Ceruloplasmin regulates iron levels in the CNS and prevents free radical injury
Open accessAbstract
Ceruloplasmin is a ferroxidase that oxidizes toxic ferrous iron to its nontoxic ferric form. We have previously reported that a glycosylphosphatidylinositol-anchored form of ceruloplasmin is expressed in the mammalian CNS. To better understand the role of ceruloplasmin in iron homeostasis in the CNS, we generated a ceruloplasmin gene-deficient (Cp(-/-)) mouse. Adult Cp(-/-) mice showed increased iron deposition in several regions of the CNS such as the cerebellum and brainstem. Increased lipid peroxidation was also seen in some CNS regions. Cerebellar cells from neonatal Cp(-/-) mice were also more susceptible to oxidative stress in vitro. Cp(-/-) mice showed deficits in motor coordination that were associated with a loss of brainstem dopaminergic neurons. These results indicate that ceruloplasmin plays an important role in maintaining iron homeostasis in the CNS and in protecting the CNS from iron-mediated free radical injury. Therefore, the antioxidant effects of ceruloplasmin could have important implications for various neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease in which iron deposition is known to occur.
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Ceruloplasmin dysfunction might be associated with Parkinson's disease.
“Ceruloplasmin dysfunction might be associated with Parkinson’s disease.135,136”
From The role of iron in brain ageing and neurodegenerative disorders (2014) · cites this paper as [135]
Ferritin H is induced by NF-κB in response to TNF-α treatment, resulting in suppression of ROS and inhibition of apoptosis.
“Ferritin H is induced by NF-κB in response to TNF-α treatment, resulting in suppression of ROS and inhibition of apoptosis (243).”
From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [243]
NF-κB is activated by TNF-α and induces mouse and human ferritin H.
“NF-κB is activated by TNF-α and has been shown to induce mouse and human ferritin H (171, 243).”
From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [243]
Ferritin H is a TNF-α- or IL-1-inducible gene.
“Ferritin H was found as a TNF-α– or IL-1–inducible gene (171, 243, 294).”
From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [243]
Apoptosis induced by TNF-α was inhibited by NF-κB.
“Apoptosis induced by TNF-α was inhibited by NF-κB”
From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [243]
Ferritin has a cytoprotective role against free-iron-catalyzed production of ROS.
“Many studies set a precedent of ferritin in cytoprotection against free-iron–catalyzed production of ROS (227, 243, 301).”
From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [243]
Ferritin is the downstream mediator of the antioxidant and protective activities of NF-κB in response to TNF-α signaling in inflammation and apoptosis.
“Ferritin was identified as the downstream mediator of the antioxidant and protective activities of NF-κB in response to TNF-α signaling in inflammation and apoptosis (243, 294).”
From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [243]
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- Authors
- Patel, B. N., Dunn, R. J., Jeong, S. Y., Zhu, Q., Julien, J.-P., & David, S.
- Affiliations
- Montreal General Hospital (CA)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2002-08-01
- Volume
- 22
- Issue
- 15
- Pages
- 6578-6586
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6758125
- OpenAlex
- W1595395957
- Cited by
- 379
- References
- 51
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 10 · 2023: 12 · 2022: 16 · 2021: 14 · 2020: 12 · 2019: 11 · 2018: 22 · 2017: 17 · 2016: 11 · 2015: 24 · 2014: 24 · 2013: 15 · 2012: 22
- FWCI
- 10.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Parkinson's Disease Foundation
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Keywords
- ceruloplasmin, iron homeostasis, central nervous system, ferroxidase, oxidative damage, oxidative stress, lipid peroxidation, cerebellum, brainstem, dopaminergic neurons, motor coordination deficits, neurodegenerative diseases, Parkinson's disease, Alzheimer's disease, iron accumulation
- MeSH terms
- Animals, Astrocytes, Brain Stem, Cell Survival, Cells, Cultured, Central Nervous System, Ceruloplasmin, Disease Models, Animal, Free Radicals, Iron, Liver, Neurons, Transferrin, Lipid Peroxidation, Mice, Knockout, Oxidative Stress, Gene Targeting, Motor Skills Disorders, Mice
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