Cited by 183Advanced Drug Delivery SystemsNanoparticle-Based Drug DeliveryAdvancements in Transdermal Drug Delivery

Solid Lipid Nanoparticles as Delivery Systems for Bromocriptine

Esposito, Elisabetta, Fantin, Martina, Marti, Matteo, Drechsler, Markus, Paccamiccio, Lydia, Mariani, Paolo, Sivieri, Elisa, Lain, Francesco +3 more·2008·Pharmaceutical Research

Abstract

Purpose The present investigation describes a formulative study for the development of innovative drug delivery systems for bromocriptine.Methods Solid lipid nanoparticles (SLN) based on different lipidic components have been produced and characterized. Morphology and dimensional distribution have been investigated by electron microscopy and Photon Correlation Spectroscopy. The antiparkinsonian activities of free bromocriptine and bromocriptine encapsulated in nanostructured lipid carriers were evaluated in 6-hydroxydopamine hemilesioned rats, a model of Parkinson's disease.Results Tristearin/tricaprin mixture resulted in nanostructured lipid carriers with stable mean diameter up to 6 months from production. Bromocriptine was encapsulated with high entrapment efficiency in all of the SLN samples, particularly in the case of tristearin/tricaprin mixture. Bromocriptine encapsulation did not change nanoparticle dimensions. In vitro release kinetics based on a dialysis method demonstrated that bromocriptine was released in a prolonged fashion for 48 h. Tristearin/tricaprin nanoparticles better controlled bromocriptine release. Both free and encapsulated bromocriptine reduced the time spent on the blocks (i.e. attenuated akinesia) in the bar test, although the action of encapsulated bromocriptine was more rapid in onset and prolonged.Conclusions It can be concluded that nanostructured lipid carriers encapsulation may represent an effective strategy to prolong the half-life of bromocriptine.

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Crossref · 10.1007/s11095-007-9514-y

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Authors
Esposito, E., Fantin, M., Marti, M., Drechsler, M., Paccamiccio, L., Mariani, P., Sivieri, E., Lain, F., Menegatti, E., Morari, M., & Cortesi, R.
Affiliations
  • University of Ferrara (IT)
  • University of Bayreuth (DE)
  • Marche Polytechnic University (IT)
Corresponding author
Esposito, Elisabetta
Venue
Pharmaceutical Research
Published
2008-01-03
Volume
25
Issue
7
Pages
1521-1530
ISSN
  • 0724-8741 (ISSN-L)
  • 1573-904X
OpenAlex
W2016097547
Cited by
183
References
46
Citations by year
2026: 2 · 2025: 3 · 2024: 8 · 2023: 10 · 2022: 12 · 2021: 15 · 2020: 14 · 2019: 15 · 2018: 10 · 2017: 14 · 2016: 11 · 2015: 12 · 2014: 10 · 2013: 10 · 2012: 5
FWCI
7.43
Type
journal article
Language
en
Open access
closed
Locations
  • Pharmaceutical Research (publishedVersion)
  • PubMed (publishedVersion)
  • Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
  • Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
  • Padua Research Archive (University of Padova) (submittedVersion)
Funders
Regione Emilia-Romagna
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
Keywords
solid lipid nanoparticles, bromocriptine, nanostructured lipid carriers, Parkinson's disease, antiparkinsonian activity, encapsulation efficiency, controlled release, nanoparticle stability, akinesia, drug delivery systems
MeSH terms
Animals, Antiparkinson Agents, Behavior, Animal, Bromocriptine, Chromatography, High Pressure Liquid, Dialysis, Kinetics, Light, Lipids, Male, Microscopy, Electron, Parkinson Disease, Secondary, Scattering, Radiation, Spectrophotometry, Ultraviolet, Triglycerides, X-Ray Diffraction, Absorptiometry, Photon, Drug Delivery Systems, Oxidopamine, Rats, Sprague-Dawley, Cryoelectron Microscopy, Rats, Nanoparticles

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