The Glutamine–Glutamate/GABA Cycle: Function, Regional Differences in Glutamate and GABA Production and Effects of Interference with GABA Metabolism

Interplay between Cortical Spreading Depolarization and Seizures

Kramer, D. R., Fujii, T., Ohiorhenuan, I. E., & Liu, C. Y. (2017) · Stereotactic and Functional Neurosurgery · doi:10.1159/000452841 · Cited by 3,721

An Energy Budget for Signaling in the Grey Matter of the Brain

Attwell, D., & Laughlin, S. B. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200110000-00001 · Cited by 3,543

Fine structural localization of glutamine synthetase in astrocytes of rat brain

Norenberg, M. D., & Martinez-Hernandez, A. (1979) · Brain Research · doi:10.1016/0006-8993(79)90071-4 · Cited by 1,349

Pyruvate car☐ylase: an astrocyte-specific enzyme implicated in the replenishment of amino acid neurotransmitter pools

Shank, R. P., Bennett, G. S., Freytag, S. O., & Campbell, G. L. (1985) · Brain Research · doi:10.1016/0006-8993(85)90552-9 · Cited by 471

A simulation study of brain compartments. Metabolism of glutamate and related substances in mouse brain

den Berg, C. J. V., & Garfinkel, D. J. (1971) · Biochemical Journal · doi:10.1042/bj1230211 · Cited by 414

Pyruvate Carboxylase Activity in Primary Cultures of Astrocytes and Neurons

Yu, A. C., Drejer, J., Hertz, L., & Schousboe, A. (1983) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1983.tb00849.x · Cited by 406

High Affinity Glutamate Transporters: Regulation of Expression and Activity

Gegelashvili, G., & Schousboe, A. (1997) · Molecular Pharmacology · doi:10.1124/mol.52.1.6 · Cited by 399

Preferential Utilization of Acetate by Astrocytes Is Attributable to Transport

Waniewski, R. A., & Martin, D. L. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-14-05225.1998 · Cited by 378

The contribution of GABA to glutamate/glutamine cycling and energy metabolism in the rat cortex in vivo

Patel, A. B., de Graaf, R. A., Mason, G. F., Rothman, D. L., Shulman, R. G., & Behar, K. L. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501703102 · Cited by 343

Metabolic compartmentation of glutamate and glutamine: Morphological evidence obtained by quantitative immunocytochemistry in rat cerebellum

Ottersen, O. P., Zhang, N., & Walberg, F. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90141-n · Cited by 335

Involvement of Astrocytes in Alzheimer’s Disease from a Neuroinflammatory and Oxidative Stress Perspective

González-Reyes, R. E., Nava-Mesa, M. O., Vargas-Sánchez, K., Ariza-Salamanca, D. F., & Mora-Muñoz, L. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00427 · Cited by 541

Glutamate and GABA Imbalance Following Traumatic Brain Injury

Guerriero, R. M., Giza, C. C., & Rotenberg, A. (2015) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-015-0545-1 · Cited by 495

Gamma-aminobutyric acid and probiotics: Multiple health benefits and their future in the global functional food and nutraceuticals market

Diez-Gutiérrez, L., Vicente, L. S., Barrón, L. J. R., Villarán, M. C., & Chávarri, M. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.103669 · Cited by 277

Central Role of Glutamate Metabolism in the Maintenance of Nitrogen Homeostasis in Normal and Hyperammonemic Brain

Cooper, A., & Jeitner, T. (2016) · Biomolecules · doi:10.3390/biom6020016 · Cited by 223

Molecular mechanisms of ischemia and glutamate excitotoxicity

Neves, D., Salazar, I. L., Almeida, R. D., & Silva, R. M. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121814 · Cited by 233

Zebrafish Get Connected: Investigating Neurotransmission Targets and Alterations in Chemical Toxicity

Horzmann, K. A., & Freeman, J. L. (2016) · Toxics · doi:10.3390/toxics4030019 · Cited by 204

Advances in the Potential Biomarkers of Epilepsy

Kobylarek, D., Iwanowski, P. S., Lewandowska, Z., Limphaibool, N., Szafranek, S., Labrzycka, A., & Kozubski, W. P. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00685 · Cited by 157

Interactions in the Metabolism of Glutamate and the Branched-Chain Amino Acids and Ketoacids in the CNS

Yudkoff, M. (2016) · Neurochemical Research · doi:10.1007/s11064-016-2057-z · Cited by 132

Crosstalk between Neuron and Glial Cells in Oxidative Injury and Neuroprotection

Lee, K. H., Cha, M., & Lee, B. H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413315 · Cited by 104

Repurposed molecules for antiepileptogenesis: Missing an opportunity to prevent epilepsy?

Klein, P., Friedman, A., Hameed, M. Q., Kaminski, R. M., Bar‐Klein, G., Klitgaard, H., Koepp, M. J., Jóźwiak, S., Prince, D. A., Rotenberg, A., et al. (2020) · Epilepsia · doi:10.1111/epi.16450 · Cited by 100

Glutamine Synthetase: Role in Neurological Disorders

Jayakumar, A., & Norenberg, M. D. (2016) · Advances in neurobiology · doi:10.1007/978-3-319-45096-4_13 · Cited by 98

Calpains and neuronal damage in the ischemic brain: The swiss knife in synaptic injury

Curcio, M., Salazar, I. L., Mele, M., Canzoniero, L. M. T., & Duarte, C. B. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.06.001 · Cited by 99

Astroglia in Alzheimer’s Disease

Verkhratsky, A., Parpura, V., Rodriguez, J. J., & Zorec, R. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-9913-8_11 · Cited by 96

Integrative Characterization of the R6/2 Mouse Model of Huntington’s Disease Reveals Dysfunctional Astrocyte Metabolism

Skotte, N. H., Andersen, J. V., Santos, A., Aldana, B. I., Willert, C. W., Nørremølle, A., Waagepetersen, H. S., & Nielsen, M. L. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.04.052 · Cited by 92

Betaine in the Brain: Characterization of Betaine Uptake, its Influence on Other Osmolytes and its Potential Role in Neuroprotection from Osmotic Stress

Knight, L. S., Piibe, Q., Lambie, I., Perkins, C., & Yancey, P. H. (2017) · Neurochemical Research · doi:10.1007/s11064-017-2397-3 · Cited by 91

Aging-induced tRNAGlu-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization

Li, D., Gao, X., Ma, X., Wang, M., Cheng, C., Xue, T., Gao, F., Shen, Y., Zhang, J., & Liu, Q. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.02.011 · Cited by 93

The tripartite glutamatergic synapse

Lalo, U., Koh, W., Lee, C. J., & Pankratov, Y. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108758 · Cited by 87

Glucose, Lactate, β-Hydroxybutyrate, Acetate, GABA, and Succinate as Substrates for Synthesis of Glutamate and GABA in the Glutamine–Glutamate/GABA Cycle

Hertz, L., & Rothman, D. L. (2016) · Advances in neurobiology · doi:10.1007/978-3-319-45096-4_2 · Cited by 85

The cellular and compartmental profile of mouse retinal glycolysis, tricarboxylic acid cycle, oxidative phosphorylation, and ~P transferring kinases.

Rueda, E. M., Johnson, J. E., Giddabasappa, A., Swaroop, A., Brooks, M. J., Sigel, I., Chaney, S. Y., & Fox, D. A. (2016) · PubMed Central · Cited by 78

Circadian Clocks and Sleep: Impact of Rhythmic Metabolism and Waste Clearance on the Brain

Albrecht, U., & Ripperger, J. A. (2018) · Trends in Neurosciences · doi:10.1016/j.tins.2018.07.007 · Cited by 75

Nutritional ketosis as an intervention to relieve astrogliosis: Possible therapeutic applications in the treatment of neurodegenerative and neuroprogressive disorders

Morris, G., Maes, M. H. J., Berk, M., Carvalho, A. F., & Puri, B. K. (2020) · European Psychiatry · doi:10.1192/j.eurpsy.2019.13 · Cited by 70

Anodal and cathodal tDCS modulate neural activity and selectively affect GABA and glutamate syntheses in the visual cortex of cats

Zhao, X.-J., Ding, J., Pan, H., Zhang, S., Pan, D., Yu, H., Ye, Z., & Hua, T. (2020) · The Journal of Physiology · doi:10.1113/jp279340 · Cited by 66

Fine Astrocyte Processes Contain Very Small Mitochondria: Glial Oxidative Capability May Fuel Transmitter Metabolism

Derouiche, A., Haseleu, J., & Korf, H. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1563-8 · Cited by 75

Antioxidant Activities of Solanum nigrum L. Leaf Extracts Determined in In Vitro Cellular Models

Campisi, A., Acquaviva, R., Raciti, G., Duro, A., Rizzo, M., & Santagati, N. (2019) · Foods · doi:10.3390/foods8020063 · Cited by 66

The astrocyte biochemistry

de Souza, D. G., Almeida, R. F., Souza, D. O., & Zimmer, E. R. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.04.002 · Cited by 70

Gamma-Aminobutyric Acid Signaling in Damage Response, Metabolism, and Disease

Kim, K., & Yoon, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054584 · Cited by 66

Minireview on Glutamine Synthetase Deficiency, an Ultra-Rare Inborn Error of Amino Acid Biosynthesis

Spodenkiewicz, M., Díez‐Fernández, C., Rüfenacht, V., Gemperle-Britschgi, C., & Häberle, J. (2016) · Biology · doi:10.3390/biology5040040 · Cited by 71

Neuroprotective potential of astroglia

Liu, B., Teschemacher, A. G., & Kasparov, S. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24140 · Cited by 65

Deletion of Neuronal GLT-1 in Mice Reveals Its Role in Synaptic Glutamate Homeostasis and Mitochondrial Function

McNair, L. F., Andersen, J. V., Aldana, B. I., Hohnholt, M. C., Nissen, J. D., Sun, Y., Fischer, K. D., Sonnewald, U., Nyberg, N. T., Webster, S. C., et al. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.0894-18.2019 · Cited by 64

Glia: A major player in glutamate–GABA dysregulation‐mediated neurodegeneration

Sood, A., Kumari, P., Fernandes, V., Khatri, D. K., & Singh, S. B. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24977 · Cited by 60

Transcranial magnetic stimulation and magnetic resonance spectroscopy: Opportunities for a bimodal approach in human neuroscience

Cuypers, K., & Marsman, A. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.117394 · Cited by 60

Increasing extracellular cGMP in cerebellum in vivo reduces neuroinflammation, GABAergic tone and motor in-coordination in hyperammonemic rats

Cabrera‐Pastor, A., Balzano, T., Hernández‐Rabaza, V., Malaguarnera, M., Llansola, M., & Felipo, V. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.12.013 · Cited by 59

The tumor-nerve circuit in breast cancer

Cui, Q., Jiang, D., Zhang, Y., & Chen, C. (2023) · Cancer and Metastasis Reviews · doi:10.1007/s10555-023-10095-1 · Cited by 55

Anterior cingulate cortex neurometabolites in bipolar disorder are influenced by mood state and medication: A meta-analysis of 1H-MRS studies

Scotti-Muzzi, E., Umla‐Runge, K., & Soeiro‐de‐Souza, M. G. (2021) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2021.01.096 · Cited by 50

Evaluation of neuron-glia integrity by in vivo proton magnetic resonance spectroscopy: Implications for psychiatric disorders

Xu, H., Zhang, H., Zhang, J., Huang, Q., Shen, Z., & Wu, R. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.09.027 · Cited by 58

Neuroimaging markers of glutamatergic and GABAergic systems in drug addiction: Relationships to resting-state functional connectivity

Moeller, S. J., London, E. D., & Northoff, G. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.11.010 · Cited by 50

Astroglial Glutamine Synthetase and the Pathogenesis of Mesial Temporal Lobe Epilepsy

Sandhu, M. R. S., Gruenbaum, B. F., Gruenbaum, S. E., Dhaher, R., Deshpande, K., Funaro, M. C., Lee, T.-S. W., Zaveri, H. P., & Eid, T. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.665334 · Cited by 47

Cultured Bacteria Provide Insight into the Functional Potential of the Coral-Associated Microbiome

Li, J., Zou, Y., Yang, J., Li, Q., Bourne, D. G., Sweet, M. J., Liu, C., Guo, A., & Zhang, S. (2022) · mSystems · doi:10.1128/msystems.00327-22 · Cited by 46

Dietary supplementation with Lactobacillus rhamnosus JB-1 restores brain neurochemical balance and mitigates the progression of mood disorder in a rat model of chronic unpredictable mild stress

Kochalska, K., Oakden, W., Słowik, T., Chudzik, A., Pankowska, A., Łazorczyk, A., Kozioł, P., Andres‐Mach, M., Pietura, R., Rola, R., et al. (2020) · Nutrition Research · doi:10.1016/j.nutres.2020.06.019 · Cited by 48

Metabolomics-based mechanisms exploration of Huang-Lian Jie-Du decoction on cerebral ischemia via UPLC-Q-TOF/MS analysis on rat serum

Zhu, B., Cao, H.-T., Sun, L., Лі, Б., Guo, L., Duan, J., Zhu, H., & Zhang, Q. (2018) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2018.01.015 · Cited by 45

Proteomics and metabolomics approach in adult and pediatric glioma diagnostics

Pienkowski, T., Kowalczyk, T., Garcia‐Romero, N., Ayuso‐Sacido, Á., & Ciborowski, M. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188721 · Cited by 41

Glutamine-to-glutamate ratio in the nucleus accumbens predicts effort-based motivated performance in humans

Strasser, A., Lukšys, G., Xin, L., Pessiglione, M., Rolf Gruetter, A., & Sandi, C. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0760-6 · Cited by 39

Proteomic phenotype of cerebral organoids derived from autism spectrum disorder patients reveal disrupted energy metabolism, cellular components, and biological processes

Ilieva, M. S., Aldana, B. I., Vinten, K. T., Hohmann, S. S., Woofenden, T. W., Lukjanska, R., Waagepetersen, H. S., & Michel, T. M. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01627-2 · Cited by 37

Characterization and application of electrically active neuronal networks established from human induced pluripotent stem cell-derived neural progenitor cells for neurotoxicity evaluation

Nimtz, L., Hartmann, J., Tigges, J., Masjosthusmann, S., Schmuck, M. R., Keßel, H. E., Theiss, S., Köhrer, K., Petzsch, P., Adjaye, J., et al. (2020) · Stem Cell Research · doi:10.1016/j.scr.2020.101761 · Cited by 34

The hippocampus associated GABAergic neural network impairment in early-stage of Alzheimer's disease

Tang, Y., Yan, Y., Mao, J., Ni, J., & Qing, H. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101865 · Cited by 34

Neuroprotection Promoted by Guanosine Depends on Glutamine Synthetase and Glutamate Transporters Activity in Hippocampal Slices Subjected to Oxygen/Glucose Deprivation

Dal-Cim, T. A., Martins, W. C., Thomaz, D. T., Coelho, V., Poluceno, G. G., Lanznaster, D., Vandresen-Filho, S., & Tasca, C. I. (2016) · Neurotoxicity Research · doi:10.1007/s12640-015-9595-z · Cited by 34

Shifts in excitatory/inhibitory balance by juvenile stress: A role for neuron–astrocyte interaction in the dentate gyrus

Albrecht, A., Ivens, S., Papageorgiou, I. E., Çalışkan, G., Saiepour, N., Brück, W., Richter‐Levin, G., Heinemann, U., & Stork, O. (2016) · Glia · doi:10.1002/glia.22970 · Cited by 33

The neuronal and astrocytic protein SLC 38A10 transports glutamine, glutamate, and aspartate, suggesting a role in neurotransmission

Hellsten, S. V., Hägglund, M. G., Eriksson, M. M., & Fredriksson, R. (2017) · FEBS Open Bio · doi:10.1002/2211-5463.12219 · Cited by 33

GABAB Receptor Agonist R-Baclofen Reverses Altered Auditory Reactivity and Filtering in the Cntnap2 Knock-Out Rat

Möhrle, D., Wang, W., Whitehead, S. N., & Schmid, S. (2021) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2021.710593 · Cited by 32

Spinal Cord Injury Provoked Neuropathic Pain and Spasticity, and Their GABAergic Connection

Bhagwani, A., Chopra, M., & Kumar, H. (2022) · Neurospine · doi:10.14245/ns.2244368.184 · Cited by 31

Astrocytic glutamine synthetase is expressed in the neuronal somatic layers and down‐regulated proportionally to neuronal loss in the human epileptic hippocampus

Papageorgiou, I. E., Valous, N. A., Lahrmann, B., Janova, H., Klaft, Z., Koch, A., Schneider, U. C., Vajkoczy, P., Heppner, F. L., Grabe, N., et al. (2018) · Glia · doi:10.1002/glia.23292 · Cited by 31

In Ovo Injection of GABA Can Help Body Weight Gain at Hatch, Increase Chick Weight to Egg Weight Ratio, and Improve Broiler Heat Resistance

Ncho, C. M., Goel, A., Jeong, C.-M., Youssouf, M., & Choi, Y. (2021) · Animals · doi:10.3390/ani11051364 · Cited by 29

Neuronal Glial Crosstalk: Specific and Shared Mechanisms in Alzheimer’s Disease

Chavda, V. K., Singh, K., Patel, V., Mishra, M., & Mishra, A. K. (2022) · Brain Sciences · doi:10.3390/brainsci12010075 · Cited by 29

Increased glucose metabolism and impaired glutamate transport in human astrocytes are potential early triggers of abnormal extracellular glutamate accumulation in hiPSC ‐derived models of Alzheimer's disease

Salcedo, C., Garcia, V. P., García‐Adán, B., Ameen, A. O., Gegelashvili, G., Waagepetersen, H. S., Freude, K., & Aldana, B. I. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.16014 · Cited by 30

Proposed mechanisms of tau: relationships to traumatic brain injury, Alzheimer’s disease, and epilepsy

Martin, S. P., & Leeman-Markowski, B. A. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2023.1287545 · Cited by 30

What Is the Role of Lactate in Brain Metabolism, Plasticity, and Neurodegeneration?

Benarroch, E. E. (2024) · Neurology · doi:10.1212/wnl.0000000000209378 · Cited by 32

The translocator protein gene is associated with endogenous pain modulation and the balance between glutamate and γ-aminobutyric acid in fibromyalgia and healthy subjects: a multimodal neuroimaging study

Fanton, S., Sandström, A., Tour, J., Kadetoff, D., Schalling, M., Jensen, K. B., Sitnikov, R., Ellerbrock, I., & Kosek, E. (2021) · Pain · doi:10.1097/j.pain.0000000000002309 · Cited by 27

Comprehensive characterization of γ-aminobutyric acid (GABA) production by Levilactobacillus brevis CRL 2013: insights from physiology, genomics, and proteomics

Cataldo, P. G., Martínez, M. P. U., Villena, J., Kitazawa, H., Saavedra, L., & Hebert, E. M. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1408624 · Cited by 29

Dietary Supplementation with γ-Aminobutyric Acid Improves Growth, Digestive Enzyme Activity, Non-Specific Immunity and Disease Resistance against Streptococcus iniae in Juvenile Olive Flounder, Paralichthys olivaceus

Farris, N. W., Hamidoghli, A., Bae, J., Won, S., Choi, W., Biró, J., Lee, S., & Bai, S. C. (2022) · Animals · doi:10.3390/ani12030248 · Cited by 27

Gamma-amino butyric acid (GABA) supplementation alleviates dexamethasone treatment-induced oxidative stress and inflammation response in broiler chickens

Fathi, M., Saeedyan, S., & Kaoosi, M. (2023) · Stress · doi:10.1080/10253890.2023.2185861 · Cited by 27

Divergent Cellular Energetics, Glutamate Metabolism, and Mitochondrial Function Between Human and Mouse Cerebral Cortex

Westi, E. W., Jakobsen, E., Voss, C. M., Bak, L. K., Pinborg, L. H., Aldana, B. I., & Andersen, J. V. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-03053-5 · Cited by 27

System N transporters are critical for glutamine release and modulate metabolic fluxes of glucose and acetate in cultured cortical astrocytes: changes induced by ammonia

Zielińska, M., Dąbrowska, K., Hadera, M. G., Sonnewald, U., & Albrecht, J. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13376 · Cited by 26

Progress of Astrocyte-Neuron Crosstalk in Central Nervous System Diseases

Zhang, Y., Wang, Z., Xu, F., Liu, Z., Zhao, Y., Yang, L. Z., & Fang, W. (2024) · Neurochemical Research · doi:10.1007/s11064-024-04241-6 · Cited by 28

Glutamate Decarboxylase 1 Overexpression as a Poor Prognostic Factor in Patients with Nasopharyngeal Carcinoma

Lee, Y., Chao, T., Sheu, M., Tian, Y., Chen, T., Lee, S., He, H.-L., Chang, I., Hsing, C., Lin, C., et al. (2016) · Journal of Cancer · doi:10.7150/jca.15667 · Cited by 24

Novel test strategies for in vitro seizure liability assessment

Tukker, A. M., & Westerink, R. H. S. (2021) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2021.1876026 · Cited by 27

Spinal Cord Injury and Loss of Cortical Inhibition

Benedetti, B., Weidenhammer, A., Reisinger, M., & Couillard‐Després, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105622 · Cited by 27

Creatine, Glutamine plus Glutamate, and Macromolecules Are Decreased in the Central White Matter of Premature Neonates around Term

Koob, M., Viola, A., Fur, Y. L., Viout, P., Ratiney, H., Sylviane Confort-gouny, A., Cozzone, P. J., & Girard, N. J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0160990 · Cited by 24

Neurointegrity and europhysiology: astrocyte, glutamate, and carbon monoxide interactions

Mahan, V. L. (2019) · Medical Gas Research · doi:10.4103/2045-9912.254639 · Cited by 24

Effects of adult male rat feminization treatments on brain morphology and metabolomic profile

Gómez, Á., Cerdán, S., Pérez-Laso, C., Ortega, E., Pásaro, E., Fernández, R., Gómez‐Gil, E., Mora, M., Marcos, A., del Cerro, M. C. R., et al. (2020) · Hormones and Behavior · doi:10.1016/j.yhbeh.2020.104839 · Cited by 23

Disruption to normal excitatory and inhibitory function within the medial prefrontal cortex in people with chronic pain

Kang, D., Hesam‐Shariati, N., McAuley, J. H., Alam, M., Trost, Z., Rae, C. D., & Gustin, S. M. (2021) · European Journal of Pain · doi:10.1002/ejp.1838 · Cited by 23

1H Magnetic Resonance Spectroscopy to Understand the Biological Basis of ALS, Diagnose Patients Earlier, and Monitor Disease Progression

Caldwell, S., & Rothman, D. L. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.701170 · Cited by 23

The glutamate/GABA system in the retina of male rats: effects of aging, neurodegeneration, and supplementation with melatonin and antioxidant SkQ1

Telegina, D. V., Antonenko, A. K., Фурсова, А. Ж., & Kolosova, N. G. (2022) · Biogerontology · doi:10.1007/s10522-022-09983-w · Cited by 23

Glutamatergic metabolites are associated with visual plasticity in humans

Wijtenburg, S. A., West, J., Korenic, S. A., Kuhney, F. S., Gaston, F. E., Chen, H., Roberts, M., Kochunov, P. V., Hong, L. E., & Rowland, L. M. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.02.020 · Cited by 23

Downregulation of GABA Transporter 3 (GAT3) is Associated with Deficient Oxidative GABA Metabolism in Human Induced Pluripotent Stem Cell-Derived Astrocytes in Alzheimer's Disease

Salcedo, C., Wagner, A., Andersen, J. V., Vinten, K. T., Waagepetersen, H. S., Schousboe, A., Freude, K., & Aldana, B. I. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03276-3 · Cited by 28

Ghrelin Causes a Decline in GABA Release by Reducing Fatty Acid Oxidation in Cortex

Mir, J. F., Zagmutt, S., Lichtenstein, M. P., García‐Villoria, J., Weber, M., Gracia, A., Fabriàs, G., Casas, J., López, M., Casals, N., et al. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-0921-3 · Cited by 24

Glutamine synthetase evolutionary history revisited: Tracing back beyond the Last Universal Common Ancestor

Fernandes, G. D. C., Turchetto‐Zolet, A. C., & Passaglia, L. M. P. (2022) · Evolution · doi:10.1111/evo.14434 · Cited by 25

Hyperammonemia After Lung Transplantation: Systematic Review and a Mini Case Series

Kamel, A. Y., Emtiazjoo, A. M., Adkins, L., Shahmohammadi, A., Alnuaimat, H., Peláez, A., Machuca, T., Pipkin, M., Lee, H., Weiner, I. D., et al. (2022) · Transplant International · doi:10.3389/ti.2022.10433 · Cited by 22

Exploring the functional roles of small-molecule metabolites in disease research: Recent advancements in metabolomics

Tan, A., & Ma, X. (2023) · Chinese Chemical Letters · doi:10.1016/j.cclet.2023.109276 · Cited by 23

Metabolomic discoveries for early diagnosis and traditional Chinese medicine efficacy in ischemic stroke

Wei, L., Chen, S., Deng, X., Liu, Y., Wang, H., Gao, X., & Huang, Y. (2024) · Biomarker Research · doi:10.1186/s40364-024-00608-7 · Cited by 22

The effect of a finishing diet supplemented with γ-aminobutyric acids on carcass characteristics and meat quality of Hanwoo steers

Barido, F. H., Lee, C. W., Park, Y. S., Kim, D. Y., & Lee, S. K. (2020) · Animal Bioscience · doi:10.5713/ajas.20.0224 · Cited by 21

Manganese-induced reactive oxygen species activate IκB kinase to upregulate YY1 and impair glutamate transporter EAAT2 function in human astrocytes in vitro

Rizor, A., Pajarillo, E. A. B., Nyarko‐Danquah, I., Digman, A., Mooneyham, L., Son, D., Aschner, M., & Lee, E.-S. (2021) · NeuroToxicology · doi:10.1016/j.neuro.2021.07.004 · Cited by 21

Glioma Stem-Like Cells and Metabolism: Potential for Novel Therapeutic Strategies

Harland, A. J., Liu, X., Ghirardello, M., Galán, M. C., Perks, C. M., & Kurian, K. M. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.743814 · Cited by 21

Positive Effect of Lactobacillus acidophilus EG004 on Cognitive Ability of Healthy Mice by Fecal Microbiome Analysis Using Full-Length 16S-23S rRNA Metagenome Sequencing

Jeon, S., Kim, H., Kim, J., Seol, D., Jo, J., Choi, Y., Cho, S., & Kim, H. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.01815-21 · Cited by 20

Gut health benefits and associated systemic effects provided by functional components from the fermentation of natural matrices

Cante, R. C., Nigro, F., Passannanti, F., Lentini, G., Gallo, M., Nigro, R., & Budelli, A. (2024) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.13356 · Cited by 21

Continuous Ingestion of Lacticaseibacillus rhamnosus JB-1 during Chronic Stress Ensures Neurometabolic and Behavioural Stability in Rats

Chudzik, A., Słowik, T., Kochalska, K., Pankowska, A., Łazorczyk, A., Andres‐Mach, M., Rola, R., Stanisz, G. J., & Orzyłowska, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23095173 · Cited by 22

Smad3 deficiency inhibits dentate gyrus LTP by enhancing GABAA neurotransmission

Muñoz, M.-D., Antolín‐Vallespín, M., Tapia‐González, S., & Sánchez‐Capelo, A. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13558 · Cited by 21

Glutamine and type 1 diabetes mellitus

Darmaun, D., Torres‐Santiago, L., & Mauras, N. (2018) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000530 · Cited by 18

Enhanced cerebral branched-chain amino acid metabolism in R6/2 mouse model of Huntington’s disease

Andersen, J. V., Skotte, N. H., Aldana, B. I., Nørremølle, A., & Waagepetersen, H. S. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03051-2 · Cited by 18

Advances in understanding the pathogenesis of post-traumatic epilepsy: a literature review

Fang, M., Liu, W., Tuo, J., Liu, M., Li, F., Zhang, L., Yu, C., & Xu, Z. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1141434 · Cited by 17

Impact of Opioids on Cellular Metabolism: Implications for Metabolic Pathways Involved in Cancer

Tarazi, D., & Maynes, J. T. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15092225 · Cited by 16

Maternal separation with early weaning impairs neuron-glia integrity: non-invasive evaluation and substructure demonstration

Zeng, H., Zhang, X., Wang, W., Shen, Z., Dai, Z., Yu, Z., Xu, S., Yan, G., Huang, Q., Wu, R., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-76640-y · Cited by 18

VIPergic neuroprotection in epileptogenesis: challenges and opportunities

Cunha‐Reis, D., Caulino‐Rocha, A., & Correia‐de‐Sá, P. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105356 · Cited by 16

Glucose, Lactate and Glutamine but not Glutamate Support Depolarization-Induced Increased Respiration in Isolated Nerve Terminals

Hohnholt, M. C., Andersen, V. H., Bak, L. K., & Waagepetersen, H. S. (2016) · Neurochemical Research · doi:10.1007/s11064-016-2036-4 · Cited by 17

Plasma amino acids profile in first-episode psychosis, unaffected siblings and community-based controls

Loureiro, C. M., da Roza, D. L., Zuelli, F. M. D. G. C., Shuhama, R., Fachim, H., Simões-Ambrósio, L. M. C., Deminice, R., Jordão, A. A., Menezes, P. R., Del‐Ben, C. M., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-78559-w · Cited by 16

Evaluation of Gamma-Aminobutyric Acid (GABA) as a Functional Feed Ingredient on Growth Performance, Immune Enhancement, and Disease Resistance in Olive Flounder (Paralichthys olivaceus) under High Stocking Density

Bae, J., Moniruzzaman, M., Je, H.-W., Lee, S., Choi, W., Min, T., Kim, K., & Bai, S. C. (2024) · Antioxidants · doi:10.3390/antiox13060647 · Cited by 16

Role of Glutamine-Glutamate/GABA cycle and potential target GLUD2 in alleviation of rheumatoid arthritis by Tripterygium hypoglaucum (levl.) Hutch based on metabolomics and molecular pharmacology

Long, C., Yang, Y., Wang, Y., Zhang, X., Zhang, L., Huang, S., Yang, D., Qiao, X., Yang, Y., & Guo, Y. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114561 · Cited by 17

Glutathione in the nucleus accumbens regulates motivation to exert reward-incentivized effort

Zalachoras, I., Ramos‐Fernández, E., Hollis, F., Trovò, L., Rodrigues, J., Strasser, A., Zanoletti, O., Steiner, P., Preitner, N., Xin, L., et al. (2022) · eLife · doi:10.7554/elife.77791 · Cited by 19

GSH and GABA decreases in IDH1-mutated low-grade gliomas detected by HERMES spectral editing at 3 T in vivo

Gong, T., Zhang, X., Wei, X., Yuan, S., Saleh, M. G., Song, Y., Edden, R. A. E., & Wang, G. (2020) · Neurochemistry International · doi:10.1016/j.neuint.2020.104889 · Cited by 15

Cortical Glutamate and GABA Changes During Early Abstinence in Alcohol Dependence and Their Associations With Benzodiazepine Medication

Wang, G., Weber‐Fahr, W., Frischknecht, U., Hermann, D., Kiefer, F., Ende, G., & Sack, M. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.656468 · Cited by 15

γ-aminobutyric acid as a metabolite: Interpreting magnetic resonance spectroscopy experiments

Myers, J. F., Nutt, D., & Lingford-Hughes, A. R. (2016) · Journal of Psychopharmacology · doi:10.1177/0269881116639298 · Cited by 15

Chapter 17: Regulatory role of astrocytes for neuronal biosynthesis and homeostasis of glutamate and GABA

Schousboe, A., Westergaard, N., Sonnewald, U., Petersen, S. B., Yu, A. C., & Hertz, L. (1992) · Progress in brain research · doi:10.1016/s0079-6123(08)61751-3 · Cited by 94

The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer

Bak, L. K., Schousboe, A., & Waagepetersen, H. S. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03913.x · Cited by 1,114

1 Glutamine, Glutamate, and GABA: Metabolic Aspects

Waagepetersen, H. S., Sonnewald, U., & Schousboe, A. (2007) · Springer eBooks · doi:10.1007/978-0-387-30373-4_1 · Cited by 42

Glial‐Neuronal Interactions as Studied by Cerebral Metabolism of [2‐13C]Acetate and [1‐13C]Glucose: An Ex Vivo 13C NMR Spectroscopic Study

Hassel, B., Sonnewald, U., & Fonnum, F. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.64062773.x · Cited by 160

Roles of glutamine in neurotransmission

Albrecht, J., Sidoryk-Węgrzynowicz, M., Zielińska, M., & Aschner, M. (2010) · Neuron Glia Biology · doi:10.1017/s1740925x11000093 · Cited by 273