Cited by 102Phosphodiesterase function and regulationNitric Oxide and Endothelin EffectsReceptor Mechanisms and Signaling

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New insight into the functioning of nitric oxide-receptive guanylyl cyclase: physiological and pharmacological implications

Garthwaite, John·2010·Molecular and Cellular Biochemistry

DOI 10.1007/s11010-009-0318-8

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Abstract

The cellular counterpart of the "soluble" guanylyl cyclase found in tissue homogenates over 30 years ago is now recognized as the physiological receptor for nitric oxide (NO). The ligand-binding site is a prosthetic haem group that, when occupied by NO, induces a conformational change in the protein that propagates to the catalytic site, triggering conversion of GTP into cGMP. This review focuses on recent research that takes this basic information forward to the beginnings of a quantitative depiction of NO signal transduction, analogous to that achieved for other major transmitters. At its foundation is an explicit enzyme-linked receptor mechanism for NO-activated guanylyl cyclase that replicates all its main properties. In cells, NO signal transduction is subject to additional, activity-dependent modifications, notably through receptor desensitization and changes in the activity of cGMP-hydrolyzing phosphodiesterases. The measurement of these parameters under varying conditions in rat platelets has made it possible to formulate a cellular model of NO-cGMP signaling. The model helps explain cellular responses to NO and their modification by therapeutic agents acting on the guanylyl cyclase or phosphodiesterase limbs of the pathway.

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Nitric oxide: physiology, pathophysiology, and pharmacology.
Moncada, S., Palmer, R. M., & Higgs, E. A. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06663-3 · Cited by 15,525
NITRIC OXIDE AND MACROPHAGE FUNCTION
MacMicking, J. D., Xie, Q. W., & Nathan, C. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.323 · Cited by 4,245
Nitric oxide activates guanylate cyclase and increases guanosine 3′:5′-cyclic monophosphate levels in various tissue preparations
Arnold, W. P., Mittal, C. K., Katsuki, S., & Murad, F. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.8.3203 · Cited by 1,459
Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one.
Garthwaite, J., Southam, E., Boulton, C. L., Nielsen, E. B., Schmidt, K., & Mayer, B. (1995) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10233-2 · Cited by 1,101
Self-citation
Binding, gating, affinity and efficacy: The interpretation of structure‐activity relationships for agonists and of the effects of mutating receptors
Colquhoun, D. M. (1998) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702164 · Cited by 893
Cyclic GMP synthesis and function.
Waldman, S. A., & Murad, F. (1987) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06656-6 · Cited by 856
Concepts of neural nitric oxide‐mediated transmission
Garthwaite, J. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06285.x · Cited by 827
Self-citation
Evidence for the inhibitory role of guanosine 3', 5'-monophosphate in ADP-induced human platelet aggregation in the presence of nitric oxide and related vasodilators
Mellion, B. T., Ignarro, L. J., Ohlstein, E. H., Pontecorvo, E., Hyman, A. L., & Kadowitz, P. (1981) · Blood · doi:10.1182/blood.v57.5.946.946 · Cited by 639
EFFECTS OF SILDENAFIL ON THE RELAXATION OF HUMAN CORPUS CAVERNOSUM TISSUE IN VITRO AND ON THE ACTIVITIES OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASE ISOZYMES
Ballard, S. A., Gingell, C., Tang, K., TURNER, L. A., Price, M. E., & NAYLOR, A. M. (1998) · The Journal of Urology · doi:10.1016/s0022-5347(01)63299-3 · Cited by 590
NO-independent regulatory site on soluble guanylate cyclase
Stasch, J., Becker, E. M., Alonso‐Alija, C., Apeler, H., Dembowsky, K., Feurer, A., Gerzer, R., Minuth, T., Perzborn, E., Pleiß, U., et al. (2001) · Nature · doi:10.1038/35065611 · Cited by 546

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Authors: Garthwaite, J.
Affiliations: University College London (GB)
Corresponding author: Garthwaite, John
ORCID: Garthwaite, John
Venue: Molecular and Cellular Biochemistry
Publisher: Springer Science and Business Media LLC
Published: 2009-12-11
Volume: 334
Issue: 1-2
Pages: 221-232
ISSN: 0300-8177 (ISSN-L)
1573-4919
DOI: 10.1007/s11010-009-0318-8
OpenAlex: W2006132439
Cited by: 102
References: 99
Citations by year: 2025: 2 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 2 · 2019: 4 · 2018: 9 · 2017: 6 · 2016: 9 · 2015: 9 · 2014: 8 · 2013: 8 · 2012: 11
FWCI: 0.84
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Molecular and Cellular Biochemistry (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Funders: Wellcome Trust (081512/Z/06/Z)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phosphodiesterase function and regulation
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords: soluble guanylate cyclase, nitric oxide signaling, cyclic GMP, conformational change, receptor desensitization, phosphodiesterase, platelets
MeSH terms: Soluble Guanylyl Cyclase, Animals, Cyclic GMP, Guanylate Cyclase, Signal Transduction, Receptors, Cytoplasmic and Nuclear, Rats

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New insight into the functioning of nitric oxide-receptive guanylyl cyclase: physiological and pharmacological implications

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