Delineating the Mechanism of Alzheimer’s Disease Aβ Peptide Neurotoxicity

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RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease

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Amyloid β-peptide is produced by cultured cells during normal metabolism

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Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model

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Natural oligomers of the amyloid-β protein specifically disrupt cognitive function

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Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP

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Regulation of NMDA receptor trafficking by amyloid-β

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Soluble Amyloid β Peptide Concentration as a Predictor of Synaptic Change in Alzheimer's Disease

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Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Aβ42 Fibrils

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Treatment with a Copper-Zinc Chelator Markedly and Rapidly Inhibits β-Amyloid Accumulation in Alzheimer's Disease Transgenic Mice

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Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

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Clearance of Alzheimer’s amyloid-β1-40 peptide from brain by LDL receptor–related protein-1 at the blood-brain barrier

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ABAD Directly Links Aß to Mitochondrial Toxicity in Alzheimer's Disease

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Correlation Between Elevated Levels of Amyloid β-Peptide in the Brain and Cognitive Decline

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The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction

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Mitochondria are a direct site of Aβ accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression

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Calcium Dysregulation and Membrane Disruption as a Ubiquitous Neurotoxic Mechanism of Soluble Amyloid Oligomers*♦

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Metal-Protein Attenuation With Iodochlorhydroxyquin (Clioquinol) Targeting Aβ Amyloid Deposition and Toxicity in Alzheimer Disease: A Pilot Phase 2 Clinical Trial

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Aβ Oligomers Induce Neuronal Oxidative Stress through an N-Methyl-D-aspartate Receptor-dependent Mechanism That Is Blocked by the Alzheimer Drug Memantine

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In vitro aging of ß-amyloid protein causes peptide aggregation and neurotoxicity

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LRP/Amyloid β-Peptide Interaction Mediates Differential Brain Efflux of Aβ Isoforms

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Tau is essential to β-amyloid-induced neurotoxicity

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Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction

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Cu(II) Potentiation of Alzheimer Aβ Neurotoxicity

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Mitochondrial Aβ: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease

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Alzheimer's Disease Amyloid-β Binds Copper and Zinc to Generate an Allosterically Ordered Membrane-penetrating Structure Containing Superoxide Dismutase-like Subunits

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Amyloid β protein forms ion channels: implications for Alzheimer's disease pathophysiology

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Metalloenzyme-like Activity of Alzheimer's Disease β-Amyloid

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The Levels of Soluble versus Insoluble Brain Aβ Distinguish Alzheimer's Disease from Normal and Pathologic Aging

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Metal Binding and Oxidation of Amyloid-β within Isolated Senile Plaque Cores: Raman Microscopic Evidence

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Globular amyloid β‐peptide 1−42 oligomer − a homogenous and stable neuropathological protein in Alzheimer's disease

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Soluble oligomers of β amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus

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Amyloid β protein immunotherapy neutralizes Aβ oligomers that disrupt synaptic plasticity in vivo

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Relative Abundance of Alzheimer A Beta Amyloid Peptide Variants in Alzheimer Disease and normal Aging

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Block of Long-Term Potentiation by Naturally Secreted and Synthetic Amyloid β-Peptide in Hippocampal Slices Is Mediated via Activation of the Kinases c-Jun N-Terminal Kinase, Cyclin-Dependent Kinase 5, and p38 Mitogen-Activated Protein Kinase as well as Metabotropic Glutamate Receptor Type 5

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Massive CA1/2 Neuronal Loss with Intraneuronal and N-Terminal Truncated Aβ42 Accumulation in a Novel Alzheimer Transgenic Model

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Alzheimer's disease and Aβ toxicity: from top to bottom

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Evidence that the β-Amyloid Plaques of Alzheimer's Disease Represent the Redox-silencing and Entombment of Aβ by Zinc

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Copper Mediates Dityrosine Cross-Linking of Alzheimer's Amyloid-β

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Oxidative stress in Alzheimer's disease brain: New insights from redox proteomics

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Different Mechanisms of Oxidative Stress and Neurotoxicity for Alzheimer‘s Aβ(1−42) and Aβ(25−35)

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RAGE potentiates Aβ‐induced perturbation of neuronal function in transgenic mice

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Copper-Dependent Inhibition of Human Cytochrome c Oxidase by a Dimeric Conformer of Amyloid-β1-42

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Degradation of the Alzheimer Disease Amyloid β-Peptide by Metal-dependent Up-regulation of Metalloprotease Activity

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Decreased glutathione transferase activity in brain and ventricular fluid in Alzheimer's disease

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Aggregation-related toxicity of synthetic β-amyloid protein in hippocampal cultures

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Amyloid β‐peptide interactions with neuronal and glial cell plasma membrane: binding sites and implications for Alzheimer's disease

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Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease β‐amyloid

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ABAD enhances Aβ‐induced cell stress via mitochondrial dysfunction

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Comparative Analysis of Amyloid-β Chemical Structure and Amyloid Plaque Morphology of Transgenic Mouse and Alzheimer's Disease Brains

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Molecular mechanisms for Alzheimer's disease: implications for neuroimaging and therapeutics

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Fresh and globular amyloid β protein (1–42) induces rapid cellular degeneration: evidence for AβP channel‐mediated cellular toxicity

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Concentration Dependent Cu2+Induced Aggregation and Dityrosine Formation of the Alzheimer's Disease Amyloid-β Peptide

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Neurotoxic, Redox-competent Alzheimer's β-Amyloid Is Released from Lipid Membrane by Methionine Oxidation

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The lipophilic metal chelator DP-109 reduces amyloid pathology in brains of human β-amyloid precursor protein transgenic mice

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Amyloid β-peptide and amyloid pathology are central to the oxidative stress and inflammatory cascades under which Alzheimer's disease brain exists

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Surface Behavior and Lipid Interaction of Alzheimer β-Amyloid Peptide 1–42: A Membrane-Disrupting Peptide

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ERK1/2 Activation Mediates Aβ Oligomer-induced Neurotoxicity via Caspase-3 Activation and Tau Cleavage in Rat Organotypic Hippocampal Slice Cultures

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β-Amyloid Induces Local Neurite Degeneration in Cultured Hippocampal Neurons: Evidence for Neuritic Apoptosis

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Fyn Kinase Modulates Synaptotoxicity, But Not Aberrant Sprouting, in Human Amyloid Precursor Protein Transgenic Mice

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Amyloid-β Peptide Disruption of Lipid Membranes and the Effect of Metal Ions

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Role of p75 Neurotrophin Receptor in the Neurotoxicity by β-amyloid Peptides and Synergistic Effect of Inflammatory Cytokines

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Synaptic plasticity: one STEP at a time

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Soluble Arctic amyloid β protein inhibits hippocampal long‐term potentiation in vivo

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Activation of the c-Jun N-terminal Kinase Signaling Cascade Mediates the Effect of Amyloid-β on Long Term Potentiation and Cell Death in Hippocampus

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Possible Causes of Alzheimer's Disease: Amyloid Fragments, Free Radicals, and Calcium Homeostasis

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