The DOI matches its Crossref record; 189 of the 189 references it cites were found in a registry or an index.
The role of oxidative stress in skeletal muscle injury and regeneration: focus on antioxidant enzymes
Open accessAbstract
Reactive oxygen species (ROS) are generated in skeletal muscle both during the rest and contractile activity. Myogenic cells are equipped with antioxidant enzymes, like superoxide dismutase, catalase, glutathione peroxidase, γ-glutamylcysteine synthetase and heme oxygenase-1. These enzymes not only neutralise excessive ROS, but also affect myogenic regeneration at several stages: influence post-injury inflammatory reaction, enhance viability and proliferation of muscle satellite cells and myoblasts and affect their differentiation. Finally, antioxidant enzymes regulate also processes accompanying muscle regeneration-induce angiogenesis and reduce fibrosis. Elevated ROS production was also observed in Duchenne muscular dystrophy (DMD), a disease characterised by degeneration of muscle tissue and therefore-increased rate of myogenic regeneration. Antioxidant enzymes are consequently considered as target for therapies counteracting dystrophic symptoms. In this review we present current knowledge regarding the role of oxidative stress and systems of enzymatic antioxidant defence in muscular regeneration after both acute injury and persistent muscular degeneration.
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1 retracted
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Ru, Q., Li, Y., Chen, L., Wu, Y., Min, J., & Wang, F. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01969-z · Cited by 724
Scioli, M. G., Storti, G., D’Amico, F., Rodríguez Guzmán, R., Centofanti, F., Doldo, E., Céspedes Miranda, E. M., & Orlandi, A. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9061995 · Cited by 281
The Role of Oxidative Stress in Skeletal Muscle Myogenesis and Muscle Disease
Lian, D., Chen, M.-M., Wu, H., Deng, S., & Hu, X. (2022) · Antioxidants · doi:10.3390/antiox11040755 · Cited by 232
“These enzymes can neutralize excessive ROS, and play an important role in the regeneration process: influencing post-injury inflammatory reaction, affecting differentiation by enhancing satellite cell viability and proliferative capacity [24].”
BackgroundSaito, Y., Chikenji, T. S., Matsumura, T., Nakano, M., & Fujimiya, M. (2020) · Nature Communications · doi:10.1038/s41467-020-14734-x · Cited by 196
Bellanti, F., Romano, A. D., Lo Buglio, A., Castriotta, V., Guglielmi, G., Greco, A., Serviddio, G., & Vendemiale, G. (2018) · Maturitas · doi:10.1016/j.maturitas.2017.12.002 · Cited by 158
Metadata
- Authors
- Kozakowska, M., Pietraszek-Gremplewicz, K., Jozkowicz, A., & Dulak, J.
- Venue
- Journal of Muscle Research and Cell Motility
- Published
- 2015-12
- Volume
- 36
- Issue
- 6
- Pages
- 377-393
- ISSN
- 0142-4319 (ISSN-L)
- 1573-2657
- OpenAlex
- W2225100482
- Cited by
- 331
- References
- 189
- FWCI
- 7.46
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Kozakowska, M., Pietraszek-Gremplewicz, K., Jozkowicz, A., & Dulak, J. (2015). The role of oxidative stress in skeletal muscle injury and regeneration: focus on antioxidant enzymes. Journal of Muscle Research and Cell Motility. https://doi.org/10.1007/s10974-015-9438-9
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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