Short-chain fatty acids reduce oligodendrocyte precursor cells loss by inhibiting the activation of astrocytes via the SGK1/IL-6 Signalling pathway
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Short-chain fatty acids (SCFAs) are known to be actively involved in neurological diseases, but their roles in hypoxic-ischaemic brain injury (HIBI) are unclear. In this study, a rat model of HIBI was established, and this study measured the changes in IL-6 and NOD-like receptor thermal protein domain associated protein 3 (NLRP3), in addition to proliferation and apoptosis indicators of oligodendrocyte precursor cells (OPCs). The mechanism of action of SCFA on astrocytes was also investigated. Astrocytes were subjected to hypoxia in vitro, and OPCs were treated with IL-6. The results showed that SCFAs significantly alleviated HIBI-induced activation of astrocytes and loss of OPCs. SCFA pretreatment (1) downregulated the expression of NLRP3, IL-6, CCL2, and IP-10; (2) had no effect on the proliferation of OPCs; (3) ameliorated the abnormal expression of Bax and Bcl-2; and (4) regulated IL-6 expression via the SGK1-related pathway in astrocytes. Our findings revealed that SCFAs alleviated the loss of OPCs by regulating astrocyte activation through the SGK1/IL-6 signalling pathway.
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SGK1-related pathways regulate IL-6 expression in astrocytes, mitigating loss of oligodendrocyte progenitor cells (OPCs).
“SGK1-related pathways regulate IL-6 expression in astrocytes, mitigating the loss of oligodendrocyte progenitor cells (OPCs)”
From Serum/glucocorticoid regulated kinase 1 (SGK1) in neurological disorders: pain or gain (2024) · cites this paper as Gao et al., 2022
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Cites
Targeting the NLRP3 inflammasome in inflammatory diseases
Mangan, M. S. J., Olhava, E. J., Roush, W. R., Seidel, H. M., Glick, G. D., & Latz, E. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.97 · Cited by 1,885 · see citing works
The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism
Frost, G., Sleeth, M. L., Sahuri-Arisoylu, M., Lizarbe, B., Cerdan, S., Brody, L., Anastasovska, J., Ghourab, S., Hankir, M., Zhang, S., et al. (2014) · Nature Communications · doi:10.1038/ncomms4611 · Cited by 1,771 · see citing works
Hu, H., Tian, M., Ding, C., & Yu, S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2018.03083 · Cited by 1,140 · see citing works
Origin of oligodendrocytes in the subventricular zone of the adult brain
Menn, B., Garcia-Verdugo, J. M., Yaschine, C., Gonzalez-Perez, O., Rowitch, D., & Alvarez-Buylla, A. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1299-06.2006 · Cited by 972 · see citing works
Astrocytes: Key Regulators of Neuroinflammation
Colombo, E., & Farina, C. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.06.006 · Cited by 901 · see citing works
Why does remyelination fail in multiple sclerosis?
Franklin, R. J. M. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn917 · Cited by 837 · see citing works
Yang, H., Wen, Y., Zhang, M., Liu, Q., Zhang, H., Zhang, J., Lü, L., Tao, Y., Bai, X., Xiao, G., et al. (2019) · Autophagy · doi:10.1080/15548627.2019.1606647 · Cited by 303 · see citing works
Fancy, S. P. J., Zhao, C., & Franklin, R. J. M. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2004.06.015 · Cited by 302 · see citing works
Molecular Control of Oligodendrocyte Development
Elbaz, B., & Popko, B. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2019.01.002 · Cited by 286 · see citing works
Oligodendrogenesis in the normal and pathological central nervous system
Waly, B. E., Macchi, M., Cayre, M., & Durbec, P. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00145 · Cited by 176 · see citing works
Dulamea, A. O. (2017) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-47861-6_7 · Cited by 128 · see citing works
SGK1 inhibition induces autophagy-dependent apoptosis via the mTOR-Foxo3a pathway
Liu, W., Wang, X., Liu, Z., Wang, Y., Yin, B., Pan, Y., Duan, X., Liao, Z., Chen, Y., Liu, C., et al. (2017) · British Journal of Cancer · doi:10.1038/bjc.2017.293 · Cited by 121 · see citing works
Self-citationInflammation and atherosclerosis: Cardiovascular evaluation in patients with autoimmune diseases
Escarcega, R. O., Lipinski, M. J., García‐Carrasco, M., Pinto, C. M., Gálvez-Romero, J. L., & Cervera, R. (2018) · Autoimmunity Reviews · doi:10.1016/j.autrev.2018.01.021 · Cited by 93 · see citing works
The active contribution of OPCs to neuroinflammation is mediated by LRP1
Fernández-Castañeda, A., Chappell, M. S., Rosen, D. A., Seki, S. M., Beiter, R. M., Johanson, D. M., Liskey, D., Farber, E., Önengüt-Gümüşcü, S., Overall, C. C., et al. (2019) · Acta Neuropathologica · doi:10.1007/s00401-019-02073-1 · Cited by 87 · see citing works
Xie, D., Shen, F., He, S., Chen, M., Han, Q., Fang, M., Zeng, H., Chen, C., & Deng, Y. (2015) · Glia · doi:10.1002/glia.22950 · Cited by 84 · see citing works
Self-citationAnti-inflammatory effect of afatinib (an EGFR-TKI) on OGD-induced neuroinflammation
Chen, Y., Hsu, C., Shiao, Y., Wang, H., Lo, Y., & Lin, A. M. Y. (2019) · Scientific Reports · doi:10.1038/s41598-019-38676-7 · Cited by 77 · see citing works
Apolloni, S., Fabbrizio, P., Parisi, C., Amadio, S., & Volonté, C. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-9019-8 · Cited by 70 · see citing works
Cayre, M., Courtes, S., Martineau, F. S., Giordano, M., Arnaud, K., Zamaron, A., & Durbec, P. L. (2013) · Development · doi:10.1242/dev.092999 · Cited by 65 · see citing works
Roberts, A. J., Khom, S., Bajo, M., Vlkolinský, R., Polis, I. Y., Cates‐Gatto, C., Roberto, M., & Gruol, D. L. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.08.185 · Cited by 65 · see citing works
Regulation and role of the ER stress transcription factor CHOP in alveolar epithelial type-II cells
Klymenko, O., Huehn, M., Wilhelm, J., Wasnick, R. M., Shalashova, I., Ruppert, C., Henneke, I., Hezel, S., Guenther, K., Mahavadi, P., et al. (2019) · Journal of Molecular Medicine · doi:10.1007/s00109-019-01787-9 · Cited by 62 · see citing works
Xie, D., Ge, X., Ma, Y., Tang, J., Wang, Y., Zhu, Y., Gao, C., & Pan, S. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1662-6 · Cited by 55 · see citing works
Self-citationWilson, M. R., Eyre, T. A., Martínez‐Calle, N., Ahearne, M. J., Parsons, K. E., Preston, G., Khwaja, J., Schofield, J., Elliot, J., kh, A. M., et al. (2020) · Blood Advances · doi:10.1182/bloodadvances.2020002421 · Cited by 54 · see citing works
Reactive oxygen species play a role in P2X7 receptor-mediated IL-6 production in spinal astrocytes
Muñoz, F. M., Patel, P. A., Gao, X., Mei, Y., Xia, J., Gilels, S., & Hu, H. (2020) · Purinergic Signalling · doi:10.1007/s11302-020-09691-5 · Cited by 49 · see citing works
VCAM1 acts in parallel with CD69 and is required for the initiation of oligodendrocyte myelination
Miyamoto, Y., Torii, T., Tanoue, A., & Yamauchi, J. (2016) · Nature Communications · doi:10.1038/ncomms13478 · Cited by 38 · see citing works
Caraganis, A., Mulder, M., Kempainen, R. R., Brown, R. Z., Oswood, M. C., Hoffman, B., & Prekker, M. E. (2020) · Neurocritical Care · doi:10.1007/s12028-019-00900-7 · Cited by 26 · see citing works
The roles of neuron-NG2 glia synapses in promoting oligodendrocyte development and remyelination
Li, R., Zhang, P., Zhang, M., & Yao, Z. (2020) · Cell and Tissue Research · doi:10.1007/s00441-020-03195-9 · Cited by 25 · see citing works
Xing, B., Brink, L. E., Maers, K., Sullivan, M. L. G., Bodnar, R. J., Stolz, D. B., & Cambi, F. (2018) · Glia · doi:10.1002/glia.23453 · Cited by 19 · see citing works
Inhalation of growth factors and apo-transferrin to protect and repair the hypoxic-ischemic brain
Clausi, M. G., Paez, P. M., Pasquini, L. A., & Pasquini, J. M. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.01.010 · Cited by 18 · see citing works
Zhou, L., Ding, Y., Gao, Y., Yang, B., Bao, J., & Ma, J. (2020) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2020.1711883 · Cited by 13 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 2
- [11]Zhang H Zahid A Ismail H An overview of disease models for NLRP3 inflammasome over-activation Expert Opin Drug Discov 2020 16 1 18 33131335
- [24]Kobayashi T Deak M Morrice N Characterization of the structure and regulation of two novel isoforms of serum-and glucocorticoid-induced protein kinase Int J Dermatol 1999 344 1193 1194 PMC1220630 10548550
Cited by
Sorted by citations
Regulation of short-chain fatty acids in the immune system
Liu, X., Shao, J.-H., Liao, Y.-T., Wang, L., Yuan, J., Dong, P.-J., Liu, Z., He, D., Li, C., & Zhang, X. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1186892 · Cited by 435 · see citing works
Mechanisms of Blood–Brain Barrier Protection by Microbiota-Derived Short-Chain Fatty Acids
Fock, E. M., & Parnova, R. G. (2023) · Cells · doi:10.3390/cells12040657 · Cited by 418 · see citing works
Kim, C.-S. (2023) · Advances in Nutrition · doi:10.1016/j.advnut.2023.10.008 · Cited by 104 · see citing works
Gut microbial metabolism in Alzheimer's disease and related dementias
Kang, J. W., Vemuganti, V., Kuehn, J. F., Ulland, T. K., Rey, F. E., & Bendlin, B. B. (2024) · Neurotherapeutics · doi:10.1016/j.neurot.2024.e00470 · Cited by 49 · see citing works
Głowacka, P., Oszajca, K., Pudlarz, A. M., Szemraj, J., & Witusik‐Perkowska, M. (2024) · Nutrients · doi:10.3390/nu16142244 · Cited by 48 · see citing works
Shiadeh, S. M. J., Chan, W. K., Rasmusson, S., Hassan, N., Joca, S. R. L., Westberg, L., Elfvin, A., Mallard, C. E., & Ardalan, M. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03504-2 · Cited by 49 · see citing works
Bashir, B., Gulati, M., Vishwas, S., Gupta, G., Dhanasekaran, M., Paudel, K. R., Chellappan, D. K., Anand, K., Negi, P., Singh, P. K., et al. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102689 · Cited by 43 · see citing works
Unraveling the role of oligodendrocytes and myelin in pain
Kim, W., & Angulo, M. C. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16206 · Cited by 34 · see citing works
Saikachain, N., Sungkaworn, T., Muanprasat, C., & Asavapanumas, N. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15827 · Cited by 29 · see citing works
Short-chain fatty acid on blood-brain barrier and glial function in ischemic stroke
Mathias, K., Machado, R. S., Stork, S. D. S., Martins, C. D., dos Santos, D., Lippert, F. W., Prophiro, J. S., & Petronilho, F. C. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122979 · Cited by 28 · see citing works
Yan, Q., Qin, Q., Zhang, S., Chen, F., Ru, Y., Zhong, Y., & Wu, G. (2025) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2025.2568606 · Cited by 27 · see citing works
Eslami, M., Adampour, Z., Dowlat, B. F., Yaghmayee, S., Tabaei, F. M., Oksenych, V., & Naderian, R. (2025) · Biomedicines · doi:10.3390/biomedicines13040915 · Cited by 26 · see citing works
Patricio-Martínez, A., Patricio, F., Macuil-Chapuli, E., Martínez-Juárez, E. Á., Flores-Díaz, S., Cedillo-Ramirez, M. L., & Limón, I. D. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1598011 · Cited by 22 · see citing works
Role of short chain fatty acids on astrocytes and microglia in Alzheimer's disease brain
Wtpsk, S., Burton, M., Fernando, W. M. K. T., Jayasena, V., Brennan, C. S., & Fernando, W. M. A. D. B. (2024) · International Journal of Food Science & Technology · doi:10.1111/ijfs.17380 · Cited by 17 · see citing works
Wang, S., Zeng, F., Ma, Y., Yu, J., Xiang, C., Feng, X., Wang, S., Wang, J., Zhao, S., & Zhu, X. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241210248 · Cited by 16 · see citing works
Zhao, H., Tao, L., Tang, C. W., Cai, W., & Shen, W. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-07176-w · Cited by 15 · see citing works
Kostiuchenko, O., Lushnikova, I., & Skibo, G. G. (2024) · Regenerative medicine reports . · doi:10.4103/regenmed.regenmed-d-24-00004 · Cited by 14 · see citing works
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Shi, C., Dong, J.-W., Hui, X., Xu, Z., Zhao, Z.-D., & Dong, L. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05538-5 · Cited by 17 · see citing works
Serum/glucocorticoid regulated kinase 1 (SGK1) in neurological disorders: pain or gain
Howard, P. G., Zou, P., Zhang, Y., Huang, F., Tesic, V., Wu, C. Y.-C., & Lee, R. H.-C. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114973 · Cited by 13 · see citing works
Recent advancements in targeting the immune system to treat hypertension
Muralitharan, R. R., Marques, F. Z., & O’Donnell, J. A. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.177008 · Cited by 14 · see citing works
Saadh, M. J., Ahmed, H. H., Kareem, R. A., Sanghvi, G. V., Ganesan, S., Agarwal, M., Kaur, P., Taher, W. M., Alwan, M., Jawad, M. J., et al. (2025) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2025.173972 · Cited by 12 · see citing works
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The role of SGK1 in neurologic diseases: A friend or foe?
Chen, X., Kang, H., & Xiao, Y. (2024) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2024.12.003 · Cited by 10 · see citing works
Relationship Between Multiple Sclerosis, Gut Dysbiosis, and Inflammation
Jank, L., & Bhargava, P. (2023) · Neurologic Clinics · doi:10.1016/j.ncl.2023.07.005 · Cited by 8 · see citing works
Long, G., Zhang, Q., Yang, X., Sun, H., & Ji, C. (2024) · Immunologic Research · doi:10.1007/s12026-024-09503-7 · Cited by 7 · see citing works
Liu, D., Wang, T., Zhao, X., Chen, J., Yang, T., Shen, Y., & Zhou, Y. (2023) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x231219115 · Cited by 7 · see citing works
Reactive Gliosis in Neonatal Disorders: Friend or Foe for Neuroregeneration?
Gargaś, J., Janowska, J., Gebala, P., Maksymiuk, W., & Sypecka, J. (2024) · Cells · doi:10.3390/cells13020131 · Cited by 7 · see citing works
Sarkar, S., Maparu, K., & Aran, K. R. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10703-2 · Cited by 7 · see citing works
Deng, J., Li, J., Li, S., Rongying, L. I., Xin, C. H. E. N., ZHANG, H., Huisi, Y. A. N. G., Li, S.-Y., De-chou, Z., & Bai, X. M. (2025) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2025.108725 · Cited by 6 · see citing works
Lipid Metabolism in Cerebral Ischemia: From Pathogenesis to Therapy
Wang, X., Liu, R., Chen, Z., Hu, W., & Jiang, L. (2025) · Current Neuropharmacology · doi:10.2174/011570159x389784250715064745 · Cited by 4 · see citing works
In vitro models of microbiota-gut-brain axis communication at the blood-brain-barrier interface
Davies, M. R., Cross, C., Aburto, M. R., Cryan, J. F., & Wardill, H. R. (2026) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x261419964 · Cited by 4 · see citing works
Miyako, K., Kajitani, N., Koga, Y., Takizawa, H., Boku, S., & Takebayashi, M. (2024) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2024.01.004 · Cited by 3 · see citing works
Cai, Y., Deng, Y., Liu, J., Zhang, M., Huang, Y., Liang, W., Zhu, J., He, Q., Zhao, Y., & Ning, W. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157093 · Cited by 2 · see citing works
Liang, M., Li, L., & Fan, J. (2025) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-025-09100-y · Cited by 2 · see citing works
Luo, G., Yu, J., Li, H., Fan, Q., Qian, Y., Zheng, L., Lin, J., Wu, G., Wu, Z., Zhao, J., et al. (2025) · Glia · doi:10.1002/glia.70116 · Cited by 2 · see citing works
Tao, R., Liu, S., Crawford, J. A., Kramer, P. R., Bender, S., & Tao, F. (2026) · International Journal of Oral Science · doi:10.1038/s41368-026-00432-9 · Cited by 2 · see citing works
Maternal and infant gut microbiome
Wang, H., Tin, F., Chen, H., Jiao, F., Wu, M., Sun, S., Lin, L., Li, D., Zheng, H., Niu, Z., et al. (2026) · iMeta · doi:10.1002/imt2.70151 · Cited by 2 · see citing works
Ruciński, J., Kurowska, E., Myślińska, D., Grembecka, B., Piekarczyk, N., Necel, A., Kosznik-Kwaśnicka, K., & Majkutewicz, I. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26094353 · Cited by 4 · see citing works
Sharma, P., Choudhury, C. S., & Sahu, B. D. (2025) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.70409 · Cited by 2 · see citing works
Jiang, J., Yu, F., He, M., Huang, R., He, H., Murong, Z., Xiong, S., & Liu, M. (2026) · International Journal of Nanomedicine · doi:10.2147/ijn.s597334 · Cited by 1 · see citing works
Gut-derived butyrate as a key regulator in the pathogenesis of multiple sclerosis
Atoom, A. M., Varma, P., Mohanty, B., Saheb, L., Ali, A. M., Arora, V., Chauhan, A. S., & Garg, G. (2026) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2026.111902
Si, J., Wang, P., Li, Z., Hao, J., Wang, J., & Zhang, L. (2026) · Molecular Medicine · doi:10.1186/s10020-026-01616-z
Deng, S., Gao, S., Zhou, C., Lan, Z., Li, H., Chen, J., Xu, Y., Li, J., Liu, P., Zhang, S., et al. (2026) · CNS Neuroscience & Therapeutics · doi:10.1002/cns.71150 · Cited by 1 · see citing works
Wang, Y., Gao, L., Xu, Y., Niu, L., 唐, 萱., Zhou, Y., Deng, X., & Bao, Z. (2026) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2026.1875196
Self-citationLi, B., Ming, R., Wu, Z., & Pan, S. (2026) · Cell Communication and Signaling · doi:10.1186/s12964-026-03299-9
- Authors
- Gao, Y., Xie, D., Wang, Y., Niu, L., & Jiang, H.
- Affiliations
- Tongji University (CN)
- Shanghai Jiao Tong University (CN)
- Corresponding author
- Jiang, Hua
- Venue
- Neurochemical Research
- Published
- 2022-09-13
- Volume
- 47
- Issue
- 11
- Pages
- 3476-3489
- ISSN
- 0364-3190 (ISSN-L)
- 1573-6903
- PMC
- PMC9546972
- OpenAlex
- W4295484465
- Cited by
- 46
- References
- 29
- Citations by year
- 2026: 9 · 2025: 16 · 2024: 13 · 2023: 8
- FWCI
- 10.14
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Neurochemical Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81901930, 81772111)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- short-chain fatty acids, oligodendrocyte precursor cells, astrocyte activation, hypoxic-ischemic brain injury, NLRP3 inflammasome, interleukin-6, OPC proliferation, neuroprotection
- MeSH terms
- NLR Family, Pyrin Domain-Containing 3 Protein, Oligodendrocyte Precursor Cells, Animals, Astrocytes, Fatty Acids, Volatile, Interleukin-6, Proto-Oncogene Proteins c-bcl-2, Hypoxia-Ischemia, Brain, bcl-2-Associated X Protein, Rats, Chemokine CXCL10
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