Cited by 298Mitochondrial Function and PathologyRedox biology and oxidative stressCell death mechanisms and regulation

Mitochondria: regulators of signal transduction by reactive oxygen and nitrogen species

Brookes, Paul S., Levonen, Anna-Liisa, Shiva, Sruti, Sarti, Paolo, Darley-Usmar, Victor M.·2002·Free Radical Biology and Medicine

Abstract

The functional role of mitochondria in cell physiology has previously centered around metabolism, with oxidative phosphorylation playing a pivotal role. Recently, however, this perspective has changed significantly with the realization that mitochondria are active participants in signal transduction pathways, not simply the passive recipients of injunctions from the rest of the cell. In this review the emerging role of the mitochondrion in cell signaling is discussed in the context of cytochrome c release, hydrogen peroxide formation from the respiratory chain, and the nitric oxide-cytochrome c oxidase signaling pathway.

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Crossref · 10.1016/s0891-5849(02)00901-2

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Authors
Brookes, P. S., Levonen, A.-L., Shiva, S., Sarti, P., & Darley-Usmar, V. M.
Affiliations
  • University of Alabama at Birmingham (US)
  • Sapienza University of Rome (IT)
Corresponding author
Darley-Usmar, Victor M.
Venue
Free Radical Biology and Medicine
Publisher
Elsevier BV
Published
2002-09
Volume
33
Issue
6
Pages
755-764
ISSN
0891-5849 (ISSN-L)
OpenAlex
W1748754899
Cited by
298
References
72
Citations by year
2025: 2 · 2024: 5 · 2023: 1 · 2022: 6 · 2021: 1 · 2020: 3 · 2019: 9 · 2018: 9 · 2017: 10 · 2016: 12 · 2015: 14 · 2014: 13 · 2013: 13 · 2012: 21
FWCI
7.09
Type
journal article
Language
en
Open access
closed
Locations
  • Free Radical Biology and Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Funders
  • American Heart Association
  • National Institutes of Health (1r03aa012613-01)
  • National Institute on Alcohol Abuse and Alcoholism (AA 12613)
  • National Heart, Lung, and Blood Institute (R01HL058031, HL-58031)
  • National Institute of Environmental Health Sciences (R01ES010167, ES-10167)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords
mitochondria, signal transduction, reactive oxygen species, reactive nitrogen species, cytochrome c release, hydrogen peroxide, electron transport chain, nitric oxide, cytochrome c oxidase, mitochondrial signaling
MeSH terms
Adenosine Triphosphate, Animals, Cytochrome c Group, Electron Transport Complex IV, Free Radicals, Humans, Hydrogen Peroxide, Mitochondria, Models, Biological, Models, Chemical, Nitric Oxide, Oxidation-Reduction, Time Factors, Signal Transduction, Apoptosis, Reactive Oxygen Species, Reactive Nitrogen Species

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