Cited by 106Ovarian function and disordersHypothalamic control of reproductive hormonesSexual Differentiation and Disorders

The DOI matches its Crossref record; 136 of the 138 references it cites were found in a registry or an index.

Clinical spectrum of premature pubarche: Links to metabolic syndrome and ovarian hyperandrogenism

Ibáñez, Lourdes, Díaz, Rubén, López-Bermejo, Abel, Marcos, Maria Victoria·2009·Reviews in Endocrine and Metabolic Disorders

DOI 10.1007/s11154-008-9096-y

Open this paper in CoChat — free account

Abstract

Premature pubarche-defined as the appearance of pubic hair before age 8 years in girls and 9 years in boys-has been traditionally considered a benign entity. However, recent evidence supports the notion that premature pubarche in girls may be a forerunner of the metabolic syndrome, and may precede the development of clinical ovarian androgen excess in adolescence. This sequence seems to occur more frequently when premature pubarche was preceded by reduced fetal growth and followed by excessive postnatal catch-up in height and particularly in weight; hyperinsulinemia appears to be a key factor in the development of this sequence of events. In girls with premature pubarche and a history of a low birth weight, puberty tends to start earlier and to have a faster course, so that final height may be moderately reduced. In these girls, metformin therapy may reverse the progression to clinical ovarian hyperandrogenism, normalize body composition and excess visceral fat, and delay pubertal progression without attenuating linear growth and bone mineralization, suggesting that adult height may be improved. Long-term follow-up of these patients is needed to fully determine the ultimate effects of insulin sensitization as well as the maintenance of these benefits after discontinuation of therapy.

Integrity signals

Registry

Crossref · 10.1007/s11154-008-9096-y

Cites

136 of 136 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome
(2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2003.10.004 · Cited by 9,050
Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)
The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group (2004) · Human Reproduction · doi:10.1093/humrep/deh098 · Cited by 6,138
Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth
Barker, D. J. P., Hales, C. N., Fall, C. H. D., Osmond, C., Phipps, K., & Clark, P. M. S. (1993) · Diabetologia · doi:10.1007/bf00399095 · Cited by 2,468
Men at risk: occupation and male infertility.
Claman, P. (2004) · Fertility and Sterility · doi:10.1016/s0015-0282(03)01188-9 · Cited by 2,219
Criteria for Defining Polycystic Ovary Syndrome as a Predominantly Hyperandrogenic Syndrome: An Androgen Excess Society Guideline
Azziz, R., Carmina, E., Dewailly, D., Diamanti-Kandarakis, E., Escobar-Morreale, H. F., Futterweit, W., Janssen, O. E., Legro, R. S., Norman, R. J., Taylor, A. E., et al. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0178 · Cited by 2,143
Profound Peripheral Insulin Resistance, Independent of Obesity, in Polycystic Ovary Syndrome
Dunaif, A., Segal, K. R., Futterweit, W., & Dobrjansky, A. (1989) · Diabetes · doi:10.2337/diab.38.9.1165 · Cited by 1,967
Polycystic Ovary Syndrome
Ehrmann, D. A. (2005) · New England Journal of Medicine · doi:10.1056/nejmra041536 · Cited by 1,920
Adipose Tissue
Scherer, P. E. (2006) · Diabetes · doi:10.2337/db06-0263 · Cited by 1,092
Which White Blood Cell Subtypes Predict Increased Cardiovascular Risk?
Horne, B. D., Anderson, J. L., John, J. M., Weaver, A. N., Bair, T. L., Jensen, K. R., Renlund, D. G., & Muhlestein, J. B. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.02.054 · Cited by 973
Genotyping steroid 21-hydroxylase deficiency: hormonal reference data
NEW, M. I., LORENZEN, F., LERNER, A. J., KOHN, B., OBERFIELD, S. E., POLLACK, M. S., DUPONT, B., STONER, E., LEVY, D. J., PANG, S., et al. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-57-2-320 · Cited by 624

Show all 138 references

Research works printed but not linked: 4

Wilkins L. Proceedings Report of Tenth Annual Meeting of the American Academy of Pediatrics: Memphis, Tenn-Nov 17, 1940. J Pediatr 1941;19:259.
Pang S. Premature pubarche. Pediatr Adolesc Endocrinol 1984;13:173–84.
Virdis R, Zampolli M, Ibáñez L, Ghizzoni L, Street ME, Vicens-Calvet E. II pubarca prematuro. Riv Ital Pediatr (IJP) 1993;19:569–579.
Ibáñez L, Potau N, Albisu MA, Enríquez G, Gussinyé M, Carrascosa A, et al. Post-pubertal assessment in girls with premature pubarche: clinical, biochemical, and echographic findings. Horm Res 1990;33(Suppl 3):37. Abstract.

Sorted by citations

The Diagnosis of Polycystic Ovary Syndrome during Adolescence
Witchel, S. F., Oberfield, S., Rosenfield, R. L., Codner, E., Bonny, A., Ibáñez, L., Pena, A., Horikawa, R., Gomez-Lobo, V., Joel, D., et al. (2015) · Hormone Research in Paediatrics · doi:10.1159/000375530 · Cited by 3,113
Self-citation
Poly Cystic Ovarian Syndrome: An Updated Overview
Hayek, S. E., Bitar, L., Hamdar, L., Mirza, F., & Daoud, G. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00124 · Cited by 342
Prevalence of Polycystic Ovarian Syndrome in Indian Adolescents
Nidhi, R., Padmalatha, V., Nagarathna, R., & Ram, A. (2011) · Journal of Pediatric and Adolescent Gynecology · doi:10.1016/j.jpag.2011.03.002 · Cited by 320
GnRH and GnRH receptors in the pathophysiology of the human female reproductive system
Maggi, R., Cariboni, A. M., Marelli, M. M., Moretti, R. M., Andrè, V., Marzagalli, M., & Limonta, P. (2015) · Human Reproduction Update · doi:10.1093/humupd/dmv059 · Cited by 285
Treatment and Outcomes of Precocious Puberty: An Update
Fuqua, J. S. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1024 · Cited by 260
Steroidogenesis: Unanswered Questions
Miller, W. L. (2017) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2017.09.002 · Cited by 226
Early Metabolic Programming of Puberty Onset: Impact of Changes in Postnatal Feeding and Rearing Conditions on the Timing of Puberty and Development of the Hypothalamic Kisspeptin System
Castellano, J. M., Overgaard, A., Sanchez-Garrido, M. A., Ruíz-Pino, F., Romero, M., García-Galiano, D., Aguilar, E., Pinilla, L., Diéguez, C., Mikkelsen, J. D., et al. (2011) · Endocrinology · doi:10.1210/en.2010-1415 · Cited by 206
Polycystic Ovary Syndrome in Insulin-Resistant Adolescents with Obesity: The Role of Nutrition Therapy and Food Supplements as a Strategy to Protect Fertility
Calcaterra, V., Verduci, E., Cena, H., Magenes, V. C., Todisco, C. F., Tenuta, E., Gregorio, C., De Giuseppe, R., Bosetti, A., Di Profio, E., et al. (2021) · Nutrients · doi:10.3390/nu13061848 · Cited by 183
Polycystic ovary syndrome throughout a woman’s life
Group of interest in Reproductive Endocrinology (GIER) of the Spanish Fertility Society (SEF), Bellver, J., Rodríguez-Tabernero, L., Robles, A., Muñoz, E., Martínez, F., Landeras, J., García-Velasco, J., Fontes, J., Álvarez, M., et al. (2018) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-017-1047-7 · Cited by 180
Premature adrenarche: novel lessons from early onset androgen excess
Idkowiak, J., Lavery, G. G., Dhir, V., Barrett, T. G., Stewart, P. M., Krone, N., & Arlt, W. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0223 · Cited by 158
Polycystic ovary syndrome and impact on health
Allahbadia, G. N., & Merchant, R. (2010) · Middle East Fertility Society Journal · doi:10.1016/j.mefs.2010.10.002 · Cited by 127
Disorders of puberty
Sultan, C., Gaspari, L., Maı̈moun, L., Kalfa, N., & Paris, F. (2017) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2017.11.004 · Cited by 102
Polycystic Ovary Syndrome in the Pediatric Population
Bremer, A. A. (2010) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2010.0039 · Cited by 101
PCOS in adolescents
Diamanti‐Kandarakis, E. (2009) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2009.09.005 · Cited by 92
Approach to the Girl with Early Onset of Pubic Hair
Oberfield, S. E., Sopher, A. B., & Gerken, A. T. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0225 · Cited by 76
Polycystic ovarian syndrome–related depression in adolescent girls: A Review
Sadeeqa, S., Mustafa, T., & Latif, S. (2018) · Journal of Pharmacy And Bioallied Sciences · doi:10.4103/jpbs.jpbs_1_18 · Cited by 72
Urban Rural Comparisons of Polycystic Ovary Syndrome Burden among Adolescent Girls in a Hospital Setting in India
Balaji, S., Amadi, C., Prasad, S., Kasav, J. B., Upadhyay, V., Singh, A. K., Surapaneni, K. M., & Joshi, A. (2015) · BioMed Research International · doi:10.1155/2015/158951 · Cited by 69
Impact of Obesity on Gynecology
Pandey, S., & Bhattacharya, S. (2010) · Women s Health · doi:10.2217/whe.09.77 · Cited by 70
Metabolic control of female puberty: potential therapeutic targets
Castellano, J. M., & Tena‐Sempere, M. (2016) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2016.1212015 · Cited by 65
Associations of Obesity with Linear Growth and Puberty
Shalitin, S., & Gat‐Yablonski, G. (2021) · Hormone Research in Paediatrics · doi:10.1159/000516171 · Cited by 65
Prepubertal Adrenarchal Androgens and Animal Protein Intake Independently and Differentially Influence Pubertal Timing
Remer, T., Shi, L., Buyken, A. E., Maser‐Gluth, C., Hartmann, M. F., & Wudy, S. A. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2583 · Cited by 58
Cortisol Stimulates Secretion of Dehydroepiandrosterone in Human Adrenocortical Cells Through Inhibition of 3βHSD2
Topor, L. S., Asai, M., Dunn, J., & Majzoub, J. A. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0692 · Cited by 57
Emerging Genetic and Epigenetic Mechanisms Underlying Pubertal Maturation in Adolescence
Aylwin, C. F., Toro, C. A., Shirtcliff, E. A., & Lomniczi, A. (2019) · Journal of Research on Adolescence · doi:10.1111/jora.12385 · Cited by 60
Probiotics and Polycystic Ovary Syndrome: A Perspective for Management in Adolescents with Obesity
Calcaterra, V., Rossi, V., Massini, G., Casini, F., Zuccotti, G., & Fabiano, V. (2023) · Nutrients · doi:10.3390/nu15143144 · Cited by 64
Keeping Puberty on Time
Tena‐Sempere, M. (2013) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-396968-2.00011-7 · Cited by 51
Endocrinology and Gynecology of Girls and Women with Low Birth Weight
Ibáñez, L., López‐Bermejo, A., Díaz, M., & Marcos, M. V. (2011) · Fetal Diagnosis and Therapy · doi:10.1159/000330366 · Cited by 46
Self-citation
Executive functioning, cortisol reactivity, and symptoms of psychopathology in girls with premature adrenarche
Sontag-Padilla, L. M., Dorn, L. D., Tissot, A. M., Susman, E. J., Beers, S. R., & Rose, S. R. (2012) · Development and Psychopathology · doi:10.1017/s0954579411000782 · Cited by 47
Nutritional, Gastrointestinal and Endo-Metabolic Challenges in the Management of Children with Spinal Muscular Atrophy Type 1
Corsello, A., Scatigno, L., Pascuzzi, M. C., Calcaterra, V., Dilillo, D., Vizzuso, S., Pelizzo, G., Zoia, E., Mandelli, A., Govoni, A., et al. (2021) · Nutrients · doi:10.3390/nu13072400 · Cited by 40
Residential proximity to traffic and female pubertal development
McGuinn, L. A., Voss, R., Laurent, C. A., Greenspan, L. C., Kushi, L. H., & Windham, G. C. (2016) · Environment International · doi:10.1016/j.envint.2016.06.031 · Cited by 38
Precocious puberty
Neely, E. K., & Crossen, S. S. (2014) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0000000000000099 · Cited by 38
Update on Adrenarche—Still a Mystery
Augsburger, P., Liimatta, J., & Flück, C. E. (2024) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgae008 · Cited by 44
Features of Polycystic Ovary Syndrome in adolescence.
Tsikouras, P. N., Liatsikos, S. A., Manav, B., Zervoudis, S., Poiană, C., Nikolaos, T. P., Petros, P., Dimitraki, M., Koukouli, C., Galazios, G. C., et al. (2015) · Europe PMC (PubMed Central) · Cited by 36
The Changes They are A-Timed: Metabolism, Endogenous Clocks, and the Timing of Puberty
Tolson, K. P., & Chappell, P. E. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00045 · Cited by 37
Alternative splicing of DENND1A, a PCOS candidate gene, generates variant 2
Tee, M. K., Speek, M., Legeza, B., Modi, B. P., Teves, M. E., McAllister, J. M., Strauss, J. F., & Miller, W. L. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.06.011 · Cited by 35
High Fat Diet and Polycystic Ovary Syndrome (PCOS) in Adolescence: An Overview of Nutritional Strategies
Calcaterra, V., Magenes, V. C., Massini, G., De Sanctis, L., Fabiano, V., & Zuccotti, G. (2024) · Nutrients · doi:10.3390/nu16070938 · Cited by 35
From Placenta to Polycystic Ovarian Syndrome: The Role of Adipokines
Sartori, C., Lazzeroni, P., Merli, S., Patianna, V. D., Viaroli, F., Cirillo, F., Amarri, S., & Street, M. E. (2016) · Mediators of Inflammation · doi:10.1155/2016/4981916 · Cited by 37
Puberty
Witchel, S. F., & Topaloglu, A. K. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-47912-7.00017-2 · Cited by 42
Body mass index at the presentation of premature adrenarche is associated with components of metabolic syndrome at puberty
Kaya, G., Abalı, Z. Y., Baş, F., Poyrazoğlu, Ş., & Darendelıler, F. (2018) · European Journal of Pediatrics · doi:10.1007/s00431-018-3211-1 · Cited by 32
Use of metformin in pediatric age
Brufani, C., Fintini, D., Nobili, V., Patera, P. I., Cappa, M., & Brufani, M. (2011) · Pediatric Diabetes · doi:10.1111/j.1399-5448.2010.00741.x · Cited by 32
IGF2/H19 hypomethylation in a patient with very low birthweight, preocious pubarche and insulin resistance
Murphy, R., Ibáñez, L., Hattersley, A. T., & Tost, J. (2012) · BMC Medical Genetics · doi:10.1186/1471-2350-13-42 · Cited by 27
Self-citation
Pubertal development in daughters of women with pre-eclampsia
Øglænd, B., Nilsen, S. T., Forman, M. R., & VATTEN, L. J. (2010) · Archives of Disease in Childhood · doi:10.1136/adc.2009.178434 · Cited by 27
Is there an association between prenatal testosterone and autistic traits in adolescents?
Dooley, N., Ruigrok, A. N. V., Holt, R., Allison, C. L., Tsompanidis, A., Waldman, J., Bonnie Auyeung, B., Lombardo, M. V., & Baron‐Cohen, S. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105623 · Cited by 29
Acne Vulgaris in Preadolescent Children: Recommendations for Evaluation
Bree, A. F., & Siegfried, E. C. (2013) · Pediatric Dermatology · doi:10.1111/pde.12238 · Cited by 25
The endocrine manifestations of spinal muscular atrophy, a real-life observational study
Brener, A., Lebenthal, Y., Shtamler, A., Levy, S., Stein, R., Fattal‐Valevski, A., & Sagi, L. (2020) · Neuromuscular Disorders · doi:10.1016/j.nmd.2020.02.011 · Cited by 22
Higher Body Fat and Lower Fat-Free Mass in Girls with Premature Adrenarche
Cebeci, A. N., & Taş, A. (2015) · Journal of Clinical Research in Pediatric Endocrinology · doi:10.4274/jcrpe.1525 · Cited by 19
Polymorphisms of POR, SULT2A1 and HSD11B1 in children with premature adrenarche
Utriainen, P., Laakso, S. M., Jääskeläinen, J., & Voutilainen, R. (2012) · Metabolism · doi:10.1016/j.metabol.2012.02.008 · Cited by 18
The good, the bad, and the ugly facets of insulin resistance
Kumar, K. V. S. H. (2020) · Medical Journal Armed Forces India · doi:10.1016/j.mjafi.2019.07.001 · Cited by 18
Precocious puberty
Gangat, M., & Radovick, S. (2021) · Minerva Pediatrics · doi:10.23736/s0026-4946.20.05970-8 · Cited by 18
Clinical Presentation of Children With Premature Adrenarche
Oettingen, J. E. V., Pou, J. S., Levitsky, L. L., & Misra, M. (2012) · Clinical Pediatrics · doi:10.1177/0009922812456238 · Cited by 17
Pubertad normal y sus variantes
Calvo, M. T. M., & Pozo, J. (2011) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) · Cited by 15
Anti-Müllerian Hormone in Girls with Premature Adrenarche: The Impact of Polycystic Ovary Syndrome History in their Mothers
Efthymiadou, A., Μπογιατζίδου, Μ., Kritikou, D., & Chrysis, D. (2018) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2018.09.064 · Cited by 15
GnRH Neuron Excitability and Action Potential Properties Change with Development But Are Not Affected by Prenatal Androgen Exposure
Jaime, J., & Moenter, S. M. (2022) · eNeuro · doi:10.1523/eneuro.0362-22.2022 · Cited by 16
Fatty acid-binding protein-4 plasma levels are associated to metabolic abnormalities and response to therapy in girls and young women with androgen excess
Lázaro, I., Díaz, M., Cabré, A., Masana, L., & Ibáñez, L. (2011) · Gynecological Endocrinology · doi:10.3109/09513590.2011.569608 · Cited by 14
Self-citation
A New Model for Adrenarche: Inhibition of 3β-Hydroxysteroid Dehydrogenase Type 2 by Intra-Adrenal Cortisol
Majzoub, J. A., & Topor, L. S. (2018) · Hormone Research in Paediatrics · doi:10.1159/000488777 · Cited by 14
Associated Effects of Endocrine Disrupting Chemicals (EDCs) on Neuroendocrine Axes and Neurotransmitter Profile in Polycystic Ovarian Syndrome Condition
Ananthasubramanian, P., Ananth, S. V., Kumaraguru, S., Seetharaman, B., Santosh, W., & Vasantharekha, R. (2021) · Proceedings of the Zoological Society · doi:10.1007/s12595-021-00411-4 · Cited by 13
Pediatric and adolescent gynecology
Bieber, E. J., Sanfilippo, J. S., Horowitz, I., & Shafi, M. I. (2015) · Cambridge University Press eBooks · doi:10.1017/cbo9781139628938.035 · Cited by 19
A Putative Adverse Outcome Pathway Network for Disrupted Female Pubertal Onset to Improve Testing and Regulation of Endocrine Disrupting Chemicals
Franssen, D., Svingen, T., Rodríguez, D. L., van Duursen, M. B. M., Boberg, J., & Parent, A. (2021) · Neuroendocrinology · doi:10.1159/000515478 · Cited by 13
Effect of Nourishing “Yin” Removing “Fire” Chinese Herbal Mixture on Hypothalamic Mammalian Target of Rapamycin Expression during Onset of Puberty in Female Rats
Zeng, G., Han, X., Yu, J., Wang, Y., & Tian, Z. (2015) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2015/157846 · Cited by 11
Regulation of Human 3β-Hydroxysteroid Dehydrogenase Type 2 by Adrenal Corticosteroids and Product-Feedback by Androstenedione in Human Adrenarche
Thomas, J. L., Rajapaksha, M., Mack, V. L., DeMars, G., Majzoub, J. A., & Bose, H. S. (2014) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.114.219550 · Cited by 11
Vitamin D receptor gene polymorphisms and sex steroid secretion in girls with precocious pubarche in Southern Brazil: A pilot study.
dos Santos, B. R., Mascarenhas, L. P. G., Satler, F., Boguszewski, M. C. D. S., & Spritzer, P. M. (2012) · PubMed · doi:10.3275/7979 · Cited by 10
Circulating TNF-Alpha and IL-6 Concentrations and TNF-Alpha -308 G > A Polymorphism in Children with Premature Adrenarche
Utriainen, P., Jääskeläinen, J., Gröhn, O., Kuusisto, J., Pulkki, K. J., & Voutilainen, R. (2010) · Frontiers in Endocrinology · doi:10.3389/fendo.2010.00006 · Cited by 10
Investigation of early puberty prevalence and time of addition thelarche to pubarche in girls with premature pubarche: two-year follow-up results
OLGUN, E. G., Çetin, S. K., Şıklar, Z., Aycan, Z., Özsu, E., Ceran, A., & Berberoğlu, M. (2021) · Clinical Pediatric Endocrinology · doi:10.1297/cpe.2021-0042 · Cited by 9
Effectiveness of ZiYin Xiehuo granules and Zishen Qinggan granules on partial precocious puberty in girls: a multicenter, randomized, single-blind, controlled trial
Wen, S., Xinghui, H., Yonghong, W., Yu, J., Weili, Y., Zhao, J., Weibin, C., & Zheng, X. Y. (2018) · 中医杂志：英文版 · doi:10.1016/s0254-6272(18)30913-0 · Cited by 9
Postprandial plasma adiponectin response is reduced in prepubertal premature pubarche girls
Larqué, E., Gil‐Campos, M., Villada, I., Ramírez-Tortosa, M. C., Cañete, R., & Gil, Á. (2010) · Metabolism · doi:10.1016/j.metabol.2009.12.009 · Cited by 9
Age at Menarche and Its Potential Role in Early Detection of Hyperandrogenic Polycystic Ovary Syndrome
Manthey, C., Lynn, C. D., Ocobock, C. J., Cepon‐Robins, T. J., & Warrener, A. G. (2025) · American Journal of Biological Anthropology · doi:10.1002/ajpa.70046 · Cited by 7
Dose inhibin B or anti-Müllerian hormone relate to precocious puberty in girls? result of a systematic review and meta-analysis
Jiang, M., Gao, Y., Qu, T., Ji, Y., Niu, Y., Zhang, J., & Huang, L. (2023) · Journal of Ovarian Research · doi:10.1186/s13048-023-01302-2 · Cited by 7
Pubertal Timing Across Asian American, Native Hawaiian, and Pacific Islander Subgroups
Kubo, A., Acker, J., Aghaee, S., Kushi, L. H., Quesenberry, C. P., Greenspan, L. C., Srinivasan, S., Kanaya, A. M., & Deardorff, J. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.10253 · Cited by 7
Increased Prepubertal Body Weight Enhances Leptin Sensitivity in Proopiomelanocortin and Neuropeptide Y Neurons Before Puberty Onset in Female Rats
Castro-González, D., Fuente-Martín, E., Sanchez-Garrido, M. A., Argente-Arizón, P., Tena‐Sempere, M., Barrios, V., Chowen, J. A., & Argente, J. (2015) · Endocrinology · doi:10.1210/en.2014-1759 · Cited by 7
Premature adrenarche and metabolic risk: a systematic review and meta-analysis
Said, W. B., Lempesis, I. G., Fernandez-Garcia, S., Thangaratinam, S., Arlt, W., & Idkowiak, J. (2025) · European Journal of Endocrinology · doi:10.1093/ejendo/lvaf167 · Cited by 6
Pelvic and breast ultrasound abnormalities and associated metabolic disturbances in girls with premature pubarche due to adrenarche
Aydın, B. K., Kadıoğlu, A., Kaya, G., Devecioğlu, E., Baş, F., Poyrazoğlu, Ş., Gökçay, G., & Darendelıler, F. (2021) · Clinical Endocrinology · doi:10.1111/cen.14662 · Cited by 5
Association of childhood dehydroepiandrosterone sulfate concentration, pubertal development, and DNA methylation at puberty-related genes
Sudman, M., Stöger, R. J., Bentley, G. R., & Melamed, P. (2024) · European Journal of Endocrinology · doi:10.1093/ejendo/lvae156 · Cited by 4
The relationship between metabolic disorders and small for gestational age with idiopathic premature adrenarche
Mejorado-Molano, F. J., Zallo, L. A., Rodríguez, M. F., Segura, P. P., Gavela‐Pérez, T., Calvo, M. L. S., & Guillén, L. S. (2017) · Anales de Pediatría (English Edition) · doi:10.1016/j.anpede.2016.10.018 · Cited by 3
Adrenarche and Adrenopause
Hughes, I. A., & Chatterjee, K. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-18907-1.00105-0 · Cited by 3
Early Metformin Therapy (Age 8–12Years) in Girls with Precocious Pubarche to Reduce Hirsutism, Androgen Excess, and Oligomenorrhea in Adolescence
Meikle, A. W. (2012) · Yearbook of Endocrinology · doi:10.1016/j.yend.2012.03.010 · Cited by 3
Evaluation of metabolic parameters and aortic elasticity in normotensive children with premature adrenarche
Topaktaş, E., Erolu, E., Dursun, F., & Kırmızıbekmez, H. (2021) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem-2021-0160 · Cited by 3
Hirsutismo y trastornos menstruales en la adolescencia
Ibáñez, L., Marcos, M. V., & Díaz, R. (2009) · Anales de Pediatría Continuada · doi:10.1016/s1696-2818(09)71118-7 · Cited by 2
Self-citation
Estudio de la asociación de adrenarquia prematura idiopática con la presencia de alteraciones metabólicas y con antecedente de pequeño para edad gestacional
Mejorado-Molano, F. J., Zallo, L. A., Rodríguez, M. F., Segura, P. P., Gavela‐Pérez, T., Calvo, M. L. S., & Guillén, L. S. (2016) · Anales de Pediatría · doi:10.1016/j.anpedi.2016.10.004 · Cited by 2
p.Gln318X and p.Val281Leu as the Major Variants of CYP21A2 Gene in Children with Idiopathic Premature Pubarche
Soveizi, M., Mahdieh, N., Setoodeh, A., Sayarifard, F., Abbasi, F., Bose, H. S., Rabbani, B., & Rabbani, A. (2020) · International Journal of Endocrinology · doi:10.1155/2020/4329791 · Cited by 2
Evolución natural de la pubarquia precoz y posibles patologías asociadas
Rodríguez, M. L. S., Bueno, G., Aizpún, J. I. L., & Muñoz, A. D. A. (2018) · Anales de Pediatría · doi:10.1016/j.anpedi.2017.11.012 · Cited by 2
Natural progression of premature pubarche and underlying diseases
Rodríguez, M. L. S., Lozano, G. B., Aizpún, J. I. L., & Muñoz, A. D. A. (2018) · Anales de Pediatría (English Edition) · doi:10.1016/j.anpede.2018.08.003 · Cited by 2
Concomitant impact of polycystic ovarian syndrome and associated comorbidities on cognitive functions, neurotransmitters, and metabolic enzymes in Indian womenPreprint
Ananthasubramanian, P., Nair, R. S., Priyanka, H. P., Seetharaman, B., & Vasantharekha, R. (2022) · Research Square · doi:10.21203/rs.3.rs-2063962/v1 · Cited by 2
Hiperandrogenismo: pubarquia precoz y síndrome de ovario poliquístico. Etiología y posibilidades terapéuticas
Blanco, L. G., & Azcona, C. (2012) · Pediatría Atención Primaria · doi:10.4321/s1139-76322012000100011 · Cited by 1
Association between 2D:4D digit ratios and metabolic markers and hormonal parameters in children with premature adrenarche: A cross-sectional study from Türkiye
Koç, P., Kömürlüoğlu, A., & Çelik, N. (2025) · Early Human Development · doi:10.1016/j.earlhumdev.2025.106391 · Cited by 1
Adrenarche and Adrenopause
Hughes, I. A., & Chatterjee, K. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-5583-9.00104-0 · Cited by 1
Pubertad precoz como motivo de consulta en endocrinología pediátrica
Fagoaga, L. B., Sáez, J., Torres, K. A., & Lurbe, E. (2010) · Acta pediátrica española/Acta pediátrica española · Cited by 1
Adolesanda Polikistik Over Sendromu
Şahi̇n, L., & Aygün, B. (2013) · DergiPark (Istanbul University) · Cited by 1
Prevalence, Symptomatology and Herbal Management of Polycystic Ovarian Syndrome
Sultana, S., Akhter, N., Akram, M., Shah, S. M. A., Munir, N., Riaz, M., Aziz-ur-Rehman, Perveen, S., & Ashraf, T. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.95319 · Cited by 1
Precocious puberty
Rowan, S., & Murray, P. J. (2015) · Cambridge University Press eBooks · doi:10.1017/cbo9781139628938.036 · Cited by 1
Body Composition Analysis in Girls With Premature Adrenarche
Cebeci, A. N., & Taş, A. (2014) · 53rd ESPE Meeting
Prevalencia de ovario poliquístico en adolescentes sanas y en adolescentes con antecedentes de pubarquía precoz. Nuevas aportaciones de la ecografía tridimensional
Cuevas, N. C. (2012) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Cardiovascular Disease Risk Factors in Girls with Isolated Premature Pubarche
Nascimento, T. B., Werle, T. V., & Vargas, D. M. (2015) · 54th Annual ESPE
The Diagnosis of Polycystic Ovary Syndrome during Adolescence
Marina, P., & Beirut, L. (2016)
Les androgènes : de la conception à la puberté féminine Androgens: from fetal life to puberty
Bouvattier, C. M. (2012)
Prematüre Pubarş Olgularının Değerlendirilmesi: Tek Merkez Deneyimi
Göktuğ, A. Y., Aycan, Z., Önder, A., Sağsak, E., Keskın, M., & Çetinkaya, S. Ç. (2016) · Turkish Journal of Pediatric Disease · doi:10.12956/tjpd.2016.249
Menstrual myths, morals and milestones: a paediatric miasma
Zacharin, M. (2017) · Archives of Disease in Childhood · doi:10.1136/archdischild-2017-313417
Evaluation of hematological parameters in cases with premature adrenarche
Çelik, N., Çamtosun, E., & Dündar, İ. (2018) · Ortadoğu Tıp Dergisi · doi:10.21601/ortadogutipdergisi.429250
Enfermedades de las gónadas
Hernández, J. Á. F.-T., Salinas, I., Bassas, L., Audí, L., & Toda, L. I. (2014) · Elsevier eBooks · doi:10.1016/b978-84-9022-595-0.00021-1
Faculty Opinions recommendation of Polycystic ovary syndrome throughout a woman's life.
dos Reis, F. M. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.731435450.793559354
Evaluation of cardiac electrophysiological features in patients with premature adrenarche
Ertaş, K., Gül, Ö., Yıldırım, R., & Özalkak, Ş. (2024) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem-2023-0460
Prevalence, Knowledge and Awareness of polycystic ovary syndrome: A study among the Bengali speaking Hindus and Muslims of Kolkata, West Bengal
Ghosh, T., Pal, B., Maji, S., & Goswami, M. (2024) · International Journal of Science and Research Archive · doi:10.30574/ijsra.2024.11.2.0480

Authors: Ibáñez, L., Díaz, R., López-Bermejo, A., & Marcos, M. V.
Affiliations: Hospital Sant Joan de Déu Barcelona (ES)
Corresponding author: Ibáñez, Lourdes
ORCID: Ibáñez, Lourdes
Venue: Reviews in Endocrine and Metabolic Disorders
Publisher: Springer Science and Business Media LLC
Published: 2008-08-26
Volume: 10
Issue: 1
Pages: 63-76
ISSN: 1389-9155 (ISSN-L)
1573-2606
DOI: 10.1007/s11154-008-9096-y
OpenAlex: W2072284140
Cited by: 106
References: 138
Citations by year: 2026: 3 · 2025: 5 · 2024: 6 · 2023: 3 · 2022: 2 · 2021: 11 · 2020: 3 · 2019: 3 · 2018: 8 · 2017: 5 · 2016: 8 · 2015: 11 · 2014: 4 · 2013: 4 · 2012: 10
FWCI: 0.94
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Reviews in Endocrine and Metabolic Disorders (publishedVersion)
PubMed (publishedVersion)
Funders: Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
Topics: Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
Keywords: premature pubarche, metabolic syndrome, ovarian hyperandrogenism, polycystic ovary syndrome, hyperinsulinemia, catch-up growth, low birth weight, fetal growth restriction, metformin, insulin sensitization, pubertal timing, adult height, visceral fat, body composition, bone mineralization
MeSH terms: Blood Pressure, Body Composition, Body Height, Female, Humans, Infant, Low Birth Weight, Infant, Newborn, Insulin, Lipids, Polycystic Ovary Syndrome, Puberty, Puberty, Precocious, Hyperandrogenism, Metabolic Syndrome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Clinical spectrum of premature pubarche: Links to metabolic syndrome and ovarian hyperandrogenism

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks