Solid Lipid Nanoparticles as Delivery Systems for Bromocriptine
Abstract
Purpose The present investigation describes a formulative study for the development of innovative drug delivery systems for bromocriptine.Methods Solid lipid nanoparticles (SLN) based on different lipidic components have been produced and characterized. Morphology and dimensional distribution have been investigated by electron microscopy and Photon Correlation Spectroscopy. The antiparkinsonian activities of free bromocriptine and bromocriptine encapsulated in nanostructured lipid carriers were evaluated in 6-hydroxydopamine hemilesioned rats, a model of Parkinson's disease.Results Tristearin/tricaprin mixture resulted in nanostructured lipid carriers with stable mean diameter up to 6 months from production. Bromocriptine was encapsulated with high entrapment efficiency in all of the SLN samples, particularly in the case of tristearin/tricaprin mixture. Bromocriptine encapsulation did not change nanoparticle dimensions. In vitro release kinetics based on a dialysis method demonstrated that bromocriptine was released in a prolonged fashion for 48 h. Tristearin/tricaprin nanoparticles better controlled bromocriptine release. Both free and encapsulated bromocriptine reduced the time spent on the blocks (i.e. attenuated akinesia) in the bar test, although the action of encapsulated bromocriptine was more rapid in onset and prolonged.Conclusions It can be concluded that nanostructured lipid carriers encapsulation may represent an effective strategy to prolong the half-life of bromocriptine.
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SLN-mediated bromocriptine and apomorphine delivery in PD rodent models improved akinesia and rotation behavior.
“Furthermore, SLN-mediated bromocriptine and apomorphine delivery in PD rodent models improved akinesia and rotation behavior.128”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [128]
Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
Solid lipid nanoparticles (SLN) for controlled drug delivery – a review of the state of the art
Müller, R. (2000) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(00)00087-4 · Cited by 3,759 · see citing works
Solid lipid nanoparticles Production, characterization and applications
Mehnert, W. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00105-3 · Cited by 3,158 · see citing works
Koppel, D. E. (1972) · The Journal of Chemical Physics · doi:10.1063/1.1678153 · Cited by 2,883 · see citing works
Ungerstedt, U., & Arbuthnott, G. W. (1970) · Brain Research · doi:10.1016/0006-8993(70)90187-3 · Cited by 1,993 · see citing works
Nanoparticulate systems for brain delivery of drugs.
Kreuter, J. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00122-8 · Cited by 1,107 · see citing works
Nanoparticulate systems for brain delivery of drugs
Kreuter, J. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.015 · Cited by 958 · see citing works
A Clinicopathologic Study of 100 Cases of Parkinson's Disease
Hughes, A. J., Daniel, S. E., Blankson, S., & Lees, A. J. (1993) · Archives of Neurology · doi:10.1001/archneur.1993.00540020018011 · Cited by 945 · see citing works
Schwarting, R. K. W., & Huston, J. P. (1996) · Progress in Neurobiology · doi:10.1016/s0301-0082(96)00040-8 · Cited by 741 · see citing works
Dynamic Light Scattering Measurement of Nanometer Particles in Liquids
Pecora, R. (2000) · Journal of Nanoparticle Research · doi:10.1023/a:1010067107182 · Cited by 621 · see citing works
Westesen, K., Bunjes, H., & Koch, M. (1997) · Journal of Controlled Release · doi:10.1016/s0168-3659(97)00046-1 · Cited by 539 · see citing works
Cubic phases of lipid-containing systems
Mariani, P., Luzzati, V., & Delacroix, H. (1988) · Journal of Molecular Biology · doi:10.1016/0022-2836(88)90607-9 · Cited by 481 · see citing works
Self-citationLevodopa motor complications in Parkinson's disease
Obeso, J. A., Olanow, C. W., & Nutt, J. G. (2000) · Trends in Neurosciences · doi:10.1016/s1471-1931(00)00031-8 · Cited by 478 · see citing works
Yang, S. C., Lu, L. F., Cai, Y., Zhu, J. B., Liang, B. W., & Yang, C. Z. (1999) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00007-3 · Cited by 475 · see citing works
Jores, K., Mehnert, W., Drechsler, M., Bunjes, H., Johann, C., & Mäder, K. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2003.11.012 · Cited by 473 · see citing works
Self-citationAlyautdin, R. N., Petrov, V. E., Langer, K., Berthold, A., Kharkevich, D. A., & Kreuter, J. (1997) · Pharmaceutical Research · doi:10.1023/a:1012098005098 · Cited by 352 · see citing works
The catalepsy test: Its ups and downs.
Sanberg, P. R., Bunsey, M. D., Giòrdano, M., et al. (1988) · Behavioral Neuroscience · doi:10.1037//0735-7044.102.5.748 · Cited by 323 · see citing works
The catalepsy test: Its ups and downs.
Sanberg, P. R., Bunsey, M. D., Giòrdano, M., et al. (1988) · Behavioral Neuroscience · doi:10.1037/0735-7044.102.5.748 · Cited by 322 · see citing works
Colloidal carriers and blood–brain barrier (BBB) translocation: A way to deliver drugs to the brain?
García-García, E., Andrieux, K., Gil, S., & Couvreur, P. (2005) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.03.031 · Cited by 314 · see citing works
A review of the receptor-binding and pharmacokinetic properties of dopamine agonists
Kvernmo, T., Härtter, S., & Bürger, E. (2006) · Clinical Therapeutics · doi:10.1016/j.clinthera.2006.08.004 · Cited by 279 · see citing works
Treatment interventions for Parkinson's disease: an evidence based assessment
Rascol, O., Goetz, C. G., Koller, W. C., Poewe, W. H., & Sampaio, C. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08520-3 · Cited by 279 · see citing works
Nanoparticle Technology for Delivery of Drugs Across the Blood–Brain Barrier
Schröeder, U., Sommerfeld, P., Ulrich, S., & Sabel, B. A. (1998) · Journal of Pharmaceutical Sciences · doi:10.1021/js980084y · Cited by 275 · see citing works
Brain uptake of thiamine-coated nanoparticles
Lockman, P. R., Oyewumi, M. O., Koziara, J. M., Roder, K. E., Mumper, R. J., & Allen, D. D. (2003) · Journal of Controlled Release · doi:10.1016/j.jconrel.2003.08.006 · Cited by 260 · see citing works
Brigger, I., Morizet, J., Aubert, G., Chacun, H., Terrier‐Lacombe, M., Couvreur, P., & Vassal, G. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.039669 · Cited by 234 · see citing works
Pearce, R. K. B., Banerji, T., Jenner, P. G., & MARSDEN, C. D. (1998) · Movement Disorders · doi:10.1002/mds.870130207 · Cited by 218 · see citing works
Olivier, J.-C., Fenart, L., Chauvet, R., Pariat, C., Cecchelli, R., & Couet, W. (1999) · Pharmaceutical Research · doi:10.1023/a:1018947208597 · Cited by 213 · see citing works
A review of nanocarrier-based CNS delivery systems.
Tiwari, S. B., & Amiji, M. (2006) · Current Drug Delivery · doi:10.2174/156720106776359230 · Cited by 200 · see citing works
In Situ Blood–Brain Barrier Transport of Nanoparticles
Koziara, J. M., Lockman, P. R., Allen, D. D., & Mumper, R. J. (2003) · Pharmaceutical Research · doi:10.1023/b:pham.0000003374.58641.62 · Cited by 182 · see citing works
Calvo, P., Gouritin, B., Villarroya, H., Eclancher, F., Giannavola, C., Klein, C., Andreux, J. P., & Couvreur, P. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.01967.x · Cited by 164 · see citing works
Medium scale production of solid lipid nanoparticles (SLN) by high pressure homogenization
Jenning, V., Lippacher, A., & Gohla, S. (2002) · Journal of Microencapsulation · doi:10.1080/713817583 · Cited by 163 · see citing works
Recent advances in the brain targeting of neuropharmaceuticals by chemical delivery systems
Bodor, N. S., & Buchwald, P. (1999) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(98)00090-8 · Cited by 158 · see citing works
Preparation of semisolid drug carriers for topical application based on solid lipid nanoparticles
Lippacher, A., Müller, R. H., & Mäder, K. (2001) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(00)00623-2 · Cited by 157 · see citing works
Production of solid lipid nanoparticles (SLN): scaling up feasibilities
Dingler, A., & Gohla, S. (2002) · Journal of Microencapsulation · doi:10.1080/02652040010018056 · Cited by 145 · see citing works
Lipid-based supramolecular systems for topical application: A preformulatory study
Esposito, E., Eblovi, N., Rasi, S., et al. (2003) · AAPS PharmSci · doi:10.1208/ps050430 · Cited by 141 · see citing works
Self-citationDrug delivery to damaged brain
Lo, E. H. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00083-2 · Cited by 136 · see citing works
New Technologies for Drug Delivery Across the Blood Brain Barrier
Kabanov, A. V., & Batrakova, E. (2004) · Current Pharmaceutical Design · doi:10.2174/1381612043384826 · Cited by 133 · see citing works
Marti, M., Mela, F., Fantin, M., et al. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2546-05.2005 · Cited by 120 · see citing works
Self-citationIncorporation of the Model Drug Ubidecarenone into Solid Lipid Nanoparticles
Bunjes, H., Drechsler, M., Koch, M. H. J., & Westesen, K. (2001) · Pharmaceutical Research · doi:10.1023/a:1011042627714 · Cited by 95 · see citing works
Self-citationThe blood–brain barrier efflux transporters as a detoxifying system for the brain
Terasaki, T., & Hosoya, K. (1999) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(98)00088-x · Cited by 93 · see citing works
Obeso, J. A., Grandas, F., Herrero, M. T., & HOROWSKI, R. (1994) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1994.tb00584.x · Cited by 83 · see citing works
Marti, M., Trapella, C., Viaro, R., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4346-06.2007 · Cited by 77 · see citing works
Self-citationMoghimi, S. M. (1995) · Advanced Drug Delivery Reviews · doi:10.1016/0169-409x(95)00024-2 · Cited by 72 · see citing works
Brain drug delivery technologies: novel approaches for transporting therapeutics
Temsamani, J., Scherrmann, J., Rees, A. R., & Kaczorek, M. (2000) · Pharmaceutical Science & Technology Today · doi:10.1016/s1461-5347(00)00258-3 · Cited by 66 · see citing works
Lane, E. L., Cheetham, S. C., & Jenner, P. G. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.06.006 · Cited by 65 · see citing works
Zr, Z., Jx, W., & Lü, J. (2001) · PubMed · Cited by 12 · see citing works
Study on Bone Marrow Targeting Daunorubicin Polybutylcyanoacrylate Nanoparticles
Ying, P. (2000) · Chinese Journal of Pharmaceuticals · Cited by 3 · see citing works
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Kuntsche, J., Horst, J. C., & Bunjes, H. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.02.001 · Cited by 363 · see citing works
Solid Lipid Nanoparticles (SLNs): An Advanced Drug Delivery System Targeting Brain through BBB
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Laserra, S., Basit, A., Sozio, P., Marinelli, L., Fornasari, E., Cacciatore, I., Ciulla, M., Türkez, H., Geyikoglu, F., & Di Stefano, A. (2015) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2015.03.001 · Cited by 72 · see citing works
Zhong, S., & Pochan, D. J. (2010) · Polymer Reviews · doi:10.1080/15583724.2010.493254 · Cited by 51 · see citing works
- Authors
- Esposito, E., Fantin, M., Marti, M., Drechsler, M., Paccamiccio, L., Mariani, P., Sivieri, E., Lain, F., Menegatti, E., Morari, M., & Cortesi, R.
- Affiliations
- University of Ferrara (IT)
- University of Bayreuth (DE)
- Marche Polytechnic University (IT)
- Corresponding author
- Esposito, Elisabetta
- Venue
- Pharmaceutical Research
- Published
- 2008-01-03
- Volume
- 25
- Issue
- 7
- Pages
- 1521-1530
- ISSN
- 0724-8741 (ISSN-L)
- 1573-904X
- OpenAlex
- W2016097547
- Cited by
- 183
- References
- 46
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 8 · 2023: 10 · 2022: 12 · 2021: 15 · 2020: 14 · 2019: 15 · 2018: 10 · 2017: 14 · 2016: 11 · 2015: 12 · 2014: 10 · 2013: 10 · 2012: 5
- FWCI
- 7.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Pharmaceutical Research (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
- Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Funders
- Regione Emilia-Romagna
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Keywords
- solid lipid nanoparticles, bromocriptine, nanostructured lipid carriers, Parkinson's disease, antiparkinsonian activity, encapsulation efficiency, controlled release, nanoparticle stability, akinesia, drug delivery systems
- MeSH terms
- Animals, Antiparkinson Agents, Behavior, Animal, Bromocriptine, Chromatography, High Pressure Liquid, Dialysis, Kinetics, Light, Lipids, Male, Microscopy, Electron, Parkinson Disease, Secondary, Scattering, Radiation, Spectrophotometry, Ultraviolet, Triglycerides, X-Ray Diffraction, Absorptiometry, Photon, Drug Delivery Systems, Oxidopamine, Rats, Sprague-Dawley, Cryoelectron Microscopy, Rats, Nanoparticles
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