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Cited by 36

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Anethole prevents hydrogen peroxide-induced apoptosis and collagen metabolism alterations in human skin fibroblasts

Galicka, Anna, Krętowski, Rafał, Nazaruk, Jolanta, Cechowska-Pasko, Marzanna·2014·Molecular and Cellular Biochemistry
DOI 10.1007/s11010-014-2097-0PMC PMC4118036
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Fig. 1 Chemical structure of anethole
Fig. 1 Chemical structure of anetholeCC BY · PubMed Central
Fig. 2 Effect of anethole on H2O2-induced cytotoxicity in human skin fibroblasts. Cells were pretreated with anethole for 1 h and then exposed to 300 µM H2O2 for 24 h. Values ± standard deviation (SD) are the mean of triplicate cultures.*P < 0.01, no treatment versus control H2O2; # P < 0.01, control versus anethole
Fig. 2 Effect of anethole on H2O2-induced cytotoxicity in human skin fibroblasts. Cells were pretreated with anethole for 1 h and then exposed to 300 µM H2O2 for 24 h. Values ± standard deviation (SD) are the mean of triplicate cultures.*P < 0.01, no treatment versus control H2O2; # P < 0.01, control versus anetholeCC BY · PubMed Central
Fig. 3 Effect of anethole on H2O2-induced changes in collagen biosynthesis (A) and the expression of COL1A1 gene (B) in human skin fibroblasts. Cells were incubated with anethole for 1 h and then exposed to 300 µM H2O2 for 24 h. *P < 0.05, **P < 0.01 no treatment versus control H2O2; # P < 0.05, ## P < 0.01 control versus anethole. Values ± standard deviation (SD) are the mean of triplicate cultures
Fig. 3 Effect of anethole on H2O2-induced changes in collagen biosynthesis (A) and the expression of COL1A1 gene (B) in human skin fibroblasts. Cells were incubated with anethole for 1 h and then exposed to 300 µM H2O2 for 24 h. *P < 0.05, **P < 0.01 no treatment versus control H2O2; # P < 0.05, ## P < 0.01 control versus anethole. Values ± standard deviation (SD) are the mean of triplicate culturesCC BY · PubMed Central
Fig. 4 Effect of anethole on collagen secreted into media in the presence of H2O2. Skin fibroblasts were pretreated with anethole for 1 h and then exposed to 300 µM H2O2 for 24 h. Values ± standard deviation (SD) are the mean of triplicate cultures. *P < 0.01, no treatment versus control H2O2; # P < 0.05, control versus anethole
Fig. 4 Effect of anethole on collagen secreted into media in the presence of H2O2. Skin fibroblasts were pretreated with anethole for 1 h and then exposed to 300 µM H2O2 for 24 h. Values ± standard deviation (SD) are the mean of triplicate cultures. *P < 0.01, no treatment versus control H2O2; # P < 0.05, control versus anetholeCC BY · PubMed Central
Fig. 5 Protective effect of anethole on H2O2-induced increase in gelatinases activity in human skin fibroblasts. A Representative zymography of pro- and active forms of MMP-2 and MMP-9. B Densitometric intensity of the zymography bands expressed as percentage of the control. Skin fibroblasts were pretreated with anethole for 1 h and then exposed to 300 µM H2O2 for 24 h. Values ± standard deviation (SD) are the mean of triplicate cultures. *P < 0.05, **P < 0.01 no treatment versus control H2O2; # P < 0.05, ## P < 0.01 control versus anethole
Fig. 5 Protective effect of anethole on H2O2-induced increase in gelatinases activity in human skin fibroblasts. A Representative zymography of pro- and active forms of MMP-2 and MMP-9. B Densitometric intensity of the zymography bands expressed as percentage of the control. Skin fibroblasts were pretreated with anethole for 1 h and then exposed to 300 µM H2O2 for 24 h. Values ± standard deviation (SD) are the mean of triplicate cultures. *P < 0.05, **P < 0.01 no treatment versus control H2O2; # P < 0.05, ## P < 0.01 control versus anetholeCC BY · PubMed Central
Fig. 6 Effect of anethole on H2O2-induced apoptosis of human skin fibroblasts. A Representative flow cytometric analysis using two color staining with annexin V-FITC and PI. B Percentage of apoptotic cells. Cells were pretreated with anethole for 1 h and then exposed to 300 µM H2O2 for 24 h. Values ± standard deviation (SD) are the mean of triplicate cultures. *P < 0.01 no treatment versus control H2O2; # P < 0.01 control versus anethole
Fig. 6 Effect of anethole on H2O2-induced apoptosis of human skin fibroblasts. A Representative flow cytometric analysis using two color staining with annexin V-FITC and PI. B Percentage of apoptotic cells. Cells were pretreated with anethole for 1 h and then exposed to 300 µM H2O2 for 24 h. Values ± standard deviation (SD) are the mean of triplicate cultures. *P < 0.01 no treatment versus control H2O2; # P < 0.01 control versus anetholeCC BY · PubMed Central

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Research works printed but not linked: 28

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Metadata

Authors
Galicka, A., Krętowski, R., Nazaruk, J., & Cechowska-Pasko, M.
Venue
Molecular and Cellular Biochemistry
Publisher
Springer Science and Business Media LLC
Published
2014-06-05
Volume
394
Issue
1-2
Pages
217-224
ISSN
  • 0300-8177
  • 1573-4919
DOI
10.1007/s11010-014-2097-0
PMC
PMC4118036
Cited by
36
References
3
Language
en
Licence
creativecommons.org/licenses/by/4.0 (unspecified)

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CoChat. (2026). Citation check: Anethole prevents hydrogen peroxide-induced apoptosis and collagen metabolism alterations in human skin fibroblasts. https://app.cochat.ai/papers/10.1007/s11010-014-2097-0
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Galicka, A., Krętowski, R., Nazaruk, J., & Cechowska-Pasko, M. (2014). Anethole prevents hydrogen peroxide-induced apoptosis and collagen metabolism alterations in human skin fibroblasts. Molecular and Cellular Biochemistry. https://doi.org/10.1007/s11010-014-2097-0