The Utility of Cerebral Blood Flow as a Biomarker of Preclinical Alzheimer’s Disease

Hays, Chelsea C.; Zlatar, Zvinka Z.; Wierenga, Christina E.

doi:10.1007/s10571-015-0261-z

Cited by 213Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsAdvanced MRI Techniques and Applications

The Utility of Cerebral Blood Flow as a Biomarker of Preclinical Alzheimer’s Disease

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Hays, Chelsea C., Zlatar, Zvinka Z., Wierenga, Christina E.·2016·Cellular and Molecular Neurobiology

DOI 10.1007/s10571-015-0261-zPMC PMC5278904

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Abstract

There is accumulating evidence suggesting that changes in brain perfusion are present long before the clinical symptoms of Alzheimer's disease (AD), perhaps even before amyloid-β accumulation or brain atrophy. This evidence, consistent with the vascular hypothesis of AD, implicates cerebral blood flow (CBF) in the pathogenesis of AD and suggests its utility as a biomarker of preclinical AD. The extended preclinical phase of AD holds particular significance for disease modification, as treatment would likely be most effective in this early asymptomatic stage of disease. This highlights the importance of identifying reliable and accurate biomarkers of AD that can differentiate normal aging from preclinical AD prior to clinical symptom manifestation. Cerebral perfusion, as measured by arterial spin labeling magnetic resonance imaging (ASL-MRI), has been shown to distinguish between normal controls and adults with AD. In addition to demonstrating diagnostic utility, CBF has shown usefulness as a tool for identifying those who are at risk for AD and for predicting subtle cognitive decline and conversion to mild cognitive impairment and AD. Taken together, this evidence not only implicates CBF as a useful biomarker for tracking disease severity and progression, but also suggests that ASL-measured CBF may be useful for identifying candidates for future AD treatment trials, especially in the preclinical, asymptomatic phases of the disease.

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Cerebral Blood Flow is Diminished in Asymptomatic Middle-Aged Adults with Maternal History of Alzheimer's Disease
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Differential age effects on cerebral blood flow and BOLD response to encoding: Associations with cognition and stroke risk
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Altered cerebral hemodynamics in early Alzheimer disease: a pilot study using transcranial Doppler
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Detecting changes in human cerebral blood flow after acute exercise using arterial spin labeling: Implications for fMRI
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Assessment of Alzheimer's Disease Risk with Functional Magnetic Resonance Imaging: An Arterial Spin Labeling Study
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Effect of Mild Cognitive Impairment and APOE Genotype on Resting Cerebral Blood Flow and its Association with Cognition
Wierenga, C. E., Dev, S. I., Shin, D. D., Clark, L. R., Bangen, K. J., Jak, A. J., Rissman, R. A., Liu, T. T., Salmon, D. P., & Bondi, M. W. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.58 · Cited by 88 · see citing works
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Interactive effects of vascular risk burden and advanced age on cerebral blood flow
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Regional cerebral perfusion in patients with Alzheimer’s disease and mild cognitive impairment: effect of APOE Epsilon4 allele
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Hypertension and Cerebral Vasoreactivity
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Variability of Familial Risk of Alzheimer Disease Across the Late Life Span
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Framingham Cardiovascular Risk Profile Correlates with Impaired Hippocampal and Cortical Vasoreactivity to Hypercapnia
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Longitudinal Cerebral Blood Flow and Amyloid Deposition: An Emerging Pattern?
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Imaging Cerebral Blood Flow in the Cognitively Normal Aging Brain with Arterial Spin Labeling: Implications for Imaging of Neurodegenerative Disease
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Characterizing Early Alzheimer's Disease and Disease Progression Using Hippocampal Volume and Arterial Spin Labeling Perfusion MRI
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Clinical Application of 3D Arterial Spin-Labeled Brain Perfusion Imaging for Alzheimer Disease: Comparison with Brain Perfusion SPECT
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Apolipoprotein E, Carbon Dioxide Vasoreactivity, and Cognition in Older Adults: Effect of Hypertension
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Changes in cerebral blood flow and vasoreactivity to CO2 measured by arterial spin labeling after 6days at 4350m
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Self-citation
CSF Biomarkers Correlate with Cerebral Blood Flow on SPECT in Healthy Elderly
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The role of brain vasculature in neurodegenerative disorders
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Authors: Hays, C. C., Zlatar, Z. Z., & Wierenga, C. E.
Affiliations: San Diego State University (US)
University of California San Diego (US)
Corresponding author: Wierenga, Christina E.
ORCID: Hays, Chelsea C.
Zlatar, Zvinka Z.
Wierenga, Christina E.
Venue: Cellular and Molecular Neurobiology
Publisher: Springer Science and Business Media LLC
Published: 2016-02-22
Volume: 36
Issue: 2
Pages: 167-179
ISSN: 0272-4340 (ISSN-L)
1573-6830
DOI: 10.1007/s10571-015-0261-z
PMC: PMC5278904
OpenAlex: W2283957277
Cited by: 213
References: 122
Citations by year: 2026: 8 · 2025: 18 · 2024: 18 · 2023: 24 · 2022: 25 · 2021: 27 · 2020: 19 · 2019: 25 · 2018: 24 · 2017: 19 · 2016: 5
Type: book review
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Cellular and Molecular Neurobiology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: VA CSR&D Merit Award (5I01CX000565)
National Institutes of Health T32 (MH019934)
National Science Foundation Graduate Research Fellowship Program (2015207525)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Keywords: cerebral blood flow, preclinical Alzheimer's disease, arterial spin labeling, cerebral perfusion, biomarkers, normal aging, mild cognitive impairment, cognitive decline prediction, disease progression
MeSH terms: Aging, Alzheimer Disease, Cerebrovascular Circulation, Humans, Risk Factors, Biomarkers, Genetic Predisposition to Disease

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The Utility of Cerebral Blood Flow as a Biomarker of Preclinical Alzheimer’s Disease

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