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Free copper, ferroxidase and SOD1 activities, lipid peroxidation and NO(x) content in the CSF. A different marker profile in four neurodegenerative diseases
Abstract
The understanding of oxidative damage in different neurodegenerative diseases could enhance therapeutic strategies. Our objective was to quantify lipoperoxidation and other oxidative products as well as the activity of antioxidant enzymes and cofactors in cerebrospinal fluid (CSF) samples. We recorded data from all new patients with a diagnosis of either one of the four most frequent neurodegenerative diseases: Parkinson's disease (PD), Alzheimer's disease (AD), Huntington's disease (HD) and lateral amyotrophic sclerosis (ALS). The sum of nitrites and nitrates as end products of nitric oxide (NO) were increased in the four degenerative diseases and fluorescent lipoperoxidation products in three (excepting ALS). A decreased Cu/Zn-dependent superoxide dismutase (SOD) activity characterized the four diseases. A significantly decreased ferroxidase activity was found in PD, HD and AD, agreeing with findings of iron deposition in these entities, while free copper was found to be increased in CSF and appeared to be a good biomarker of PD.
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“A contributing factor to the increased iron accumulation in Parkinson’s disease might be increased DMT1 activity or decreased ferroxidase activity of ceruloplasmin, both of which would increase total intracellular iron, as reported in an animal model of Parkinson’s disease109 and in patients.131–134”
From The role of iron in brain ageing and neurodegenerative disorders (2014) · cites this paper as [132]
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Metadata
- Authors
- Boll, M.-C., Alcaraz-Zubeldia, M., Montes, S., & Rios, C.
- Affiliations
- Instituto Nacional de Neurología y Neurocirugía (MX)
- Venue
- Neurochemical Research
- Published
- 2008-02-29
- Volume
- 33
- Issue
- 9
- Pages
- 1717-1723
- ISSN
- 0364-3190 (ISSN-L)
- 1573-6903
- OpenAlex
- W1987004867
- Cited by
- 173
- References
- 40
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 3 · 2023: 3 · 2022: 7 · 2021: 8 · 2020: 7 · 2019: 4 · 2018: 7 · 2017: 11 · 2016: 12 · 2015: 2 · 2014: 21 · 2013: 17 · 2012: 12
- FWCI
- 8.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neurochemical Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Consejo Nacional de Ciencia y Tecnología
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- neurodegenerative diseases, cerebrospinal fluid biomarkers, oxidative stress, lipid peroxidation, nitric oxide, nitrite/nitrate, ferroxidase, copper-zinc superoxide dismutase, free copper, Parkinson's disease, Alzheimer's disease, Huntington's disease, amyotrophic lateral sclerosis, iron accumulation
- MeSH terms
- Superoxide Dismutase-1, Alzheimer Disease, Amyotrophic Lateral Sclerosis, Animals, Antioxidants, Ceruloplasmin, Copper, Humans, Huntington Disease, Nitric Oxide, Parkinson Disease, ROC Curve, Superoxide Dismutase, Lipid Peroxidation, Biomarkers, Neurodegenerative Diseases
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