The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Mannan-Modified Solid Lipid Nanoparticles for Targeted Gene Delivery to Alveolar Macrophages
Abstract
Purpose Cationic solid lipid nanoparticles (SLN) have established themselves during the past decades. They can efficiently bind DNA directly via ionic interaction and mediate gene transfection. One major problem with SLN is the lack of cell-targeting ability. In the present study, a mannan-based PE-grafted ligand was synthesized and used for the surface modification of DNA-loaded cationic SLN to prepare Man-SLN-DNA.Methods For in vitro test, the cytotoxicity and transfection investigation was carried out on murine macrophage cell line RAW 264.7. For in vivo evaluation, Man-SLN-DNA was delivered into the lung of the rats, and the alveolar macrophages (AM) were isolated for the fluorescence determination of transfection efficiency.Results When compared with non-modified SLN-DNA and Lipofectamine 2000-DNA, Man-SLN-DNA produced the highest gene expressions, especially in vivo.Conclusion These results demonstrated the active targeting ability of this kind of mannan-modified DNA-loaded vehicles, which may have great potential for targeted gene delivery.
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“Additionally, it is also possible to change the surface chemistry of lipid NPs to achieve active targeting of alveolar macrophages of the lung.”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [214]
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“Mannose is a common ligand associated with lipid NPs.214”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [214]
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Metadata
- Authors
- Yu, W., Liu, C., Liu, Y., Zhang, N., & Xu, W.
- Affiliations
- Shandong University (CN)
- Corresponding author
- Zhang, Na
- Venue
- Pharmaceutical Research
- Published
- 2010-04-27
- Volume
- 27
- Issue
- 8
- Pages
- 1584-1596
- ISSN
- 0724-8741 (ISSN-L)
- 1573-904X
- OpenAlex
- W2008296427
- Cited by
- 137
- References
- 39
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 7 · 2023: 8 · 2022: 15 · 2021: 9 · 2020: 14 · 2019: 8 · 2018: 6 · 2017: 7 · 2016: 11 · 2015: 10 · 2014: 10 · 2013: 7 · 2012: 9
- FWCI
- 3.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Pharmaceutical Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Keywords
- solid lipid nanoparticles, mannan, cationic liposomes, gene delivery, alveolar macrophages, targeted gene delivery, surface modification, DNA transfection, pulmonary gene delivery, RAW 264.7 macrophages
- MeSH terms
- Animals, Cell Line, Cell Survival, Concanavalin A, Ligands, Lipids, Male, Mannans, Phosphatidylethanolamines, Genetic Therapy, Molecular Structure, Drug Delivery Systems, Macrophages, Alveolar, Rats, Wistar, Cell Line, Tumor, Microscopy, Electron, Transmission, Mice, Rats, Nanoparticles
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