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Cited by 49Cholinesterase and Neurodegenerative DiseasesNeuroscience and Neuropharmacology ResearchPesticide Exposure and Toxicity

Diet-induced changes in AChE activity after long-term exposure

Kaizer, Rosilene R., da Silva, Adriane C., Morsch, Vera M., Corr�a, Maisa C., Schetinger, Maria R. C.·2004·Neurochemical Research
DOI 10.1007/s11064-004-7033-3
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Abstract

In the present study we investigated a potential mechanism by which high sugar (HS) and high fat (HF) diets could affect acetylcholinesterase (AChE) activity. The treatment with HS and HF diet was done for six months on male and female rats. The results showed decreased hippocampal AChE activity in male and females receiving HS and HF diets (HS 24% and 36%; HF 38% and 32%, males and females, respectively; P < 0.05). The activity in the cerebral cortex was reduced in males (49 and 40%) and females (19 and 17%) (P < 0.05) on HS and HF diets, respectively. In the hypothalamus AChE activity was decreased on HS diet in males (46%) and female (25%) (P < 0.05) and also on HF diet in males (34%) and females (21%) (P < 0.05). However, in the cerebellum no changes in AChE activity were observed. These results indicate that HS and HF diets produced mainly inhibition in acetylcholine degradation. It probably indicates a chronic alteration induced by these diets on the cholinergic system.

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Crossref · 10.1007/s11064-004-7033-3

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  • Long-term maintenance on a high-fat/high-sugar diet significantly down-regulated levels of AChE in a number of brain areas, particularly pronounced in the hypothalamus.

    “long-term maintenance on a high-fat/high-sugar diet significantly down-regulated levels of ACh-esterase (AChE) in a number of brain areas that was particularly pronounced in the hypothalamus (Kaizer et al., 2004).”

    From Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior (2012) · cites this paper as Kaizer et al., 2004

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Authors
Kaizer, R. R., da Silva, A. C., Morsch, V. M., Corr�a, M. C., & Schetinger, M. R. C.
Affiliations
Universidade Federal de Santa Maria (BR)
Corresponding author
Schetinger, Maria R. C.
ORCID
Venue
Neurochemical Research
Publisher
Springer Science and Business Media LLC
Published
2004-12
Volume
29
Issue
12
Pages
2251-2255
ISSN
  • 0364-3190 (ISSN-L)
  • 1573-6903
DOI
10.1007/s11064-004-7033-3
OpenAlex
W2035142210
Cited by
49
References
18
Citations by year
2026: 2 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 5 · 2021: 3 · 2020: 4 · 2019: 2 · 2018: 1 · 2017: 6 · 2016: 3 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 7
FWCI
0.63
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Neurochemical Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Pesticide Exposure and Toxicity
Keywords
acetylcholinesterase activity, high-sugar diet, high-fat diet, cholinergic system, hippocampus, cerebral cortex, hypothalamus, sex differences, chronic dietary exposure, acetylcholine degradation, rats
MeSH terms
Acetylcholinesterase, Animals, Catalase, Cerebellum, Cerebral Cortex, Diet, Dietary Fats, Female, Hippocampus, Hypothalamus, Lipids, Liver, Male, Nerve Tissue Proteins, Sex Characteristics, Rats, Wistar, Thiobarbituric Acid Reactive Substances, Dietary Sucrose, Rats

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