The DOI matches its Crossref record.
THE ROUTE OF ABSORPTION OF INTRAPERITONEALLY ADMINISTERED COMPOUNDS
Abstract
Although the i.p. route is widely used for the administration of compounds to animals, it has not been established whether absorption from the peritoneal cavity occurs through the portal or the systemic circulation. This problem has now been investigated in two species by two experimental approaches. The initial (10 seconds to 5 minutes) rates of appearance of radioactivity in the liver and in the systemic circulation of the rat after the administration of labeled compounds were compared. The substances studied (atropine, caffeine, glucose, glycine and progesterone) represented a variety of physicochemical and biochemical properties. The appearance of radioactivity in the portal vein and in the inferior vena cava of the dog after administration of glucose was also investigated. The results demonstrate that compounds administered i.p. are absorbed primarily through the portal circulation and, therefore, must pass through the liver before reaching other organs.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Intraperitoneal Route of Drug Administration: Should it Be Used in Experimental Animal Studies?
Al Shoyaib, A., Archie, S. R., & Karamyan, V. T. (2020) · Pharmaceutical Research · doi:10.1007/s11095-019-2745-x · Cited by 631
Kanoski, S. E., Rupprecht, L. E., Fortin, S. M., De Jonghe, B. C., & Hayes, M. R. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.12.022 · Cited by 273
Effects of a ketamine metabolite on synaptic NMDAR function
Suzuki, K., Nosyreva, E., Hunt, K. W., Kavalali, E. T., & Monteggia, L. M. (2017) · Nature · doi:10.1038/nature22084 · Cited by 180
Hayes, M. R., Kanoski, S. E., De Jonghe, B. C., Leichner, T. M., Alhadeff, A. L., Fortin, S. M., Arnold, M., Langhans, W., & Grill, H. J. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00356.2011 · Cited by 86
Intraperitoneal chemotherapy in the management of ovarian cancer
Markman, M., Reichman, B., Hakes, T., Curtin, J., Jones, W., Lewis, J. L., Barakat, R., Rubin, S., Mychalczak, B., Saigo, P., et al. (1993) · Cancer · doi:10.1002/cncr.2820710423 · Cited by 67
Metadata
- Authors
- LUKAS, G., BRINDLE, S. D., & GREENGARD, P.
- Venue
- The Journal of Pharmacology and Experimental Therapeutics
- Publisher
- Elsevier BV
- Published
- 1971-09
- Volume
- 178
- Issue
- 3
- Pages
- 562-566
- ISSN
- 0022-3565 (ISSN-L)
- OpenAlex
- W2103032351
- Cited by
- 388
- References
- 0
- FWCI
- 5.20
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: THE ROUTE OF ABSORPTION OF INTRAPERITONEALLY ADMINISTERED COMPOUNDS. https://app.cochat.ai/papers/10.1016/s0022-3565(25)28988-1
- The paper
- LUKAS, G., BRINDLE, S. D., & GREENGARD, P. (1971). THE ROUTE OF ABSORPTION OF INTRAPERITONEALLY ADMINISTERED COMPOUNDS. The Journal of Pharmacology and Experimental Therapeutics. https://doi.org/10.1016/s0022-3565(25)28988-1
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
