Chronic Cerebral Hypoperfusion Promotes Amyloid-Beta Pathogenesis via Activating β/γ-Secretases

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Nicastrin Is Critical for Stability and Trafficking but Not Association of Other Presenilin/γ-Secretase Components

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Upregulation of BACE1 and β-Amyloid Protein Mediated by Chronic Cerebral Hypoperfusion Contributes to Cognitive Impairment and Pathogenesis of Alzheimer’s Disease

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Alzheimer’s disease-associated mutations increase amyloid precursor protein resistance to γ-secretase cleavage and the Aβ42/Aβ40 ratio

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Interleukin‐1α stimulates non‐amyloidogenic pathway by α‐secretase (ADAM‐10 and ADAM‐17) cleavage of APP in human astrocytic cells involving p38 MAP kinase

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Strong Impact of Chronic Cerebral Hypoperfusion on Neurovascular Unit, Cerebrovascular Remodeling, and Neurovascular Trophic Coupling in Alzheimer’s Disease Model Mouse

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Chronic Cerebral Hypoperfusion Accelerates Alzheimer’s Disease Pathology with Cerebrovascular Remodeling in a Novel Mouse Model

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Determination of the Proteolytic Cleavage Sites of the Amyloid Precursor-Like Protein 2 by the Proteases ADAM10, BACE1 and γ-Secretase

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Amyloid deposition after cerebral hypoperfusion: Evidenced on [18F]AV-45 positron emission tomography

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BACE1 and presenilin/γ‐secretase regulate proteolytic processing of KCNE1 and 2, auxiliary subunits of voltage‐gated potassium channels

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Hydrogen Sulfide Ameliorates Homocysteine-Induced Cognitive Dysfunction by Inhibition of Reactive Aldehydes Involving Upregulation of ALDH2

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The Metabolic Pathway Generating p3, an Aβ-Peptide Fragment, Is Probably Non-Amyloidogenic

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Berberine Improves Cognitive Impairment by Simultaneously Impacting Cerebral Blood Flow and β-Amyloid Accumulation in an APP/tau/PS1 Mouse Model of Alzheimer’s Disease

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Gastrodin and Gastrodigenin Improve Energy Metabolism Disorders and Mitochondrial Dysfunction to Antagonize Vascular Dementia

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Cognitive Impairments and blood-brain Barrier Damage in a Mouse Model of Chronic Cerebral Hypoperfusion

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Abnormal circadian blood pressure regulation and cognitive impairment in α-synucleinopathies

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Metabolomic analysis of vascular cognitive impairment due to hepatocellular carcinoma

Zhu, D., Zhu, Y., Liu, L., He, X., & Fu, S. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2022.1109019 · Cited by 13 · see citing works

Vascular Function and Ion Channels in Alzheimer's Disease

Taylor, J. L., Baudel, M. A. S. M., Nieves‐Cintrón, M., & Navedo, M. F. (2024) · Microcirculation · doi:10.1111/micc.12881 · Cited by 13 · see citing works

Deep Reinforcement Learning-Based Retinal Imaging in Alzheimer’s Disease: Potential and Perspectives

Hui, H. Y. H., Ran, A. R., Dai, J. J., & Cheung, C. Y.-L. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230055 · Cited by 13 · see citing works

Effect of Global Brain Ischemia on Amyloid Precursor Protein Metabolism and Expression of Amyloid-Degrading Enzymes in Rat Cortex: Role in Pathogenesis of Alzheimer’s Disease

Babušíková, E., Dobrota, D., Turner, A., & Nalivaeva, N. (2021) · Biochemistry (Moscow) · doi:10.1134/s0006297921060067 · Cited by 14 · see citing works

A Non-Peptidic MAS1 Agonist AVE0991 Alleviates Hippocampal Synaptic Degeneration in Rats with Chronic Cerebral Hypoperfusion

Xiao, X., Duan, R., Zhang, Q.-Q., Wang, S., Gong, P., Yan, E., Zhang, Y., & Jiang, T. (2021) · Current Neurovascular Research · doi:10.2174/1567202618666211012095210 · Cited by 10 · see citing works

Cerebral blood flow, tau imaging, and memory associations in cognitively unimpaired older adults

Weigand, A. J., Hamlin, A. M., Breton, J., & Clark, A. L. (2022) · Cerebral Circulation - Cognition and Behavior · doi:10.1016/j.cccb.2022.100153 · Cited by 10 · see citing works

Effect of amyloid toxicity or chronic cerebral hypoperfusion on brain insulin resistance in a rat model with intracerebroventricular streptozotocin

Choi, B., Seo, J.-H., Back, D. B., Han, J., Choi, D., Kwon, K. J., Shin, C. Y., Lee, J., & Kim, H. Y. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.02.012 · Cited by 8 · see citing works

Toll-Like Receptor 4-Mediated Neuroinflammation: Updates on Pathological Roles and Therapeutic Strategies in Chronic Cerebral Hypoperfusion

Yawoot, N., Tocharus, J., & Tocharus, C. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04718-7 · Cited by 7 · see citing works

Expression of Amyloid Precursor Protein, Caveolin-1, Alpha-, Beta-, and Gamma-Secretases in Penumbra Cells after Photothrombotic Stroke and Evaluation of Neuroprotective Effect of Secretase and Caveolin-1 Inhibitors

Sharifulina, S., Khaitin, A. M., Guzenko, V., Kalyuzhnaya, Y. N., Dzreyan, V., Logvinov, A., DOBAEVA, N. M., Li, Y., Chen, L., He, B., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10102655 · Cited by 5 · see citing works

Acorus tatarinowii alleviates D-galactose-induced Alzheimer’s-like disease cognitive impairment and Aβ-induced pericytes dysfunction in mice

Zhang, T., Yang, J., Xu, H., Cao, Y., Du, X., Guo, L., Liang, B., Su, L., Chai, L., Yuan, Q., et al. (2024) · Brain Research · doi:10.1016/j.brainres.2024.149312 · Cited by 4 · see citing works

Inhibition of autophagy attenuates cognitive decline and mitochondrial dysfunction in an Alzheimer’s disease mouse model with chronic cerebral hypoperfusion

Yang, Q., Chen, T., Li, S., Yang, C., Zheng, X., Mao, S., Liu, N., Mo, S., Li, D., Yang, M., et al. (2024) · Brain Research · doi:10.1016/j.brainres.2024.149416 · Cited by 4 · see citing works

Association between hemoglobin-to-red blood cell distribution width ratio and cognitive function in older US adults: a cross-sectional study based on the NHANES 2011–2014

Wang, F., Wang, X., Wang, C., Liu, H., Xu, Z., Li, D., Zhao, X., Zhao, J., Li, S., & Zhao, J. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1571159 · Cited by 3 · see citing works

Inflammation mediates the association between metabolic syndrome and vascular dementia: A large prospective cohort study

Jiang, T., Zuo, Q., Song, L., Gao, X., Fu, X., Qin, S., & Wu, J. (2025) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2025.120554 · Cited by 2 · see citing works

Amyloid Precursor Protein, Alpha-, Beta- and Gamma-Secretases Expression in Penumbra Cells after Photothrombotic Stroke. Evaluation of the Neuroprotective Effect of Secretase InhibitorsPreprint

Sharifulina, S., Guzenko, V., Logvinov, A., Khaitin, A. M., Kalyuzhnaya, Y. N., DOBAEVA, N. M., Li, Y., Chen, L., He, B., & Demyanenko, S. V. (2022) · Preprints.org · doi:10.20944/preprints202205.0184.v1

Влияние глобальной ишемии головного мозга на метаболизм белка-предшественника β-амилоида и экспрессию амилоид-деградирующих ферментов в коре головного мозга крыс: роль в патогенезе болезни Альцгеймера

Babušíková, E., Dobrota, Đ., Тернер, Э. Д., & Наливаева, Н. Н. (2021) · Биохимия · doi:10.31857/s0320972521060063

CeRNA regulatory network of cerebral microvascular dysfunction in early development of APP/PS1 mice model of Alzheimer's disease

Gu, Q., Xie, Y., Zhao, Z., Zhuang, Z., 杨淋清, Huang, H., Li, H., Pi, S., Chen, F., Gong, C., et al. (2026) · Journal of Alzheimer s Disease · doi:10.1177/13872877261435563

PrPC modulates BACE1-dependent amyloid pathology under chronic cerebral hypoperfusion: Implications for vascular cognitive impairment

Sun, Q., Yin, X., Lang, Y., Zhang, B., Shao, J., Zhang, Y., Wang, Y., Wang, Y., & Cui, L. (2026) · Neurotherapeutics · doi:10.1016/j.neurot.2026.e00957

Upregulation of BACE1 and β-Amyloid Protein Mediated by Chronic Cerebral Hypoperfusion Contributes to Cognitive Impairment and Pathogenesis of Alzheimer’s Disease

Zhiyou, C., Yong, Y., Shanquan, S., Jun, Z., Liangguo, H., Ling, Y., & Li, J. (2009) · Neurochemical Research · doi:10.1007/s11064-008-9899-y · Cited by 96 · see citing works

P2‐070: CHRONIC CEREBRAL HYPOPERFUSION INCREASES AMYLOID PLAQUES BY ACCELERATING AMYLOID BETA AGGREGATION IN APP/PS1 TRANSGENIC MICE

Bannai, T., Iwata, A., Mano, T., Ohtomo, R., Ohtomo, G., Hashimoto, T., Iwatsubo, T., & Toda, T. (2018) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2018.06.755 · Cited by 1 · see citing works

IC‐P‐081: The effect of chronic cerebral hypoperfusion on clearance and production of β‐amyloid peptide

Li, L. (2009) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2009.05.635

P2‐062: The effect of chronic cerebral hypoperfusion on clearance and production of β‐amyloid peptide

Li, L. (2009) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2009.04.372

Regulation of β-amyloid level in the brain of rats with cerebrovascular hypoperfusion

Liu, H., Xing, A., Wang, X., Liu, G., & Li, L. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.05.027 · Cited by 31 · see citing works