The DOI matches its Crossref record; 105 of the 105 references it cites were found in a registry or an index.
Ammonia toxicity: from head to toe?
Open accessAbstract
Ammonia is diffused and transported across all plasma membranes. This entails that hyperammonemia leads to an increase in ammonia in all organs and tissues. It is known that the toxic ramifications of ammonia primarily touch the brain and cause neurological impairment. However, the deleterious effects of ammonia are not specific to the brain, as the direct effect of increased ammonia (change in pH, membrane potential, metabolism) can occur in any type of cell. Therefore, in the setting of chronic liver disease where multi-organ dysfunction is common, the role of ammonia, only as neurotoxin, is challenged. This review provides insights and evidence that increased ammonia can disturb many organ and cell types and hence lead to dysfunction.
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Self-citationMetabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass
Spinelli, J. B., Yoon, H., Ringel, A. E., Jeanfavre, S., Clish, C. B., & Haigis, M. C. (2017) · Science · doi:10.1126/science.aam9305 · Cited by 468
“0 mM in patients with hyperammonemia (25).”
Sood, Y., Singh, K., Mudila, H., Lokhande, P. E., Singh, L., Kumar, D., Kumar, A., Mubarak, N. M., & Dehghani, M. H. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e33643 · Cited by 106
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Metadata
- Authors
- Dasarathy, S., Mookerjee, R. P., Rackayova, V., Rangroo Thrane, V., Vairappan, B., Ott, P., & Rose, C. F.
- Venue
- Metabolic Brain Disease
- Published
- 2016-12-24
- Volume
- 32
- Issue
- 2
- Pages
- 529-538
- ISSN
- 0885-7490 (ISSN-L)
- 1573-7365
- OpenAlex
- W2562815196
- Cited by
- 288
- References
- 105
- FWCI
- 10.73
- Type
- journal article
- Language
- en
- Open access
- green
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- Dasarathy, S., Mookerjee, R. P., Rackayova, V., Rangroo Thrane, V., Vairappan, B., Ott, P., & Rose, C. F. (2017). Ammonia toxicity: from head to toe? Metabolic Brain Disease. https://doi.org/10.1007/s11011-016-9938-3
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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