Ultra-large-scale syntheses of monodisperse nanocrystals
Abstract
The development of nanocrystals has been intensively pursued, not only for their fundamental scientific interest, but also for many technological applications. The synthesis of monodisperse nanocrystals (size variation <5%) is of key importance, because the properties of these nanocrystals depend strongly on their dimensions. For example, the colour sharpness of semiconductor nanocrystal-based optical devices is strongly dependent on the uniformity of the nanocrystals, and monodisperse magnetic nanocrystals are critical for the next-generation multi-terabit magnetic storage media. For these monodisperse nanocrystals to be used, an economical mass-production method needs to be developed. Unfortunately, however, in most syntheses reported so far, only sub-gram quantities of monodisperse nanocrystals were produced. Uniform-sized nanocrystals of CdSe (refs 10,11) and Au (refs 12,13) have been produced using colloidal chemical synthetic procedures. In addition, monodisperse magnetic nanocrystals such as Fe (refs 14,15), Co (refs 16-18), gamma-Fe(2)O(3) (refs 19,20), and Fe(3)O(4) (refs 21,22) have been synthesized by using various synthetic methods. Here, we report on the ultra-large-scale synthesis of monodisperse nanocrystals using inexpensive and non-toxic metal salts as reactants. We were able to synthesize as much as 40 g of monodisperse nanocrystals in a single reaction, without a size-sorting process. Moreover, the particle size could be controlled simply by varying the experimental conditions. The current synthetic procedure is very general and nanocrystals of many transition metal oxides were successfully synthesized using a very similar procedure.
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Thermolysis of a metal oleate precursor has achieved a yield value of 40 grams of iron oxide nanoparticles per batch.
“As an example of PLAL productivity compared to high-yield chemical methods, the thermolysis of a metal oleate precursor has achieved a yield value of 40 grams of iron oxide NPs per batch.51”
From Green nanoparticle synthesis at scale: a perspective on overcoming the limits of pulsed laser ablation in liquids for high-throughput production (2023) · cites this paper as [51]
SPION with high control over size and shape, narrow size distribution and good crystallinity can be prepared via thermal decomposition of organoiron precursors in high-boiling point organic solvents in the presence of stabilizing surfactants.
“SPION with high control over size and shape, narrow size distribution and good crystallinity can be prepared via thermal decomposition of organoiron precursors in high-boiling point organic solvents in the presence of stabilizing surfactants [38, 39].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [38]
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- Authors
- Park, J., An, K., Hwang, Y., Park, J.-G., Noh, H.-J., Kim, J.-Y., Park, J.-H., Hwang, N.-M., & Hyeon, T.
- Affiliations
- Seoul National University (KR)
- Sungkyunkwan University (KR)
- Pohang University of Science and Technology (KR)
- Corresponding author
- Hyeon, Taeghwan
- ORCID
- Venue
- Nature Materials
- Published
- 2004-11-28
- Volume
- 3
- Issue
- 12
- Pages
- 891-895
- ISSN
- 1476-1122 (ISSN-L)
- 1476-4660
- OpenAlex
- W2118969052
- Cited by
- 4,076
- References
- 32
- Citations by year
- 2026: 64 · 2025: 108 · 2024: 123 · 2023: 145 · 2022: 165 · 2021: 212 · 2020: 199 · 2019: 252 · 2018: 234 · 2017: 215 · 2016: 254 · 2015: 269 · 2014: 287 · 2013: 250 · 2012: 266
- FWCI
- 52.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Materials (publishedVersion)
- PubMed (publishedVersion)
- Open Access System for Information Sharing (Pohang University of Science and Technology) (submittedVersion)
- Seoul National University Open Repository (Seoul National University) (submittedVersion)
- Scholarworks@UNIST (Ulsan National Institute of Science and Technology) (submittedVersion)
- Funders
- Seoul National University
- Korea Science and Engineering Foundation
- Division of Materials Research
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Quantum Dots Synthesis And Properties
- Physical Sciences › Materials Science › Materials Chemistry › Chemical and Physical Properties of Materials
- Physical Sciences › Materials Science › Electronic, Optical and Magnetic Materials › Gold and Silver Nanoparticles Synthesis and Applications
- Keywords
- monodisperse nanocrystals, size control, transition metal oxides, magnetic nanocrystals, quantum dots, mass production, particle size uniformity
- MeSH terms
- Crystallization, Ferric Compounds, Hot Temperature, Manufactured Materials, Molecular Conformation, Solvents, Surface Properties, Equipment Failure Analysis, Nanostructures
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