The DOI matches its Crossref record; 215 of the 215 references it cites were found in a registry or an index.
Bile Acid Transporters: Structure, Function, Regulation and Pathophysiological Implications
Abstract
Specific transporters expressed in the liver and the intestine, play a critical role in driving the enterohepatic circulation of bile acids. By preserving a circulating pool of bile acids, an important factor influencing bile flow, these transporters are involved in maintaining bile acid and cholesterol homeostasis. Enterohepatic circulation of bile acids is fundamentally composed of two major processes: secretion from the liver and absorption from the intestine. In the hepatocytes, the vectorial transport of bile acids from blood to bile is ensured by Na+ taurocholate co-transporting peptide (NTCP) and organic anion transport polypeptides (OATPs). After binding to a cytosolic bile acid binding protein, bile acids are secreted into the canaliculus via ATP-dependent bile salt excretory pump (BSEP) and multi drug resistant proteins (MRPs). Bile acids are then delivered to the intestinal lumen through bile ducts where they emulsify dietary lipids and cholesterol to facilitate their absorption. Intestinal epithelial cells reabsorb the majority of the secreted bile acids through the apical sodium dependent bile acid transporter (ASBT) and sodium independent organic anion transporting peptide (OATPs). Cytosolic ileal bile acid binding protein (IBABP) mediates the transcellular movement of bile acids to the basolateral membrane across which they exit the cells via organic solute transporters (OST). An essential role of bile acid transporters is evident from the pathology associated with their genetic disruption or dysregulation of their function. Malfunctioning of hepatic and intestinal bile acid transporters is implicated in the pathophysiology of cholestatic liver disease and the depletion of circulating pool of bile acids, respectively. Extensive efforts have been recently made to enhance our understanding of the structure, function and regulation of the bile acid transporters and exploring new potential therapeutics to treat bile acid or cholesterol related diseases. This review will highlight current knowledge about structure, function and molecular characterization of bile acid transporters and discuss the implications of their defects in various hepatic and intestinal disorders.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Recently, it was found that ASBT plays a key role in the enterohepatic recycling of BAs and indirectly contributes to cholesterol homoeostasis (26).”
In the citing paper
“This might also result in the decrease in ileal BA content, because the ileal BA transporters prefer conjugated BAs to unconjugated BAs (26).”
Citations
Cites
Items 201–215 of 215
The Role of Glucocorticoids in the Postnatal Development of Heal Active Bile Salt Transport
Heubi, J. E., & GUNN, T. D. (1985) · Pediatric Research · doi:10.1203/00006450-198511000-00006 · Cited by 19
Landrier, J., Thomas, C., Grober, J., Zaghini, I., Petit, V., Poirier, H., Niot, I., & Besnard, P. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2005.05.002 · Cited by 18
Lowes, S., & Simmons, N. L. (2001) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s004240100686 · Cited by 18
Reymann, A., Braun, W., Drobik, C., et al. (1989) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(89)90203-6 · Cited by 18
Lin, M. C., Mullady, E., & Wilson, F. A. (1993) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1993.265.1.g56 · Cited by 18
Bear, C. E., Davison, J. S., & Shaffer, E. A. (1987) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(87)90230-6 · Cited by 17
Efflux Mechanism of Taurocholate across the Rat Intestinal Basolateral Membrane
Sakamoto, S. X., Suzuki, H. I., Kusuhara, H., et al. (2006) · Molecular Pharmaceutics · doi:10.1021/mp050101+ · Cited by 16
Assignment of a rat liver Na+/bile acid cotransporter gene to Chromosome 6q24
Cohn, M. A., ROUNDS, D., Karpen, S. J., et al. (1995) · Mammalian Genome · doi:10.1007/bf00350902 · Cited by 15
Takikawa, H., Sugiyama, Y., Fernández-Checa, J. C., et al. (1996) · Hepatology · doi:10.1002/hep.510230647 · Cited by 12
SAEKI, T., KURODA, T., Matsumoto, M., Kanamoto, R., & Iwami, K. (2002) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.66.467 · Cited by 12
Monteiro, I. M., David, E. S., & Ferraris, R. P. (2004) · Pediatric Research · doi:10.1203/01.pdr.0000112126.07230.9a · Cited by 11
Lammert, F., Cohen, D. E., Paigen, B. J., et al. (1998) · Mammalian Genome · doi:10.1007/s003359900689 · Cited by 10
Transhepatic solute transport and bile formation.
Anwer, M. S. (1993) · PubMed · Cited by 10
Schlattjan, J. H., Benger, S., Herrler, A., et al. (2004) · Nephron Physiology · doi:10.1159/000082870 · Cited by 9
Genetic mapping of the Na + -taurocholate cotransporting polypeptide to mouse Chromosome 12
Green, R. M., Ananthanarayanan, M., Suchy, F. J., et al. (1998) · Mammalian Genome · doi:10.1007/s003359900826 · Cited by 7
Flagged first, then by citations
Research works printed but not linked: 3
- A. F. Hofmann. Biliary secretion and excretion: the hepatobiliary component of the enterohepatic circulation of bile acids. Raven Press, 1994.
- W. A. Alrefai, S. Saksena, S. Tyagi, R. K. Gill, K. Ramaswamy, and P. K. Dudeja. Taurodeoxycholic bile acid inhibits chloride uptake in Caco2 cells. Dig. Dis. Sci. In press:(2007).
- W. A. Alrefai, Z. Sarwar, F. Annaba, S. Saksena, A. Dwivedi, P. K. Dudeja, and R. K. Gill. Evidence for the association of Apical Ileal Bile Acid Transporter (ASBT) with lipid rafts. Gastroenterology 130:A100 (2006). · DOI
Cited by
Sorted by citations
Chen, M.-L., Yi, L., Zhang, Y., Zhou, X., Ran, L., Yang, J., Zhu, J.-D., Zhang, Q.-Y., & Mi, M.-T. (2016) · mBio · doi:10.1128/mbio.02210-15 · Cited by 754
“It has been demonstrated that the apical sodium bile acid transporter (ASBT) is responsible for ileal BA uptake, with a preference for conjugated over unconjugated BAs (26).”
BackgroundWEDLAKE, L., A’HERN, R., RUSSELL, D., THOMAS, K., WALTERS, J. R. F., & ANDREYEV, H. J. N. (2009) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2009.04081.x · Cited by 435
Degirolamo, C., Rainaldi, S., Bovenga, F., Murzilli, S., & Moschetta, A. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.02.032 · Cited by 356
Joyce, S. A., & Gahan, C. G. M. (2016) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-041715-033159 · Cited by 241
Aleo, M. D., Luo, Y., Swiss, R., Bonin, P. D., Potter, D. M., & Will, Y. (2014) · Hepatology · doi:10.1002/hep.27206 · Cited by 215
Metadata
- Authors
- Alrefai, W. A., & Gill, R. K.
- Affiliations
- University of Illinois Chicago (US)
- Corresponding author
- Alrefai, Waddah A.
- Venue
- Pharmaceutical Research
- Published
- 2007-04-03
- Volume
- 24
- Issue
- 10
- Pages
- 1803-1823
- ISSN
- 0724-8741 (ISSN-L)
- 1573-904X
- OpenAlex
- W2071450296
- Cited by
- 500
- References
- 215
- Citations by year
- 2026: 20 · 2025: 19 · 2024: 24 · 2023: 21 · 2022: 33 · 2021: 27 · 2020: 23 · 2019: 34 · 2018: 33 · 2017: 24 · 2016: 27 · 2015: 22 · 2014: 28 · 2013: 29 · 2012: 27
- FWCI
- 2.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Pharmaceutical Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 71596)
- Topics
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Keywords
- bile acid transporters, enterohepatic circulation, bile acid homeostasis, cholesterol homeostasis, normal tissue complication probability, organic anion transporting polypeptides, bile salt export pump, MRP, ASBT, ileal bile acid binding protein, cholestatic liver disease
- MeSH terms
- Animals, Bile Acids and Salts, Bile Canaliculi, Bile Ducts, Carrier Proteins, Cholestasis, Enterohepatic Circulation, Epithelial Cells, Humans, Intestinal Mucosa, Kidney Tubules, Proximal, Liver, Membrane Glycoproteins, Protein Conformation, Cell Polarity, ATP-Binding Cassette Transporters, Enterocytes, Hepatocytes, Symporters, Organic Anion Transporters, Sodium-Independent, Organic Anion Transporters, Sodium-Dependent
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
