The DOI matches its Crossref record; 106 of the 106 references it cites were found in a registry or an index.
Delineating the Mechanism of Alzheimer’s Disease Aβ Peptide Neurotoxicity
Abstract
The Alzheimer's disease neurotoxic amyloid-beta (A beta) peptide is derived from the larger amyloid precursor protein (APP) and is the principal component of the senile plaques in Alzheimer's disease (AD) brains. This mechanism by which A beta mediates neurotoxicity or neuronal dysfunction is not fully resolved. This review will outline some of the key determinants that modulate A beta's activity and the cellular pathways and mechanisms involved.
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“as well as lead to formation of reactive oxygen species (ROS) and oxidative stress.3,26–31,33–36”
From Bifunctional Compounds for Controlling Metal-Mediated Aggregation of the Aβ42Peptide (2012) · cites this paper as [33]
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1 retracted
RETRACTED ARTICLE: A specific amyloid-β protein assembly in the brain impairs memory
Lesné, S., Koh, M. T., Kotilinek, L., Kayed, R., Glabe, C. G., Yang, A., Gallagher, M., & Ashe, K. H. (2006) · Nature · doi:10.1038/nature04533 · Cited by 2,769
RetractedThe Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864
Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359
Control of inositol 1,4,5-trisphosphate-induced Ca2+ release by cytosolic Ca2+
Bootman, M. D., Missiaen, L., Parys, J. B., SMEDT, H. D., & Casteels, R. (1995) · Biochemical Journal · doi:10.1042/bj3060445 · Cited by 5,131
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
Kang, J., Lemaire, H.-G., Unterbeck, A., Salbaum, J. M., Masters, C. L., Grzeschik, K.-H., Multhaup, G., Beyreuther, K., & Müller-Hill, B. (1987) · Nature · doi:10.1038/325733a0 · Cited by 4,619
Walsh, D. M., Klyubin, I., Fadeeva, J. V., Cullen, W. K., Anwyl, R., Wolfe, M. S., Rowan, M. J., & Selkoe, D. J. (2002) · Nature · doi:10.1038/416535a · Cited by 4,291
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
Kayed, R., Head, E., Thompson, J. L., McIntire, T. M., Milton, S. C., Cotman, C. W., & Glabe, C. G. (2003) · Science · doi:10.1126/science.1079469 · Cited by 4,064
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837
Diffusible, nonfibrillar ligands derived from Aβ 1–42 are potent central nervous system neurotoxins
Lambert, M. P., Barlow, A. K., Chromy, B. A., Edwards, C., Freed, R., Liosatos, M., Morgan, T. E., Rozovsky, I., Trommer, B., Viola, K. L., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6448 · Cited by 3,506
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β
Nakagawa, T., Zhu, H., Morishima, N., Li, E., Xu, J., Yankner, B. A., & Yuan, J. (2000) · Nature · doi:10.1038/47513 · Cited by 3,292
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Items 101–108 of 108
O'Regan, J. (2014) · TSpace (University of Toronto)
Perspective, Summary, and Directions for Future Research on Alzheimer’s Disease
Farooqui, A. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809937-7.00010-0
Combining bioscaffolds and iPSCs in the treatment of neural trauma and Alzheimer’s disease
Brice, R., Kehler, J., & Yao, L. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-85766-6.00007-3
Gries, M., Puhl, H. R., Schulte, S., Christmann, A., Rommel, S., Baller, M. K., Martin, M., Hartmann, T., Grimm, M. O. W., & Schäfer, K. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.26.678722
Neuroprotective effects of pectolinarin against cognitive impairment in Aβ25-35-induced mouse model
Noh, B. W., He, M. T., Kim, J.-H., & Cho, E. J. (2025) · Journal of Applied Biological Chemistry · doi:10.3839/jabc.2025.052
Hsieh, C.-J., Hou, C., Zhu, Y., Lee, J. Y., Kohli, N., Gallagher, E. P., Xu, K., Lee, H. S., Li, S., McManus, M. J., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20390984
Mitochondria, neurosteroids and biological rhythms : implications in health and disease states
Grimm, A. (2015) · theses.fr (ABES) · doi:10.70675/8aac5aa9z77cdz49bdz9cf5z0ff0b5dd0f84
Metadata
- Authors
- Cappai, R., & Barnham, K. J.
- Affiliations
- The University of Melbourne (AU)
- Mental Health Research Institute (AU)
- Corresponding author
- Cappai, Roberto
- Venue
- Neurochemical Research
- Published
- 2007-08-31
- Volume
- 33
- Issue
- 3
- Pages
- 526-532
- ISSN
- 0364-3190 (ISSN-L)
- 1573-6903
- OpenAlex
- W1985110467
- Cited by
- 108
- References
- 106
- Citations by year
- 2025: 3 · 2023: 1 · 2022: 4 · 2021: 4 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 7 · 2016: 2 · 2015: 7 · 2014: 13 · 2013: 7 · 2012: 17
- FWCI
- 0.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neurochemical Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, amyloid-beta, neurotoxicity, amyloid precursor protein, amyloid plaques, neuronal dysfunction, cellular pathways
- MeSH terms
- Alzheimer Disease, Animals, Humans, Metals, Oxidation-Reduction, Amyloid beta-Peptides, Neurotoxicity Syndromes
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