeck, L. A., Kolb, F. A., Haap, W. J., Schindler, T. H., & Trendelenburg, M. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.10.001 · Cited by 46 · see citing works
Avian pathogenic Escherichia coli (APEC) infection alters bone marrow transcriptome in chickens
Sun, H., Liu, P., Nolan, L. K., & Lamont, S. J. (2015) · BMC Genomics · doi:10.1186/s12864-015-1850-4 · Cited by 44 · see citing works
Interleukin 4 and STAT6 gene polymorphisms are associated with systemic lupus erythematosus in Chinese patients
Yu, H., Liu, P., Lin, Y., Chen, W. J., Lee, J., Wang, L., Yang, Y., & Chiang, B. (2010) · Lupus · doi:10.1177/0961203310371152 · Cited by 44 · see citing works
Stage Dependent Aberrant Regulation of Cytokine-STAT Signaling in Murine Systemic Lupus Erythematosus
Hale, M. B., Krutzik, P. O., Samra, S. S., Crane, J., & Nolan, G. P. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006756 · Cited by 44 · see citing works
Esculetin alleviates murine lupus nephritis by inhibiting complement activation and enhancing Nrf2 signaling pathway
Zhang, Y., Li, Z., Wu, H., Wang, J., & Zhang, S. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115004 · Cited by 43 · see citing works
The Function of CD3+CD56+NKT-Like Cells in HIV-Infected Individuals
Jiang, Y., Cui, X., Chen, C., Zhang, J., Zhou, F., Zhang, Z., Fu, Y., Xu, J., Chu, Z., Liu, J., et al. (2014) · BioMed Research International · doi:10.1155/2014/863625 · Cited by 43 · see citing works
BAFF-R and TACI expression on CD3+ T cells: Interplay among BAFF, APRIL and T helper cytokines profile in systemic lupus erythematosus
Salazar‐Camarena, D. C., Ortiz‐Lazareno, P. C., Marín‐Rosales, M., Cruz, Á., Muñoz‐Valle, F., Tapia‐Llanos, R., Orozco‐Barocio, G., Machado-Contreras, J. R., & Palafox‐Sánchez, C. A. (2018) · Cytokine · doi:10.1016/j.cyto.2018.11.008 · Cited by 42 · see citing works
Macrophages and neutrophils in SLE—An online molecular catalog
Orme, J. J., & Mohan, C. (2011) · Autoimmunity Reviews · doi:10.1016/j.autrev.2011.10.010 · Cited by 42 · see citing works
“Contrary to its classical designation as an anti-inflammatory cytokine, IL-10 contributes directly to SLE pathogenesis.”
BackgroundInfluential
The effect of interleukin-10 and of interleukin-12 on the in vitro production of anti-double-stranded DNA antibodies from patients with systemic lupus erythematosus
Tyrrell-Price, J., Lydyard, P. M., & Isenberg, D. A. (2001) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2001.01466.x · Cited by 42 · see citing works
Clinical Studies of Immunomodulatory Activities of Yunzhi-Danshen in Patients with Nasopharyngeal Carcinoma
Bao, Y. X., Wong, C. K., Leung, S. F., Chan, A. T. �., Li, P. W., Wong, E. L., Leung, P., Fung, K., Yin, Y. B., & Lam, C. W. K. (2006) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2006.12.771 · Cited by 41 · see citing works
Interferon-γ polymorphisms in systemic lupus erythematosus
Lee, J., GOLDMAN, D. W., Piliero, L. M., Petri, M., & Sullivan, K. E. (2001) · Genes and Immunity · doi:10.1038/sj.gene.6363775 · Cited by 41 · see citing works
Activation of Peripheral Th17 Lymphocytes in Patients with Asthma
Wong, C. K., Lun, S. W., Ko, F. W. S., Wong, P. T. Y., Hu, S. Q., Chan, I. H.-S., Hui, D. S. C., & Lam, C. W. K. (2009) · Immunological Investigations · doi:10.1080/08820130903062756 · Cited by 40 · see citing works
Cytokine imbalance in systemic lupus erythematosus: a study on northern Indian subjects
Arora, V., Verma, J., Marwah, V., Kumar, A., Anand, D., & Das, N. (2012) · Lupus · doi:10.1177/0961203311434937 · Cited by 40 · see citing works
Increased serum IL-10 in lupus patients promotes apoptosis of T cell subsets via the caspase 8 pathway initiated by Fas signaling
Yang, X., Sun, B., Wang, H., Cheng, Y., Xiaole, W., & Ji, X. (2015) · Journal of Biomedical Research · doi:10.7555/jbr.29.20130037 · Cited by 39 · see citing works
The CXCR4–STAT3–IL-10 Pathway Controls the Immunoregulatory Function of Chronic Lymphocytic Leukemia and Is Modulated by Lenalidomide
Shaim, H., Estrov, Z. E., Harris, D., Sanabria, M. H., Liu, Z., Ruvolo, P. P., Thompson, P. A., Ferrajoli, A., Daher, M., Burger, J. A., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01773 · Cited by 38 · see citing works
Sulfated Mesona chinensis Benth polysaccharide enhance the immunomodulatory activities of cyclophosphamide-treated mice
Shen, M., Chen, X., Huang, L., Yu, Q., Chen, Y., & Xie, J. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104321 · Cited by 38 · see citing works
Immunological tolerance loss vs. erythrocyte self antigens and cytokine network disregulation in autoimmune hemolytic anaemia
Fagiolo, E. (2003) · Autoimmunity Reviews · doi:10.1016/s1568-9972(03)00085-5 · Cited by 38 · see citing works
Aberrant Expression of Soluble Co-stimulatory Molecules and Adhesion Molecules in Type 2 Diabetic Patients with Nephropathy
Wong, C. K., Ho, A. M. ‐., Tong, P. C. Y., Yeung, C. Y., Chan, J. C. N., Kong, A. P. S., & Lam, C. W. K. (2007) · Journal of Clinical Immunology · doi:10.1007/s10875-007-9137-4 · Cited by 38 · see citing works
Immunological alterations in newly diagnosed primary Sjögren's syndrome characterized by skewed peripheral T‐cell subsets and inflammatory cytokines
Szodoray, P., Gál, I., Baráth, S., Aleksza, M., Horváth, I. F., Gergely, P., Szegedi, G., Nakken, B., & Zeher, M. (2008) · Scandinavian Journal of Rheumatology · doi:10.1080/03009740801910361 · Cited by 38 · see citing works
“IL-10 and IFN-c levels depend strongly on the level of immune activation in patients with autoimmune diseases (38).”
Background
Interleukin-12 inhibits pathological neovascularization in mouse model of oxygen-induced retinopathy
Zhou, Y., Yoshida, S., Kubo, Y., Kobayashi, Y., Nakama, T., Yamaguchi, M., Ishikawa, K., Nakao, S., Ikeda, Y., Ishibashi, T., et al. (2016) · Scientific Reports · doi:10.1038/srep28140 · Cited by 38 · see citing works
The role of interleukins 4, 17 and interferon gamma as biomarkers in patients with Systemic Lupus Erythematosus and their correlation with disease activity
Elewa, E. A., Zakaria, O., Mohamed, E. I., & Boghdadi, G. (2013) · The Egyptian Rheumatologist · doi:10.1016/j.ejr.2013.10.003 · Cited by 37 · see citing works
Inhibition of Lupus by Genetic Alteration of the Interferon-α/β Receptor
Kono, D. H., Baccalà, R., & Theofilopoulos, A. N. (2003) · Autoimmunity · doi:10.1080/08916930310001624665 · Cited by 37 · see citing works
IL-10 and the Cytokine Network in the Pathogenesis of Human Autoimmune Hemolytic Anemia
Toriani-Terenzi, C., & Fagiolo, E. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1361.044 · Cited by 37 · see citing works
Amidase, a cell wall hydrolase, elicits protective immunity against Staphylococcus aureus and S. epidermidis
Nair, N., Vinod, V., Suresh, M. K., Vijayrajratnam, S., Biswas, L., Peethambaran, R., Vasudevan, A. K., & Biswas, R. (2015) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2015.03.047 · Cited by 36 · see citing works
Changes in Serum Cytokines May Predict Therapeutic Efficacy of Tofacitinib in Rheumatoid Arthritis
Li, Y., Yuan, L., Yang, J. W., Lei, Y., Zhang, H., Xia, L., Shen, H., & Lu, J. (2019) · Mediators of Inflammation · doi:10.1155/2019/5617431 · Cited by 36 · see citing works
“CD4+Th lymphocytes can be divided into Th1 (IFN-γ, IL-2, and TNF-β) and Th2 (IL-4, IL-6, IL-10, and IL-13) subsets on the basis of their cytokines secretion profile [15].”
Background
Lupus patients with pulmonary involvement have a pro-inflammatory cytokines profile
Al-Mutairi, S., Al-Awadhi, A. M., Raghupathy, R., Al-Khawari, H., Sada, P. N., Al-Herz, A. A., & Rawoot, P. (2006) · Rheumatology International · doi:10.1007/s00296-006-0268-3 · Cited by 36 · see citing works
Increased lipid and protein oxidation and lowered anti-oxidant defenses in systemic lupus erythematosus are associated with severity of illness, autoimmunity, increased adhesion molecules, and Th1 and Th17 immune shift
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Increased interferon-gamma (IFN-γ), IL-10 and decreased IL-4 mRNA expression in peripheral blood mononuclear cells (PBMC) from patients with systemic lupus erythematosus (SLE)
Csiszár, A., Nagy, G. Y., Gergely, P., Pozsonyi, T., & Pócsik, É. (2000) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2000.01369.x · Cited by 147 · see citing works
Disease severity in patients with systemic lupus erythematosus correlates with an increased ratio of interleukin‐10: Interferon‐γ–secreting cells in the peripheral blood
Hagiwara, E., Gourley, M. F., Lee, S., & Klinman, D. M. (1996) · Arthritis & Rheumatism · doi:10.1002/art.1780390305 · Cited by 287 · see citing works
Level and significance of Interleukin-10 and Interferon-γ secreted by peripheral blood mononuclear cells in patients with systemic lupus erythematosus
Xu, J. (2002) · Zhonghua fengshibingxue zazhi
Monocytes and T lymphocytes contribute to a predominance of interleukin 6 and interleukin 10 in systemic lupus erythematosus
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Level and significance of Th1/Th2 cytokine in patients with systemic lupus erythe matosus
Suo, X. (2007) · Zhongguo xiandai yixue/Zhongguo xiandai yixue zazhi

Authors: VIALLARD, J. F., PELLEGRIN, J. L., RANCHIN, V, SCHAEVERBEKE, T., DEHAIS, J., LONGY-BOURSIER, M., RAGNAUD, J. M., LENG, B., & MOREAU, J. F.
Affiliations: Centre National de la Recherche Scientifique (FR)
Hôpital Cardiologique du Haut-Lévêque (FR)
Laboratoire Immunotech, Marseille
Hôpital Pellegrin (FR)
Service de Médecine Interne, Hôpital Saint-André
Corresponding author: VIALLARD, J F
ORCID: VIALLARD, J F
PELLEGRIN, J L
SCHAEVERBEKE, T
MOREAU, J F
Venue: Clinical and Experimental Immunology
Publisher: Oxford University Press (OUP)
Published: 1999-01
Volume: 115
Issue: 1
Pages: 189-195
ISSN: 0009-9104 (ISSN-L)
1365-2249
DOI: 10.1046/j.1365-2249.1999.00766.x
PMC: PMC1905189
OpenAlex: W2030175762
Cited by: 247
References: 48
Citations by year: 2026: 8 · 2025: 9 · 2024: 8 · 2023: 13 · 2022: 10 · 2021: 7 · 2020: 9 · 2019: 9 · 2018: 5 · 2017: 7 · 2016: 12 · 2015: 11 · 2014: 16 · 2013: 4 · 2012: 13
FWCI: 6.46
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: Clinical & Experimental Immunology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
Keywords: systemic lupus erythematosus, Th1/Th2 balance, interleukin-2, interferon-gamma, IL-10, IL-4, peripheral blood mononuclear cells, disease activity, cytokine ratios, immune activation, tissue damage
MeSH terms: Adolescent, Adult, Female, Humans, Interferon-gamma, Interleukin-2, Leukocytes, Mononuclear, Lupus Erythematosus, Systemic, Male, Middle Aged, Interleukin-4, Cytokines, Interleukin-10, Th1 Cells, Th2 Cells

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Th1 (IL-2, interferon-gamma (IFN-γ)) and Th2 (IL-10, IL-4) cytokine production by peripheral blood mononuclear cells (PBMC) from patients with systemic lupus erythematosus (SLE)

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