The DOI matches its Crossref record; 136 of the 138 references it cites were found in a registry or an index.
Clinical spectrum of premature pubarche: Links to metabolic syndrome and ovarian hyperandrogenism
Abstract
Premature pubarche-defined as the appearance of pubic hair before age 8 years in girls and 9 years in boys-has been traditionally considered a benign entity. However, recent evidence supports the notion that premature pubarche in girls may be a forerunner of the metabolic syndrome, and may precede the development of clinical ovarian androgen excess in adolescence. This sequence seems to occur more frequently when premature pubarche was preceded by reduced fetal growth and followed by excessive postnatal catch-up in height and particularly in weight; hyperinsulinemia appears to be a key factor in the development of this sequence of events. In girls with premature pubarche and a history of a low birth weight, puberty tends to start earlier and to have a faster course, so that final height may be moderately reduced. In these girls, metformin therapy may reverse the progression to clinical ovarian hyperandrogenism, normalize body composition and excess visceral fat, and delay pubertal progression without attenuating linear growth and bone mineralization, suggesting that adult height may be improved. Long-term follow-up of these patients is needed to fully determine the ultimate effects of insulin sensitization as well as the maintenance of these benefits after discontinuation of therapy.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“For those with NCAH, ACTH-stimulated 17-OHP values usually exceed 1,500-10,000 ng/dl [106]”
From The Diagnosis of Polycystic Ovary Syndrome during Adolescence (2015) · cites this paper as [106]
Citations
Cites
(2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2003.10.004 · Cited by 9,050
The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group (2004) · Human Reproduction · doi:10.1093/humrep/deh098 · Cited by 6,138
Barker, D. J. P., Hales, C. N., Fall, C. H. D., Osmond, C., Phipps, K., & Clark, P. M. S. (1993) · Diabetologia · doi:10.1007/bf00399095 · Cited by 2,468
Men at risk: occupation and male infertility.
Claman, P. (2004) · Fertility and Sterility · doi:10.1016/s0015-0282(03)01188-9 · Cited by 2,219
Azziz, R., Carmina, E., Dewailly, D., Diamanti-Kandarakis, E., Escobar-Morreale, H. F., Futterweit, W., Janssen, O. E., Legro, R. S., Norman, R. J., Taylor, A. E., et al. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0178 · Cited by 2,143
Profound Peripheral Insulin Resistance, Independent of Obesity, in Polycystic Ovary Syndrome
Dunaif, A., Segal, K. R., Futterweit, W., & Dobrjansky, A. (1989) · Diabetes · doi:10.2337/diab.38.9.1165 · Cited by 1,967
Ehrmann, D. A. (2005) · New England Journal of Medicine · doi:10.1056/nejmra041536 · Cited by 1,920
Scherer, P. E. (2006) · Diabetes · doi:10.2337/db06-0263 · Cited by 1,092
Which White Blood Cell Subtypes Predict Increased Cardiovascular Risk?
Horne, B. D., Anderson, J. L., John, J. M., Weaver, A. N., Bair, T. L., Jensen, K. R., Renlund, D. G., & Muhlestein, J. B. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.02.054 · Cited by 973
Genotyping steroid 21-hydroxylase deficiency: hormonal reference data
NEW, M. I., LORENZEN, F., LERNER, A. J., KOHN, B., OBERFIELD, S. E., POLLACK, M. S., DUPONT, B., STONER, E., LEVY, D. J., PANG, S., et al. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-57-2-320 · Cited by 624
Research works printed but not linked: 4
- Wilkins L. Proceedings Report of Tenth Annual Meeting of the American Academy of Pediatrics: Memphis, Tenn-Nov 17, 1940. J Pediatr 1941;19:259.
- Pang S. Premature pubarche. Pediatr Adolesc Endocrinol 1984;13:173–84.
- Virdis R, Zampolli M, Ibáñez L, Ghizzoni L, Street ME, Vicens-Calvet E. II pubarca prematuro. Riv Ital Pediatr (IJP) 1993;19:569–579.
- Ibáñez L, Potau N, Albisu MA, Enríquez G, Gussinyé M, Carrascosa A, et al. Post-pubertal assessment in girls with premature pubarche: clinical, biochemical, and echographic findings. Horm Res 1990;33(Suppl 3):37. Abstract.
Cited by
Sorted by citations
Items 101–106 of 106
Polycystic Ovarian Syndrome (PCOS) among young adult women: an anthropological insight
Ghosh, T., Pal, B., Maji, S., & Goswami, M. (2023) · Papers on Anthropology · doi:10.12697/poa.2023.32.2.06
Ghosh, T., Pal, B., Maji, S., & Goswami, M. (2025) · Medical Reports · doi:10.1016/j.hmedic.2025.100215
Khan, A., Sundus, H., Zaidi, S., Khan, H., & Khan, S. (2025) · Sleep and Vigilance · doi:10.1007/s41782-025-00326-6 · Cited by 1
Sudman, M., Gruber, H., Bar-Sadeh, B., Refael, T., Golan, G., Shvartsman, N., Pnueli, L., Kronfeld‐Schor, N., & Melamed, P. (2026) · BMC Biology · doi:10.1186/s12915-026-02619-2
HDAC2-mediated H3K27ac Governs ZFP42 transcription and autophagy in granulosa cells of pigs
Liao, W., Li, N., Jiang, Y., Huang, E., Mao, K., Ma, B., Zhao, J., & Yuan, X. (2026) · Life Sciences · doi:10.1016/j.lfs.2026.124527
Acer, İ., İçer, S., Hatipoğlu, N., Karadag, A., Şıraz, Ü. G., Demi̇rci̇, E., & Karaman, Z. F. (2026) · Applied Sciences · doi:10.3390/app16189126
Metadata
- Authors
- Ibáñez, L., Díaz, R., López-Bermejo, A., & Marcos, M. V.
- Affiliations
- Hospital Sant Joan de Déu Barcelona (ES)
- Corresponding author
- Ibáñez, Lourdes
- ORCID
- Ibáñez, Lourdes
- Venue
- Reviews in Endocrine and Metabolic Disorders
- Published
- 2008-08-26
- Volume
- 10
- Issue
- 1
- Pages
- 63-76
- ISSN
- 1389-9155 (ISSN-L)
- 1573-2606
- OpenAlex
- W2072284140
- Cited by
- 106
- References
- 138
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 6 · 2023: 3 · 2022: 2 · 2021: 11 · 2020: 3 · 2019: 3 · 2018: 8 · 2017: 5 · 2016: 8 · 2015: 11 · 2014: 4 · 2013: 4 · 2012: 10
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Reviews in Endocrine and Metabolic Disorders (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Keywords
- premature pubarche, metabolic syndrome, ovarian hyperandrogenism, polycystic ovary syndrome, hyperinsulinemia, catch-up growth, low birth weight, fetal growth restriction, metformin, insulin sensitization, pubertal timing, adult height, visceral fat, body composition, bone mineralization
- MeSH terms
- Blood Pressure, Body Composition, Body Height, Female, Humans, Infant, Low Birth Weight, Infant, Newborn, Insulin, Lipids, Polycystic Ovary Syndrome, Puberty, Puberty, Precocious, Hyperandrogenism, Metabolic Syndrome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
