Cited by 223Neuroscience and Neuropharmacology ResearchAmino Acid Enzymes and MetabolismAdvanced MRI Techniques and Applications

The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.

The Glutamine–Glutamate/GABA Cycle: Function, Regional Differences in Glutamate and GABA Production and Effects of Interference with GABA Metabolism

Walls, Anne B., Waagepetersen, Helle S., Bak, Lasse K., Schousboe, Arne, Sonnewald, Ursula·2015·Neurochemical Research

DOI 10.1007/s11064-014-1473-1

Open this paper in CoChat — free account

Abstract

The operation of a glutamine-glutamate/GABA cycle in the brain consisting of the transfer of glutamine from astrocytes to neurons and neurotransmitter glutamate or GABA from neurons to astrocytes is a well-known concept. In neurons, glutamine is not only used for energy production and protein synthesis, as in other cells, but is also an essential precursor for biosynthesis of amino acid neurotransmitters. An excellent tool for the study of glutamine transfer from astrocytes to neurons is [(14)C]acetate or [(13)C]acetate and the glial specific enzyme inhibitors, i.e. the glutamine synthetase inhibitor methionine sulfoximine and the tricarboxylic acid cycle (aconitase) inhibitors fluoro-acetate and -citrate. Acetate is metabolized exclusively by glial cells, and [(13)C]acetate is thus capable when used in combination with magnetic resonance spectroscopy or mass spectrometry, to provide information about glutamine transfer. The present review will give information about glutamine trafficking and the tools used to map it as exemplified by discussions of published work employing brain cell cultures as well as intact animals. It will be documented that considerably more glutamine is transferred from astrocytes to glutamatergic than to GABAergic neurons. However, glutamine does have an important role in GABAergic neurons despite their capability of re-utilizing their neurotransmitter by re-uptake.

Integrity signals

Registry

Crossref · 10.1007/s11064-014-1473-1

Cites

46 of 46 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Interplay between Cortical Spreading Depolarization and Seizures
Kramer, D. R., Fujii, T., Ohiorhenuan, I. E., & Liu, C. Y. (2017) · Stereotactic and Functional Neurosurgery · doi:10.1159/000452841 · Cited by 3,721
An Energy Budget for Signaling in the Grey Matter of the Brain
Attwell, D., & Laughlin, S. B. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200110000-00001 · Cited by 3,543
Fine structural localization of glutamine synthetase in astrocytes of rat brain
Norenberg, M. D., & Martinez-Hernandez, A. (1979) · Brain Research · doi:10.1016/0006-8993(79)90071-4 · Cited by 1,349
Pyruvate car☐ylase: an astrocyte-specific enzyme implicated in the replenishment of amino acid neurotransmitter pools
Shank, R. P., Bennett, G. S., Freytag, S. O., & Campbell, G. L. (1985) · Brain Research · doi:10.1016/0006-8993(85)90552-9 · Cited by 471
A simulation study of brain compartments. Metabolism of glutamate and related substances in mouse brain
den Berg, C. J. V., & Garfinkel, D. J. (1971) · Biochemical Journal · doi:10.1042/bj1230211 · Cited by 414
Pyruvate Carboxylase Activity in Primary Cultures of Astrocytes and Neurons
Yu, A. C., Drejer, J., Hertz, L., & Schousboe, A. (1983) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1983.tb00849.x · Cited by 406
Self-citation
High Affinity Glutamate Transporters: Regulation of Expression and Activity
Gegelashvili, G., & Schousboe, A. (1997) · Molecular Pharmacology · doi:10.1124/mol.52.1.6 · Cited by 399
Self-citation
Preferential Utilization of Acetate by Astrocytes Is Attributable to Transport
Waniewski, R. A., & Martin, D. L. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-14-05225.1998 · Cited by 378
The contribution of GABA to glutamate/glutamine cycling and energy metabolism in the rat cortex in vivo
Patel, A. B., de Graaf, R. A., Mason, G. F., Rothman, D. L., Shulman, R. G., & Behar, K. L. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501703102 · Cited by 343
Metabolic compartmentation of glutamate and glutamine: Morphological evidence obtained by quantitative immunocytochemistry in rat cerebellum
Ottersen, O. P., Zhang, N., & Walberg, F. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90141-n · Cited by 335

Show all 46 references

Research works printed but not linked: 2

Berl S, Clarke DD (1983) The metabolic compartmentation concept. In: Hertz L, Kvamme E, McGeer EG, Schousboe A (eds) Glutamine glutamate and GABA in the central nervous system Alan R. Liss Inc, New York, pp 205–217
Hassel B, Bachelard H, Jones P, Fonnum F, Sonnewald U (1997) Trafficking of amino acids between neurons and glia in vivo. Effects of inhibition of glial metabolism by fluoroacetate. J Cereb Blood Flow Metab 17(11):1230–1238. doi: 10.1097/00004647-199711000-00012 · DOI

Sorted by citations

Items 101–200 of 223

Early and Late Pathomechanisms in Alzheimer’s Disease: From Zinc to Amyloid-β Neurotoxicity
Szutowicz, A., Bielarczyk, H., Zyśk, M., Dyś, A., Ronowska, A., Gul‐Hinc, S., & Klimaszewska‐Łata, J. (2016) · Neurochemical Research · doi:10.1007/s11064-016-2154-z · Cited by 15
An easy-to-use liquid chromatography method with fluorescence detection for the simultaneous determination of five neuroactive amino acids in different regions of rat brain
Fonseca, B. M., Cristóvão, A. C., & Alves, G. (2018) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/j.vascn.2018.02.002 · Cited by 14
Cortical glutamate and gamma-aminobutyric acid over the course of a provoked migraine attack, a 7 Tesla magnetic resonance spectroscopy study
Onderwater, G. L. J., Wijnen, J. P., Najac, C., van Dongen, R. M., Ronen, I., WEBB, A. G., Zielman, R., van Zwet, E. W., Ferrari, M. D., Kan, H. E., et al. (2021) · NeuroImage Clinical · doi:10.1016/j.nicl.2021.102889 · Cited by 14
In vivo proton magnetic resonance spectroscopy detection of metabolite abnormalities in aged Tat-transgenic mouse brain
Paris, J. J., Chen, X., Anderson, J., Qrareya, A. N., Mahdi, F., Du, F., McLaughlin, J. P., & Kaufman, M. J. (2021) · GeroScience · doi:10.1007/s11357-021-00354-w · Cited by 13
Astrocyte dysregulation as an epileptogenic factor: a systematic review
Sumadewi, K. T., de Liyis, B. G., Linawati, N. M., Widyadharma, I. P. E., & Astawa, I. N. M. (2024) · The Egyptian Journal of Neurology Psychiatry and Neurosurgery · doi:10.1186/s41983-024-00843-7 · Cited by 13
Evaluation of Branched-Chain Amino Acids in Children with Autism Spectrum Disorder and Epilepsy
Meguid, N. A., Hashem, H. S., Ghanem, M. H., Helal, S. A., Semenova, Y. M., Hashem, S., Hashish, A. F., Chirumbolo, S., Elwan, A. M., & Bjørklund, G. (2023) · Molecular Neurobiology · doi:10.1007/s12035-022-03202-w · Cited by 12
Spatial amine metabolomics and histopathology reveal localized brain alterations in subacute traumatic brain injury and the underlying mechanism of herbal treatment
Hu, E., Tang, T., Li, Y., Li, T., Zhu, L., Ding, R., Wu, Y., Huang, Q., Zhang, W., Wu, Q., et al. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14231 · Cited by 12
Continuous production of gamma aminobutyric acid by engineered and immobilized Escherichia coli whole-cells in a small-scale reactor system
Ham, S., Kim, H., Shin, N., Hwang, J. H., Oh, S. J., Park, J. Y., Joo, J. C., Kim, H. T., Bhatia, S. K., & Yang, Y. (2023) · Enzyme and Microbial Technology · doi:10.1016/j.enzmictec.2023.110258 · Cited by 12
Influences of glutamine administration on response selection and sequence learning: a randomized-controlled trial
Jongkees, B. J., Immink, M. A., & Colzato, L. S. (2017) · Scientific Reports · doi:10.1038/s41598-017-02957-w · Cited by 12
Proteome changes in muscles, ganglia, and gills in Corbicula fluminea clams exposed to crude oil: Relationship with behavioural disturbances
Miserazzi, A., Perrigault, M., Sow, M., Gelber, C., Ciret, P., Lomenech, A., Dalens, J. M., Weber, C., Floch, S. L., Lacroix, C., et al. (2020) · Aquatic Toxicology · doi:10.1016/j.aquatox.2020.105482 · Cited by 12
Gliovascular alterations in sporadic and familial Alzheimer's disease: APOE3 Christchurch homozygote glioprotection
Henao‐Restrepo, J., López‐Murillo, C., Valderrama‐Carmona, P., Orozco‐Santa, N., Gomez, J., Gutiérrez‐Vargas, J., Moraga, R., Toledo, J., Littau, J. L., Härtel, S., et al. (2023) · Brain Pathology · doi:10.1111/bpa.13119 · Cited by 11
Ion Channels and Metal Ions in Parkinson’s Disease: Historical Perspective to the Current Scenario
Vaidya, B., Padhy, D. S., Joshi, H. C., Sharma, S. S., & Singh, J. N. (2024) · Methods in molecular biology · doi:10.1007/978-1-0716-3662-6_36 · Cited by 11
Magnetic resonance spectroscopy studies of substance use disorders: Current landscape and potential future directions
Kohut, S. J., & Kaufman, M. J. (2020) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2020.173090 · Cited by 12
Neurochemical Alterations in Social Anxiety Disorder (SAD): A Systematic Review of Proton Magnetic Resonance Spectroscopic Studies
Elsaid, S., Rubin-Kahana, D. S., Kloiber, S. M., Kennedy, S. H., Chavez, S., & Foll, B. L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094754 · Cited by 11
Exogenous putrescine plays a switch-like influence on the pH stress adaptability of biofilm-based activated sludge
Jiang, G., Wang, C., Wang, Y., Wang, J., Xue, Y., Lin, Y.-T., Hu, X., & Lv, Y. (2024) · Applied and Environmental Microbiology · doi:10.1128/aem.00569-24 · Cited by 10
Regulatory effects of head acupuncture on the GABAergic system and Wnt7a/β-catenin pathway in post-stroke spasticity rats
Kang, X., Chen, S., Ma, L., Kong, Y., Huang, Y., & Shi, S. (2025) · Journal of Molecular Histology · doi:10.1007/s10735-025-10505-4 · Cited by 10
Selective cerebral perfusion prevents abnormalities in glutamate cycling and neuronal apoptosis in a model of infant deep hypothermic circulatory arrest and reperfusion
Kajimoto, M., Ledee, D. R., Olson, A. K., Isern, N., Frayne, I. R., Rosiers, C. D., & Portman, M. A. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16666846 · Cited by 10
Effect of in ovo feeding of γ-aminobutyric acid combined with embryonic thermal manipulation on hatchability, growth, and hepatic gene expression in broilers
Ncho, C. M., Goel, A., Gupta, V., Jeong, C.-M., & Choi, Y. (2022) · Animal Bioscience · doi:10.5713/ab.22.0099 · Cited by 10
Age-dependent effects of (+)-MK801 treatment on glutamate release and metabolism in the rat medial prefrontal cortex
Zou, Y., Zhang, H., Chen, X., Ji, W., Mao, L., & Lei, H. C. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.104503 · Cited by 10
Exocrine pancreas glutamate secretion help to sustain enterocyte nutritional needs under protein restriction
Araya, S., Kuster, E., Gluch, D., Mariotta, L., Lutz, C., Reding, T. V., Graf, R., Verrey, F., & Camargo, S. M. R. (2017) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00135.2017 · Cited by 9
Elimination of human folypolyglutamate synthetase alters programming and plasticity of somatic cells
Srivastava, A. C., Thompson, Y., Singhal, J., Stellern, J., Srivastava, A., Du, J., O'Connor, T. R., & Riggs, A. D. (2019) · The FASEB Journal · doi:10.1096/fj.201901721r · Cited by 9
Glutamate, Glutamine, GABA and Oxidative Products in the Pons Following Cortical Injury and Their Role in Motor Functional Recovery
Ramos-Languren, L. E., Ávila-Luna, A., García-Díaz, G., Rodríguez‐Labrada, R., Vázquez‐Mojena, Y., Parra-Cid, C., Montes, S., Bueno-Nava, A., & González-Piña, R. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03417-8 · Cited by 9
Expression of glutamine transporter isoforms in cerebral cortex of rats with chronic hepatic encephalopathy
Leke, R., Escobar, T. D. C., Rao, K. V. R., da Silveira, T. R., Norenberg, M. D., & Schousboe, A. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.03.005 · Cited by 9
Self-citation
Astroglia and Brain Metabolism: Focus on Energy and Neurotransmitter Amino Acid Homeostasis
Schousboe, A., Walls, A. B., Bak, L. K., & Waagepetersen, H. S. (2015) · Colloquium Series on Neuroglia in Biology and Medicine From Physiology to Disease · doi:10.4199/c00130ed1v01y201506ngl007 · Cited by 9
Self-citation
Antinociceptive Behavior, Glutamine/Glutamate, and Neopterin in Early-Stage Streptozotocin-Induced Diabetic Neuropathy in Liraglutide-Treated Mice under a Standard or Enriched Environment
Andreeva-Gateva, P. A., Hristov, M., Ivanova, N. M., Vasileva, D., Ivanova, A., Sabit, Z., Bogdanov, T. G., Apostolova, S. N., & Tzoneva, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251910786 · Cited by 8
Functional characteristics, intercellular interactions and pathophysiological associations of astrocytes in Parkinson’s disease
Li, Z., Cao, M., Yin, Z., Li, X., Wang, Q., Dong, P., & Zhou, C. (2025) · PeerJ · doi:10.7717/peerj.19998 · Cited by 10
Molecular Basis of GABA Aminotransferase Inhibition in Epilepsy: Structure, Mechanisms, and Drug Development
Yasir, M., Choe, J., Han, J., & Chun, W. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47121032 · Cited by 8
The effects of hypothermia on glutamate and γ-aminobutyric acid metabolism during ischemia in monkeys: a repeated-measures ANOVA study
Liu, B.-H., Pu, J., Li, Z., & Zhang, X.-R. (2022) · Scientific Reports · doi:10.1038/s41598-022-18783-8 · Cited by 8
CA-g-CS/PLA film packaging improved storage stability through the MAPK signaling pathway of postharvest Agaricus bisporus
Bai, S., Zhou, Z., Mariga, A. M., Shang, X., Ma, N., Fang, D., Yang, W., Hu, Q., Gao, H., Chen, H., et al. (2023) · Postharvest Biology and Technology · doi:10.1016/j.postharvbio.2023.112688 · Cited by 8
Association between CACNA1C gene rs100737 polymorphism and glutamatergic neurometabolites in bipolar disorder
Scotti-Muzzi, E., Chile, T., Vallada, H., Otaduy, M. C. G., & Soeiro‐de‐Souza, M. G. (2022) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2022.04.001 · Cited by 8
GAT inhibition preserves cerebral blood flow and reduces oxidant damage to mitochondria in rodents exposed to extreme hyperbaric oxygen
It, D., Suliman, H. B., Zhilyaey, S. Y., Alekseeva, O. S., Платонова, Т. Ф., Makowski, M. S., Piantadosi, C. A., & Gasier, H. G. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1062410 · Cited by 8
Comparison of Glutamate Turnover in Nerve Terminals and Brain Tissue During [1,6-13C2]Glucose Metabolism in Anesthetized Rats
Patel, A. B., Lai, J. C. K., Chowdhury, G. M. I., Rothman, D. L., & Behar, K. L. (2016) · Neurochemical Research · doi:10.1007/s11064-016-2103-x · Cited by 8
Key Metabolic Enzymes Underlying Astrocytic Upregulation of GABAergic Plasticity
Kaczor, P. T., & Mozrzymas, J. W. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00144 · Cited by 10
Nicotine Exposure in a Phencyclidine-Induced Mice Model of Schizophrenia: Sex-Selective Medial Prefrontal Cortex Protein Markers of the Combined Insults in Adolescent Mice
Rodríguez-Vega, A., Dutra-Tavares, A. C., de Souza, T. P., Semeão, K. A., Filgueiras, C. C., Ribeiro‐Carvalho, A., Manhães, A. C., & Abreu‐Villaça, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914634 · Cited by 7
Gamma-aminobutyric acid enrichment optimized methods in probiotics foods: a systematic review
Zamanpour, S., Jami, P. B., & Afshari, A. (2023) · Nutrition & Food Science · doi:10.1108/nfs-02-2023-0036 · Cited by 7
Harmonic activity of glutamate dehydrogenase and neuroplasticity: The impact on aging, cognitive dysfunction, and neurodegeneration
Salarvandian, S., Digaleh, H., Khodagholi, F., Javadpour, P., Asadi, S., Zaman, A. A. O., & Dargahi, L. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.115399 · Cited by 7
A longitudinal, multi-parametric functional MRI study to determine age-related changes in the rodent brain
Crofts, A., Trotman‐Lucas, M., Janus, J., Kelly, M., & Gibson, C. L. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.116976 · Cited by 6
Post-Traumatic Expressions of Aromatase B, Glutamine Synthetase, and Cystathionine-Beta-Synthase in the Cerebellum of Juvenile Chum Salmon, Oncorhynchus keta
Pushchina, E. V., Bykova, M. E., & Alekseevich, V. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063299 · Cited by 6
Genome assembly, gene content, and plastic gene expression responses to salinity changes in the Brackishwater Clam (Corbicula japonica) from a dynamic estuarine environment
Choi, H., An, Y. K., Lee, C.-J., Song, C.-U., Kim, E., Lee, C. E., Cho, S.-J., & Eyun, S. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.136627 · Cited by 6
The Long Noncoding RNA Cytoskeleton Regulator RNA (CYTOR)/miRNA-24-3p Axis Facilitates Nasopharyngeal Carcinoma Progression by Modulating GAD1 Expression
Du, J., Yu, W., Peng, L., & Zhang, T. (2023) · Journal of Oncology · doi:10.1155/2023/6027860 · Cited by 6
Early metabolic alterations in the normal‑appearing grey and white matter of patients with clinically isolated syndrome suggestive of multiple sclerosis: A proton MR spectroscopic study
Tzanetakos, D., Kyrozis, A., Karavasilis, E., Velonakis, G., Tzartos, J. S., Toulas, P., Sotirli, S. A., Evdokimidis, I., Tsivgoulis, G. K., Potagas, C. M., et al. (2023) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2023.12048 · Cited by 6
Double-edged effect of astrocyte in the transition of physiopathological states in Parkinson’s disease
Cao, Z., Du, L., Zhang, H., Shen, Z., & Deng, Z. (2024) · Chaos Solitons & Fractals · doi:10.1016/j.chaos.2024.115154 · Cited by 6
Hepatic Encephalopathy: Insights Into the Impact of Metabolic Precipitates
Dash, U. K., Tripathi, A., Mazumdar, D., Dusmanta, P., & Singh, S. (2025) · Developmental Neurobiology · doi:10.1002/dneu.22999 · Cited by 6
Longitudinal Multimodal fMRI to Investigate Neurovascular Changes in Spontaneously Hypertensive Rats
Crofts, A., Trotman‐Lucas, M., Janus, J., Kelly, M., & Gibson, C. L. (2020) · Journal of Neuroimaging · doi:10.1111/jon.12753 · Cited by 5
Glutamine synthetase expression in the brain during experimental acute liver failure (immunohistochemical study)
Shulyatnikova, T. V., & Tumanskiy, V. A. (2021) · Journal of Education Health and Sport · doi:10.12775/jehs.2021.11.10.033 · Cited by 5
Non‐invasive in vivo measurements of metabolic alterations in the type 2 diabetic brain by 1H magnetic resonance spectroscopy
Choi, I., Wang, W. T., Kim, B., Hur, J., Robbins, D. C., Jang, D., Savelieff, M. G., Feldman, E. L., & Lee, P. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15996 · Cited by 5
Glutamine-glutamate centered metabolism as the potential therapeutic target against Japanese encephalitis virus-induced encephalitis
Li, M., Yuan, H., Yang, X., Lei, Y., & Lian, J. (2025) · Cell & Bioscience · doi:10.1186/s13578-024-01340-3 · Cited by 6
Evaluating Back-to-Back and Day-to-Day Reproducibility of Cortical GABA+ Measurements Using Proton Magnetic Resonance Spectroscopy (1H MRS)
Elsaid, S., Truong, P., Sailasuta, N., & Foll, B. L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24097713 · Cited by 5
Effects of the Acute and Chronic Ethanol Intoxication on Acetate Metabolism and Kinetics in the Rat Brain
Hsieh, Y., Wu, L., Ke, C., Chang, C., Kuo, J., Huang, W., Chen, F., Yang, B., Tai, H., Chen, S. C.-J., et al. (2017) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13573 · Cited by 5
Amino Acids | Glutamine
Watford, M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819460-7.00028-1 · Cited by 5
A description of the bat star nervous system throughout larval ontogeny
Pagowski, V. (2023) · Evolution & Development · doi:10.1111/ede.12468 · Cited by 4
An Overview of Machine Learning Applications in Mood Disorders
Topolski, N., Jeong, S. H., & Mwangi, B. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.017 · Cited by 4
BDNF rs6265 differentially influences neurometabolites in the anterior cingulate of healthy and bipolar disorder subjects
Scotti-Muzzi, E., Chile, T., Vallada, H., Otaduy, M. C. G., & Soeiro‐de‐Souza, M. G. (2023) · Brain Imaging and Behavior · doi:10.1007/s11682-023-00757-7 · Cited by 4
The Role of Neurotransmitters in Epileptogenesis: Focus on GABA and Glutamate
Choo, B. K. M., & Shaikh, M. F. (2023) · Springer eBooks · doi:10.1007/978-981-19-3949-5_17-1 · Cited by 3
Mood Disorders
(2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018 · Cited by 3
Inheritance of social dominance is associated with global sperm DNA methylation in inbred male mice
Hou, G.-M., Zhang, Y., & Zhang, J. (2022) · Current Zoology · doi:10.1093/cz/zoac030 · Cited by 3
Omics combined with network pharmacology reveal the neuroprotective mechanism of Sophora tonkinensis based on the biolabel research pattern: The treatment of Parkinson’s disease against oxidative stress and neuroexcitatory toxicity
Zhang, S., Li, H., Liu, Q., Li, X., Yang, W., & Zhou, Y. (2022) · Biomedical Chromatography · doi:10.1002/bmc.5557 · Cited by 3
Ca2+-regulated expression of high affinity methylaminoisobutryic acid transport in hippocampal neurons inhibited by riluzole and novel neuroprotective aminothiazoles
Erickson, J. D., Kyllo, T., & Wulff, H. (2023) · Current Research in Physiology · doi:10.1016/j.crphys.2023.100109 · Cited by 3
Repeated inhalation of sevoflurane inhibits the information transmission of Purkinje cells and delays motor development via the GABAA receptor ε subunit in neonatal mice
Fang, H., Wang, Z., Bu, Y., Yuan, Z., Wang, G., Guo, Y. H., Xiao-yun, C., & Qiu, W. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7941 · Cited by 3
The Role of Neurotransmitters in Epileptogenesis: Focus on GABA and Glutamate
Choo, B. K. M., & Shaikh, M. F. (2023) · Springer eBooks · doi:10.1007/978-981-19-3949-5_17-2 · Cited by 2
A Proton Magnetic Resonance Spectroscopy (1H MRS) Pilot Study Revealing Altered Glutamatergic and Gamma-Aminobutyric Acid (GABA)ergic Neurotransmission in Social Anxiety Disorder (SAD)
Elsaid, S., Wang, R., Kloiber, S. M., Desmond, K. L., & Foll, B. L. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26146915 · Cited by 2
Neuroimaging Studies of Effects of Psychotherapy in Depression
Bauer, I. E., & Meyer, T. D. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.021 · Cited by 2
The Role of Nanotechnology in Understanding the Pathophysiology of Traumatic Brain Injury
Selvaraj, S. A., & Weerasinghe, L. (2024) · Central Nervous System Agents in Medicinal Chemistry · doi:10.2174/0118715249291999240418112531 · Cited by 2
Fueling Brain Inhibition: Integrating GABAergic Neurotransmission and Energy Metabolism
Walls, A. B., Andersen, J. V., Waagepetersen, H. S., & Bak, L. K. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04384-0 · Cited by 3
Self-citation
Revisiting Our Quantum World
Ingber, L. (2021) · Advances in human and social aspects of technology book series · doi:10.4018/978-1-7998-6772-2.ch006 · Cited by 3
Huperzine aggravated neurochemical and volumetric changes induced by D-galactose in the model of neurodegeneration in rats
Melicherčík, Ľ., Tvrdík, T., Novakova, K., Nemec, M., Kaliňák, M., Bačiak, L., & Kašparová, S. (2022) · Neurochemistry International · doi:10.1016/j.neuint.2022.105365 · Cited by 2
Effect of Interleukin-1Beta (IL-1β) on the Cortical Neurons Survival and Neurites Outgrowth
Abd‐El‐Basset, E. M. (2016) · Advances in Bioscience and Biotechnology · doi:10.4236/abb.2016.71004 · Cited by 2
Electrophysiological Biomarkers for Mood Disorders
Ramakrishnan, N., Murphy, N., Selvaraj, S., & Cho, R. Y. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.015 · Cited by 2
Gender differences in the pool of free amino acid neurotransmitters in Krushinsky-Molodkina rats
Krivopalov, S., Yushkov, B. G., Bykova, M. Y., & Zabegalov, K. N. (2020) · Biomeditsinskaya Khimiya · doi:10.18097/pbmc20206602124 · Cited by 2
Immunohistochemical Characterization of the Nervous System of Culex pipiens (Diptera, Culicidae)
Gregor, K. M., Becker, S. C., Hellhammer, F., Baumgärtner, W., & Puff, C. (2022) · Biology · doi:10.3390/biology11010057 · Cited by 2
Revisiting Our Quantum WorldPreprint
Ingber, L. (2020) · Preprints.org · doi:10.20944/preprints202009.0590.v1 · Cited by 2
Genomic comparison of GABA-producing Levilactobacillus brevis and Companilactobacillus zhachilii strains from Thai fermented foodsPreprint
Pakdeeto, A., Phuengjayaem, S., Kingkaew, E., Tungkajiwangkoon, S., Phitchayaphon, C., & Tanasupawat, S. (2025) · Research Square · doi:10.21203/rs.3.rs-5821336/v1 · Cited by 2
Ceftriaxone Treatment of TBI
Hameed, M. Q., & Rotenberg, A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802686-1.00015-8 · Cited by 2
Impact of fluoxetine exposure on Lymnaea stagnalis and its developing eggs: integrating untargeted lipidomics, targeted metabolomics, and classical risk assessment
Ilyaskina, D., Nakadera, Y., Lamoree, M. H., Koene, J. M., & Leonards, P. E. G. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1536438 · Cited by 2
Gut microbiota: contributing to high CVD prevalence in people living with schizophrenia?
Fu, C., Zhang, X., Qian, Y., Wang, X., Chen, X., Zeng, J. S., Zhang, N., Wang, L., Li, M., Li, Z., et al. (2025) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-025-02103-y · Cited by 1
Seasonal impact on the thermal tolerance window of a keystone coastal grazer, the common periwinkle Littorina littorea
García, T. A., Bedulina, D., Sokolova, I. M., & Lannig, G. (2026) · Journal of Comparative Physiology B · doi:10.1007/s00360-026-01670-3 · Cited by 1
Role of Reactive Astrocytes in Alzheimer’s Disease
Sarkar, S., Guha, S., & Biswas, S. C. (2022) · Springer eBooks · doi:10.1007/978-981-16-8313-8_9 · Cited by 1
Quality properties of salt-fermented mealworms (Tenebrio molitor larvae) with added millet
Kim, Y., Cho, S., & Kim, Y. (2024) · International Journal of Gastronomy and Food Science · doi:10.1016/j.ijgfs.2024.101007 · Cited by 1
The Role of Neurotransmitters in Epileptogenesis: Focus on GABA and Glutamate
Choo, B. K. M., & Shaikh, M. F. (2024) · Springer eBooks · doi:10.1007/978-981-99-7557-0_17 · Cited by 1
Brain Imaging and the Mechanisms of Antidepressant Action
Godlewska, B. R., Selvaraj, S., & Cowen, P. J. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.020 · Cited by 1
Effects of Lithium on Brain Structure in Bipolar Disorder
Kaur, J., Kafantaris, V., & Szeszko, P. R. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.018 · Cited by 1
Functional Connectome in Bipolar Disorder
Cha, J., & Anand, A. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.008 · Cited by 1
Identification of Glutamine Synthetase as a Contryphan-Bt Binding Protein by His-Tag Pull-Down
Han, P., Cao, Y., Dai, X., Liu, S., Fan, C., Wu, W., & Chen, J. (2021) · Protein and Peptide Letters · doi:10.2174/0929866528666211213100054 · Cited by 1
Neuron-glia Integrity: Functional Assessment, Molecular Underpinnings, and Implication for Higher Brain FunctionsPreprint
Zeng, H., Zhang, X., Wang, W., Shen, Z., Dai, Z., Yu, Z., Xu, S., Yan, G., Huang, Q., Wu, R., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.03.23.003681
Imaging Genetic and Epigenetic Markers in Mood Disorders
Poletti, S., Mazza, E. A., Vai, B., & Benedetti, F. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.012
Brain Imaging of Reward Dysfunction in Unipolar and Bipolar Disorders
Kumar, P., Jiang, Y., & Whitton, A. E. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.006
Resting-State Functional Connectivity in Unipolar Depression
Chen, Z., & Gong, Q. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.007
Brain Imaging Methods in Mood Disorders
Selvaraj, S., Brambilla, P., & Soares, J. C. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.002
Magnetic Resonance Spectroscopy Investigations of Bioenergy and Mitochondrial Function in Mood Disorders
Kious, B. M., & Renshaw, P. F. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.009
Neuroimaging Brain Inflammation in Mood Disorders
Meyer, J. H. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.011
Functional Near-Infrared Spectroscopy Studies in Mood Disorders
Matsuo, K., & Matsubara, T. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.014
Neuroanatomical Findings in Unipolar Depression and the Role of the Hippocampus
Arnone, D. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.003
Neuroimaging Biomarkers in Pediatric Mood Disorders
West, M. P., Tang, W. J., & Singh, M. K. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.005
fMRI Neurofeedback as Treatment for Depression
Skottnik, L., & Linden, D. E. J. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.013
Neuroanatomical Findings in Bipolar Disorder
Tronchin, G., & McDonald, C. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.004
Imaging Glutamatergic and GABAergic Abnormalities in Mood Disorders
Scotti-Muzzi, E., Otaduy, M. C. G., Soeiro‐de‐Souza, M. G., & Machado‐Vieira, R. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.010
Molecular Imaging of Dopamine and Antipsychotics in Bipolar Disorder
Jauhar, S. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.019
Magnetoencephalography Studies in Mood Disorders
Nugent, A. C. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.016
Estudo translacional do receptor N-metil-d-aspartato em primeiro episódio psicótico e em modelos animais de psicose
Loureiro, C. M. (2021) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2021.tde-04082021-134444
THE FIRST LAW OF THERMODYNAMICS ANALYSIS OF TRANSPORTERS INVOLVED IN THE GLUTAMATE/GABA-GLUTAMINE CYCLE
Gur, M., Yilmaz, S., & Taka, E. (2021) · Isı Bilimi ve Tekniği Dergisi · doi:10.47480/isibted.1025952

Authors: Walls, A. B., Waagepetersen, H. S., Bak, L. K., Schousboe, A., & Sonnewald, U.
Affiliations: University of Copenhagen (DK)
Norwegian University of Science and Technology (NO)
Corresponding author: Sonnewald, Ursula
ORCID: Walls, Anne B.
Waagepetersen, Helle S.
Bak, Lasse K.
Schousboe, Arne
Sonnewald, Ursula
Venue: Neurochemical Research
Publisher: Springer Science and Business Media LLC
Published: 2014-11-08
Volume: 40
Issue: 2
Pages: 402-409
ISSN: 0364-3190 (ISSN-L)
1573-6903
DOI: 10.1007/s11064-014-1473-1
OpenAlex: W2020838403
Cited by: 223
References: 46
Citations by year: 2026: 9 · 2025: 13 · 2024: 21 · 2023: 28 · 2022: 27 · 2021: 48 · 2020: 21 · 2019: 11 · 2018: 7 · 2017: 11 · 2016: 21 · 2015: 6
FWCI: 1.44
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Neurochemical Research (publishedVersion)
PubMed (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Keywords: astrocytes, neurons, glutamate, GABA, glutamine synthetase, methionine sulfoximine, aconitase inhibition, fluoroacetate, citrate, glutamatergic neurons, GABAergic neurons, brain energy metabolism
MeSH terms: Animals, Brain, gamma-Aminobutyric Acid, Glutamine, Humans, Magnetic Resonance Spectroscopy, Glutamic Acid, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The Glutamine–Glutamate/GABA Cycle: Function, Regional Differences in Glutamate and GABA Production and Effects of Interference with GABA Metabolism

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks