The DOI matches its Crossref record; 39 of the 40 references it cites were found in a registry or an index.
Improved functionalization of oleic acid-coated iron oxide nanoparticles for biomedical applications
Open accessAbstract
Superparamagnetic iron oxide nanoparticles can provide multiple benefits for biomedical applications in aqueous environments such as magnetic separation or magnetic resonance imaging. To increase the colloidal stability and allow subsequent reactions, the introduction of hydrophilic functional groups onto the particles' surface is essential. During this process, the original coating is exchanged by preferably covalently bonded ligands such as trialkoxysilanes. The duration of the silane exchange reaction, which commonly takes more than 24 h, is an important drawback for this approach. In this paper, we present a novel method, which introduces ultrasonication as an energy source to dramatically accelerate this process, resulting in high-quality water-dispersible nanoparticles around 10 nm in size. To prove the generic character, different functional groups were introduced on the surface including polyethylene glycol chains, carboxylic acid, amine, and thiol groups. Their colloidal stability in various aqueous buffer solutions as well as human plasma and serum was investigated to allow implementation in biomedical and sensing applications. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11051-012-1100-5) contains supplementary material, which is available to authorized users.
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“Prototypic examples of materials used to coat iron oxide nanoparticles are polymers [28, 47, 50], fatty acids (like oleic acid, stearic acid, lauric acid and dodecylphosphonic acid) [51–55], amino acids (like phenyl alanine, tyrosine, arginine, lysine and cysteine) [56–58],_metals (like gold, gadolinium and silver) [59–61] and oxides (like silica and TiO2) [62–64].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [53]
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Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications
Dadfar, S. M., Roemhild, K., Drude, N. I., von Stillfried, S., Knüchel, R., Kiessling, F., & Lammers, T. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.01.005 · Cited by 1,181
A review of current coupling agents for modification of metal oxide nanoparticles
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Barrow, M., Taylor, A., Murray, P. A., Rosseinsky, M. J., & Adams, D. J. (2015) · Chemical Society Reviews · doi:10.1039/c5cs00331h · Cited by 204
Dupont, D., Brullot, W., Bloemen, M., Verbiest, T., & Binnemans, K. (2014) · ACS Applied Materials & Interfaces · doi:10.1021/am406027y · Cited by 184
Al-Mawali, K. S., Osman, A. I., Al-Muhtaseb, A. H., Mehta, N., Jamil, F., Mjalli, F., Vakili-Nezhaad, G. R., & Rooney, D. W. (2021) · Renewable Energy · doi:10.1016/j.renene.2021.02.027 · Cited by 158
Metadata
- Authors
- Bloemen, M., Brullot, W., Luong, T. T., Geukens, N., Gils, A., & Verbiest, T.
- Affiliations
- KU Leuven (BE)
- Corresponding author
- Bloemen, Maarten
- Venue
- Journal of Nanoparticle Research
- Published
- 2012-08-07
- Volume
- 14
- Issue
- 9
- Pages
- 1100-1100
- ISSN
- 1388-0764 (ISSN-L)
- 1572-896X
- PMC
- PMC3460177
- OpenAlex
- W2008890153
- Cited by
- 206
- References
- 40
- Citations by year
- 2026: 8 · 2025: 12 · 2024: 10 · 2023: 15 · 2022: 13 · 2021: 18 · 2020: 19 · 2019: 14 · 2018: 14 · 2017: 24 · 2016: 25 · 2015: 16 · 2014: 14 · 2013: 4
- FWCI
- 6.20
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Journal of Nanoparticle Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Lirias (submittedVersion, other-oa)
- Funders
- Fonds Wetenschappelijk Onderzoek
- KU Leuven
- Vlaamse regering
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Physical Sciences › Materials Science › Materials Chemistry › Magnetic Properties and Synthesis of Ferrites
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- superparamagnetic iron oxide nanoparticles, oleic acid coating, surface functionalization, sonication, colloidal stability, polyethylene glycol, carboxylic acids, amines, sulfhydryl groups, magnetic separation, magnetic resonance imaging, water-dispersible nanoparticles
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