The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Intraperitoneal Route of Drug Administration: Should it Be Used in Experimental Animal Studies?
Open accessAbstract
Intraperitoneal (IP) route of drug administration in laboratory animals is a common practice in many in vivo studies of disease models. While this route is an easy to master, quick, suitable for chronic treatments and with low impact of stress on laboratory rodents, there is a common concern that it may not be an acceptable route for drug administration in experimental studies. The latter is likely due to sparsity of information regarding pharmacokinetics of pharmacological agents and the mechanisms through which agents get systemic exposure after IP administration. In this review, we summarize the main mechanisms involved in bioavailability of IP administered drugs and provide examples of pharmacokinetic profiles for small and large molecules in comparison to other routes of administration. We conclude with a notion that IP administration of drugs in experimental studies involving rodents is a justifiable route for pharmacological and proof-of-concept studies where the goal is to evaluate the effect(s) of target engagement rather than properties of a drug formulation and/or its pharmacokinetics for clinical translation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
THE ULTRASTRUCTURAL BASIS OF CAPILLARY PERMEABILITY STUDIED WITH PEROXIDASE AS A TRACER
Karnovsky, M. J. (1967) · The Journal of Cell Biology · doi:10.1083/jcb.35.1.213 · Cited by 1,491
Turner, P. V., Brabb, T., Pekow, C. A., & Vasbinder, M. A. (2011) · PubMed · Cited by 1,032
Cunningham's Text-Book of Anatomy.
(1952) · Annals of Internal Medicine · doi:10.7326/0003-4819-36-1-204_2 · Cited by 574
Bruns, R. R., & Palade, G. E. (1968) · The Journal of Cell Biology · doi:10.1083/jcb.37.2.277 · Cited by 447
Isolation, culture and characterization of human peritoneal mesothelial cells
Stylianou, E., Jenner, L. A., Davies, M., Coles, G. A., & Williams, J. D. (1990) · Kidney International · doi:10.1038/ki.1990.150 · Cited by 389
THE ROUTE OF ABSORPTION OF INTRAPERITONEALLY ADMINISTERED COMPOUNDS
LUKAS, G., BRINDLE, S. D., & GREENGARD, P. (1971) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)28988-1 · Cited by 388
Refining procedures for the administration of substances
Morton, D. B., Jennings, M., Buckwell, A., Ewbank, R., Godfrey, C., Holgate, B., Inglis, I., James, R., Page, C., Sharman, I., et al. (2001) · Laboratory Animals · doi:10.1258/0023677011911345 · Cited by 251
The UFAW handbook on the care and management of laboratory animals
(1973) · Food and Cosmetics Toxicology · doi:10.1016/0015-6264(73)90163-6 · Cited by 237
Veronese, F. M., Caliceti, P., Pastorino, A., Schiavon, O., Sartore, L., Banci, L., & Scolaro, L. M. (1989) · Journal of Controlled Release · doi:10.1016/0168-3659(89)90025-4 · Cited by 224
Nanoemulsion formulation of fisetin improves bioavailability and antitumour activity in mice
Ragelle, H., Crauste-Manciet, S., Seguin, J., Brossard, D., Scherman, D., Arnaud, P., & Chabot, G. G. (2012) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2012.02.025 · Cited by 213
Cited by
Skrzypczak-Wiercioch, A., & Sałat, K. (2022) · Molecules · doi:10.3390/molecules27175481 · Cited by 406
Biosafety of mesoporous silica nanoparticles; towards clinical translation
Lérida-Viso, A., Estepa-Fernández, A., García-Fernández, A., Martí-Centelles, V., & Martínez-Máñez, R. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.115049 · Cited by 279
(2024) · doi:10.1002/advs.202406305 · Cited by 55
Van Hees, L., Didone, V., Charlet‐Briart, M., Van Ingelgom, T., Alexandre, A., Quertemont, E., Nguyen, L., & Laguesse, S. (2022) · Addiction Biology · doi:10.1111/adb.13102 · Cited by 27
Evaluation of acute and sub-chronic toxicity of bitter melon seed extract in Wistar rats
Chung, W.-Y., Jadhav, S., Hsu, P.-K., & Kuan, C.-M. (2022) · Toxicology Reports · doi:10.1016/j.toxrep.2022.04.024 · Cited by 19
Metadata
- Authors
- Al Shoyaib, A., Archie, S. R., & Karamyan, V. T.
- Venue
- Pharmaceutical Research
- Published
- 2019-12-23
- Volume
- 37
- Issue
- 1
- Pages
- 12-12
- ISSN
- 0724-8741 (ISSN-L)
- 1573-904X
- OpenAlex
- W2997805831
- Cited by
- 631
- References
- 60
- FWCI
- 45.01
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Intraperitoneal Route of Drug Administration: Should it Be Used in Experimental Animal Studies? https://app.cochat.ai/papers/10.1007/s11095-019-2745-x
- The paper
- Al Shoyaib, A., Archie, S. R., & Karamyan, V. T. (2020). Intraperitoneal Route of Drug Administration: Should it Be Used in Experimental Animal Studies? Pharmaceutical Research. https://doi.org/10.1007/s11095-019-2745-x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
