Cited by 56Bone Metabolism and DiseasesBone health and osteoporosis researchMesenchymal stem cell research

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Calcitonin gene-related peptide stimulates proliferation and osteogenic differentiation of osteoporotic rat-derived bone mesenchymal stem cells

Liang, Wei, Zhuo, Xianglong, Tang, Zhongfei, Wei, Xiaomou, Li, Bing·2015·Molecular and Cellular Biochemistry

Abstract

Osteoporosis, a systemic bone disorder, is prevalent in postmenopausal woman. Bone mesenchymal stem cells (BMSCs), precursors of osteogenic cells, may contribute to prevention or treatment of bone frustrate in osteoporosis. Recently, two studies suggested a role of calcitonin gene-related peptide (CGRP) in promoting osteogenesis of BMSCs under physiological conditions. However, the role of CGRP on BMSCs, which are derived from osteoporotic tissues, is unclear. Here, we investigated the role of CGRP on BMSCs isolated from female osteoporotic rats. Data showed that CGRP stimulated cell proliferation and inhibited cell apoptosis for short-term culture of BMSCs. Instead, CGRP induced BMSCs differentiation into the osteoblasts and promoted formation of calcified nodules after long-term culture. Moreover, CGRP gradually up-regulated expression levels of osteoporotic differentiation-related genes including alkaline phosphatase, Collagen type I, Bmp2, Osteonectin, and Runx2 during osteogenic differentiation. In conclusion, CGRP promoted proliferation and induced osteogenic differentiation and mineralization during female osteoporotic rat-derived BMSC differentiation. These findings support a potential role of CGRP on the prevention or treatment of osteoporotic fracture.

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Crossref · 10.1007/s11010-014-2318-6

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Metadata

Authors
Liang, W., Zhuo, X., Tang, Z., Wei, X., & Li, B.
Affiliations
Guangxi Medical University (CN)
Corresponding author
Li, Bing
Venue
Molecular and Cellular Biochemistry
Published
2015-01-07
Volume
402
Issue
1-2
Pages
101-110
ISSN
  • 0300-8177 (ISSN-L)
  • 1573-4919
OpenAlex
W2040863684
Cited by
56
References
37
Citations by year
2026: 1 · 2025: 2 · 2024: 4 · 2023: 3 · 2022: 8 · 2021: 4 · 2020: 10 · 2019: 6 · 2018: 9 · 2017: 2 · 2016: 6 · 2015: 1
FWCI
2.60
Type
journal article
Language
en
Open access
closed
Locations
  • Molecular and Cellular Biochemistry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Keywords
calcitonin gene-related peptide, bone mesenchymal stem cells, osteoporosis, osteogenic differentiation, cell proliferation, apoptosis, mineralization, osteoblasts, Runx2, BMP-2, osteoporotic fractures
MeSH terms
Alkaline Phosphatase, Animals, Cell Differentiation, Cells, Cultured, Female, Osteogenesis, Osteoporosis, Calcitonin Gene-Related Peptide, Up-Regulation, Rats, Sprague-Dawley, Cell Proliferation, Mesenchymal Stem Cells

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